Nat2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nat2
Entrez Gene ID	116632
Full Name	N-acetyltransferase 2
Synonyms	Nat2a
General protein information	Preferred Names N-acetyltransferase 2 Names arylamine N-acetyltransferase 2 AT-2 N-Acetyltransferase-2 (arylamine N-acetyltransferase) N-acetyltransferase 2 (arylamine N-acetyltransferase) N-acetyltransferase type 2 NAT-2 arylamide acetylase 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p14
Summary	enzyme that acetylates only aryl amines; may have a role in carcinogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006253007.1	XP_006253069.1	arylamine N-acetyltransferase 2 isoform X1
XM_006253009.1	XP_006253071.1	arylamine N-acetyltransferase 2 isoform X1
XM_006253008.2	XP_006253070.1	arylamine N-acetyltransferase 2 isoform X1
NM_053854.1	NP_446306.1	arylamine N-acetyltransferase 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	NAT	NP_990857.1
Danio rerio (zebrafish)	zgc:103601	NP_001005974.1
Homo sapiens (human)	NAT1	NP_001153648.1
Pan troglodytes (chimpanzee)	NAT1	XP_519630.2
	NAT1	XP_002805323.1
Gallus gallus (chicken)	PNAT3	NP_001004373.1
Danio rerio (zebrafish)	si:dkey-78a14.5	XP_005169078.1
Rattus norvegicus (Norway rat)	Nat2	NP_446306.1
Bos taurus (cattle)	NAT1	NP_001069040.1
Mus musculus (house mouse)	Nat2	NP_001162049.1
Gallus gallus (chicken)	PNAT10	NP_990671.1
Danio rerio (zebrafish)	zgc:101040	NP_001003588.1
Danio rerio (zebrafish)	LOC794381	XP_005169079.1

Gene Ontology
Bibliography

Related articles in PubMed

Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism.
Stepp MW, Doll MA, Samuelson DJ, Sanders MA, States JC, Hein DW
BMC cancer17(1)233(2017 03)

N-Acetyltransferase 2 (NAT2) polymorphism as a risk modifier of susceptibility to pediatric acute lymphoblastic leukemia.
Kamel AM, Ebid GT, Moussa HS
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(8)6341-8(2015 Aug)

Effect of exposure to acute and chronic high-altitude hypoxia on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats.
Li X, Wang X, Li Y, Yuan M, Zhu J, Su X, Yao X, Fan X, Duan Y
Pharmacology93(1-2)76-83(2014)

CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome.
Silveira VS, Canalle R, Scrideli CA, Queiroz RG, Lopes LF, Tone LG
Molecular and cellular biochemistry364(1-2)217-23(2012 May)

Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study.
Potts LF, Cambon AC, Ross OA, Rademakers R, Dickson DW, Uitti RJ, Wszolek ZK, Rai SN, Farrer MJ, Hein DW, Litvan I
BMC medical genetics1316(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High NAT2 expression is associated with mammary tumor susceptibility.
Title: Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism.

High-altitude hypoxia decreases the activity and expression of CYP1A1 and NAT2, but increases that of CYP2D6.
Title: Effect of exposure to acute and chronic high-altitude hypoxia on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats.

Results demonstrate differential tissue-specific and developmental regulation of the rat Nat1 and Nat2 genes.
Title: Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat.

In homozygous rapid, homozygous slow, and heterozygous intermediate Nat2 congenic rat lines, Nat2 activities were observed in all tested tissues and found to be Nat2-genotype-dependent.
Title: Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat.

RT-PCR experiments demonstrated that the relative expression of the rNat transcripts in liver and 12 extrahepatic tissues was rNat1 > rNat2, while rNat3 transcripts were not detected.
Title: Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant.

The following Nat2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nat2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13686	NM_053854.1 Latest version!	Rattus norvegicus N-acetyltransferase 2 (Nat2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa37304	XM_006253007.1 Latest version!	Rattus norvegicus N-acetyltransferase 2 (Nat2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa37304	XM_006253008.2 Latest version!	Rattus norvegicus N-acetyltransferase 2 (Nat2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa37304	XM_006253009.1 Latest version!	Rattus norvegicus N-acetyltransferase 2 (Nat2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nat2 ( NM_053854.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446306.1 Rattus norvegicus N-acetyltransferase 2 (Nat2), mRNA.

