Vegfc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vegfc
Entrez Gene ID	114111
Full Name	vascular endothelial growth factor C
General protein information	Preferred Names vascular endothelial growth factor C Names vascular endothelial growth factor C VEGF-C VRP flt4 ligand flt4-L vascular endothelial growth factor-related protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p11
Summary	platelet-derived growth factor/vascular derived growth factor (PDGF/VEGF); active in angiogenesis and endothelial cell growth [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053653.1	NP_446105.1	vascular endothelial growth factor C precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	VEGFC	NP_005420.1
Canis lupus familiaris (dog)	VEGFC	XP_540047.2
Xenopus tropicalis (tropical clawed frog)	vegfc	XP_002933363.1
Bos taurus (cattle)	VEGFC	NP_776913.1
Rattus norvegicus (Norway rat)	Vegfc	NP_446105.1
Pan troglodytes (chimpanzee)	VEGFC	XP_526740.1
	VEGFC	NP_001129571.1
Danio rerio (zebrafish)	vegfc	NP_991297.1
Mus musculus (house mouse)	Vegfc	NP_033532.1
Gallus gallus (chicken)	VEGFC	XP_420532.2

Gene Ontology
Bibliography

Related articles in PubMed

Developmental expression of vascular endothelial growth factor receptor 3 and vascular endothelial growth factor C in forebrain.
Ward MC, Cunningham AM
Neuroscience303544-57(2015 Sep)

VEGF-C induces lymphangiogenesis and angiogenesis in the rat mesentery culture model.
Sweat RS, Sloas DC, Murfee WL
Microcirculation (New York, N.Y. : 1994)21(6)532-40(2014 Aug)

Novel DOX-MTX nanoparticles improve oral SCC clinical outcome by down regulation of lymph dissemination factor VEGF-C expression in vivo: oral and IV modalities.
Abbasi MM, Monfaredan A, Hamishehkar H, Seidi K, Jahanban- Esfahlan R
Asian Pacific journal of cancer prevention : APJCP15(15)6227-32(2014)

Expression of vascular endothelial growth factor family messenger RNA in diseased thyroid tissues.
Tanaka K, Kurebayashi J, Sonoo H, Otsuki T, Yamamoto Y, Ohkubo S, Yamamoto S, Shimozuma K
Surgery today32(9)761-8(2002)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings of this study suggest an important role for VEGFC/VEGFR3 signaling in neuronal proliferation in early forebrain development, and ongoing functions with niche neurogenesis, glial and ependymal function in the maturing postnatal brain.
Title: Developmental expression of vascular endothelial growth factor receptor 3 and vascular endothelial growth factor C in forebrain.

VEGF-C treatment resulted in an increase in the density of blood vessel sprouting compared to controls by day 3. By day 5, lymphatic sprouting was increased compared to controls.
Title: VEGF-C induces lymphangiogenesis and angiogenesis in the rat mesentery culture model.

COX-2 could increase vascular endothelial growth factor (VEGF)-A and VEGF-C expressions in peritoneal tissue, resulting in increased formation of peritoneal and lymphatic microvessels playing pivotal roles in the development of ultrafiltration failure.
Title: Cyclooxygenase-2 and vascular endothelial growth factor expressions are involved in ultrafiltration failure.

VEGF-C is involved in fibrogenesis through stimulation of myofibroblast proliferation, migration, and collagen synthesis, via activation of the TGF-beta1 and ERK pathways.
Title: Vascular endothelial growth factor-C: its unrevealed role in fibrogenesis.

High vascular endothelial growth factor C expession is associated with oral squamous cell carcinoma.
Title: Novel DOX-MTX nanoparticles improve oral SCC clinical outcome by down regulation of lymph dissemination factor VEGF-C expression in vivo: oral and IV modalities.

The following Vegfc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vegfc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13579	NM_053653.1 Latest version!	Rattus norvegicus vascular endothelial growth factor C (Vegfc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vegfc ( NM_053653.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446105.1 Rattus norvegicus vascular endothelial growth factor C (Vegfc), mRNA.

