Lct cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lct
Entrez Gene ID	116569
Full Name	lactase
Synonyms	Lph
General protein information	Preferred Names lactase Names lactase-phlorizin hydrolase lactase-glycosylceramidase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q13
Summary	catalyzes the hydrolysis of pyridoxine-5'-beta-D-glucoside to release pyridoxine; also catalyses the hydrolysis of lactose to D-glucose and D-galactose [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053841.1	NP_446293.1	lactase-phlorizin hydrolase preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LCT	XP_003954409.1
	LCT	XP_001096426.2
Canis lupus familiaris (dog)	LCT	XP_005632060.1
Mus musculus (house mouse)	Lct	NP_001074547.1
Danio rerio (zebrafish)	lct	XP_001336765.5
Xenopus tropicalis (tropical clawed frog)	LOC101732850	XP_004917683.1
Rattus norvegicus (Norway rat)	Lct	NP_446293.1
Gallus gallus (chicken)	LCT	NP_001104816.1
Xenopus tropicalis (tropical clawed frog)	lct.2	XP_002934014.2
Homo sapiens (human)	LCT	NP_002290.2
Bos taurus (cattle)	LCT	NP_001192716.1

Gene Ontology
Bibliography

Related articles in PubMed

Hormone induced changes in lactase glycosylation in developing rat intestine.
Chaudhry KK, Mahmood S, Mahmood A
Molecular and cellular biochemistry318(1-2)183-90(2008 Nov)

Hormone induced expression of brush border lactase in suckling rat intestine.
Chaudhry KK, Mahmood S, Mahmood A
Molecular and cellular biochemistry312(1-2)11-6(2008 May)

Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats.
Akiyama K, Morita H, Suetsugu S, Kuraba S, Numata Y, Yamamoto Y, Inui K, Ideura T, Wakisaka N, Nakano K, Oniki H, Takenawa T, Matsuyama M, Yoshimura A
Mammalian genome : official journal of the International Mammalian Genome Society19(1)41-50(2008 Jan)

Morphological and biochemical alterations in the jejunum following iodoacetamide-induced colitis in rats.
Jurjus A, Barada K, Khoury N, Assef MD, Foltzer CJ, Reimund JM, Kedinger M
Canadian journal of physiology and pharmacology84(11)1191-203(2006 Nov)

Dietary sucrose enhances intestinal lactase gene expression in euthyroid rats.
Kuranuki S, Mochizuki K, Goda T
Journal of nutritional science and vitaminology52(5)347-51(2006 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings suggest the role of these hormones in inducing changes in lactase glycosylation during postnatal development of intestine, which may contribute to adult-type hypolactasia in rats.
Title: Hormone induced changes in lactase glycosylation in developing rat intestine.

Thyroxine, insulin or cortisone induced changes in lactase expression in suckling rat intestine.
Title: Hormone induced expression of brush border lactase in suckling rat intestine.

the mechanism of absorption of quercetin-4'-glucoside involves both an interaction with SGLT1 and luminal hydrolysis by LPH, whereas quercetin-3-glucoside appears to be absorbed only following hydrolysis by LPH.
Title: Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter.

results indicate that LPH may play an important role in the bioavailability of pyridoxine-5'-beta-D-glucoside (PNG)
Title: Enzymatic hydrolysis of pyridoxine-5'-beta-D-glucoside is catalyzed by intestinal lactase-phlorizin hydrolase.

role of promoter in regulating intestine-specific spatiotemporal expression
Title: Regulation of intestine-specific spatiotemporal expression by the rat lactase promoter.

The following Lct gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lct cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10823	NM_053841.1 Latest version!	Rattus norvegicus lactase (Lct), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$951.30 $1359.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lct ( NM_053841.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446293.1 Rattus norvegicus lactase (Lct), mRNA.

