Map3k1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Map3k1
Entrez Gene ID	116667
Full Name	mitogen-activated protein kinase kinase kinase 1
Synonyms	Mekk1
General protein information	Preferred Names mitogen-activated protein kinase kinase kinase 1 Names mitogen-activated protein kinase kinase kinase 1 MAPK/ERK kinase kinase 1 MEK kinase 1 MEKK 1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q14
Summary	kinase that has E3 ubiquitin ligase to mediate ubiquitination and degradation of ERK1/2 [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053887.1	NP_446339.1	mitogen-activated protein kinase kinase kinase 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MAP3K1	NP_005912.1
Rattus norvegicus (Norway rat)	LOC100912399	XP_006231988.1
	MAP3K1	XP_002804414.1
Canis lupus familiaris (dog)	MAP3K1	XP_535240.4
Xenopus tropicalis (tropical clawed frog)	map3k1	XP_002940279.2
Rattus norvegicus (Norway rat)	Map3k1	NP_446339.1
Pan troglodytes (chimpanzee)	MAP3K1	XP_003310777.1
Bos taurus (cattle)	MAP3K1	NP_001192835.1
Mus musculus (house mouse)	Map3k1	NP_036075.2
Gallus gallus (chicken)	MAP3K1	XP_424734.3
Danio rerio (zebrafish)	map3k1	XP_002663531.2

Gene Ontology
Bibliography

Related articles in PubMed

MEKK1 Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.
Lu H, Ning X, Tao X, Ren J, Song X, Tao W, Zhu L, Han L, Tao T, Yang J
Neurochemical research41(12)3308-3321(2016 Dec)

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.
Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E
The EMBO journal33(21)2581-96(2014 Nov)

Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1.
Meng Q, Mongan M, Wang J, Tang X, Zhang J, Kao W, Xia Y
Developmental biology395(1)29-37(2014 Nov)

Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis.
Jin C, Chen J, Meng Q, Carreira V, Tam NN, Geh E, Karyala S, Ho SM, Zhou X, Medvedovic M, Xia Y
Developmental biology374(1)96-107(2013 Feb)

Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene.
denDekker AD, Xu X, Vaughn MD, Puckett AH, Gardner LL, Lambring CJ, Deschenes L, Samuelson DJ
Cancer research72(22)6002-12(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MEKK1 may play a role in promoting the brain damage following intracerebral hemorrhage
Title: MEKK1 Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.

Zinc-deficient rats had significantly decreased protein expression of pMEK, pERK1/2, and pCREB in the hippocampus.
Title: Depressed hippocampal MEK/ERK phosphorylation correlates with impaired cognitive and synaptic function in zinc-deficient rats.

Signaling pathways that augment or diminish beta-cell MEKK-1 activity may aid in the generation of novel therapeutic strategies in the treatment of type 1 diabetes.
Title: The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death.

ischemia/reperfusion induces caspase-3 mediated proteolytic cleavage of MEKK1 and promotes p53 transcriptional activity via JNK-independent mechanisms
Title: Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity.

MEKK1 probably activates a transcriptional partner of c-Jun whose activity is maintained or increased in the presence of the rat cholecystokinin 1 receptor but repressed in the presence of the mouse cholecystokinin 1 receptor.
Title: Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptor.

The following Map3k1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Map3k1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10966	NM_053887.1 Latest version!	Rattus norvegicus mitogen-activated protein kinase kinase kinase 1 (Map3k1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$727.30 $1039.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Map3k1 ( NM_053887.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446339.1 Rattus norvegicus mitogen-activated protein kinase kinase kinase 1 (Map3k1), mRNA.

