Slc26a3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc26a3
Entrez Gene ID	114629
Full Name	solute carrier family 26 member 3
General protein information	Preferred Names solute carrier family 26 member 3 Names chloride anion exchanger down-regulated in adenoma solute carrier family 26 (anion exchanger), member 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q16
Summary	transmembrane chloride/bicarbonate exchanger; plays a role in mediating electrolyte and fluid absorption in the colon [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053755.2	NP_446207.1	chloride anion exchanger

Pathways from BioSystems

Homologies

	SLC26A3	XP_001090155.2
Gallus gallus (chicken)	SLC26A3	NP_001186373.1
Homo sapiens (human)	SLC26A3	NP_000102.1
Mus musculus (house mouse)	Slc26a3	NP_067328.1
Rattus norvegicus (Norway rat)	Slc26a3	NP_446207.1
Pan troglodytes (chimpanzee)	SLC26A3	XP_527858.2
Bos taurus (cattle)	SLC26A3	NP_001077145.1
Caenorhabditis elegans (roundworm)	sulp-6	NP_491138.2
Xenopus tropicalis (tropical clawed frog)	LOC101731072	XP_004913063.1
Canis lupus familiaris (dog)	SLC26A3	XP_540380.3
Danio rerio (zebrafish)	slc26a3	NP_001129155.1
Danio rerio (zebrafish)	si:dkey-31f5.1	NP_001035265.1

Gene Ontology
Bibliography

Related articles in PubMed

[Expression pattern of congenital chloride diarrhea pathogenic gene Slc26a3 in the reproductive tract of male rodents].
Chen L, Xu W
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics31(5)654-8(2014 Oct)

Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation.
Ch?vez JC, Hern?ndez-Gonz?lez EO, Wertheimer E, Visconti PE, Darszon A, Trevi?o CL
Biology of reproduction86(1)1-14(2012 Jan)

Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells.
Barmeyer C, Ye JH, Sidani S, Geibel J, Binder HJ, Rajendran VM
Pflugers Archiv : European journal of physiology454(3)441-50(2007 Jun)

Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum.
Jacob P, Rossmann H, Lamprecht G, Kretz A, Neff C, Lin-Wu E, Gregor M, Groneberg DA, Kere J, Seidler U
Gastroenterology122(3)709-24(2002 Mar)

Regulation of DRA and AE1 in rat colon by dietary Na depletion.
Rajendran VM, Black J, Ardito TA, Sangan P, Alper SL, Schweinfest C, Kashgarian M, Binder HJ
American journal of physiology. Gastrointestinal and liver physiology279(5)G931-42(2000 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that solute carrier family 26, member 3 protein (Slc26a3) is expressed in male reproductive tract, and its expression pattern is related to the function.
Title: [Expression pattern of congenital chloride diarrhea pathogenic gene Slc26a3 in the reproductive tract of male rodents].

in addition to mediating pH-sensitive Cl(-) uptake, DRA may function as a modifier of other anion transport proteins
Title: Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells.

The following Slc26a3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc26a3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10528	NM_053755.2 Latest version!	Rattus norvegicus solute carrier family 26 member 3 (Slc26a3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc26a3 ( NM_053755.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446207.1 Rattus norvegicus solute carrier family 26 member 3 (Slc26a3), mRNA.

Price & Availability↑

CloneID	ORa10528
Clone ID Related Accession (Same CDS sequence)	NM_053755.2
Accession Version	NM_053755.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2274bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	chloride anion exchanger
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF337809.1. On Feb 21, 2013 this sequence version replaced NM_053755.1. ##Evidence-Data-START## Transcript exon combination :: AF337809.1 [ECO:0000332] ##Evidence-Data-END##

