Npr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Npr2
Entrez Gene ID	116564
Full Name	natriuretic peptide receptor 2
Synonyms	GC-B,NPR-B
General protein information	Preferred Names natriuretic peptide receptor 2 Names atrial natriuretic peptide receptor 2 ANP-B ANPR-B ANPRB atrial natriuretic peptide B-type receptor atrial natriuretic peptide receptor B atrial natriuretic peptide receptor type B guanylate cyclase B natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) natriuretic peptide receptor-B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q22
Summary	receptor for atrial natriuretic peptide, brain natriuretic peptide and atriopeptin; has guanylate cyclase activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006238010.3	XP_006238072.1	atrial natriuretic peptide receptor 2 isoform X1
NM_053838.1	NP_446290.1	atrial natriuretic peptide receptor 2 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Npr2	NP_446290.1
Mus musculus (house mouse)	Npr2	NP_776149.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003283	XP_307791.5
Gallus gallus (chicken)	NPR2	XP_004937202.1
Drosophila melanogaster (fruit fly)	CG31183	NP_650505.2
Homo sapiens (human)	NPR2	NP_003986.2
Pan troglodytes (chimpanzee)	NPR2	XP_001168194.1
	NPR2	XP_001085221.1
Canis lupus familiaris (dog)	NPR2	XP_005626847.1
Caenorhabditis elegans (roundworm)	gcy-28	NP_001249628.1

Gene Ontology
Bibliography

Related articles in PubMed

Dephosphorylation is the mechanism of fibroblast growth factor inhibition of guanylyl cyclase-B.
Robinson JW, Egbert JR, Davydova J, Schmidt H, Jaffe LA, Potter LR
Cellular signalling40222-229(2017 Dec)

Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in?vitro.
Manivasagam S, Vellaichamy E
Biochemical and biophysical research communications491(2)250-256(2017 09)

Elevated C-type natriuretic peptide elicits exercise preconditioning-induced cardioprotection against myocardial injury probably via the up-regulation of NPR-B.
Lu J, Pan SS
The journal of physiological sciences : JPS67(4)475-487(2017 Jul)

C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.
Buttgereit J, Shanks J, Li D, Hao G, Athwal A, Langenickel TH, Wright H, da Costa Goncalves AC, Monti J, Plehm R, Popova E, Qadri F, Lapidus I, Ryan B, ?zcelik C, Paterson DJ, Bader M, Herring N
Cardiovascular research112(3)637-644(2016 Dec)

Catalytically Active Guanylyl Cyclase B Requires Endoplasmic Reticulum-mediated Glycosylation, and Mutations That Inhibit This Process Cause Dwarfism.
Dickey DM, Edmund AB, Otto NM, Chaffee TS, Robinson JW, Potter LR
The Journal of biological chemistry291(21)11385-93(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in cardiomyocytes in vitro.
Title: Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in?vitro.

C-type natriuretic peptide reduces cardiac sympathetic neurotransmission via a reduction in neuronal calcium signalling and NE release through the NPR-B receptor. Situations impairing CNP-NPR-B signalling lead to hypertension, tachycardia, and impaired left ventricular systolic function secondary to sympatho-excitation.
Title: C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.

Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the luteinizing hormone-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.
Title: Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.

Provide direct evidence for the presence and synthesis of ANP and its receptors in both neuronal and non-neuronal cells within the cochlear spiral ganglion.
Title: Expression patterns of atrial natriuretic peptide and its receptors within the cochlear spiral ganglion of the postnatal rat.

These data indicate common and distinct properties of particulate guanylyl cyclase receptors in somatotropes.
Title: Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.

The following Npr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Npr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13772	NM_053838.1 Latest version!	Rattus norvegicus natriuretic peptide receptor 2 (Npr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$559.30 $799.00
ORa28111	XM_006238010.3 Latest version!	Rattus norvegicus natriuretic peptide receptor 2 (Npr2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Npr2 ( NM_053838.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446290.1 Rattus norvegicus natriuretic peptide receptor 2 (Npr2), mRNA.