Price & Availability↑

CloneID	ORa10966
Clone ID Related Accession (Same CDS sequence)	NM_053887.1
Accession Version	NM_053887.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase kinase kinase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U48596.1. On Jun 25, 2006 this sequence version replaced XM_001074670.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U48596.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCGG CGGCGGGCGA TCGCGCCTCG TCGTCGGGAT TCCCGGGCGC CGCGGCGGCG 
AGCCCCGAGG CGGGCGGCGG CGGCGGAGCT CTCCAGGGAA GCGGCGCGCC CGCAGCGGGC 
GCGGGGCTGC TGCGGGAGAC TGGCAGCGCG GGCCGCGAGC GCGCGGACTG GCGGCGGCAG 
CAGCTGCGCA AAGTAAGGAG TGTGGAGCTG GACCAGCTGC CGGAGCAGCC GCTCTTCCTC 
ACCGCCTCGC CGCCCTGCCC ATCTACTTCC CCGTCGCCGG AGCCCGCGGA CGCGGCTGCA 
GGAGCGAGTG GCTTCCAGCC TGCGGCGGGA CCGCCACCCC CGGGAGCAGC GAGTCGCTGC 
GGCTCCCACT CTGCCGAGCT GGCGGCCGCG CGGGACAGCG GCGCCCGGAG CCCCGCGGGG 
GCCGAGCCGC CCTCTGCAGC GGCCCCCTCC GGTCGAGAGA TGGAGAATAA AGAAACCCTC 
AAAGGATTGC ACAAGATGGA TGACCGCCCA GAGGAGCGAA TGATCAGGGA GAAGCTCAAG 
GCGACCTGTA TGCCTGCCTG GAAGCACGAG TGGTTAGAAA GGAGGAACAG GAGAGGCCCT 
GTGGTGGTGA AACCAATCCC TATTAAAGGA GATGGATCTG AAATGAGTAA CTTGGCAGCT 
GAGCTCCAAG GAGAGGGCCA GGCAGGCTCT GCTGCACCAG CTCCCAAGGG CCGACGAAGC 
CCGTCTCCTG GAAGCTCCCC ATCAGGGCGC TCAGGGAAGC CGGAATCCCC AGGAGTGAGA 
CGGAAACGAG TGTCCCCAGT GCCTTTCCAG AGTGGCAGAA TCACACCACC TCGAAGAGCC 
CCGTCGCCAG ATGGCTTCTC ACCGTACAGC CCAGAGGAGA CGAGCCGCCG TGTGAACAAA 
GTGATGAGGG CCAGGCTGTA CCTCCTGCAG CAGATAGGAC CCAACTCTTT CCTGATTGGA 
GGAGACAGTC CAGACAATAA ATACCGCGTG TTTATTGGGC CACAGAACTG CAGCTGTGGG 
CGTGGGACAT TCTGCATTCA CCTCTTGTTT GTCATGCTCC GGGTGTTCCA GCTAGAACCC 
TCCGACCCCA TGCTATGGAG AAAAACTTTA AAAAATTTTG AGGTTGAGAG TTTGTTCCAG 
AAATACCACA GTAGGCGTAG CTCAAGAATC AAAGCTCCAT CTCGGAACAC CATCCAGAAG 
TTTGTCTCAC GCATGTCAAA CTGTCACACA TTGTCATCGT CTAGCACATC CACATCTAGT 
TCAGAAAACA GCATCAAGGA TGAAGAGGAG CAGATGTGTC CCATCTGCTT GTTGGGCATG 
CTGGATGAGG AGAGCCTGAC TGTGTGTGAA GACGGCTGCA GGAACAAGCT GCACCACCAC 
TGCATGTCAA TCTGGGCAGA AGAATGTAGA AGAAATAGAG AACCGTTAAT ATGTCCCCTT 
TGTAGATCTA AGTGGAGATC CCATGACTTC TACAGCCATG AGTTATCAAG CCCTGTGGAT 
TCCCCTACCT CCCTGCGAGG TGTACAGCAG CCCTCCTCCC CGCAACAGCC TGTGGCCGGA 
TCACAGCGGA GGAATCAGGA AAGCAATTTT AACCTTACTC ATTATGGAAC CCAGCAGATT 
