Crcp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Crcp
Entrez Gene ID	114205
Full Name	CGRP receptor component
Synonyms	Cgrp-rcp
General protein information	Preferred Names CGRP receptor component Names DNA-directed RNA polymerase III subunit RPC9 CGRP-receptor component protein CGRPRCP RNA polymerase III subunit C9 calcitonin gene-related peptide-receptor component protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q12
Summary	may play a role in a neuroendocrine stress response [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053670.3	NP_446122.1	DNA-directed RNA polymerase III subunit RPC9

Pathways from BioSystems

Homologies

Homo sapiens (human)	CRCP	NP_055293.1
Rattus norvegicus (Norway rat)	Crcp	NP_446122.1
Canis lupus familiaris (dog)	CRCP	XP_536833.2
Danio rerio (zebrafish)	crcp	NP_001038838.1
Pan troglodytes (chimpanzee)	CRCP	NP_001229358.1
Mus musculus (house mouse)	Crcp	NP_031787.1
Gallus gallus (chicken)	CRCP	XP_415793.1
Drosophila melanogaster (fruit fly)	Rcp	NP_996493.1
Xenopus tropicalis (tropical clawed frog)	crcp	NP_001016478.1
Bos taurus (cattle)	CRCP	NP_001071338.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007220	XP_308566.3

Gene Ontology
Bibliography

Related articles in PubMed

Non-excitatory electrical stimulation attenuates myocardial infarction via homeostasis of calcitonin gene-related peptide in myocardium.
Guo ZJ, Guo Z
Peptides6546-52(2015 Mar)

Peripheral calcitonin gene-related peptide receptor activation and mechanical sensitization of the joint in rat models of osteoarthritis pain.
Bullock CM, Wookey P, Bennett A, Mobasheri A, Dickerson I, Kelly S
Arthritis & rheumatology (Hoboken, N.J.)66(8)2188-200(2014 Aug)

mRNA distribution of CGRP and its receptor components in the trigeminovascular system and other pain related structures in rat brain, and effect of intracerebroventricular administration of CGRP on Fos expression in the TNC.
Bhatt DK, Gupta S, Ploug KB, Jansen-Olesen I, Olesen J
Neuroscience letters55999-104(2014 Jan)

Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular system.
Eftekhari S, Warfvinge K, Blixt FW, Edvinsson L
The journal of pain : official journal of the American Pain Society14(11)1289-303(2013 Nov)

Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.
Eftekhari S, Edvinsson L
BMC neuroscience12112(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The alleviating effect of non-excitatory electrical stimulation in myocardial infarction may be associated with modulation of endogenous CGRP expression in the myocardium.
Title: Non-excitatory electrical stimulation attenuates myocardial infarction via homeostasis of calcitonin gene-related peptide in myocardium.

CGRP receptor is widely distributed in the trigeminovascular system and other pain- processing brain structures.
Title: mRNA distribution of CGRP and its receptor components in the trigeminovascular system and other pain related structures in rat brain, and effect of intracerebroventricular administration of CGRP on Fos expression in the TNC.

These data suggest that CGRP is expressed in C-fibers and may act on A-fibers, rodent mast cells, and vascular smooth muscle cells that express the CGRP receptor.
Title: Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular system.

This study demonstrates the detailed expression of CGRP and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level
Title: Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.

Functional CGRP receptors are detected in trigeminal satellite cells, a specialized type of glia found within the sensory ganglia.
Title: Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1? pro-inflammatory effects.

The following Crcp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crcp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10271	NM_053670.3 Latest version!	Rattus norvegicus CGRP receptor component (Crcp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Crcp ( NM_053670.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446122.1 Rattus norvegicus CGRP receptor component (Crcp), mRNA.