Price & Availability↑

CloneID	ORa13772
Clone ID Related Accession (Same CDS sequence)	NM_053838.1
Accession Version	NM_053838.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3144bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	atrial natriuretic peptide receptor 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M26896.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M26896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCACTGC CATCCCTGCT ACTGGTGGTG GCAGCCCTGG CAGGTGGGGT GCGTCCTCCG 
GGGGCACGGA ACCTGACGCT GGCGGTGGTG CTGCCAGAAC ACAACCTGAG CTATGCCTGG 
GCCTGGCCAC GGGTGGGTCC TGCTGTGGCA CTGGCTGTGG AGGCGCTGGG CCGGGCACTG 
CCCGTGGACC TGCGGTTTGT CAGCTCCGAA CTAGACGGCG CCTGCTCTGA GTACCTGGCA 
CCACTGCGCG CTGTGGATCT CAAGCTGTAC CATGACCCCG ACCTTCTGTT GGGCCCTGGT 
TGTGTGTACC CTGCTGCCTC TGTGGCTCGC TTTGCCTCGC ACTGGCACCT TCCCCTCCTG 
ACTGCGGGTG CAGTGGCCTC TGGCTTTGCA GCTAAGAATG AGCATTATCG TACCCTGGTT 
CGCACTGGCC CCTCTGCGCC CAAGCTGGGT GAGTTCGTAG TGACATTACA CGGGCACTTC 
AATTGGACTG CTCGGGCTGC TTTGCTGTAT CTGGATGCTC GCACAGATGA CCGGCCCCAC 
TACTTCACCA TCGAGGGGGT GTTTGAGGCC CTGCAGGGCA GCAACCTCAG TGTGCAACAC 
CAGGTGTATA CCCGAGAGCC AGGTGGCCCT GAGCAAGCCA CCCACTTCAT CAGAGCCAAC 
GGGCGCATTG TGTATATCTG CGGCCCGCTG GAGATGCTTC ATGAGATCCT GCTTCAGGCC 
CAGAGGGAGA ACCTGACCAA TGGGGACTAT GTCTTCTTTT ACCTTGATGT CTTTGGGGAG 
AGTCTACGAG CAGGCCCCAC ACGTGCGACA GGCCGGCCAT GGCAGGACAA TCGAACCCAG 
GAACAAGCTC AGGCCCTCAG AGAGGCCTTT CAGACTGTCC TGGTGATCAC GTACCGAGAG 
CCCCCGAATC CCGAGTATCA GGAGTTCCAG AACCGCCTGC TGATCAGAGC CCGGGAAGAC 
TTCGGCGTGG AGCTGGCCCC ATCCCTGATG AACCTCATTG CGGGCTGCTT CTATGATGGA 
ATCCTGCTCT ATGCCCAAGT CCTGAATGAG ACAATACAGG AAGGGGGCAC CCGGGAAGAT 
GGACTTCGAA TTGTGGAGAA GATGCAGGGA CGAAGATACC ATGGTGTAAC TGGACTGGTT 
GTTATGGACA AGAACAATGA CAGAGAGACT GATTTCGTCC TGTGGGCCAT GGGAGACTTG 
GAGTCTGGCG ACTTTCAGCC TGCAGCCCAT TACTCAGGAG CTGAGAAGCA GATTTGGTGG 
ACAGGCCGGC CAATTCCCTG GGTGAAGGGG GCCCCACCTT TGGACAACCC CCCCTGTGCC 
TTTGACTTGG ACGACCCATC CTGTGATAAA ACTCCACTTT CCACTCTGGC AATTGTGGCC 
CTGGGCACGG GAATCACTTT CATCATGTTT GGTGTTTCCA GCTTCCTAAT TTTCCGAAAA 
CTGATGCTGG AGAAGGAGCT GGCTAGCATG CTGTGGCGCA TTCGCTGGGA AGAACTGCAG 