ATGATCGAAG CCATAGGGAA TCAGTATGTG GTGGCCAGAC CGGTGTATTC CACAAAGGCT 
TTCGGAGAGG AGTTTAAGAA GACATACGGA CATCACAAGA CATTCCTGGA TCATCTCAAA 
GGGTGTTGTA GCTGCTCCTC ACAAAAGGCC AAGAAAATTG CCCTGTCTTT GTTCCCCATA 
GCATCTTGGT TGCCAGCATA CAAGATAAAG GAATGGCTTC TCAGTGACAT CGTCTCTGGC 
ATCAGCACTG GGCTGGTGGC TGTGCTGCAA GGTTTAGCAT TTGCTCTGCT GGTCAACATC 
CCTCCTGCCT ATGGGTTGTA CGCAGCCTTT TTCCCAGTTA TCACCTACTT CTTCTTGGGC 
ACATCTAGAC ACATATCTGT GGGTCCGTTT CCAGTTCTGA GCATGATGGT GGGAGTTGTA 
GTTACAAGAG TGGCCTCGGG CTCCGATACT TCTCCAGCAT TGTCCTCAAG CTCGGCAGAA 
AATGATTCAA TGATAGAGGA GAAGGTAATG GTGGCCGCAT CGGTGACTGT TCTTTCTGGA 
ATCATTCAGT TGCTCCTGGG GGTTCTGCAG ATAGGCTTTG TGGTGATATA CCTATCCGAG 
TCCCTAATCA GCGGCTTCAC CACGGCTGCT GCCATTCACG TTCTGGTTTC TCAACTGAAA 
TTCATGCTAC AGCTGACGGT CCCAGCACAC AGCGACCCAT TCTCTATATT CAAAGTCCTG 
GAGTCAGTCT TCTCACAAAT TCAGAAGACG AACATCGCAG ACCTGGTGAC ATCTGTGATT 
ATCCTCGTGG TCGTGTTTGT CGTCAAGGAA ATCAACCAGC GCTACAGGAG CAAGCTTCCG 
GTGCCCATCC CCATCGAACT CATCATGACT GTAATTGCAA CAGGCATATC CTATGGCTGT 
AACTTTGAAC AGAGGTTTGG CGTGGCCGTG GTTGGGAACA TGAGTCTTGG GTTTCAACCC 
CCTATTACCC CCAGTGTGGA AGTTTTCCAA GACACCATAG GAGACTGCTT TGGCATTGCG 
ATTGTCGGCT TTGCCGTGGC CTTTTCAGTT GCTAGCGTGT ATTCCCTCAA ATACGATTAT 
CCCATTGATG GCAACCAGGA GTTAATTGCC TTGGGGGTGA GCAACATATT CACTGGAGCT 
TTCAAAGGAT TTGCAGGGAG CACAGCCCTT TCCAGATCAG GGGTTCAGGA GAGCACGGGA 
GGCAAAACAC AGGTCGCGGG GCTTCTCTCG GCTGTCATTG TGCTGATAGT CATAGTTGCC 
ATCGGATTTC TCCTGCAGCC TCTACAAAAG TCTGTCCTGG CAGCTCTGGC GCTTGGAAAC 
TTGAAGGGAA TGCTGATGCA GTTTGCCGAG ATAGGCAGGC TGTGGAAAAA GGATAAATAC 
GATTGTTTAA TCTGGATCAT GACCTTCATC TTTGCCATCG TCCTTGGGCT CGGATTAGGC 
CTGGCAGCAA GTGTGGCATT TCAGCTCCTA ACTATTGTGT TCAGGACCCA ATTCCCAAAA 
TGCAGCACAC TGGCTAATGT TGGAAGGAGC AACATCTACA AGAATAAAAA AAATTATGCT 
GACGTTTATG AGCCAGAAGG AGTGAAAATT TTCAGATGTC CGTCTCCAAT CTACTTCGCA 
AACATTGGTT TCTTTAAGCA GAAACTTATT GACGCTGTTG GCTTTAACCC ACTTCGAATT 
CTACGCAAGC GCAATAAAGC TTTGAAGAAA ATCCGAAAAC TGCAGAAGCA AGGACTGATA 
CAAGTGACAC CTAAAGGATT TATATGCACC TCTGATGGCT TCAAAGACTC TGATGAAGAA 
TTGGACAACA ACCAGATAGA AGAACTGGAT CAGCCGATCA ATACCACGGA CCTGCCCTTT 
GAAATAGACT GGAACGCCGA TCTCCCCCTC AACATCACCA TCCCCAAAAT CAGCCTCCAC 
AGCCTCATCC TCGATTTTTC AGCAGTATCC TTCCTTGACA TCTCCTCAAT GAGGGGCCTC 
AGAACGATTT TACAAGAGTT TATTAGGATC AAGGTGGACG TATATATTGT GGGAACCGAT 
GATGATTTCA TTGACAAACT TGCTCGGTGT GAATTCTTTG ATGACGAAGT CACAGACTCA 
ATATTTTTCT TAACAATCCA TGATGCTATT TTGCATATTT GGATGAAGAA GGACTACAGC 
ACTTCAAAGT TCAATTCCAG CCAGGAAAAA GAAAGGAAAT TTGACTTTAC CATAAATACA 
AATGGAGGAT TACGTAATCG GGAATGTCAG GTACCAGTTG AAACGAAATT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446207.1
CDS	186..2459
Translation	MIEAIGNQYVVARPVYSTKAFGEEFKKTYGHHKTFLDHLKGCCSCSSQKAKKIALSLFPIASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLGTSRHISVGPFPVLSMMVGVVVTRVASGSDTSPALSSSSAENDSMIEEKVMVAASVTVLSGIIQLLLGVLQIGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLTVPAHSDPFSIFKVLESVFSQIQKTNIADLVTSVIILVVVFVVKEINQRYRSKLPVPIPIELIMTVIATGISYGCNFEQRFGVAVVGNMSLGFQPPITPSVEVFQDTIGDCFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIALGVSNIFTGAFKGFAGSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVAIGFLLQPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTFIFAIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYADVYEPEGVKIFRCPSPIYFANIGFFKQKLIDAVGFNPLRILRKRNKALKKIRKLQKQGLIQVTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLPFEIDWNADLPLNITIPKISLHSLILDFSAVSFLDISSMRGLRTILQEFIRIKVDVYIVGTDDDFIDKLARCEFFDDEVTDSIFFLTIHDAILHIWMKKDYSTSKFNSSQEKERKFDFTINTNGGLRNRECQVPVETKF