Price & Availability↑

CloneID	ORa10271
Clone ID Related Accession (Same CDS sequence)	NM_053670.3
Accession Version	NM_053670.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Rattus norvegicus(Norway rat)
Product	DNA-directed RNA polymerase III subunit RPC9
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF440799.2. On Jun 10, 2007 this sequence version replaced NM_053670.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF440799.2, BC059117.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGAAGTGA AGGATGCGAA CGCTGCCCTG CTCAGTAACT ACGAGGTGTT CCAGTTACTG 
ACAGACCTCA AAGAGCAGCG GAAGGAGAGC GGGAAGAACA AGCATAGCGC CGGGCAGCAG 
AACTTGAACG CCATCACCTA CGAGACATTA AAATACATAT CGAAAACTCC ATGTAAGAAC 
CAGAGTCCGG CGATTGTCCA AGAATTCCTC ACAGCAATGA AGAGCCACAA GCTGACCAAA 
GCCGAGAAGC TTCAGCTGCT GAATCACAGG CCAATGACCG CTGTTGAGAT CCAGCTGATG 
GTGGAAGAGA GTGAAGAGCG GCTCACGGAG GAGCAGATTG AAGCTCTCCT GCACACTGTC 
ACCAGCATCC TGCCTGCAGG TCCAGAGGAT GAGCAGAGCA AAAGCACTAG CAATGACGCG 
GCAATGGAAG AGGAGGAGCC TGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446122.1
CDS	15..461
Translation	MEVKDANAALLSNYEVFQLLTDLKEQRKESGKNKHSAGQQNLNAITYETLKYISKTPCKNQSPAIVQEFLTAMKSHKLTKAEKLQLLNHRPMTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAGPEDEQSKSTSNDAAMEEEEPA

Target ORF information:

RefSeq Version	NM_053670.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CGRP receptor component (Crcp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053670.3

ORF Insert Sequence:

ATGGAAGTGA AGGATGCGAA CGCTGCCCTG CTCAGTAACT ACGAGGTGTT CCAGTTACTG 
ACAGACCTCA AAGAGCAGCG GAAGGAGAGC GGGAAGAACA AGCATAGCGC CGGGCAGCAG 
AACTTGAACG CCATCACCTA CGAGACATTA AAATACATAT CGAAAACTCC ATGTAAGAAC 
CAGAGTCCGG CGATTGTCCA AGAATTCCTC ACAGCAATGA AGAGCCACAA GCTGACCAAA 
GCCGAGAAGC TTCAGCTGCT GAATCACAGG CCAATGACCG CTGTTGAGAT CCAGCTGATG 
GTGGAAGAGA GTGAAGAGCG GCTCACGGAG GAGCAGATTG AAGCTCTCCT GCACACTGTC 
ACCAGCATCC TGCCTGCAGG TCCAGAGGAT GAGCAGAGCA AAAGCACTAG CAATGACGCG 
GCAATGGAAG AGGAGGAGCC TGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Non-excitatory electrical stimulation attenuates myocardial infarction via homeostasis of calcitonin gene-related peptide in myocardium.
Peptides6546-52(2015 Mar)
Guo ZJ,Guo Z

Peripheral calcitonin gene-related peptide receptor activation and mechanical sensitization of the joint in rat models of osteoarthritis pain.
Arthritis & rheumatology (Hoboken, N.J.)66(8)2188-200(2014 Aug)
Bullock CM,Wookey P,Bennett A,Mobasheri A,Dickerson I,Kelly S

mRNA distribution of CGRP and its receptor components in the trigeminovascular system and other pain related structures in rat brain, and effect of intracerebroventricular administration of CGRP on Fos expression in the TNC.
Neuroscience letters55999-104(2014 Jan)
Bhatt DK,Gupta S,Ploug KB,Jansen-Olesen I,Olesen J

Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular system.
The journal of pain : official journal of the American Pain Society14(11)1289-303(2013 Nov)
Eftekhari S,Warfvinge K,Blixt FW,Edvinsson L

Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.
BMC neuroscience12112(2011 Nov)
Eftekhari S,Edvinsson L