Price & Availability↑

CloneID	ORa13686
Clone ID Related Accession (Same CDS sequence)	NM_053854.1
Accession Version	NM_053854.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	arylamine N-acetyltransferase 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U01348.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U01348.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906349, SAMN02642722 [ECO:0000348] ##Evidence-Data-END##

ATGGACATTG AAGCATACTT TGAAAGAATT GGTTATCAGA GTTCCAGGAA CAAACTGGAC 
TTGGAAGAAT TAACTGAAAT TCTTCAACAC CAGATACGGG CTATTCCCTT TGAAAACTTG 
AACATCCATT GCGGGGAATC CATGGAGCTG AATTTAGAAG TCATCTTTGA TCAAGTTGTG 
AGGAAGAAGC GTGGTGGATG GTGTCTCCAG GTTAATCATC TGCTGTACTG GGCTCTGACC 
AAAATGGGCT TTGAAGCCAC AATGTTGGGA GGGTATGTCT TTAACACTCC AGCCAATAAG 
TACAGCAGTG GCATGATTCA CTTACTAGTG CAGGTGACCC TCAGTGGAAA GGACTACATT 
GTTGATGCTG GGTTTGGACG TTCCTACCAG ATGTGGGAGC CTCTGGAATT AACATCAGGG 
AAGGATCAGC CTCAGGTGCC TGCCATCTTT CGTTTGACAG AAGAGAATGG AACCTGGTAC 
TTGGACCAAA TCAGAAGAGA GCAGTATGTT CCAAACCAAG AGTTTGTTAA CTCAGACCTC 
CTTGAAAAGA ACAAATATCG AAAAATCTAT TCCTTTACTC TTGAGCCCCG CACTATTGAG 
GATTTTGAGT CCATTAATAC CTATCTTCAG ACATCGCCAG CATCCTTGTT TACAAGTAAA 
TCATTTTGTT CCTTGCAGAC CCTAGAAGGG GTTCACTGTT TGGTTGGCTC CACCCTCACT 
TATAGGAGAT TCAGTTATAA GGACAATATA GATCTTGTAG AGTTTAAGAG TCTGACTGAG 
GAAGAAATAG AAGACGTACT GAAAACTATA TTTGGGGTTT CTTTAGAGAG AAAGCTTGTG 
CCTAAACATG GTGATCGATT TTTTACCATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446306.1
CDS	322..1194
Translation	MDIEAYFERIGYQSSRNKLDLEELTEILQHQIRAIPFENLNIHCGESMELNLEVIFDQVVRKKRGGWCLQVNHLLYWALTKMGFEATMLGGYVFNTPANKYSSGMIHLLVQVTLSGKDYIVDAGFGRSYQMWEPLELTSGKDQPQVPAIFRLTEENGTWYLDQIRREQYVPNQEFVNSDLLEKNKYRKIYSFTLEPRTIEDFESINTYLQTSPASLFTSKSFCSLQTLEGVHCLVGSTLTYRRFSYKDNIDLVEFKSLTEEEIEDVLKTIFGVSLERKLVPKHGDRFFTI

Target ORF information:

RefSeq Version	NM_053854.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus N-acetyltransferase 2 (Nat2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053854.1

ORF Insert Sequence:

ATGGACATTG AAGCATACTT TGAAAGAATT GGTTATCAGA GTTCCAGGAA CAAACTGGAC 
TTGGAAGAAT TAACTGAAAT TCTTCAACAC CAGATACGGG CTATTCCCTT TGAAAACTTG 
AACATCCATT GCGGGGAATC CATGGAGCTG AATTTAGAAG TCATCTTTGA TCAAGTTGTG 
AGGAAGAAGC GTGGTGGATG GTGTCTCCAG GTTAATCATC TGCTGTACTG GGCTCTGACC 
AAAATGGGCT TTGAAGCCAC AATGTTGGGA GGGTATGTCT TTAACACTCC AGCCAATAAG 
TACAGCAGTG GCATGATTCA CTTACTAGTG CAGGTGACCC TCAGTGGAAA GGACTACATT 
GTTGATGCTG GGTTTGGACG TTCCTACCAG ATGTGGGAGC CTCTGGAATT AACATCAGGG 
AAGGATCAGC CTCAGGTGCC TGCCATCTTT CGTTTGACAG AAGAGAATGG AACCTGGTAC 
TTGGACCAAA TCAGAAGAGA GCAGTATGTT CCAAACCAAG AGTTTGTTAA CTCAGACCTC 
CTTGAAAAGA ACAAATATCG AAAAATCTAT TCCTTTACTC TTGAGCCCCG CACTATTGAG 
GATTTTGAGT CCATTAATAC CTATCTTCAG ACATCGCCAG CATCCTTGTT TACAAGTAAA 
TCATTTTGTT CCTTGCAGAC CCTAGAAGGG GTTCACTGTT TGGTTGGCTC CACCCTCACT 
TATAGGAGAT TCAGTTATAA GGACAATATA GATCTTGTAG AGTTTAAGAG TCTGACTGAG 
GAAGAAATAG AAGACGTACT GAAAACTATA TTTGGGGTTT CTTTAGAGAG AAAGCTTGTG 
CCTAAACATG GTGATCGATT TTTTACCATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nat2 ( XM_006253007.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006253069.1 Rattus norvegicus N-acetyltransferase 2 (Nat2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa37304
Clone ID Related Accession (Same CDS sequence)	XM_006253007.1 , XM_006253009.1 , XM_006253008.2
Accession Version	XM_006253007.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	arylamine N-acetyltransferase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACATTG AAGCATACTT TGAAAGAATT GGTTATCAGA GTTCCAGGAA CAAACTGGAC 
TTGGAAGAAT TAACTGAAAT TCTTCAACAC CAGATACGGG CTATTCCCTT TGAAAACTTG 
AACATCCATT GCGGGGAATC CATGGAGCTG AATTTAGAAG TCATCTTTGA TCAAGTTGTG 
AGGAAGAAGC GTGGTGGATG GTGTCTCCAG GTTAATCATC TGCTGTACTG GGCTCTGACC 
AAAATGGGCT TTGAAGCCAC AATGTTGGGA GGGTATGTCT TTAACACTCC AGCCAATAAG 
TACAGCAGTG GCATGATTCA CTTACTAGTG CAGGTGACCC TCAGTGGAAA GGACTACATT 
GTTGATGCTG GGTTTGGACG TTCCTACCAG ATGTGGGAGC CTCTGGAATT AACATCAGGG 
AAGGATCAGC CTCAGGTGCC TGCCGTCTTT CGTTTGACAG AAGAGAATGG AACCTGGTAC 
TTGGACCAAA TCAGAAGAGA GCAGTATGTT CCAAACCAAG AGTTTGTTAA CTCAGACCTC 
CTTGAAAAGA ACAAATATCG AAAAATCTAT TCCTTTACTC TTGAGCCCCG CACTATTGAG 
GATTTTGAGT CCATTAATAC CTATCTTCAG ACATCGCCAG CATCCTTGTT TACAAGTAAA 
TCATTTTGTT CCTTGCAGAC CCTAGAAGGG GTTCACTGTT TGGTTGGCTC CACCCTCACT 
TATAGGAGAT TCAGTTATAA GGACAATATA GATCTTGTAG AGTTTAAGAG TCTGACTGAG 
GAAGAAATAG AAGACGTACT GAAAACTATA TTTGGGGTTT CTTTAGAGAG AAAGCTTGTG 
CCTAAACATG GTGATCGATT TTTTACCATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006253069.1
CDS	1913..2785
Translation	MDIEAYFERIGYQSSRNKLDLEELTEILQHQIRAIPFENLNIHCGESMELNLEVIFDQVVRKKRGGWCLQVNHLLYWALTKMGFEATMLGGYVFNTPANKYSSGMIHLLVQVTLSGKDYIVDAGFGRSYQMWEPLELTSGKDQPQVPAVFRLTEENGTWYLDQIRREQYVPNQEFVNSDLLEKNKYRKIYSFTLEPRTIEDFESINTYLQTSPASLFTSKSFCSLQTLEGVHCLVGSTLTYRRFSYKDNIDLVEFKSLTEEEIEDVLKTIFGVSLERKLVPKHGDRFFTI

Target ORF information:

RefSeq Version	XM_006253007.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus N-acetyltransferase 2 (Nat2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006253007.1

ORF Insert Sequence:

ATGGACATTG AAGCATACTT TGAAAGAATT GGTTATCAGA GTTCCAGGAA CAAACTGGAC 
TTGGAAGAAT TAACTGAAAT TCTTCAACAC CAGATACGGG CTATTCCCTT TGAAAACTTG 
AACATCCATT GCGGGGAATC CATGGAGCTG AATTTAGAAG TCATCTTTGA TCAAGTTGTG 
AGGAAGAAGC GTGGTGGATG GTGTCTCCAG GTTAATCATC TGCTGTACTG GGCTCTGACC 
AAAATGGGCT TTGAAGCCAC AATGTTGGGA GGGTATGTCT TTAACACTCC AGCCAATAAG 
TACAGCAGTG GCATGATTCA CTTACTAGTG CAGGTGACCC TCAGTGGAAA GGACTACATT 
GTTGATGCTG GGTTTGGACG TTCCTACCAG ATGTGGGAGC CTCTGGAATT AACATCAGGG 
AAGGATCAGC CTCAGGTGCC TGCCGTCTTT CGTTTGACAG AAGAGAATGG AACCTGGTAC 
TTGGACCAAA TCAGAAGAGA GCAGTATGTT CCAAACCAAG AGTTTGTTAA CTCAGACCTC 
CTTGAAAAGA ACAAATATCG AAAAATCTAT TCCTTTACTC TTGAGCCCCG CACTATTGAG 
GATTTTGAGT CCATTAATAC CTATCTTCAG ACATCGCCAG CATCCTTGTT TACAAGTAAA 
TCATTTTGTT CCTTGCAGAC CCTAGAAGGG GTTCACTGTT TGGTTGGCTC CACCCTCACT 
TATAGGAGAT TCAGTTATAA GGACAATATA GATCTTGTAG AGTTTAAGAG TCTGACTGAG 
GAAGAAATAG AAGACGTACT GAAAACTATA TTTGGGGTTT CTTTAGAGAG AAAGCTTGTG 
CCTAAACATG GTGATCGATT TTTTACCATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nat2 ( XM_006253009.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006253071.1 Rattus norvegicus N-acetyltransferase 2 (Nat2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa37304
Clone ID Related Accession (Same CDS sequence)	XM_006253007.1 , XM_006253009.1 , XM_006253008.2
Accession Version	XM_006253009.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	arylamine N-acetyltransferase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACATTG AAGCATACTT TGAAAGAATT GGTTATCAGA GTTCCAGGAA CAAACTGGAC 
TTGGAAGAAT TAACTGAAAT TCTTCAACAC CAGATACGGG CTATTCCCTT TGAAAACTTG 
AACATCCATT GCGGGGAATC CATGGAGCTG AATTTAGAAG TCATCTTTGA TCAAGTTGTG 
AGGAAGAAGC GTGGTGGATG GTGTCTCCAG GTTAATCATC TGCTGTACTG GGCTCTGACC 
AAAATGGGCT TTGAAGCCAC AATGTTGGGA GGGTATGTCT TTAACACTCC AGCCAATAAG 
TACAGCAGTG GCATGATTCA CTTACTAGTG CAGGTGACCC TCAGTGGAAA GGACTACATT 
GTTGATGCTG GGTTTGGACG TTCCTACCAG ATGTGGGAGC CTCTGGAATT AACATCAGGG 
AAGGATCAGC CTCAGGTGCC TGCCGTCTTT CGTTTGACAG AAGAGAATGG AACCTGGTAC 
TTGGACCAAA TCAGAAGAGA GCAGTATGTT CCAAACCAAG AGTTTGTTAA CTCAGACCTC 
CTTGAAAAGA ACAAATATCG AAAAATCTAT TCCTTTACTC TTGAGCCCCG CACTATTGAG 
GATTTTGAGT CCATTAATAC CTATCTTCAG ACATCGCCAG CATCCTTGTT TACAAGTAAA 
TCATTTTGTT CCTTGCAGAC CCTAGAAGGG GTTCACTGTT TGGTTGGCTC CACCCTCACT 
TATAGGAGAT TCAGTTATAA GGACAATATA GATCTTGTAG AGTTTAAGAG TCTGACTGAG 
GAAGAAATAG AAGACGTACT GAAAACTATA TTTGGGGTTT CTTTAGAGAG AAAGCTTGTG 
CCTAAACATG GTGATCGATT TTTTACCATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006253071.1
CDS	1100..1972
Translation	MDIEAYFERIGYQSSRNKLDLEELTEILQHQIRAIPFENLNIHCGESMELNLEVIFDQVVRKKRGGWCLQVNHLLYWALTKMGFEATMLGGYVFNTPANKYSSGMIHLLVQVTLSGKDYIVDAGFGRSYQMWEPLELTSGKDQPQVPAVFRLTEENGTWYLDQIRREQYVPNQEFVNSDLLEKNKYRKIYSFTLEPRTIEDFESINTYLQTSPASLFTSKSFCSLQTLEGVHCLVGSTLTYRRFSYKDNIDLVEFKSLTEEEIEDVLKTIFGVSLERKLVPKHGDRFFTI