Price & Availability↑

CloneID	ORa10823
Clone ID Related Accession (Same CDS sequence)	NM_053841.1
Accession Version	NM_053841.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5790bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	lactase-phlorizin hydrolase preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07020887.1 and AABR07020886.1. On or before Dec 17, 2009 this sequence version replaced XM_001055660.1, XM_001055600.1, XM_341115.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTGC CTTGGACAGC ACTCTTCCTG AGTACTGTCC TCCTGGGTCT TTCATGCCAG 
GGCTCTGACT GGGAATCCGA CAGAAATTTT ATTTCAGCCG CTGGTCCTCT AACAAATGAC 
TTAGTGCTTA ATCTGAACTA TCCACCGGGA AAGCAGGGCT CTGATGTGGT ATCCGGTAAC 
ACCGACATCT ACATCTGCCA GCAGCCACTG CCCTCTTTCT TGTCTCAGTA TTTCAGCAGT 
CTTCGTGCCA GCCAGGTTAC CCATTACAAA GTTCTTCTGT CATGGGCACA ACTTCTCCCA 
ACTGGAAGCT CCAAGAATCC AGACCAGGAA GCAGTGCAGT GCTACCGACA ACTCCTCCAG 
TCCCTGAAGG ATGCCCAGCT TGAGCCCATG GTGGTCCTGT GCCATCAGAC GCCACCCACC 
AGCAGCGCCA TCCAGAGAGA AGGGGCCTTT GCTGACCTCT TTGCTGACTA TGCCACATTG 
GCTTTTCAGT CCTTTGGGGA CCTTGTTGAG ATCTGGTTCA CCTTCAGTGA CTTGGAGAAA 
GTGATCATGG ATCTTCCCCA CAAAGATCTG AAAGCTTCTG CTCTTCAAAC CCTCAGCAAT 
GCCCACAGGA GAGCCTTTGA CATTTACCAC AGAAAGTTCT CATCTCAGGG GGGAAAGCTG 
TCTGTGGTCC TGAAGGCTGA AGATATTCCA GAGCTTCTGC CAGACCCGGC ATTGGCTGCT 
CTCGTCCAGG GCTCGGTGGA TTTCCTCTCT CTTGATTTGT CTTACGAATG CCAAAGTGTG 
GCGACTCTAC CACAGAAGCT GAGTGAATTG CAGAACCTTG AGCCAAAAGT GAAAGTTTTC 
ATCTACACCC TAAAACTTGA GGACTGCCCA GCGACCGGGA CGAGCCCCTC CTCACTGCTC 
ATCAGCCTCC TGGAAGCCAT AAATAAAGAC CAAATCCAAA CTGTTGGCTT TGATGTTAAT 
GCATTCCTGA GCTGTACGTC CAATTCTGAG GAGAGCCCAT CTTGTTCTTT AACCGACAGC 
CTGGCCCTTC AGACTGAGCA GCAGCAGGAG ACAGCTGTAC CCTCATCCCC TGGATCAGCC 
TACCAGAGAG TTTGGGCAGC CTTTGCTAAC CAGTCTAGGG AGGAAAGGGA TGCTTTCCTA 
CAAGATGTGT TTCCAGAAGG GTTCCTCTGG GGCATATCCA CGGGAGCCTT TAATGTGGAG 
GGAGGCTGGG CAGAAGGCGG CAGAGGGCCG AGCATCTGGG ATCACTACGG TAACCTGAAT 
GCTGCCGAGG GACAAGCCAC AGCAAAAGTG GCCAGTGACA GTTACCACAA ACCAGCTTCT 
GATGTCGCCC TCCTCCGAGG CATCAGGGCT CAGGTGTACA AGTTCTCCAT CTCCTGGTCC 
CGCCTCTTCC CCACTGGGCA GAAGAGCACC CCCAACCGCC AAGGTGTCGC CTACTACAAC 
AAACTGATCG ACCGCCTGCT GGACTCACAC ATCGAGCCCA TGGCTACACT GTTCCACTGG 
GACCTGCCTC AGGCCCTGCA GGAGCAAGGC GGCTGGCAGA ACGAGAGTGT GGTGGAGGCC 