TTCGGCAACT CGGATCGATA TCACAAAGGT GCAGGCAGTC GCCTGACGCT GTCGCTGCGG 
GGATCCAGTT ACGGCTCGCT CATGACAGCC CATGGGAAAT ACCAGATCTT TGCCAACACC 
GGTCACTTCA AGGGAAATGT CGTTGCCATC AAACATGTGA ATAAGAAGCG CATTGAGCTG 
ACCCGGCAAG TTCTGTTTGA ACTCAAACAC ATGAGAGATG TTCAGTTCAA CCATCTTACT 
CGATTCATCG GAGCTTGCAT AGACCCTCCC AACATCTGCA TCGTCACCGA GTATTGTCCT 
CGGGGGAGCT TACAAGATAT TCTAGAAAAT GACAGCATCA ATTTGGACTG GATGTTTCGC 
TACTCGCTCA TTAATGACCT TGTGAAGGGT ATGGCCTTTC TCCACAACAG CATTATTTCA 
TCTCATGGAA GCCTCAAGTC CTCTAACTGC GTGGTGGATA GTCGATTTGT GCTCAAAATA 
ACGGATTACG GGCTGGCTAG CTTCCGATCA ACTGCTGAAC CAGATGACAG TCATGCCCTC 
TATGCCAAGA AGCTGTGGAC TGCTCCAGAA CTTCTTAGTG GGAACCCCCT GCCAACCACG 
GGCATGCAGA AGGCGGATGT CTATAGCTTT GCCATCATTC TGCAGGAAAT AGCGCTCCGC 
AGTGGTCCTT TCTACTTGGA AGGCCTGGAC CTCAGTCCCA AAGAGATTGT CCAGAAGGTG 
CGAAATGGTC AGAGGCCGTA TTTCCGGCCA AGCATTGACC GGACACAACT GAACGAAGAG 
TTAGTTTTGC TGATGGAGAG GTGCTGGGCC CAGGACCCAA CAGAACGTCC AGACTTTGGG 
CAAATCAAGG GCTTCATTCG CCGGTTTAAC AAGGAGGGTG GTACCAGCAT ATTGGACAAC 
CTCTTGCTTC GCATGGAACA GTATGCCAAT AACCTGGAAA AACTGGTGGA GGAGCGCACA 
CAGGCCTACC TAGAGGAGAA GCGCAAGGCT GAGGCTCTGC TGTACCAAAT TCTACCCCAC 
TCTGTGGCAG AGCAGTTAAA ACGGGGAGAG ACGGTTCAGG CGGAGGCCTT TGACAGTGTC 
ACTATCTACT TCAGTGACAT CGTGGGCTTC ACAGCGCTGT CAGCTGAGAG CACCCCCATG 
CAGGTGGTGA CACTTCTTAA TGACCTTTAT ACCTGCTTTG ATGCCATAAT CGACAACTTT 
GATGTCTACA AGGTGGAAAC CATTGGGGAT GCCTACATGG TGGTATCTGG CCTTCCGGGC 
CGAAATGGTC AGCGCCATGC ACCAGAAATT GCTCGAATGG CTCTAGCATT ACTAGATGCA 
GTTTCTTCCT TCCGCATTCG CCATCGACCC CACGACCAGC TAAGGTTACG CATAGGCGTC 
CATACTGGGC CAGTCTGTGC TGGGGTTGTT GGCCTGAAGA TGCCCCGGTA CTGTCTTTTT 
GGAGACACAG TAAACACTGC TTCTCGAATG GAGTCTAATG GTCAAGCTCT AAAGATCCAT 
GTCTCCTCGA CCACCAAGGA TGCCCTGGAT GAGCTAGGAT GCTTCCAGCT AGAACTCCGT 
GGGGATGTGG AGATGAAGGG AAAAGGAAAA ATGCGAACTT ATTGGCTCTT AGGAGAGCGA 
AAAGGACCTC CTGGACTCCT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446290.1
CDS	73..3216
Translation	MALPSLLLVVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASHWHLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYTREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLESGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKGPPGLL

Target ORF information:

RefSeq Version	NM_053838.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus natriuretic peptide receptor 2 (Npr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053838.1

ORF Insert Sequence:

ATGGCACTGC CATCCCTGCT ACTGGTGGTG GCAGCCCTGG CAGGTGGGGT GCGTCCTCCG 
GGGGCACGGA ACCTGACGCT GGCGGTGGTG CTGCCAGAAC ACAACCTGAG CTATGCCTGG 
GCCTGGCCAC GGGTGGGTCC TGCTGTGGCA CTGGCTGTGG AGGCGCTGGG CCGGGCACTG 
CCCGTGGACC TGCGGTTTGT CAGCTCCGAA CTAGACGGCG CCTGCTCTGA GTACCTGGCA 
CCACTGCGCG CTGTGGATCT CAAGCTGTAC CATGACCCCG ACCTTCTGTT GGGCCCTGGT 
TGTGTGTACC CTGCTGCCTC TGTGGCTCGC TTTGCCTCGC ACTGGCACCT TCCCCTCCTG 
ACTGCGGGTG CAGTGGCCTC TGGCTTTGCA GCTAAGAATG AGCATTATCG TACCCTGGTT 
CGCACTGGCC CCTCTGCGCC CAAGCTGGGT GAGTTCGTAG TGACATTACA CGGGCACTTC 
AATTGGACTG CTCGGGCTGC TTTGCTGTAT CTGGATGCTC GCACAGATGA CCGGCCCCAC 
TACTTCACCA TCGAGGGGGT GTTTGAGGCC CTGCAGGGCA GCAACCTCAG TGTGCAACAC 
CAGGTGTATA CCCGAGAGCC AGGTGGCCCT GAGCAAGCCA CCCACTTCAT CAGAGCCAAC 
GGGCGCATTG TGTATATCTG CGGCCCGCTG GAGATGCTTC ATGAGATCCT GCTTCAGGCC 
CAGAGGGAGA ACCTGACCAA TGGGGACTAT GTCTTCTTTT ACCTTGATGT CTTTGGGGAG 
AGTCTACGAG CAGGCCCCAC ACGTGCGACA GGCCGGCCAT GGCAGGACAA TCGAACCCAG 
GAACAAGCTC AGGCCCTCAG AGAGGCCTTT CAGACTGTCC TGGTGATCAC GTACCGAGAG 
CCCCCGAATC CCGAGTATCA GGAGTTCCAG AACCGCCTGC TGATCAGAGC CCGGGAAGAC 
TTCGGCGTGG AGCTGGCCCC ATCCCTGATG AACCTCATTG CGGGCTGCTT CTATGATGGA 
ATCCTGCTCT ATGCCCAAGT CCTGAATGAG ACAATACAGG AAGGGGGCAC CCGGGAAGAT 
GGACTTCGAA TTGTGGAGAA GATGCAGGGA CGAAGATACC ATGGTGTAAC TGGACTGGTT 
GTTATGGACA AGAACAATGA CAGAGAGACT GATTTCGTCC TGTGGGCCAT GGGAGACTTG 
GAGTCTGGCG ACTTTCAGCC TGCAGCCCAT TACTCAGGAG CTGAGAAGCA GATTTGGTGG 
ACAGGCCGGC CAATTCCCTG GGTGAAGGGG GCCCCACCTT TGGACAACCC CCCCTGTGCC 
TTTGACTTGG ACGACCCATC CTGTGATAAA ACTCCACTTT CCACTCTGGC AATTGTGGCC 
CTGGGCACGG GAATCACTTT CATCATGTTT GGTGTTTCCA GCTTCCTAAT TTTCCGAAAA 
CTGATGCTGG AGAAGGAGCT GGCTAGCATG CTGTGGCGCA TTCGCTGGGA AGAACTGCAG 
TTCGGCAACT CGGATCGATA TCACAAAGGT GCAGGCAGTC GCCTGACGCT GTCGCTGCGG 
GGATCCAGTT ACGGCTCGCT CATGACAGCC CATGGGAAAT ACCAGATCTT TGCCAACACC 
GGTCACTTCA AGGGAAATGT CGTTGCCATC AAACATGTGA ATAAGAAGCG CATTGAGCTG 
ACCCGGCAAG TTCTGTTTGA ACTCAAACAC ATGAGAGATG TTCAGTTCAA CCATCTTACT 
CGATTCATCG GAGCTTGCAT AGACCCTCCC AACATCTGCA TCGTCACCGA GTATTGTCCT 
CGGGGGAGCT TACAAGATAT TCTAGAAAAT GACAGCATCA ATTTGGACTG GATGTTTCGC 
TACTCGCTCA TTAATGACCT TGTGAAGGGT ATGGCCTTTC TCCACAACAG CATTATTTCA 
TCTCATGGAA GCCTCAAGTC CTCTAACTGC GTGGTGGATA GTCGATTTGT GCTCAAAATA 
ACGGATTACG GGCTGGCTAG CTTCCGATCA ACTGCTGAAC CAGATGACAG TCATGCCCTC 
TATGCCAAGA AGCTGTGGAC TGCTCCAGAA CTTCTTAGTG GGAACCCCCT GCCAACCACG 
GGCATGCAGA AGGCGGATGT CTATAGCTTT GCCATCATTC TGCAGGAAAT AGCGCTCCGC 
AGTGGTCCTT TCTACTTGGA AGGCCTGGAC CTCAGTCCCA AAGAGATTGT CCAGAAGGTG 