Target ORF information:

RefSeq Version	NM_053755.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 26 member 3 (Slc26a3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053755.2

ORF Insert Sequence:

ATGATCGAAG CCATAGGGAA TCAGTATGTG GTGGCCAGAC CGGTGTATTC CACAAAGGCT 
TTCGGAGAGG AGTTTAAGAA GACATACGGA CATCACAAGA CATTCCTGGA TCATCTCAAA 
GGGTGTTGTA GCTGCTCCTC ACAAAAGGCC AAGAAAATTG CCCTGTCTTT GTTCCCCATA 
GCATCTTGGT TGCCAGCATA CAAGATAAAG GAATGGCTTC TCAGTGACAT CGTCTCTGGC 
ATCAGCACTG GGCTGGTGGC TGTGCTGCAA GGTTTAGCAT TTGCTCTGCT GGTCAACATC 
CCTCCTGCCT ATGGGTTGTA CGCAGCCTTT TTCCCAGTTA TCACCTACTT CTTCTTGGGC 
ACATCTAGAC ACATATCTGT GGGTCCGTTT CCAGTTCTGA GCATGATGGT GGGAGTTGTA 
GTTACAAGAG TGGCCTCGGG CTCCGATACT TCTCCAGCAT TGTCCTCAAG CTCGGCAGAA 
AATGATTCAA TGATAGAGGA GAAGGTAATG GTGGCCGCAT CGGTGACTGT TCTTTCTGGA 
ATCATTCAGT TGCTCCTGGG GGTTCTGCAG ATAGGCTTTG TGGTGATATA CCTATCCGAG 
TCCCTAATCA GCGGCTTCAC CACGGCTGCT GCCATTCACG TTCTGGTTTC TCAACTGAAA 
TTCATGCTAC AGCTGACGGT CCCAGCACAC AGCGACCCAT TCTCTATATT CAAAGTCCTG 
GAGTCAGTCT TCTCACAAAT TCAGAAGACG AACATCGCAG ACCTGGTGAC ATCTGTGATT 
ATCCTCGTGG TCGTGTTTGT CGTCAAGGAA ATCAACCAGC GCTACAGGAG CAAGCTTCCG 
GTGCCCATCC CCATCGAACT CATCATGACT GTAATTGCAA CAGGCATATC CTATGGCTGT 
AACTTTGAAC AGAGGTTTGG CGTGGCCGTG GTTGGGAACA TGAGTCTTGG GTTTCAACCC 
CCTATTACCC CCAGTGTGGA AGTTTTCCAA GACACCATAG GAGACTGCTT TGGCATTGCG 
ATTGTCGGCT TTGCCGTGGC CTTTTCAGTT GCTAGCGTGT ATTCCCTCAA ATACGATTAT 
CCCATTGATG GCAACCAGGA GTTAATTGCC TTGGGGGTGA GCAACATATT CACTGGAGCT 
TTCAAAGGAT TTGCAGGGAG CACAGCCCTT TCCAGATCAG GGGTTCAGGA GAGCACGGGA 
GGCAAAACAC AGGTCGCGGG GCTTCTCTCG GCTGTCATTG TGCTGATAGT CATAGTTGCC 
ATCGGATTTC TCCTGCAGCC TCTACAAAAG TCTGTCCTGG CAGCTCTGGC GCTTGGAAAC 
TTGAAGGGAA TGCTGATGCA GTTTGCCGAG ATAGGCAGGC TGTGGAAAAA GGATAAATAC 
GATTGTTTAA TCTGGATCAT GACCTTCATC TTTGCCATCG TCCTTGGGCT CGGATTAGGC 
CTGGCAGCAA GTGTGGCATT TCAGCTCCTA ACTATTGTGT TCAGGACCCA ATTCCCAAAA 
TGCAGCACAC TGGCTAATGT TGGAAGGAGC AACATCTACA AGAATAAAAA AAATTATGCT 
GACGTTTATG AGCCAGAAGG AGTGAAAATT TTCAGATGTC CGTCTCCAAT CTACTTCGCA 