TTCCTGGACT ACGCAGCCTT CTGCTTCTCC ACTTTCGGGG ACCGTGTGAA ACTGTGGGTG 
ACCTTCCACG AGCCATGGGT GATGAGCTAT GCAGGCTATG GTACTGGACA GCACGCACCA 
GCCATCTCTG ACCCAGGAAT GGCTTCCTTT AAGGTGGCTC ACCTGATCCT CAAGGCACAT 
GCCAGAACTT GGCATCTCTA CGACCTTCAC CATCGCCTAC AGCAGCAGGG GCGCGTGGGC 
ATCGTCCTCA ATTCAGACTG GGCGGAGCCC CTGGATAGGA AGAGTCCTCA GGACCTTGCT 
GCTGCTGAGC GCTTCCTACA CTTCATGCTG GGCTGGTTCG CACACCCCAT CTTTGTAGAT 
GGGGACTACC CCACTACCCT TCGGGCCCAG ATCCAGCACA TAAACCAGCA GTGTGGCCAT 
CCTCTGGCCC AACTCCCAGA GTTCACTGAA GCGGAGAAGC GGCTCCTTAA GGGCTCTGCG 
GATTTCCTGG GTCTGTCTCA TTACACCTCC CGCCTCATCA GCAAGGCTGG GCGGCAGACC 
TGCACCTCCA GCTACGATAA CATCGGAGGC TTCTCCCAGC ATGTGGACCC CGAGTGGCCC 
CAGACTGCAT CTCCCTGGAT CCGAGTGGTG CCCTGGGGCA TAAGGAGGCT GCTTCGGTTC 
GCGTCTATGG AGTACACGAA AGGGAAACTT CCAATCTTCT TGGCTGGGAA TGGCATGCCA 
GTAGGGGAAG AAGCGGACCT CTTTGACGAC TCAGTGAGAG TAAACTACTT CAACTTGTAC 
ATCAACGAGG TGCTCAAGGC TGTCAAGGAG GATTTGGTGG ATGTCCGTTC ATACATTGTT 
CGTTCCCTCA TTGACGGCTA TGAAGGACCC CTGGGCTTCA GTCAGAGGTT TGGGCTATAC 
CATGTCAACT TCAATGACAG CAGCAGGCCA CGAACTCCCA GGAAATCTGC ATACTTCTTC 
ACCAGCATCA TTGAAAAGAA TGGTTTTTCA GCCAAGAAAG TCAAAAGAAA CCCACTGCCC 
GTGAGAGCAG ACTTCACCTC CAGAGCCAGG GTCACCGACA GCCTTCCATC GGAGGTGCCC 
TCCAAGGCTA AAATAGTGTG GGAGAAGTTC TCCAAGCAGC CCAGGTTTGA AAGAGACTTG 
TTCTATCACG GCACATTCCG GGATGACTTC CTGTGGGGTG TATCCTCTTC AGCCTATCAG 
ATCGAAGGAG GATGGAATGC TGATGGCAAA GGCCCCAGCA TCTGGGATAA CTTCACCCAC 
ACCCCAGGGA ATGGTGTGAA AGACAATGCC ACCGGAGACG TAGCGTGCGA CAGCTATCAC 
CAACTGGACG CCGACCTAAA CATCCTTCGA ACCCTGAAGG TCAAGTCCTA TCGATTTTCC 
ATCTCCTGGT CTCGAATTTT CCCAACAGGA AGAAACAGTA CCATCAACAA ACAAGGCGTT 
GATTATTACA ACAGACTGAT TGACAGCTTG GTGGACAACA ACATCTTCCC CATGGTGACA 
CTGTTTCACT GGGACCTGCC CCAGGCCCTC CAGGATATTG GAGGTTGGGA GAACCCTTCT 
TTGATTGAGT TGTTTGACAG CTATGCAGAC TTCTGCTTTA AGACCTTTGG TGACAGAGTC 
AAGTTCTGGA TGACCTTTAA CGAGCCCTGG TGTCACGTGG TGTTAGGCTA CAGTTCAGGG 
ATATTTCCCC CAAGTGTTCA GGAGCCAGGC TGGCTACCTT ATAAGGTTAG CCATATCGTC 
ATTAAGGCAC ATGCTAGGGT CTACCATACT TACGATGAGA AGTACCGCTC GGAGCAGAAA 
GGTGTCATCT CTCTCAGCCT CAACACTCAC TGGGCAGAAC CCAAGGACCC AGGGCTCCAA 
AGGGATGTGG AAGCCGCTGA CCGGATGCTG CAGTTTACCA TGGGCTGGTT TGCCCACCCG 
ATTTTTAAAA ACGGGGACTA TCCAGACGTC ATGAAATGGA CTGTGGGGAA CAGGAGTGAG 
CTGCAGCACC TGGCCAGCTC CCGCCTGCCT ACCTTCACAG AGGAAGAGAA GAATTACGTC 