CCTCCCGCTT ACAAAGATTT AGCCGAGCCA TGGATTCAGG CATTCGGAAT GGAGCTCGTT 
GGCTGCTTAT TCTCTAGAAA CTGGAACGTA AGGGAGATGG CCCTTAGGCG CCTTTCCCAC 
GATGTTAGCG GGGCCCTGTT GTTGGCGAAC GGGGAGAGCA CTGGAACTTC TGGAGGCGGC 
AGCGGAGGCA GCCTAAGTGC TGGCGCCGCC AGTGGGTCTT CCCAGCCCAG CATCTCAGGG 
GACGTGGTGG AGGCGTTCTG CAGCGTCCTG TCTATCGTGT GCGCTGACCC TGTCTACAAA 
GTGTACGTTG CTGCTTTAAA AACACTGAGA GCCATGCTGG TATACACTCC TTGCCACAGC 
CTGGCAGAAA GAATCAAACT TCAGAGACTT CTCCGGCCAG TGGTAGACAC CATCCTAGTG 
AAGTGCGCAG ACGCCAATAG CCGCACGAGT CAGCTGTCCA TATCAACACT GTTGGAGCTC 
TGCAAGGGCC AAGCGGGGGA GTTGGCAGTT GGACGAGAAA TACTTAAAGC TGGATCCATC 
GGTGTTGGTG GCGTTGATTA CGTCTTAAGT TGTATTCTTG GAAACCAAGC TGAATCAAAC 
AACTGGCAAG AACTCCTGGG TCGCCTCTGT CTTATAGACA GATTGCTCTT GGAAATTTCT 
GCGGAATTTT ATCCTCATAT TGTCAGTACC GATGTCTCAC AAGCCGAGCC TGTTGAAATC 
AGGTATAAGA AGCTGCTGTC CCTCTTAGCC TTTGCCTTGC AATCCATTGA CAATTCCCAC 
TCTATGGTCG GCAAACTCTC GCGGAGGATT TATCTGAGCT CAGCACGAAT GGTGACCACA 
GTGCCCCCCC TGTTTTCCAA GCTGGTAACC ATGCTAAGTG CTTCTGGATC CTCCCACTTC 
GCCAGGATGC GCCGGCGTCT GATGGCCATT GCAGACGAGG TAGAAATTGC CGAGGTCATC 
CAGCTGGGTT CGGAAGACAC TTTGGATGGC CAGCAGGACA GCTCGCAGGC ATTGGCCCCT 
CCCCGCTATC CAGAGAGCAG CTCCCTTGAG CACACAGCCC ATGTAGAGAA AACTGGAAAA 
GGATTAAAAG CTACGAGACT GAGTGCCAGC TCAGAGGACA TTTCTGACAG ACTGGCTGGC 
GTTTCTGTAG GACTTCCTAG TTCAGCAACA ACAGAACAAC CAAAGCCAAC AGTTCAAACA 
AAAGGCAGAC CCCACAGTCA GTGTTTGAAC TCCTCTCCTT TGTCTCCTCC TCAGTTAATG 
TTTCCAGCAA TATCAGCCCC ATGTTCATCT GCCCCGTCTG TCCCAGCTGG CTCTGTAACA 
GATGCTTCTA AGCATAGACC TCGGGCGTTT GTTCCCTGTA AAATACCCTC TGCGTCTCCC 
CAAACACAGC GCAAGTTTTC CCTACAGTTC CAGAGGACCT GCTCTGAGAA CCGAGACTCA 
GAAAAACTCT CCCCAGTCTT TACTCAGTCG AGACCCCCAC CCTCCAGTAA CATACACAGG 
GCAAAGGCAT CCCGACCCGT TCCGGGTAGC ACAAGCAAAC TAGGGGATGC CTCAAAAAAC 
AGCATGACAC TCGACCTGAA CAGTGCTTCC CAGTGTGATG ACAGCTTTGG CAGTGGCAGC 
AACAGTGGCA GCGCCGTCAT ACCCAGTGAG GAGACGGCAT TCACCCCAGC AGAGGACAAG 
TGCAGGTTAG ATGTCAACCC CGAGCTCAAC TCCAGTATCG AGGACCTTCT TGAAGCATCT 
ATGCCTTCAA GTGACACAAC AGTCACTTTC AAGTCCGAAG TCGCCGTCCT CTCTCCTGAG 
AAGGCCGAAA GTGATGACAC CTACAAAGAT GACGTCAATC ACAATCAAAA GTGCAAAGAG 
AAGATGGAGG CTGAGGAAGA GGAGGCGCTC GCGATTGCCA TGGCAATGTC GGCTTCTCAG 
GACGCCCTCC CCATAGTCCC TCAGCTGCAG GTGGAAAATG GAGAGGATAT CATCATCATC 
