Upb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Upb1
Entrez Gene ID	116593
Full Name	beta-ureidopropionase 1
Synonyms	Bup1
General protein information	Preferred Names beta-ureidopropionase 1 Names beta-ureidopropionase N-carbamoyl-beta-alanine amidohydrolase beta-alanine synthase ureidopropionase, beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	catalyzes the biosynthesis of beta-alanine; the third and final step in the catabolism of the pyrimidine bases uracil or thymine to produce beta-alanine or 2-methyl-beta-alanine [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053845.1	NP_446297.1	beta-ureidopropionase

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Upb1	NP_598756.1
	UPB1	XP_001095304.2
Rattus norvegicus (Norway rat)	Upb1	NP_446297.1
Danio rerio (zebrafish)	upb1	NP_955910.1
Oryza sativa (rice)	Os07g0485100	NP_001059656.1
Pan troglodytes (chimpanzee)	UPB1	XP_003953895.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010229	XP_319417.2
Arabidopsis thaliana (thale cress)	BETA-UP	NP_201242.2
Gallus gallus (chicken)	UPB1	XP_415242.1
Xenopus tropicalis (tropical clawed frog)	upb1	NP_001120264.1
Homo sapiens (human)	UPB1	NP_057411.1
Canis lupus familiaris (dog)	UPB1	XP_543524.2
Bos taurus (cattle)	UPB1	NP_001094520.1
Drosophila melanogaster (fruit fly)	pyd3	NP_649732.1
Caenorhabditis elegans (roundworm)	upb-1	NP_495261.1

Gene Ontology
Bibliography

Related articles in PubMed

?-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients.
van Kuilenburg AB, Dobritzsch D, Meijer J, Krumpel M, Selim LA, Rashed MS, Assmann B, Meinsma R, Lohkamp B, Ito T, Abeling NG, Saito K, Eto K, Smitka M, Engvall M, Zhang C, Xu W, Zoetekouw L, Hennekam RC
Biochimica et biophysica acta1822(7)1096-108(2012 Jul)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities.
van Kuilenburg AB, Meinsma R, Beke E, Assmann B, Ribes A, Lorente I, Busch R, Mayatepek E, Abeling NG, van Cruchten A, Stroomer AE, van Lenthe H, Zoetekouw L, Kulik W, Hoffmann GF, Voit T, Wevers RA, Rutsch F, van Gennip AH
Human molecular genetics13(22)2793-801(2004 Nov)

Cloning, sequencing, and expression of a cDNA encoding beta-alanine synthase from rat liver.
Kvalnes-Krick KL, Traut TW
The Journal of biological chemistry268(8)5686-93(1993 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Upb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Upb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10836	NM_053845.1 Latest version!	Rattus norvegicus beta-ureidopropionase 1 (Upb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Upb1 ( NM_053845.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446297.1 Rattus norvegicus beta-ureidopropionase 1 (Upb1), mRNA.

Price & Availability↑

CloneID	ORa10836
Clone ID Related Accession (Same CDS sequence)	NM_053845.1
Accession Version	NM_053845.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	beta-ureidopropionase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M97662.1. ##Evidence-Data-START## Transcript exon combination :: M97662.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01906356 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGGAC CTGAGTGGCA GTCCCTGGAG CAGTGCCTGG AAAAGCATCT GCCGCCTGAC 
GATTTGAGCC AGGTGAAGCG AATTCTCTAC GGCAAGCAAA CTAGGAATCT TGATCTGCCC 
AGAAAAGCTT TAGAAGCTGC CTCAGAAAGA AACTTCGAAC TGAAGGGATA CGCCTTCGGG 
GCAGCCAAGG AACAGCAGAG ATGTCCCCAG ATCGTGCGCG TGGGGCTCGT TCAGAACAGA 
ATCCCGCTCC CCACTTCCGC CCCTGTGGCA GAACAGGTCT CTGCCCTCCA CAAACGCATA 
GAGGAAATAG CTGAGGTGGC AGCAATGTGC GGAGTCAACA TCATCTGTTT CCAGGAAGCC 
TGGAATATGC CCTTCGCTTT TTGTACACGA GAGAAACTTC CTTGGACAGA ATTTGCTGAG 
TCAGCAGAGG ACGGGCTCAC CACCAGGTTC TGTCAGAAGC TGGCAAAGAA GCACAACATG 
GTGGTGATAT CTCCAATCTT GGAGCGTGAC AGAGATCACG GGGGAGTTCT ATGGAACACA 
GCTGTGGTGA TCTCCAACTC GGGACTGGTC ATGGGAAAGA CCAGAAAGAA TCACATCCCC 
AGAGTGGGCG ACTTCAATGA GTCCACTTAC TACATGGAGG GAAACCTCGG CCACCCCGTG 
TTCCAGACCC AGTTTGGCAG GATTGCCGTG AACATCTGCT ATGGGCGGCA CCACCCCCTC 
AACTGGCTCA TGTACAGCGT CAACGGAGCT GAAATCATCT TCAACCCTTC AGCCACCATT 
GGAGAACTCA GTGAGTCCAT GTGGCCGATC GAAGCCAGAA ACGCAGCCAT CGCTAATCAC 
TGCTTCACCT GTGCCCTCAA CCGTGTGGGT CAGGAACACT ACCCCAATGA GTTTACTTCT 
GGAGATGGAA AGAAAGCTCA CCATGACCTC GGCTACTTCT ACGGTTCGAG CTACGTGGCA 
GCTCCTGACG GTAGCCGGAC CCCCGGCCTC TCACGCAATC AGGACGGGCT GCTGGTCACT 
GAGCTCAACC TCAACCTATG CCAGCAGATT AATGATTTCT GGACTTTCAA GATGACGGGC 
CGACTTGAGA TGTATGCCCG GGAGCTTGCC GAAGCTGTCA AACCCAACTA CAGTCCCAAC 
ATTGTGAAGG AAGACCTGGT TCTAGCCCCT AGCTCGGGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446297.1
CDS	34..1215
Translation	MAGPEWQSLEQCLEKHLPPDDLSQVKRILYGKQTRNLDLPRKALEAASERNFELKGYAFGAAKEQQRCPQIVRVGLVQNRIPLPTSAPVAEQVSALHKRIEEIAEVAAMCGVNIICFQEAWNMPFAFCTREKLPWTEFAESAEDGLTTRFCQKLAKKHNMVVISPILERDRDHGGVLWNTAVVISNSGLVMGKTRKNHIPRVGDFNESTYYMEGNLGHPVFQTQFGRIAVNICYGRHHPLNWLMYSVNGAEIIFNPSATIGELSESMWPIEARNAAIANHCFTCALNRVGQEHYPNEFTSGDGKKAHHDLGYFYGSSYVAAPDGSRTPGLSRNQDGLLVTELNLNLCQQINDFWTFKMTGRLEMYARELAEAVKPNYSPNIVKEDLVLAPSSG