AGAGGCACCG CTGATGTCTT TTGCATCAAC ACCTACACGT CTGTGTTTGT GCAGCACAGC 
ACTCCCAGGC TGAACCCACC CAGCTATGAT GATGACATGG AGTTGAAGCT AATCGAAATG 
AACTCGTCGA CGGGTGTGAT GCACCCAGAC GTGCCCTGGG GGACGAGGAG GCTGCTGAAC 
TGGATCAAGG AGGAGTATGG CAACATTCCT ATTTATATCA CTGAAAATGG ACAGGGACTG 
GAAAACCCCA CACTGGATGA CACAGAAAGG ATCTTCTACC ACAAAACCTA TATCAACGAG 
GCTCTGAAAG CCTACAAGCT GGATGGTGTG GACCTTCGAG GGTACTCTGC CTGGACGCTG 
ATGGACGACT TCGAGTGGCT GCTTGGCTAC ACCATGAGAT TTGGATTGTA TCACGTTGAC 
TTTAATCATG TGAGCAGACC TCGCACAGCA AGAGCCTCAG CCAGATACTA TGCAGAGGTC 
ATTGCCAACA ATGGCATGCC CCTGGCCAGG GAAGATGAGT TCCTGTATGG AGAGTTTCCC 
AAGGGCTTCA TCTGGAGTGC GGCTTCTGCT TCATACCAGG TTGAAGGCGC GTGGAGAGCA 
GATGGCAAAG GACTCAGTAT CTGGGACACA TTTTCCCACA CACCACTGAG GATCGGGAAT 
GATGACAACG GAGACGTGGC ATGTGACAGT TACCACAAGA TTGCCGAGGA TGTGGTGGCC 
CTTCAGAACC TGGGCGTGTC CCACTATCGC TTCTCCATTG CCTGGTCTAG AATCCTCCCA 
GACGGAACCA CCAAGTTCAT CAATGAAGCG GGCCTCAGTT ACTATGTTCG ATTCATTGAT 
GCCCTGCTGG CTGCTGGCAT CACACCACAG GTGACCATTT ATCACTGGGA CCTGCCCCAG 
GCACTGCAAG ACGTGGGGGG CTGGGAGAAC GAGACAATTG TGCAGCGGTT TAAGGAGTAC 
GCGGATGTGC TCTTCCAGAG GCTGGGGGAC AGAGTCAAGT TCTGGATCAC TCTGAACGAG 
CCCTTCGTCA TTGCAGCCCA AGGCTACGGC ACTGGGGTGT CTGCTCCAGG AATCTCCTTC 
AGGCCTGGCA CAGCTCCGTA CATTGCTGGA CACAACCTAA TAAAGGCCCA CGCTGAGGCC 
TGGCATCTCT ACAACGATGT ATACCGCGCC CGCCAGGGAG GCACCATCTC CATCACGATC 
AGCAGTGACT GGGCTGAACC CAGGGATCCC ACCAACCAGG GAGACGTGGA GGCAGCCAGG 
AGATACGTAC AGTTTATGGG GGGCTGGTTT GCTCACCCCA TCTTCAAAAA CGGAGATTAC 
CCGGAGGTGA TGAAGACACG GATCCGCGAC AGAAGCCTGG CGGCAGGCCT CAACAAGTCC 
AGGCTCCCTG AGTTTACGGA GAGTGAGAAG AGTAGGATCA AGGGCACCTT TGACTTTTTC 
GGGTTCAACC ACTACACCAC TGTCCTAGCT TACAACCTCG ACTACCCGGC TGCCTTCTCC 
TCCTTTGATG CAGACAGGGG CGTTGCTTCC ATTGCAGACA GCTCTTGGCC AGTCTCTGGC 
TCCTTCTGGC TGAAGGTGAC CCCTTTTGGC TTCCGGAGGA TCTTGAACTG GCTGAAGGAG 
GAGTACAATA ATCCTCCGAT TTATGTCACC GAGAATGGTG TCTCCAGACG AGGAGAGCCG 
GAACTCAACG ACACCGACAG GATCTACTAC CTGCGCAGCT ACATTAACGA AGCCCTCAAG 
GCTGTACAGG ACAAGGTGGA CCTTCGAGGC TACACGGTAT GGAGCATCAT GGACAACTTT 
GAATGGGCCA CAGGCTTCGC AGAGAGGTTC GGTGTGCACT TTGTGAACCG CTCTGACCCA 
TCTTTGCCAA GGATCCCCAA GGCATCAGCC AAGTTCTATG CCACCATCGT CCGCTGCAAT 
GGCTTTCCCG ACCCTGCACA AGGACCTCAT CCTTGTCTCC AGCAACCAGA AGACGCTGCA 