CAGCAGGATA CACCAGAAAC CCTACCAGGG CATACCAAAG CGAACGAGCC CTACAGAGAA 
GACACCGAGT GGCTGAAAGG GCAGCAGATA GGCCTCGGAG CATTTTCTTC TTGTTACCAA 
GCACAGGATG TGGGCACTGG AACTTTAATG GCTGTGAAAC AGGTGACCTA CGTCAGAAAC 
ACATCTTCTG AGCAGGAGGA AGTGGTGGAA GCCTTGAGGG AAGAGATCAG GATGATGAGC 
CACCTCAACC ATCCGAACAT CATCAGGATG CTGGGGGCCA CGTGCGAGAA GAGCAACTAC 
AACCTCTTCA TCGAGTGGAT GGCGGGAGCC TCCGTGGCTC ACCTCTTGAG TAAATATGGA 
GCTTTCAAGG AGTCAGTGGT CATTAACTAC ACAGAGCAGT TACTCCGTGG CCTTTCCTAT 
CTCCACGAGA ACCAGATCAT TCACAGAGAC GTCAAAGGGG CCAATCTGCT CATTGACAGC 
ACCGGTCAGC GGCTGAGAAT TGCAGACTTC GGTGCTGCCG CCAGGTTGGC ATCCAAAGGA 
ACTGGTGCAG GAGAGTTCCA GGGACAGTTA CTGGGGACAA TTGCATTCAT GGCGCCTGAG 
GTACTAAGAG GTCAGCAGTA CGGTAGGAGC TGTGACGTCT GGAGTGTTGG CTGCGCCATT 
ATAGAAATGG CCTGTGCAAA ACCACCCTGG AACGCAGAAA AGCACTCCAA TCATCTTGCT 
TTGATATTTA AGATTGCGAG TGCAACTACT GCACCATCCA TCCCGTCACA CCTGTCCCCG 
GGCCTGCGAG ACGTGGCTCT GCGCTGTTTA GAACTTCAAC CTCAGGACAG ACCTCCGTCA 
AGAGAGCTAC TGAAGCATCC TGTCTTCCGT ACAACATGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446339.1
CDS	516..4997
Translation	MAAAAGDRASSSGFPGAAAASPEAGGGGGALQGSGAPAAGAGLLRETGSAGRERADWRRQQLRKVRSVELDQLPEQPLFLTASPPCPSTSPSPEPADAAAGASGFQPAAGPPPPGAASRCGSHSAELAAARDSGARSPAGAEPPSAAAPSGREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEMSNLAAELQGEGQAGSAAPAPKGRRSPSPGSSPSGRSGKPESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNCHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPTSLRGVQQPSSPQQPVAGSQRRNQESNFNLTHYGTQQIPPAYKDLAEPWIQAFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGTSGGGSGGSLSAGAASGSSQPSISGDVVEAFCSVLSIVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILGNQAESNNWQELLGRLCLIDRLLLEISAEFYPHIVSTDVSQAEPVEIRYKKLLSLLAFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPPLFSKLVTMLSASGSSHFARMRRRLMAIADEVEIAEVIQLGSEDTLDGQQDSSQALAPPRYPESSSLEHTAHVEKTGKGLKATRLSASSEDISDRLAGVSVGLPSSATTEQPKPTVQTKGRPHSQCLNSSPLSPPQLMFPAISAPCSSAPSVPAGSVTDASKHRPRAFVPCKIPSASPQTQRKFSLQFQRTCSENRDSEKLSPVFTQSRPPPSSNIHRAKASRPVPGSTSKLGDASKNSMTLDLNSASQCDDSFGSGSNSGSAVIPSEETAFTPAEDKCRLDVNPELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAESDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKANEPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGASVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW

Target ORF information:

RefSeq Version	NM_053887.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen-activated protein kinase kinase kinase 1 (Map3k1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053887.1

ORF Insert Sequence:

ATGGCGGCGG CGGCGGGCGA TCGCGCCTCG TCGTCGGGAT TCCCGGGCGC CGCGGCGGCG 
AGCCCCGAGG CGGGCGGCGG CGGCGGAGCT CTCCAGGGAA GCGGCGCGCC CGCAGCGGGC 
GCGGGGCTGC TGCGGGAGAC TGGCAGCGCG GGCCGCGAGC GCGCGGACTG GCGGCGGCAG 
CAGCTGCGCA AAGTAAGGAG TGTGGAGCTG GACCAGCTGC CGGAGCAGCC GCTCTTCCTC 
ACCGCCTCGC CGCCCTGCCC ATCTACTTCC CCGTCGCCGG AGCCCGCGGA CGCGGCTGCA 
GGAGCGAGTG GCTTCCAGCC TGCGGCGGGA CCGCCACCCC CGGGAGCAGC GAGTCGCTGC 
GGCTCCCACT CTGCCGAGCT GGCGGCCGCG CGGGACAGCG GCGCCCGGAG CCCCGCGGGG 
GCCGAGCCGC CCTCTGCAGC GGCCCCCTCC GGTCGAGAGA TGGAGAATAA AGAAACCCTC 
AAAGGATTGC ACAAGATGGA TGACCGCCCA GAGGAGCGAA TGATCAGGGA GAAGCTCAAG 
GCGACCTGTA TGCCTGCCTG GAAGCACGAG TGGTTAGAAA GGAGGAACAG GAGAGGCCCT 
GTGGTGGTGA AACCAATCCC TATTAAAGGA GATGGATCTG AAATGAGTAA CTTGGCAGCT 
GAGCTCCAAG GAGAGGGCCA GGCAGGCTCT GCTGCACCAG CTCCCAAGGG CCGACGAAGC 
CCGTCTCCTG GAAGCTCCCC ATCAGGGCGC TCAGGGAAGC CGGAATCCCC AGGAGTGAGA 
CGGAAACGAG TGTCCCCAGT GCCTTTCCAG AGTGGCAGAA TCACACCACC TCGAAGAGCC 
CCGTCGCCAG ATGGCTTCTC ACCGTACAGC CCAGAGGAGA CGAGCCGCCG TGTGAACAAA 
GTGATGAGGG CCAGGCTGTA CCTCCTGCAG CAGATAGGAC CCAACTCTTT CCTGATTGGA 
GGAGACAGTC CAGACAATAA ATACCGCGTG TTTATTGGGC CACAGAACTG CAGCTGTGGG 
CGTGGGACAT TCTGCATTCA CCTCTTGTTT GTCATGCTCC GGGTGTTCCA GCTAGAACCC 
TCCGACCCCA TGCTATGGAG AAAAACTTTA AAAAATTTTG AGGTTGAGAG TTTGTTCCAG 
AAATACCACA GTAGGCGTAG CTCAAGAATC AAAGCTCCAT CTCGGAACAC CATCCAGAAG 
TTTGTCTCAC GCATGTCAAA CTGTCACACA TTGTCATCGT CTAGCACATC CACATCTAGT 
TCAGAAAACA GCATCAAGGA TGAAGAGGAG CAGATGTGTC CCATCTGCTT GTTGGGCATG 
CTGGATGAGG AGAGCCTGAC TGTGTGTGAA GACGGCTGCA GGAACAAGCT GCACCACCAC 
TGCATGTCAA TCTGGGCAGA AGAATGTAGA AGAAATAGAG AACCGTTAAT ATGTCCCCTT 
TGTAGATCTA AGTGGAGATC CCATGACTTC TACAGCCATG AGTTATCAAG CCCTGTGGAT 
TCCCCTACCT CCCTGCGAGG TGTACAGCAG CCCTCCTCCC CGCAACAGCC TGTGGCCGGA 
TCACAGCGGA GGAATCAGGA AAGCAATTTT AACCTTACTC ATTATGGAAC CCAGCAGATT 