CGAAATGGTC AGAGGCCGTA TTTCCGGCCA AGCATTGACC GGACACAACT GAACGAAGAG 
TTAGTTTTGC TGATGGAGAG GTGCTGGGCC CAGGACCCAA CAGAACGTCC AGACTTTGGG 
CAAATCAAGG GCTTCATTCG CCGGTTTAAC AAGGAGGGTG GTACCAGCAT ATTGGACAAC 
CTCTTGCTTC GCATGGAACA GTATGCCAAT AACCTGGAAA AACTGGTGGA GGAGCGCACA 
CAGGCCTACC TAGAGGAGAA GCGCAAGGCT GAGGCTCTGC TGTACCAAAT TCTACCCCAC 
TCTGTGGCAG AGCAGTTAAA ACGGGGAGAG ACGGTTCAGG CGGAGGCCTT TGACAGTGTC 
ACTATCTACT TCAGTGACAT CGTGGGCTTC ACAGCGCTGT CAGCTGAGAG CACCCCCATG 
CAGGTGGTGA CACTTCTTAA TGACCTTTAT ACCTGCTTTG ATGCCATAAT CGACAACTTT 
GATGTCTACA AGGTGGAAAC CATTGGGGAT GCCTACATGG TGGTATCTGG CCTTCCGGGC 
CGAAATGGTC AGCGCCATGC ACCAGAAATT GCTCGAATGG CTCTAGCATT ACTAGATGCA 
GTTTCTTCCT TCCGCATTCG CCATCGACCC CACGACCAGC TAAGGTTACG CATAGGCGTC 
CATACTGGGC CAGTCTGTGC TGGGGTTGTT GGCCTGAAGA TGCCCCGGTA CTGTCTTTTT 
GGAGACACAG TAAACACTGC TTCTCGAATG GAGTCTAATG GTCAAGCTCT AAAGATCCAT 
GTCTCCTCGA CCACCAAGGA TGCCCTGGAT GAGCTAGGAT GCTTCCAGCT AGAACTCCGT 
GGGGATGTGG AGATGAAGGG AAAAGGAAAA ATGCGAACTT ATTGGCTCTT AGGAGAGCGA 
AAAGGACCTC CTGGACTCCT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Npr2 ( XM_006238010.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006238072.1 Rattus norvegicus natriuretic peptide receptor 2 (Npr2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa28111
Clone ID Related Accession (Same CDS sequence)	XM_006238010.3
Accession Version	XM_006238010.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3069bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	atrial natriuretic peptide receptor 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006238010.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCACTGC CATCCCTGCT ACTGGTGGTG GCAGCCCTGG CAGGTGGGGT GCGTCCTCCG 
GGGGCACGGA ACCTGACGCT GGCGGTGGTG CTGCCAGAAC ACAACCTGAG CTATGCCTGG 
GCCTGGCCAC GGGTGGGTCC TGCTGTGGCA CTGGCTGTGG AGGCGCTGGG CCGGGCACTG 
CCCGTGGACC TGCGGTTTGT CAGCTCCGAA CTAGACGGCG CCTGCTCTGA GTACCTGGCA 
CCACTGCGCG CTGTGGATCT CAAGCTGTAC CATGACCCCG ACCTTCTGTT GGGCCCTGGT 
TGTGTGTACC CTGCTGCCTC TGTGGCTCGC TTTGCCTCGC ACTGGCACCT TCCCCTCCTG 
ACTGCGGGTG CAGTGGCCTC TGGCTTTGCA GCTAAGAATG AGCATTATCG TACCCTGGTT 
CGCACTGGCC CCTCTGCGCC CAAGCTGGGT GAGTTCGTAG TGACATTACA CGGGCACTTC 
AATTGGACTG CTCGGGCTGC TTTGCTGTAT CTGGATGCTC GCACAGATGA CCGGCCCCAC 
TACTTCACCA TCGAGGGGGT GTTTGAGGCC CTGCAGGGCA GCAACCTCAG TGTGCAACAC 
CAGGTGTATA CCCGAGAGCC AGGTGGCCCT GAGCAAGCCA CCCACTTCAT CAGAGCCAAC 
GGGCGCATTG TGTATATCTG CGGCCCGCTG GAGATGCTTC ATGAGATCCT GCTTCAGGCC 
CAGAGGGAGA ACCTGACCAA TGGGGACTAT GTCTTCTTTT ACCTTGATGT CTTTGGGGAG 
AGTCTACGAG CAGGCCCCAC ACGTGCGACA GGCCGGCCAT GGCAGGACAA TCGAACCCAG 
GAACAAGCTC AGGCCCTCAG AGAGGCCTTT CAGACTGTCC TGGTGATCAC GTACCGAGAG 
CCCCCGAATC CCGAGTATCA GGAGTTCCAG AACCGCCTGC TGATCAGAGC CCGGGAAGAC 