CCCACTGCCA GTCCCGTGCA GTCGGAAGTG CCCTTCCTGG GGCTGATGCT GGGCATCGCA 
GAAGCACAGA CAGCGCTGTA CGTGCTCTTC GCTCTGCTGC TGCTTGGAGC CTGCAGCCTG 
GCATTTCTGA CCTACAAATA CTGCCGGCGC TCCAAGCAAG GGAACGCGCA GCCAAGCCAG 
CACCAGCTGA GTCCAATTTC CTCCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446293.1
CDS	2..5791
Translation	MELPWTALFLSTVLLGLSCQGSDWESDRNFISAAGPLTNDLVLNLNYPPGKQGSDVVSGNTDIYICQQPLPSFLSQYFSSLRASQVTHYKVLLSWAQLLPTGSSKNPDQEAVQCYRQLLQSLKDAQLEPMVVLCHQTPPTSSAIQREGAFADLFADYATLAFQSFGDLVEIWFTFSDLEKVIMDLPHKDLKASALQTLSNAHRRAFDIYHRKFSSQGGKLSVVLKAEDIPELLPDPALAALVQGSVDFLSLDLSYECQSVATLPQKLSELQNLEPKVKVFIYTLKLEDCPATGTSPSSLLISLLEAINKDQIQTVGFDVNAFLSCTSNSEESPSCSLTDSLALQTEQQQETAVPSSPGSAYQRVWAAFANQSREERDAFLQDVFPEGFLWGISTGAFNVEGGWAEGGRGPSIWDHYGNLNAAEGQATAKVASDSYHKPASDVALLRGIRAQVYKFSISWSRLFPTGQKSTPNRQGVAYYNKLIDRLLDSHIEPMATLFHWDLPQALQEQGGWQNESVVEAFLDYAAFCFSTFGDRVKLWVTFHEPWVMSYAGYGTGQHAPAISDPGMASFKVAHLILKAHARTWHLYDLHHRLQQQGRVGIVLNSDWAEPLDRKSPQDLAAAERFLHFMLGWFAHPIFVDGDYPTTLRAQIQHINQQCGHPLAQLPEFTEAEKRLLKGSADFLGLSHYTSRLISKAGRQTCTSSYDNIGGFSQHVDPEWPQTASPWIRVVPWGIRRLLRFASMEYTKGKLPIFLAGNGMPVGEEADLFDDSVRVNYFNLYINEVLKAVKEDLVDVRSYIVRSLIDGYEGPLGFSQRFGLYHVNFNDSSRPRTPRKSAYFFTSIIEKNGFSAKKVKRNPLPVRADFTSRARVTDSLPSEVPSKAKIVWEKFSKQPRFERDLFYHGTFRDDFLWGVSSSAYQIEGGWNADGKGPSIWDNFTHTPGNGVKDNATGDVACDSYHQLDADLNILRTLKVKSYRFSISWSRIFPTGRNSTINKQGVDYYNRLIDSLVDNNIFPMVTLFHWDLPQALQDIGGWENPSLIELFDSYADFCFKTFGDRVKFWMTFNEPWCHVVLGYSSGIFPPSVQEPGWLPYKVSHIVIKAHARVYHTYDEKYRSEQKGVISLSLNTHWAEPKDPGLQRDVEAADRMLQFTMGWFAHPIFKNGDYPDVMKWTVGNRSELQHLASSRLPTFTEEEKNYVRGTADVFCINTYTSVFVQHSTPRLNPPSYDDDMELKLIEMNSSTGVMHPDVPWGTRRLLNWIKEEYGNIPIYITENGQGLENPTLDDTERIFYHKTYINEALKAYKLDGVDLRGYSAWTLMDDFEWLLGYTMRFGLYHVDFNHVSRPRTARASARYYAEVIANNGMPLAREDEFLYGEFPKGFIWSAASASYQVEGAWRADGKGLSIWDTFSHTPLRIGNDDNGDVACDSYHKIAEDVVALQNLGVSHYRFSIAWSRILPDGTTKFINEAGLSYYVRFIDALLAAGITPQVTIYHWDLPQALQDVGGWENETIVQRFKEYADVLFQRLGDRVKFWITLNEPFVIAAQGYGTGVSAPGISFRPGTAPYIAGHNLIKAHAEAWHLYNDVYRARQGGTISITISSDWAEPRDPTNQGDVEAARRYVQFMGGWFAHPIFKNGDYPEVMKTRIRDRSLAAGLNKSRLPEFTESEKSRIKGTFDFFGFNHYTTVLAYNLDYPAAFSSFDADRGVASIADSSWPVSGSFWLKVTPFGFRRILNWLKEEYNNPPIYVTENGVSRRGEPELNDTDRIYYLRSYINEALKAVQDKVDLRGYTVWSIMDNFEWATGFAERFGVHFVNRSDPSLPRIPKASAKFYATIVRCNGFPDPAQGPHPCLQQPEDAAPTASPVQSEVPFLGLMLGIAEAQTALYVLFALLLLGACSLAFLTYKYCRRSKQGNAQPSQHQLSPISSF