CCTCCCGCTT ACAAAGATTT AGCCGAGCCA TGGATTCAGG CATTCGGAAT GGAGCTCGTT 
GGCTGCTTAT TCTCTAGAAA CTGGAACGTA AGGGAGATGG CCCTTAGGCG CCTTTCCCAC 
GATGTTAGCG GGGCCCTGTT GTTGGCGAAC GGGGAGAGCA CTGGAACTTC TGGAGGCGGC 
AGCGGAGGCA GCCTAAGTGC TGGCGCCGCC AGTGGGTCTT CCCAGCCCAG CATCTCAGGG 
GACGTGGTGG AGGCGTTCTG CAGCGTCCTG TCTATCGTGT GCGCTGACCC TGTCTACAAA 
GTGTACGTTG CTGCTTTAAA AACACTGAGA GCCATGCTGG TATACACTCC TTGCCACAGC 
CTGGCAGAAA GAATCAAACT TCAGAGACTT CTCCGGCCAG TGGTAGACAC CATCCTAGTG 
AAGTGCGCAG ACGCCAATAG CCGCACGAGT CAGCTGTCCA TATCAACACT GTTGGAGCTC 
TGCAAGGGCC AAGCGGGGGA GTTGGCAGTT GGACGAGAAA TACTTAAAGC TGGATCCATC 
GGTGTTGGTG GCGTTGATTA CGTCTTAAGT TGTATTCTTG GAAACCAAGC TGAATCAAAC 
AACTGGCAAG AACTCCTGGG TCGCCTCTGT CTTATAGACA GATTGCTCTT GGAAATTTCT 
GCGGAATTTT ATCCTCATAT TGTCAGTACC GATGTCTCAC AAGCCGAGCC TGTTGAAATC 
AGGTATAAGA AGCTGCTGTC CCTCTTAGCC TTTGCCTTGC AATCCATTGA CAATTCCCAC 
TCTATGGTCG GCAAACTCTC GCGGAGGATT TATCTGAGCT CAGCACGAAT GGTGACCACA 
GTGCCCCCCC TGTTTTCCAA GCTGGTAACC ATGCTAAGTG CTTCTGGATC CTCCCACTTC 
GCCAGGATGC GCCGGCGTCT GATGGCCATT GCAGACGAGG TAGAAATTGC CGAGGTCATC 
CAGCTGGGTT CGGAAGACAC TTTGGATGGC CAGCAGGACA GCTCGCAGGC ATTGGCCCCT 
CCCCGCTATC CAGAGAGCAG CTCCCTTGAG CACACAGCCC ATGTAGAGAA AACTGGAAAA 
GGATTAAAAG CTACGAGACT GAGTGCCAGC TCAGAGGACA TTTCTGACAG ACTGGCTGGC 
GTTTCTGTAG GACTTCCTAG TTCAGCAACA ACAGAACAAC CAAAGCCAAC AGTTCAAACA 
AAAGGCAGAC CCCACAGTCA GTGTTTGAAC TCCTCTCCTT TGTCTCCTCC TCAGTTAATG 
TTTCCAGCAA TATCAGCCCC ATGTTCATCT GCCCCGTCTG TCCCAGCTGG CTCTGTAACA 
GATGCTTCTA AGCATAGACC TCGGGCGTTT GTTCCCTGTA AAATACCCTC TGCGTCTCCC 
CAAACACAGC GCAAGTTTTC CCTACAGTTC CAGAGGACCT GCTCTGAGAA CCGAGACTCA 
GAAAAACTCT CCCCAGTCTT TACTCAGTCG AGACCCCCAC CCTCCAGTAA CATACACAGG 
GCAAAGGCAT CCCGACCCGT TCCGGGTAGC ACAAGCAAAC TAGGGGATGC CTCAAAAAAC 
AGCATGACAC TCGACCTGAA CAGTGCTTCC CAGTGTGATG ACAGCTTTGG CAGTGGCAGC 
AACAGTGGCA GCGCCGTCAT ACCCAGTGAG GAGACGGCAT TCACCCCAGC AGAGGACAAG 
TGCAGGTTAG ATGTCAACCC CGAGCTCAAC TCCAGTATCG AGGACCTTCT TGAAGCATCT 
ATGCCTTCAA GTGACACAAC AGTCACTTTC AAGTCCGAAG TCGCCGTCCT CTCTCCTGAG 
