Sdc3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sdc3
Entrez Gene ID	116673
Full Name	syndecan 3
General protein information	Preferred Names syndecan 3 Names syndecan-3 N-syndecan SYND3 neuroglycan
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	mediates adhesion of Schwann cells to alpha4 type (V) collagen [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053893.3	NP_446345.3	syndecan-3 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Sdc3	NP_035650.2
Rattus norvegicus (Norway rat)	Sdc3	NP_446345.3
Gallus gallus (chicken)	SDC3	NP_990714.1
Xenopus tropicalis (tropical clawed frog)	sdc3	XP_002938874.1
Homo sapiens (human)	SDC3	NP_055469.3
Pan troglodytes (chimpanzee)	SDC3	XP_001149044.2
	SDC3	XP_001092729.2
Canis lupus familiaris (dog)	SDC3	XP_005617740.1
Bos taurus (cattle)	SDC3	NP_001193460.1

Gene Ontology
Bibliography

Related articles in PubMed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

The Conserved Phenylalanine in the Transmembrane Domain Enhances Heteromeric Interactions of Syndecans.
Kwon MJ, Park J, Jang S, Eom CY, Oh ES
The Journal of biological chemistry291(2)872-81(2016 Jan)

Binding of Y-P30 to syndecan 2/3 regulates the nuclear localization of CASK.
Landgraf P, Mikhaylova M, Macharadze T, Borutzki C, Zenclussen AC, Wahle P, Kreutz MR
PloS one9(2)e85924(2014)

A novel role for syndecan-3 in angiogenesis.
De Rossi G, Whiteford JR
F1000Research2270(2013)

The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity.
Landgraf P, Wahle P, Pape HC, Gundelfinger ED, Kreutz MR
The Journal of biological chemistry283(36)25036-45(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that Y-P30 can control the nuclear localization of Calcium/calmodulin-dependent serine kinase (CASK) in a syndecan (SDC) -2 and -3 -dependent manner.
Title: Binding of Y-P30 to syndecan 2/3 regulates the nuclear localization of CASK.

pleiotrophin (PTN) and syndecan-2 and -3 as direct binding partners of Y-P30.
Title: The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity.

Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly expressed in the striatum during developmen
Title: Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.

Because AGRP is cleaved before secretion, syndecan-3 must influence food intake independently of the MC4-R.
Title: Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3.

Syndecan-3 is synthesized by oligodendrocyte progenitors (but not terminally differentiated oligodendrocytes) and is up-regulated by FGF-2.
Title: Syndecan-3 and perlecan are differentially expressed by progenitors and mature oligodendrocytes and accumulate in the extracellular matrix.

The following Sdc3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sdc3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa40024	NM_053893.3 Latest version!	Rattus norvegicus syndecan 3 (Sdc3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sdc3 ( NM_053893.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446345.3 Rattus norvegicus syndecan 3 (Sdc3), mRNA.