Target ORF information:

RefSeq Version	NM_053841.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lactase (Lct), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053841.1

ORF Insert Sequence:

ATGGAGCTGC CTTGGACAGC ACTCTTCCTG AGTACTGTCC TCCTGGGTCT TTCATGCCAG 
GGCTCTGACT GGGAATCCGA CAGAAATTTT ATTTCAGCCG CTGGTCCTCT AACAAATGAC 
TTAGTGCTTA ATCTGAACTA TCCACCGGGA AAGCAGGGCT CTGATGTGGT ATCCGGTAAC 
ACCGACATCT ACATCTGCCA GCAGCCACTG CCCTCTTTCT TGTCTCAGTA TTTCAGCAGT 
CTTCGTGCCA GCCAGGTTAC CCATTACAAA GTTCTTCTGT CATGGGCACA ACTTCTCCCA 
ACTGGAAGCT CCAAGAATCC AGACCAGGAA GCAGTGCAGT GCTACCGACA ACTCCTCCAG 
TCCCTGAAGG ATGCCCAGCT TGAGCCCATG GTGGTCCTGT GCCATCAGAC GCCACCCACC 
AGCAGCGCCA TCCAGAGAGA AGGGGCCTTT GCTGACCTCT TTGCTGACTA TGCCACATTG 
GCTTTTCAGT CCTTTGGGGA CCTTGTTGAG ATCTGGTTCA CCTTCAGTGA CTTGGAGAAA 
GTGATCATGG ATCTTCCCCA CAAAGATCTG AAAGCTTCTG CTCTTCAAAC CCTCAGCAAT 
GCCCACAGGA GAGCCTTTGA CATTTACCAC AGAAAGTTCT CATCTCAGGG GGGAAAGCTG 
TCTGTGGTCC TGAAGGCTGA AGATATTCCA GAGCTTCTGC CAGACCCGGC ATTGGCTGCT 
CTCGTCCAGG GCTCGGTGGA TTTCCTCTCT CTTGATTTGT CTTACGAATG CCAAAGTGTG 
GCGACTCTAC CACAGAAGCT GAGTGAATTG CAGAACCTTG AGCCAAAAGT GAAAGTTTTC 
ATCTACACCC TAAAACTTGA GGACTGCCCA GCGACCGGGA CGAGCCCCTC CTCACTGCTC 
ATCAGCCTCC TGGAAGCCAT AAATAAAGAC CAAATCCAAA CTGTTGGCTT TGATGTTAAT 
GCATTCCTGA GCTGTACGTC CAATTCTGAG GAGAGCCCAT CTTGTTCTTT AACCGACAGC 
CTGGCCCTTC AGACTGAGCA GCAGCAGGAG ACAGCTGTAC CCTCATCCCC TGGATCAGCC 
TACCAGAGAG TTTGGGCAGC CTTTGCTAAC CAGTCTAGGG AGGAAAGGGA TGCTTTCCTA 
CAAGATGTGT TTCCAGAAGG GTTCCTCTGG GGCATATCCA CGGGAGCCTT TAATGTGGAG 
GGAGGCTGGG CAGAAGGCGG CAGAGGGCCG AGCATCTGGG ATCACTACGG TAACCTGAAT 
GCTGCCGAGG GACAAGCCAC AGCAAAAGTG GCCAGTGACA GTTACCACAA ACCAGCTTCT 
GATGTCGCCC TCCTCCGAGG CATCAGGGCT CAGGTGTACA AGTTCTCCAT CTCCTGGTCC 
CGCCTCTTCC CCACTGGGCA GAAGAGCACC CCCAACCGCC AAGGTGTCGC CTACTACAAC 
AAACTGATCG ACCGCCTGCT GGACTCACAC ATCGAGCCCA TGGCTACACT GTTCCACTGG 
GACCTGCCTC AGGCCCTGCA GGAGCAAGGC GGCTGGCAGA ACGAGAGTGT GGTGGAGGCC 
TTCCTGGACT ACGCAGCCTT CTGCTTCTCC ACTTTCGGGG ACCGTGTGAA ACTGTGGGTG 
ACCTTCCACG AGCCATGGGT GATGAGCTAT GCAGGCTATG GTACTGGACA GCACGCACCA 
GCCATCTCTG ACCCAGGAAT GGCTTCCTTT AAGGTGGCTC ACCTGATCCT CAAGGCACAT 
GCCAGAACTT GGCATCTCTA CGACCTTCAC CATCGCCTAC AGCAGCAGGG GCGCGTGGGC 
ATCGTCCTCA ATTCAGACTG GGCGGAGCCC CTGGATAGGA AGAGTCCTCA GGACCTTGCT 
GCTGCTGAGC GCTTCCTACA CTTCATGCTG GGCTGGTTCG CACACCCCAT CTTTGTAGAT 
GGGGACTACC CCACTACCCT TCGGGCCCAG ATCCAGCACA TAAACCAGCA GTGTGGCCAT 
CCTCTGGCCC AACTCCCAGA GTTCACTGAA GCGGAGAAGC GGCTCCTTAA GGGCTCTGCG 
GATTTCCTGG GTCTGTCTCA TTACACCTCC CGCCTCATCA GCAAGGCTGG GCGGCAGACC 
TGCACCTCCA GCTACGATAA CATCGGAGGC TTCTCCCAGC ATGTGGACCC CGAGTGGCCC 
CAGACTGCAT CTCCCTGGAT CCGAGTGGTG CCCTGGGGCA TAAGGAGGCT GCTTCGGTTC 