AAGGCCGAAA GTGATGACAC CTACAAAGAT GACGTCAATC ACAATCAAAA GTGCAAAGAG 
AAGATGGAGG CTGAGGAAGA GGAGGCGCTC GCGATTGCCA TGGCAATGTC GGCTTCTCAG 
GACGCCCTCC CCATAGTCCC TCAGCTGCAG GTGGAAAATG GAGAGGATAT CATCATCATC 
CAGCAGGATA CACCAGAAAC CCTACCAGGG CATACCAAAG CGAACGAGCC CTACAGAGAA 
GACACCGAGT GGCTGAAAGG GCAGCAGATA GGCCTCGGAG CATTTTCTTC TTGTTACCAA 
GCACAGGATG TGGGCACTGG AACTTTAATG GCTGTGAAAC AGGTGACCTA CGTCAGAAAC 
ACATCTTCTG AGCAGGAGGA AGTGGTGGAA GCCTTGAGGG AAGAGATCAG GATGATGAGC 
CACCTCAACC ATCCGAACAT CATCAGGATG CTGGGGGCCA CGTGCGAGAA GAGCAACTAC 
AACCTCTTCA TCGAGTGGAT GGCGGGAGCC TCCGTGGCTC ACCTCTTGAG TAAATATGGA 
GCTTTCAAGG AGTCAGTGGT CATTAACTAC ACAGAGCAGT TACTCCGTGG CCTTTCCTAT 
CTCCACGAGA ACCAGATCAT TCACAGAGAC GTCAAAGGGG CCAATCTGCT CATTGACAGC 
ACCGGTCAGC GGCTGAGAAT TGCAGACTTC GGTGCTGCCG CCAGGTTGGC ATCCAAAGGA 
ACTGGTGCAG GAGAGTTCCA GGGACAGTTA CTGGGGACAA TTGCATTCAT GGCGCCTGAG 
GTACTAAGAG GTCAGCAGTA CGGTAGGAGC TGTGACGTCT GGAGTGTTGG CTGCGCCATT 
ATAGAAATGG CCTGTGCAAA ACCACCCTGG AACGCAGAAA AGCACTCCAA TCATCTTGCT 
TTGATATTTA AGATTGCGAG TGCAACTACT GCACCATCCA TCCCGTCACA CCTGTCCCCG 
GGCCTGCGAG ACGTGGCTCT GCGCTGTTTA GAACTTCAAC CTCAGGACAG ACCTCCGTCA 
AGAGAGCTAC TGAAGCATCC TGTCTTCCGT ACAACATGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MEKK1 Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.
Neurochemical research41(12)3308-3321(2016 Dec)
Lu H,Ning X,Tao X,Ren J,Song X,Tao W,Zhu L,Han L,Tao T,Yang J

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.
The EMBO journal33(21)2581-96(2014 Nov)
Charlaftis N,Suddason T,Wu X,Anwar S,Karin M,Gallagher E

Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1.
Developmental biology395(1)29-37(2014 Nov)
Meng Q,Mongan M,Wang J,Tang X,Zhang J,Kao W,Xia Y

Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis.
Developmental biology374(1)96-107(2013 Feb)
Jin C,Chen J,Meng Q,Carreira V,Tam NN,Geh E,Karyala S,Ho SM,Zhou X,Medvedovic M,Xia Y

Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene.
Cancer research72(22)6002-12(2012 Nov)
denDekker AD,Xu X,Vaughn MD,Puckett AH,Gardner LL,Lambring CJ,Deschenes L,Samuelson DJ