TTCGGCGTGG AGCTGGCCCC ATCCCTGATG AACCTCATTG CGGGCTGCTT CTATGATGGA 
ATCCTGCTCT ATGCCCAAGT CCTGAATGAG ACAATACAGG AAGGGGGCAC CCGGGAAGAT 
GGACTTCGAA TTGTGGAGAA GATGCAGGGA CGAAGATACC ATGGTGTAAC TGGACTGGTT 
GTTATGGACA AGAACAATGA CAGAGAGACT GATTTCGTCC TGTGGGCCAT GGGAGACTTG 
GAGTCTGGCG ACTTTCAGCC TGCAGCCCAT TACTCAGGAG CTGAGAAGCA GATTTGGTGG 
ACAGGCCGGC CAATTCCCTG GGTGAAGGGG GCCCCACCTT TGGACAACCC CCCCTGTGCC 
TTTGACTTGG ACGACCCATC CTGTGATAAA ACTCCACTTT CCACTCTGGC AATTGTGGCC 
CTGGGCACGG GAATCACTTT CATCATGTTT GGTGTTTCCA GCTTCCTAAT TTTCCGAAAA 
CTGATGCTGG AGAAGGAGCT GGCTAGCATG CTGTGGCGCA TTCGCTGGGA AGAACTGCAG 
TTCGGCAACT CGGATCGATA TCACAAAGGT GCAGGCAGTC GCCTGACGCT GTCGCTGGGA 
AATGTCGTTG CCATCAAACA TGTGAATAAG AAGCGCATTG AGCTGACCCG GCAAGTTCTG 
TTTGAACTCA AACACATGAG AGATGTTCAG TTCAACCATC TTACTCGATT CATCGGAGCT 
TGCATAGACC CTCCCAACAT CTGCATCGTC ACCGAGTATT GTCCTCGGGG GAGCTTACAA 
GATATTCTAG AAAATGACAG CATCAATTTG GACTGGATGT TTCGCTACTC GCTCATTAAT 
GACCTTGTGA AGGGTATGGC CTTTCTCCAC AACAGCATTA TTTCATCTCA TGGAAGCCTC 
AAGTCCTCTA ACTGCGTGGT GGATAGTCGA TTTGTGCTCA AAATAACGGA TTACGGGCTG 
GCTAGCTTCC GATCAACTGC TGAACCAGAT GACAGTCATG CCCTCTATGC CAAGAAGCTG 
TGGACTGCTC CAGAACTTCT TAGTGGGAAC CCCCTGCCAA CCACGGGCAT GCAGAAGGCG 
GATGTCTATA GCTTTGCCAT CATTCTGCAG GAAATAGCGC TCCGCAGTGG TCCTTTCTAC 
TTGGAAGGCC TGGACCTCAG TCCCAAAGAG ATTGTCCAGA AGGTGCGAAA TGGTCAGAGG 
CCGTATTTCC GGCCAAGCAT TGACCGGACA CAACTGAACG AAGAGTTAGT TTTGCTGATG 
GAGAGGTGCT GGGCCCAGGA CCCAACAGAA CGTCCAGACT TTGGGCAAAT CAAGGGCTTC 
ATTCGCCGGT TTAACAAGGA GGGTGGTACC AGCATATTGG ACAACCTCTT GCTTCGCATG 
GAACAGTATG CCAATAACCT GGAAAAACTG GTGGAGGAGC GCACACAGGC CTACCTAGAG 
GAGAAGCGCA AGGCTGAGGC TCTGCTGTAC CAAATTCTAC CCCACTCTGT GGCAGAGCAG 
TTAAAACGGG GAGAGACGGT TCAGGCGGAG GCCTTTGACA GTGTCACTAT CTACTTCAGT 
GACATCGTGG GCTTCACAGC GCTGTCAGCT GAGAGCACCC CCATGCAGGT GGTGACACTT 
CTTAATGACC TTTATACCTG CTTTGATGCC ATAATCGACA ACTTTGATGT CTACAAGGTG 
GAAACCATTG GGGATGCCTA CATGGTGGTA TCTGGCCTTC CGGGCCGAAA TGGTCAGCGC 
CATGCACCAG AAATTGCTCG AATGGCTCTA GCATTACTAG ATGCAGTTTC TTCCTTCCGC 
ATTCGCCATC GACCCCACGA CCAGCTAAGG TTACGCATAG GCGTCCATAC TGGGCCAGTC 
TGTGCTGGGG TTGTTGGCCT GAAGATGCCC CGGTACTGTC TTTTTGGAGA CACAGTAAAC 
ACTGCTTCTC GAATGGAGTC TAATGGTCAA GCTCTAAAGA TCCATGTCTC CTCGACCACC 
AAGGATGCCC TGGATGAGCT AGGATGCTTC CAGCTAGAAC TCCGTGGGGA TGTGGAGATG 
AAGGGAAAAG GAAAAATGCG AACTTATTGG CTCTTAGGAG AGCGAAAAGG ACCTCCTGGA 
CTCCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006238072.1
CDS	790..3858
Translation	MALPSLLLVVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASHWHLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYTREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLESGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSRLTLSLGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKGPPGLL

Target ORF information:

RefSeq Version	XM_006238010.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus natriuretic peptide receptor 2 (Npr2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006238010.3

ORF Insert Sequence:

ATGGCACTGC CATCCCTGCT ACTGGTGGTG GCAGCCCTGG CAGGTGGGGT GCGTCCTCCG 
GGGGCACGGA ACCTGACGCT GGCGGTGGTG CTGCCAGAAC ACAACCTGAG CTATGCCTGG 
GCCTGGCCAC GGGTGGGTCC TGCTGTGGCA CTGGCTGTGG AGGCGCTGGG CCGGGCACTG 
CCCGTGGACC TGCGGTTTGT CAGCTCCGAA CTAGACGGCG CCTGCTCTGA GTACCTGGCA 
CCACTGCGCG CTGTGGATCT CAAGCTGTAC CATGACCCCG ACCTTCTGTT GGGCCCTGGT 
TGTGTGTACC CTGCTGCCTC TGTGGCTCGC TTTGCCTCGC ACTGGCACCT TCCCCTCCTG 
ACTGCGGGTG CAGTGGCCTC TGGCTTTGCA GCTAAGAATG AGCATTATCG TACCCTGGTT 
CGCACTGGCC CCTCTGCGCC CAAGCTGGGT GAGTTCGTAG TGACATTACA CGGGCACTTC 
AATTGGACTG CTCGGGCTGC TTTGCTGTAT CTGGATGCTC GCACAGATGA CCGGCCCCAC 
TACTTCACCA TCGAGGGGGT GTTTGAGGCC CTGCAGGGCA GCAACCTCAG TGTGCAACAC 
CAGGTGTATA CCCGAGAGCC AGGTGGCCCT GAGCAAGCCA CCCACTTCAT CAGAGCCAAC 
GGGCGCATTG TGTATATCTG CGGCCCGCTG GAGATGCTTC ATGAGATCCT GCTTCAGGCC 
CAGAGGGAGA ACCTGACCAA TGGGGACTAT GTCTTCTTTT ACCTTGATGT CTTTGGGGAG 
AGTCTACGAG CAGGCCCCAC ACGTGCGACA GGCCGGCCAT GGCAGGACAA TCGAACCCAG 
GAACAAGCTC AGGCCCTCAG AGAGGCCTTT CAGACTGTCC TGGTGATCAC GTACCGAGAG 
CCCCCGAATC CCGAGTATCA GGAGTTCCAG AACCGCCTGC TGATCAGAGC CCGGGAAGAC 
TTCGGCGTGG AGCTGGCCCC ATCCCTGATG AACCTCATTG CGGGCTGCTT CTATGATGGA 
ATCCTGCTCT ATGCCCAAGT CCTGAATGAG ACAATACAGG AAGGGGGCAC CCGGGAAGAT 
GGACTTCGAA TTGTGGAGAA GATGCAGGGA CGAAGATACC ATGGTGTAAC TGGACTGGTT 
GTTATGGACA AGAACAATGA CAGAGAGACT GATTTCGTCC TGTGGGCCAT GGGAGACTTG 
GAGTCTGGCG ACTTTCAGCC TGCAGCCCAT TACTCAGGAG CTGAGAAGCA GATTTGGTGG 
ACAGGCCGGC CAATTCCCTG GGTGAAGGGG GCCCCACCTT TGGACAACCC CCCCTGTGCC 
TTTGACTTGG ACGACCCATC CTGTGATAAA ACTCCACTTT CCACTCTGGC AATTGTGGCC 
CTGGGCACGG GAATCACTTT CATCATGTTT GGTGTTTCCA GCTTCCTAAT TTTCCGAAAA 
CTGATGCTGG AGAAGGAGCT GGCTAGCATG CTGTGGCGCA TTCGCTGGGA AGAACTGCAG 
TTCGGCAACT CGGATCGATA TCACAAAGGT GCAGGCAGTC GCCTGACGCT GTCGCTGGGA 
AATGTCGTTG CCATCAAACA TGTGAATAAG AAGCGCATTG AGCTGACCCG GCAAGTTCTG 
TTTGAACTCA AACACATGAG AGATGTTCAG TTCAACCATC TTACTCGATT CATCGGAGCT 
TGCATAGACC CTCCCAACAT CTGCATCGTC ACCGAGTATT GTCCTCGGGG GAGCTTACAA 
GATATTCTAG AAAATGACAG CATCAATTTG GACTGGATGT TTCGCTACTC GCTCATTAAT 
GACCTTGTGA AGGGTATGGC CTTTCTCCAC AACAGCATTA TTTCATCTCA TGGAAGCCTC 
AAGTCCTCTA ACTGCGTGGT GGATAGTCGA TTTGTGCTCA AAATAACGGA TTACGGGCTG 
GCTAGCTTCC GATCAACTGC TGAACCAGAT GACAGTCATG CCCTCTATGC CAAGAAGCTG 