GCGTCTATGG AGTACACGAA AGGGAAACTT CCAATCTTCT TGGCTGGGAA TGGCATGCCA 
GTAGGGGAAG AAGCGGACCT CTTTGACGAC TCAGTGAGAG TAAACTACTT CAACTTGTAC 
ATCAACGAGG TGCTCAAGGC TGTCAAGGAG GATTTGGTGG ATGTCCGTTC ATACATTGTT 
CGTTCCCTCA TTGACGGCTA TGAAGGACCC CTGGGCTTCA GTCAGAGGTT TGGGCTATAC 
CATGTCAACT TCAATGACAG CAGCAGGCCA CGAACTCCCA GGAAATCTGC ATACTTCTTC 
ACCAGCATCA TTGAAAAGAA TGGTTTTTCA GCCAAGAAAG TCAAAAGAAA CCCACTGCCC 
GTGAGAGCAG ACTTCACCTC CAGAGCCAGG GTCACCGACA GCCTTCCATC GGAGGTGCCC 
TCCAAGGCTA AAATAGTGTG GGAGAAGTTC TCCAAGCAGC CCAGGTTTGA AAGAGACTTG 
TTCTATCACG GCACATTCCG GGATGACTTC CTGTGGGGTG TATCCTCTTC AGCCTATCAG 
ATCGAAGGAG GATGGAATGC TGATGGCAAA GGCCCCAGCA TCTGGGATAA CTTCACCCAC 
ACCCCAGGGA ATGGTGTGAA AGACAATGCC ACCGGAGACG TAGCGTGCGA CAGCTATCAC 
CAACTGGACG CCGACCTAAA CATCCTTCGA ACCCTGAAGG TCAAGTCCTA TCGATTTTCC 
ATCTCCTGGT CTCGAATTTT CCCAACAGGA AGAAACAGTA CCATCAACAA ACAAGGCGTT 
GATTATTACA ACAGACTGAT TGACAGCTTG GTGGACAACA ACATCTTCCC CATGGTGACA 
CTGTTTCACT GGGACCTGCC CCAGGCCCTC CAGGATATTG GAGGTTGGGA GAACCCTTCT 
TTGATTGAGT TGTTTGACAG CTATGCAGAC TTCTGCTTTA AGACCTTTGG TGACAGAGTC 
AAGTTCTGGA TGACCTTTAA CGAGCCCTGG TGTCACGTGG TGTTAGGCTA CAGTTCAGGG 
ATATTTCCCC CAAGTGTTCA GGAGCCAGGC TGGCTACCTT ATAAGGTTAG CCATATCGTC 
ATTAAGGCAC ATGCTAGGGT CTACCATACT TACGATGAGA AGTACCGCTC GGAGCAGAAA 
GGTGTCATCT CTCTCAGCCT CAACACTCAC TGGGCAGAAC CCAAGGACCC AGGGCTCCAA 
AGGGATGTGG AAGCCGCTGA CCGGATGCTG CAGTTTACCA TGGGCTGGTT TGCCCACCCG 
ATTTTTAAAA ACGGGGACTA TCCAGACGTC ATGAAATGGA CTGTGGGGAA CAGGAGTGAG 
CTGCAGCACC TGGCCAGCTC CCGCCTGCCT ACCTTCACAG AGGAAGAGAA GAATTACGTC 
AGAGGCACCG CTGATGTCTT TTGCATCAAC ACCTACACGT CTGTGTTTGT GCAGCACAGC 
ACTCCCAGGC TGAACCCACC CAGCTATGAT GATGACATGG AGTTGAAGCT AATCGAAATG 
AACTCGTCGA CGGGTGTGAT GCACCCAGAC GTGCCCTGGG GGACGAGGAG GCTGCTGAAC 
TGGATCAAGG AGGAGTATGG CAACATTCCT ATTTATATCA CTGAAAATGG ACAGGGACTG 
GAAAACCCCA CACTGGATGA CACAGAAAGG ATCTTCTACC ACAAAACCTA TATCAACGAG 
GCTCTGAAAG CCTACAAGCT GGATGGTGTG GACCTTCGAG GGTACTCTGC CTGGACGCTG 
ATGGACGACT TCGAGTGGCT GCTTGGCTAC ACCATGAGAT TTGGATTGTA TCACGTTGAC 
TTTAATCATG TGAGCAGACC TCGCACAGCA AGAGCCTCAG CCAGATACTA TGCAGAGGTC 
ATTGCCAACA ATGGCATGCC CCTGGCCAGG GAAGATGAGT TCCTGTATGG AGAGTTTCCC 
AAGGGCTTCA TCTGGAGTGC GGCTTCTGCT TCATACCAGG TTGAAGGCGC GTGGAGAGCA 
GATGGCAAAG GACTCAGTAT CTGGGACACA TTTTCCCACA CACCACTGAG GATCGGGAAT 
GATGACAACG GAGACGTGGC ATGTGACAGT TACCACAAGA TTGCCGAGGA TGTGGTGGCC 
CTTCAGAACC TGGGCGTGTC CCACTATCGC TTCTCCATTG CCTGGTCTAG AATCCTCCCA 
GACGGAACCA CCAAGTTCAT CAATGAAGCG GGCCTCAGTT ACTATGTTCG ATTCATTGAT 
GCCCTGCTGG CTGCTGGCAT CACACCACAG GTGACCATTT ATCACTGGGA CCTGCCCCAG 
GCACTGCAAG ACGTGGGGGG CTGGGAGAAC GAGACAATTG TGCAGCGGTT TAAGGAGTAC 