Target ORF information:

RefSeq Version	XM_006253009.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus N-acetyltransferase 2 (Nat2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006253009.1

ORF Insert Sequence:

ATGGACATTG AAGCATACTT TGAAAGAATT GGTTATCAGA GTTCCAGGAA CAAACTGGAC 
TTGGAAGAAT TAACTGAAAT TCTTCAACAC CAGATACGGG CTATTCCCTT TGAAAACTTG 
AACATCCATT GCGGGGAATC CATGGAGCTG AATTTAGAAG TCATCTTTGA TCAAGTTGTG 
AGGAAGAAGC GTGGTGGATG GTGTCTCCAG GTTAATCATC TGCTGTACTG GGCTCTGACC 
AAAATGGGCT TTGAAGCCAC AATGTTGGGA GGGTATGTCT TTAACACTCC AGCCAATAAG 
TACAGCAGTG GCATGATTCA CTTACTAGTG CAGGTGACCC TCAGTGGAAA GGACTACATT 
GTTGATGCTG GGTTTGGACG TTCCTACCAG ATGTGGGAGC CTCTGGAATT AACATCAGGG 
AAGGATCAGC CTCAGGTGCC TGCCGTCTTT CGTTTGACAG AAGAGAATGG AACCTGGTAC 
TTGGACCAAA TCAGAAGAGA GCAGTATGTT CCAAACCAAG AGTTTGTTAA CTCAGACCTC 
CTTGAAAAGA ACAAATATCG AAAAATCTAT TCCTTTACTC TTGAGCCCCG CACTATTGAG 
GATTTTGAGT CCATTAATAC CTATCTTCAG ACATCGCCAG CATCCTTGTT TACAAGTAAA 
TCATTTTGTT CCTTGCAGAC CCTAGAAGGG GTTCACTGTT TGGTTGGCTC CACCCTCACT 
TATAGGAGAT TCAGTTATAA GGACAATATA GATCTTGTAG AGTTTAAGAG TCTGACTGAG 
GAAGAAATAG AAGACGTACT GAAAACTATA TTTGGGGTTT CTTTAGAGAG AAAGCTTGTG 
CCTAAACATG GTGATCGATT TTTTACCATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nat2 ( XM_006253008.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006253070.1 Rattus norvegicus N-acetyltransferase 2 (Nat2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa37304
Clone ID Related Accession (Same CDS sequence)	XM_006253007.1 , XM_006253009.1 , XM_006253008.2
Accession Version	XM_006253008.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	arylamine N-acetyltransferase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006253008.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACATTG AAGCATACTT TGAAAGAATT GGTTATCAGA GTTCCAGGAA CAAACTGGAC 
TTGGAAGAAT TAACTGAAAT TCTTCAACAC CAGATACGGG CTATTCCCTT TGAAAACTTG 
AACATCCATT GCGGGGAATC CATGGAGCTG AATTTAGAAG TCATCTTTGA TCAAGTTGTG 
AGGAAGAAGC GTGGTGGATG GTGTCTCCAG GTTAATCATC TGCTGTACTG GGCTCTGACC 
AAAATGGGCT TTGAAGCCAC AATGTTGGGA GGGTATGTCT TTAACACTCC AGCCAATAAG 
TACAGCAGTG GCATGATTCA CTTACTAGTG CAGGTGACCC TCAGTGGAAA GGACTACATT 
GTTGATGCTG GGTTTGGACG TTCCTACCAG ATGTGGGAGC CTCTGGAATT AACATCAGGG 
AAGGATCAGC CTCAGGTGCC TGCCGTCTTT CGTTTGACAG AAGAGAATGG AACCTGGTAC 
TTGGACCAAA TCAGAAGAGA GCAGTATGTT CCAAACCAAG AGTTTGTTAA CTCAGACCTC 
CTTGAAAAGA ACAAATATCG AAAAATCTAT TCCTTTACTC TTGAGCCCCG CACTATTGAG 
GATTTTGAGT CCATTAATAC CTATCTTCAG ACATCGCCAG CATCCTTGTT TACAAGTAAA 
TCATTTTGTT CCTTGCAGAC CCTAGAAGGG GTTCACTGTT TGGTTGGCTC CACCCTCACT 
TATAGGAGAT TCAGTTATAA GGACAATATA GATCTTGTAG AGTTTAAGAG TCTGACTGAG 
GAAGAAATAG AAGACGTACT GAAAACTATA TTTGGGGTTT CTTTAGAGAG AAAGCTTGTG 
CCTAAACATG GTGATCGATT TTTTACCATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006253070.1
CDS	88..960
Translation	MDIEAYFERIGYQSSRNKLDLEELTEILQHQIRAIPFENLNIHCGESMELNLEVIFDQVVRKKRGGWCLQVNHLLYWALTKMGFEATMLGGYVFNTPANKYSSGMIHLLVQVTLSGKDYIVDAGFGRSYQMWEPLELTSGKDQPQVPAVFRLTEENGTWYLDQIRREQYVPNQEFVNSDLLEKNKYRKIYSFTLEPRTIEDFESINTYLQTSPASLFTSKSFCSLQTLEGVHCLVGSTLTYRRFSYKDNIDLVEFKSLTEEEIEDVLKTIFGVSLERKLVPKHGDRFFTI