AACATTGGTT TCTTTAAGCA GAAACTTATT GACGCTGTTG GCTTTAACCC ACTTCGAATT 
CTACGCAAGC GCAATAAAGC TTTGAAGAAA ATCCGAAAAC TGCAGAAGCA AGGACTGATA 
CAAGTGACAC CTAAAGGATT TATATGCACC TCTGATGGCT TCAAAGACTC TGATGAAGAA 
TTGGACAACA ACCAGATAGA AGAACTGGAT CAGCCGATCA ATACCACGGA CCTGCCCTTT 
GAAATAGACT GGAACGCCGA TCTCCCCCTC AACATCACCA TCCCCAAAAT CAGCCTCCAC 
AGCCTCATCC TCGATTTTTC AGCAGTATCC TTCCTTGACA TCTCCTCAAT GAGGGGCCTC 
AGAACGATTT TACAAGAGTT TATTAGGATC AAGGTGGACG TATATATTGT GGGAACCGAT 
GATGATTTCA TTGACAAACT TGCTCGGTGT GAATTCTTTG ATGACGAAGT CACAGACTCA 
ATATTTTTCT TAACAATCCA TGATGCTATT TTGCATATTT GGATGAAGAA GGACTACAGC 
ACTTCAAAGT TCAATTCCAG CCAGGAAAAA GAAAGGAAAT TTGACTTTAC CATAAATACA 
AATGGAGGAT TACGTAATCG GGAATGTCAG GTACCAGTTG AAACGAAATT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[Expression pattern of congenital chloride diarrhea pathogenic gene Slc26a3 in the reproductive tract of male rodents].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics31(5)654-8(2014 Oct)
Chen L,Xu W

Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation.
Biology of reproduction86(1)1-14(2012 Jan)
Ch?vez JC,Hern?ndez-Gonz?lez EO,Wertheimer E,Visconti PE,Darszon A,Trevi?o CL

Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells.
Pflugers Archiv : European journal of physiology454(3)441-50(2007 Jun)
Barmeyer C,Ye JH,Sidani S,Geibel J,Binder HJ,Rajendran VM

Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum.
Gastroenterology122(3)709-24(2002 Mar)
Jacob P,Rossmann H,Lamprecht G,Kretz A,Neff C,Lin-Wu E,Gregor M,Groneberg DA,Kere J,Seidler U

Regulation of DRA and AE1 in rat colon by dietary Na depletion.
American journal of physiology. Gastrointestinal and liver physiology279(5)G931-42(2000 Nov)
Rajendran VM,Black J,Ardito TA,Sangan P,Alper SL,Schweinfest C,Kashgarian M,Binder HJ

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Slc26a3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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