GCGGATGTGC TCTTCCAGAG GCTGGGGGAC AGAGTCAAGT TCTGGATCAC TCTGAACGAG 
CCCTTCGTCA TTGCAGCCCA AGGCTACGGC ACTGGGGTGT CTGCTCCAGG AATCTCCTTC 
AGGCCTGGCA CAGCTCCGTA CATTGCTGGA CACAACCTAA TAAAGGCCCA CGCTGAGGCC 
TGGCATCTCT ACAACGATGT ATACCGCGCC CGCCAGGGAG GCACCATCTC CATCACGATC 
AGCAGTGACT GGGCTGAACC CAGGGATCCC ACCAACCAGG GAGACGTGGA GGCAGCCAGG 
AGATACGTAC AGTTTATGGG GGGCTGGTTT GCTCACCCCA TCTTCAAAAA CGGAGATTAC 
CCGGAGGTGA TGAAGACACG GATCCGCGAC AGAAGCCTGG CGGCAGGCCT CAACAAGTCC 
AGGCTCCCTG AGTTTACGGA GAGTGAGAAG AGTAGGATCA AGGGCACCTT TGACTTTTTC 
GGGTTCAACC ACTACACCAC TGTCCTAGCT TACAACCTCG ACTACCCGGC TGCCTTCTCC 
TCCTTTGATG CAGACAGGGG CGTTGCTTCC ATTGCAGACA GCTCTTGGCC AGTCTCTGGC 
TCCTTCTGGC TGAAGGTGAC CCCTTTTGGC TTCCGGAGGA TCTTGAACTG GCTGAAGGAG 
GAGTACAATA ATCCTCCGAT TTATGTCACC GAGAATGGTG TCTCCAGACG AGGAGAGCCG 
GAACTCAACG ACACCGACAG GATCTACTAC CTGCGCAGCT ACATTAACGA AGCCCTCAAG 
GCTGTACAGG ACAAGGTGGA CCTTCGAGGC TACACGGTAT GGAGCATCAT GGACAACTTT 
GAATGGGCCA CAGGCTTCGC AGAGAGGTTC GGTGTGCACT TTGTGAACCG CTCTGACCCA 
TCTTTGCCAA GGATCCCCAA GGCATCAGCC AAGTTCTATG CCACCATCGT CCGCTGCAAT 
GGCTTTCCCG ACCCTGCACA AGGACCTCAT CCTTGTCTCC AGCAACCAGA AGACGCTGCA 
CCCACTGCCA GTCCCGTGCA GTCGGAAGTG CCCTTCCTGG GGCTGATGCT GGGCATCGCA 
GAAGCACAGA CAGCGCTGTA CGTGCTCTTC GCTCTGCTGC TGCTTGGAGC CTGCAGCCTG 
GCATTTCTGA CCTACAAATA CTGCCGGCGC TCCAAGCAAG GGAACGCGCA GCCAAGCCAG 
CACCAGCTGA GTCCAATTTC CTCCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hormone induced changes in lactase glycosylation in developing rat intestine.
Molecular and cellular biochemistry318(1-2)183-90(2008 Nov)
Chaudhry KK,Mahmood S,Mahmood A

Hormone induced expression of brush border lactase in suckling rat intestine.
Molecular and cellular biochemistry312(1-2)11-6(2008 May)
Chaudhry KK,Mahmood S,Mahmood A

Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats.
Mammalian genome : official journal of the International Mammalian Genome Society19(1)41-50(2008 Jan)
Akiyama K,Morita H,Suetsugu S,Kuraba S,Numata Y,Yamamoto Y,Inui K,Ideura T,Wakisaka N,Nakano K,Oniki H,Takenawa T,Matsuyama M,Yoshimura A

Morphological and biochemical alterations in the jejunum following iodoacetamide-induced colitis in rats.
Canadian journal of physiology and pharmacology84(11)1191-203(2006 Nov)
Jurjus A,Barada K,Khoury N,Assef MD,Foltzer CJ,Reimund JM,Kedinger M

Dietary sucrose enhances intestinal lactase gene expression in euthyroid rats.
Journal of nutritional science and vitaminology52(5)347-51(2006 Oct)
Kuranuki S,Mochizuki K,Goda T

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Lct cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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