Price & Availability↑

CloneID	ORa40024
Clone ID Related Accession (Same CDS sequence)	NM_053893.3
Accession Version	NM_053893.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1329bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Rattus norvegicus(Norway rat)
Product	syndecan-3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U73184.1, U52825.1 and AABR07050041.1. On Oct 11, 2007 this sequence version replaced NM_053893.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U52825.1, U73184.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCCG GGCCGCCGCG CCGCGGGACC GCACAGGGGC AGCGCGTGGA CACCGCCACC 
CATGGGCCCG GGGCCCGCGG GTTGTTACTG CCACCGCTGC TGCTGCTGTT GCTGGCCGGC 
CGCGCCGCGG GGGCTCAACG CTGGCGCAAT GAGAACTTCG AGAGGCCGGT GGATCTTGAG 
GGCTCAGGGG ACGACGACTC ATTTCCTGAT GATGAACTGG ATGACCTCTA CTCGGGGTCG 
GGCTCTGGCT ACTTCGAGCA GGAGTCCGGC CTTGAGACAG CCATGCGGTT CATTCCTGAC 
ATAGCCCTGG CTGCACCCAC CGCACCTGCC ATGCTACCCA CGACCGTTAT CCAGCCCGTG 
GATACCCCGT TTGAGGAACT CCTTTCTGAG CATCCCGGCC CCGAACCAGT CACCAGTCCC 
CCACTGGTGA CAGAGGTGAC AGAAGTTGTA GAAGAGCCCA GTCAGAGAGC CACCACTATC 
TCCACCACCA CATCTACCAC TGCAGCCACC ACCACAGGGG CCCCAACTAT GGCCACAGCA 
CCTGCTACAG CAGCCACCAC TGCCCCTAGC ACTCCCGCGG CACCCCCTGC CACGGCCACC 
ACGGCTGACA TAAGGACCAC CGGCATACAA GGGCTGCTGC CTCTTCCCCT GACCACGGCT 
GCCACAGCCA AGGCCACTAC CCCAGCAGTA CCCTCACCAC CCACTACTGT GGCTACCTTG 
GACACAGAGG CCCCGACACC TAGGCTGGTC AACACAGCTA CCTCTCGGCC ACGAGCCCTT 
CCTCGGCCAG TCACCACCCA GGAGCCTGAA GTTGCTGAGA GGAGTACCCT GCCGTTGGGG 
ACCACCGCTC CTGGACCCAC AGAGGTGGCT CAGACCCCAA CTCCAGAGTC CCTTCTGACC 
ACGACCCAGG ATGAGCCAGA GGTGCCAGTA AGCGGGGGGC CCAGCGGGGA CTTTGAGCTG 
CAAGAAGAGA CCACACAGCC AGACACAGCC AATGAAGTGG TGGCGGTGGA AGGAGCCGCG 
GCCAAGCCAT CACCTCCACT GGGGACACTA CCCAAGGGTG CCCGCCCAGG CCTTGGCCTC 
CACGACAATG CCATCGACTC GGGCAGCTCT GCTGCCCAGC TCCCTCAGAA GAGCATACTA 
GAGCGGAAGG AGGTGCTCGT AGCTGTGATC GTAGGTGGCG TGGTGGGCGC CCTCTTCGCT 
GCCTTCCTGG TCACGTTGCT CATCTACCGC ATGAAGAAGA AGGACGAAGG CAGCTACACC 
TTGGAAGAGC CCAAGCAGGC AAGCGTCACA TACCAGAAGC CCGACAAGCA GGAGGAGTTC 
TATGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446345.3
CDS	47..1375
Translation	MKPGPPRRGTAQGQRVDTATHGPGARGLLLPPLLLLLLAGRAAGAQRWRNENFERPVDLEGSGDDDSFPDDELDDLYSGSGSGYFEQESGLETAMRFIPDIALAAPTAPAMLPTTVIQPVDTPFEELLSEHPGPEPVTSPPLVTEVTEVVEEPSQRATTISTTTSTTAATTTGAPTMATAPATAATTAPSTPAAPPATATTADIRTTGIQGLLPLPLTTAATAKATTPAVPSPPTTVATLDTEAPTPRLVNTATSRPRALPRPVTTQEPEVAERSTLPLGTTAPGPTEVAQTPTPESLLTTTQDEPEVPVSGGPSGDFELQEETTQPDTANEVVAVEGAAAKPSPPLGTLPKGARPGLGLHDNAIDSGSSAAQLPQKSILERKEVLVAVIVGGVVGALFAAFLVTLLIYRMKKKDEGSYTLEEPKQASVTYQKPDKQEEFYA

Target ORF information:

RefSeq Version	NM_053893.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus syndecan 3 (Sdc3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053893.3

ORF Insert Sequence:

ATGAAGCCCG GGCCGCCGCG CCGCGGGACC GCACAGGGGC AGCGCGTGGA CACCGCCACC 
CATGGGCCCG GGGCCCGCGG GTTGTTACTG CCACCGCTGC TGCTGCTGTT GCTGGCCGGC 
CGCGCCGCGG GGGCTCAACG CTGGCGCAAT GAGAACTTCG AGAGGCCGGT GGATCTTGAG 
GGCTCAGGGG ACGACGACTC ATTTCCTGAT GATGAACTGG ATGACCTCTA CTCGGGGTCG 
GGCTCTGGCT ACTTCGAGCA GGAGTCCGGC CTTGAGACAG CCATGCGGTT CATTCCTGAC 
ATAGCCCTGG CTGCACCCAC CGCACCTGCC ATGCTACCCA CGACCGTTAT CCAGCCCGTG 
GATACCCCGT TTGAGGAACT CCTTTCTGAG CATCCCGGCC CCGAACCAGT CACCAGTCCC 
CCACTGGTGA CAGAGGTGAC AGAAGTTGTA GAAGAGCCCA GTCAGAGAGC CACCACTATC 
TCCACCACCA CATCTACCAC TGCAGCCACC ACCACAGGGG CCCCAACTAT GGCCACAGCA 
CCTGCTACAG CAGCCACCAC TGCCCCTAGC ACTCCCGCGG CACCCCCTGC CACGGCCACC 
ACGGCTGACA TAAGGACCAC CGGCATACAA GGGCTGCTGC CTCTTCCCCT GACCACGGCT 
GCCACAGCCA AGGCCACTAC CCCAGCAGTA CCCTCACCAC CCACTACTGT GGCTACCTTG 
GACACAGAGG CCCCGACACC TAGGCTGGTC AACACAGCTA CCTCTCGGCC ACGAGCCCTT 
CCTCGGCCAG TCACCACCCA GGAGCCTGAA GTTGCTGAGA GGAGTACCCT GCCGTTGGGG 
ACCACCGCTC CTGGACCCAC AGAGGTGGCT CAGACCCCAA CTCCAGAGTC CCTTCTGACC 
ACGACCCAGG ATGAGCCAGA GGTGCCAGTA AGCGGGGGGC CCAGCGGGGA CTTTGAGCTG 
CAAGAAGAGA CCACACAGCC AGACACAGCC AATGAAGTGG TGGCGGTGGA AGGAGCCGCG 
GCCAAGCCAT CACCTCCACT GGGGACACTA CCCAAGGGTG CCCGCCCAGG CCTTGGCCTC 
CACGACAATG CCATCGACTC GGGCAGCTCT GCTGCCCAGC TCCCTCAGAA GAGCATACTA 
GAGCGGAAGG AGGTGCTCGT AGCTGTGATC GTAGGTGGCG TGGTGGGCGC CCTCTTCGCT 
GCCTTCCTGG TCACGTTGCT CATCTACCGC ATGAAGAAGA AGGACGAAGG CAGCTACACC 
TTGGAAGAGC CCAAGCAGGC AAGCGTCACA TACCAGAAGC CCGACAAGCA GGAGGAGTTC 
TATGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

The Conserved Phenylalanine in the Transmembrane Domain Enhances Heteromeric Interactions of Syndecans.
The Journal of biological chemistry291(2)872-81(2016 Jan)
Kwon MJ,Park J,Jang S,Eom CY,Oh ES

Binding of Y-P30 to syndecan 2/3 regulates the nuclear localization of CASK.
PloS one9(2)e85924(2014)
Landgraf P,Mikhaylova M,Macharadze T,Borutzki C,Zenclussen AC,Wahle P,Kreutz MR

A novel role for syndecan-3 in angiogenesis.
F1000Research2270(2013)
De Rossi G,Whiteford JR

The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity.
The Journal of biological chemistry283(36)25036-45(2008 Sep)
Landgraf P,Wahle P,Pape HC,Gundelfinger ED,Kreutz MR