Target ORF information:

RefSeq Version	XM_006253008.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus N-acetyltransferase 2 (Nat2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006253008.2

ORF Insert Sequence:

ATGGACATTG AAGCATACTT TGAAAGAATT GGTTATCAGA GTTCCAGGAA CAAACTGGAC 
TTGGAAGAAT TAACTGAAAT TCTTCAACAC CAGATACGGG CTATTCCCTT TGAAAACTTG 
AACATCCATT GCGGGGAATC CATGGAGCTG AATTTAGAAG TCATCTTTGA TCAAGTTGTG 
AGGAAGAAGC GTGGTGGATG GTGTCTCCAG GTTAATCATC TGCTGTACTG GGCTCTGACC 
AAAATGGGCT TTGAAGCCAC AATGTTGGGA GGGTATGTCT TTAACACTCC AGCCAATAAG 
TACAGCAGTG GCATGATTCA CTTACTAGTG CAGGTGACCC TCAGTGGAAA GGACTACATT 
GTTGATGCTG GGTTTGGACG TTCCTACCAG ATGTGGGAGC CTCTGGAATT AACATCAGGG 
AAGGATCAGC CTCAGGTGCC TGCCGTCTTT CGTTTGACAG AAGAGAATGG AACCTGGTAC 
TTGGACCAAA TCAGAAGAGA GCAGTATGTT CCAAACCAAG AGTTTGTTAA CTCAGACCTC 
CTTGAAAAGA ACAAATATCG AAAAATCTAT TCCTTTACTC TTGAGCCCCG CACTATTGAG 
GATTTTGAGT CCATTAATAC CTATCTTCAG ACATCGCCAG CATCCTTGTT TACAAGTAAA 
TCATTTTGTT CCTTGCAGAC CCTAGAAGGG GTTCACTGTT TGGTTGGCTC CACCCTCACT 
TATAGGAGAT TCAGTTATAA GGACAATATA GATCTTGTAG AGTTTAAGAG TCTGACTGAG 
GAAGAAATAG AAGACGTACT GAAAACTATA TTTGGGGTTT CTTTAGAGAG AAAGCTTGTG 
CCTAAACATG GTGATCGATT TTTTACCATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism.
BMC cancer17(1)233(2017 03)
Stepp MW,Doll MA,Samuelson DJ,Sanders MA,States JC,Hein DW

N-Acetyltransferase 2 (NAT2) polymorphism as a risk modifier of susceptibility to pediatric acute lymphoblastic leukemia.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(8)6341-8(2015 Aug)
Kamel AM,Ebid GT,Moussa HS

Effect of exposure to acute and chronic high-altitude hypoxia on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats.
Pharmacology93(1-2)76-83(2014)
Li X,Wang X,Li Y,Yuan M,Zhu J,Su X,Yao X,Fan X,Duan Y

CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome.
Molecular and cellular biochemistry364(1-2)217-23(2012 May)
Silveira VS,Canalle R,Scrideli CA,Queiroz RG,Lopes LF,Tone LG

Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study.
BMC medical genetics1316(2012 Mar)
Potts LF,Cambon AC,Ross OA,Rademakers R,Dickson DW,Uitti RJ,Wszolek ZK,Rai SN,Farrer MJ,Hein DW,Litvan I

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Nat2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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