Target ORF information:

RefSeq Version	NM_053845.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus beta-ureidopropionase 1 (Upb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053845.1

ORF Insert Sequence:

ATGGCGGGAC CTGAGTGGCA GTCCCTGGAG CAGTGCCTGG AAAAGCATCT GCCGCCTGAC 
GATTTGAGCC AGGTGAAGCG AATTCTCTAC GGCAAGCAAA CTAGGAATCT TGATCTGCCC 
AGAAAAGCTT TAGAAGCTGC CTCAGAAAGA AACTTCGAAC TGAAGGGATA CGCCTTCGGG 
GCAGCCAAGG AACAGCAGAG ATGTCCCCAG ATCGTGCGCG TGGGGCTCGT TCAGAACAGA 
ATCCCGCTCC CCACTTCCGC CCCTGTGGCA GAACAGGTCT CTGCCCTCCA CAAACGCATA 
GAGGAAATAG CTGAGGTGGC AGCAATGTGC GGAGTCAACA TCATCTGTTT CCAGGAAGCC 
TGGAATATGC CCTTCGCTTT TTGTACACGA GAGAAACTTC CTTGGACAGA ATTTGCTGAG 
TCAGCAGAGG ACGGGCTCAC CACCAGGTTC TGTCAGAAGC TGGCAAAGAA GCACAACATG 
GTGGTGATAT CTCCAATCTT GGAGCGTGAC AGAGATCACG GGGGAGTTCT ATGGAACACA 
GCTGTGGTGA TCTCCAACTC GGGACTGGTC ATGGGAAAGA CCAGAAAGAA TCACATCCCC 
AGAGTGGGCG ACTTCAATGA GTCCACTTAC TACATGGAGG GAAACCTCGG CCACCCCGTG 
TTCCAGACCC AGTTTGGCAG GATTGCCGTG AACATCTGCT ATGGGCGGCA CCACCCCCTC 
AACTGGCTCA TGTACAGCGT CAACGGAGCT GAAATCATCT TCAACCCTTC AGCCACCATT 
GGAGAACTCA GTGAGTCCAT GTGGCCGATC GAAGCCAGAA ACGCAGCCAT CGCTAATCAC 
TGCTTCACCT GTGCCCTCAA CCGTGTGGGT CAGGAACACT ACCCCAATGA GTTTACTTCT 
GGAGATGGAA AGAAAGCTCA CCATGACCTC GGCTACTTCT ACGGTTCGAG CTACGTGGCA 
GCTCCTGACG GTAGCCGGAC CCCCGGCCTC TCACGCAATC AGGACGGGCT GCTGGTCACT 
GAGCTCAACC TCAACCTATG CCAGCAGATT AATGATTTCT GGACTTTCAA GATGACGGGC 
CGACTTGAGA TGTATGCCCG GGAGCTTGCC GAAGCTGTCA AACCCAACTA CAGTCCCAAC 
ATTGTGAAGG AAGACCTGGT TCTAGCCCCT AGCTCGGGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

?-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients.
Biochimica et biophysica acta1822(7)1096-108(2012 Jul)
van Kuilenburg AB,Dobritzsch D,Meijer J,Krumpel M,Selim LA,Rashed MS,Assmann B,Meinsma R,Lohkamp B,Ito T,Abeling NG,Saito K,Eto K,Smitka M,Engvall M,Zhang C,Xu W,Zoetekouw L,Hennekam RC

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities.
Human molecular genetics13(22)2793-801(2004 Nov)
van Kuilenburg AB,Meinsma R,Beke E,Assmann B,Ribes A,Lorente I,Busch R,Mayatepek E,Abeling NG,van Cruchten A,Stroomer AE,van Lenthe H,Zoetekouw L,Kulik W,Hoffmann GF,Voit T,Wevers RA,Rutsch F,van Gennip AH

Cloning, sequencing, and expression of a cDNA encoding beta-alanine synthase from rat liver.
The Journal of biological chemistry268(8)5686-93(1993 Mar)
Kvalnes-Krick KL,Traut TW