TGGACTGCTC CAGAACTTCT TAGTGGGAAC CCCCTGCCAA CCACGGGCAT GCAGAAGGCG 
GATGTCTATA GCTTTGCCAT CATTCTGCAG GAAATAGCGC TCCGCAGTGG TCCTTTCTAC 
TTGGAAGGCC TGGACCTCAG TCCCAAAGAG ATTGTCCAGA AGGTGCGAAA TGGTCAGAGG 
CCGTATTTCC GGCCAAGCAT TGACCGGACA CAACTGAACG AAGAGTTAGT TTTGCTGATG 
GAGAGGTGCT GGGCCCAGGA CCCAACAGAA CGTCCAGACT TTGGGCAAAT CAAGGGCTTC 
ATTCGCCGGT TTAACAAGGA GGGTGGTACC AGCATATTGG ACAACCTCTT GCTTCGCATG 
GAACAGTATG CCAATAACCT GGAAAAACTG GTGGAGGAGC GCACACAGGC CTACCTAGAG 
GAGAAGCGCA AGGCTGAGGC TCTGCTGTAC CAAATTCTAC CCCACTCTGT GGCAGAGCAG 
TTAAAACGGG GAGAGACGGT TCAGGCGGAG GCCTTTGACA GTGTCACTAT CTACTTCAGT 
GACATCGTGG GCTTCACAGC GCTGTCAGCT GAGAGCACCC CCATGCAGGT GGTGACACTT 
CTTAATGACC TTTATACCTG CTTTGATGCC ATAATCGACA ACTTTGATGT CTACAAGGTG 
GAAACCATTG GGGATGCCTA CATGGTGGTA TCTGGCCTTC CGGGCCGAAA TGGTCAGCGC 
CATGCACCAG AAATTGCTCG AATGGCTCTA GCATTACTAG ATGCAGTTTC TTCCTTCCGC 
ATTCGCCATC GACCCCACGA CCAGCTAAGG TTACGCATAG GCGTCCATAC TGGGCCAGTC 
TGTGCTGGGG TTGTTGGCCT GAAGATGCCC CGGTACTGTC TTTTTGGAGA CACAGTAAAC 
ACTGCTTCTC GAATGGAGTC TAATGGTCAA GCTCTAAAGA TCCATGTCTC CTCGACCACC 
AAGGATGCCC TGGATGAGCT AGGATGCTTC CAGCTAGAAC TCCGTGGGGA TGTGGAGATG 
AAGGGAAAAG GAAAAATGCG AACTTATTGG CTCTTAGGAG AGCGAAAAGG ACCTCCTGGA 
CTCCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dephosphorylation is the mechanism of fibroblast growth factor inhibition of guanylyl cyclase-B.
Cellular signalling40222-229(2017 Dec)
Robinson JW,Egbert JR,Davydova J,Schmidt H,Jaffe LA,Potter LR

Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in?vitro.
Biochemical and biophysical research communications491(2)250-256(2017 09)
Manivasagam S,Vellaichamy E

Elevated C-type natriuretic peptide elicits exercise preconditioning-induced cardioprotection against myocardial injury probably via the up-regulation of NPR-B.
The journal of physiological sciences : JPS67(4)475-487(2017 Jul)
Lu J,Pan SS

C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.
Cardiovascular research112(3)637-644(2016 Dec)
Buttgereit J,Shanks J,Li D,Hao G,Athwal A,Langenickel TH,Wright H,da Costa Goncalves AC,Monti J,Plehm R,Popova E,Qadri F,Lapidus I,Ryan B,?zcelik C,Paterson DJ,Bader M,Herring N

Catalytically Active Guanylyl Cyclase B Requires Endoplasmic Reticulum-mediated Glycosylation, and Mutations That Inhibit This Process Cause Dwarfism.
The Journal of biological chemistry291(21)11385-93(2016 May)
Dickey DM,Edmund AB,Otto NM,Chaffee TS,Robinson JW,Potter LR