Price & Availability↑

CloneID	ORa13579
Clone ID Related Accession (Same CDS sequence)	NM_053653.1
Accession Version	NM_053653.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Rattus norvegicus(Norway rat)
Product	vascular endothelial growth factor C precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY032729.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY032729.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347 [ECO:0000348] ##Evidence-Data-END##

ATGCACTTGC TGTGCTTCTT GTCTCTGGCG TGTTCCTTGC TCGCCGCTGC GCTGATCCCC 
GGTCCGCGCG AGGCGCCCGC CACCGTCGCC GCCTTCGAGT CGGGACTGGG CTTCTCGGAA 
GCAGAGCCGG ACGGGGGCGA GGTCAAGGGT TTCGAAGGCA AAGACCTGGA GGAGCAGTTG 
CGGTCTGTGT CCAGTGTAGA TGAGCTCATG TCTGTCCTGT ACCCAGACTA CTGGAAAATG 
TACAAGTGCC AGCTAAGGAA AGGCGGCTGG CAGCAGCCCT CCCTCAACAT GAGGACAGGG 
GACACTGTAA AACTTGCTGC TGCACATTAC AACACTGAGA TCCTGAAAAG TATTGATAAT 
GAGTGGAGAA AGACTCAATG CATGCCACGT GAGGTGTGTA TAGATGTGGG GAAGGAGTTT 
GGAGCAGCCA CAAACACCTT CTTTAAACCT CCATGTGTGT CCGTCTACAG ATGTGGGGGT 
TGCTGCAACA GTGAAGGGCT GCAATGCATG AACACCAGCA CAGGTTACCT CAGCAAGACG 
TTGTTTGAAA TTACAGTGCC TCTCTCTCAA GGCCCCAAAC CAGTCACAAT CAGTTTTGCC 
AATCACACTT CCTGCCGGTG CATGTCTAAA CTGGATGTTT ACAGACAAGT TCATTCAATT 
ATTAGACGTT CTCTGCCAGC AACATTACCA CAGTGTCAGG CAGCTAACAA GACTTGTCCA 
GCAAACTACG TGTGGAATAA CTACATGTGT CAATGCCTGG CTCAGCAGGA TTTTATCTTT 
TATTCAAATG TTGAGGATGA CTCATCCAAT GGATTCCATG ATGTCTGTGG ACCCAACAAG 
GAGTTGGATG AAGACACCTG CCAGTGTGTC TGCAAGGGGG GGCTTCGACC ATCCAGCTGT 
GGACCCCACA AAGAGCTAGA TAGAGACTCA TGCCAGTGTG TCTGTAAAAA CAAACTTTTC 
CTTAATTCAT GTGGAGCCAA CAGGGAATTT GATGAGAACA CATGCCAGTG TGTCTGCAAG 
AGAACATGTC CAAGAAATCA ACCCCTGAAT CCTGGAAAAT GTGCCTGTGA ATGTACAGAA 
AACACACAGA AGTGCTTCCT AAAAGGGAAG AAATTCCACC ATCAAACATG CAGCTGTTAC 
AGACGACCAT GTACAAATCG ACTGAAGCAT TGTGATCCGG GACTGTCATT TAGTGAAGAG 
GTGTGTCGCT GTGTCCCATC ATATTGGAAA AGACCACATC TGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446105.1
CDS	88..1335
Translation	MHLLCFLSLACSLLAAALIPGPREAPATVAAFESGLGFSEAEPDGGEVKGFEGKDLEEQLRSVSSVDELMSVLYPDYWKMYKCQLRKGGWQQPSLNMRTGDTVKLAAAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGAATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTGYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRRSLPATLPQCQAANKTCPANYVWNNYMCQCLAQQDFIFYSNVEDDSSNGFHDVCGPNKELDEDTCQCVCKGGLRPSSCGPHKELDRDSCQCVCKNKLFLNSCGANREFDENTCQCVCKRTCPRNQPLNPGKCACECTENTQKCFLKGKKFHHQTCSCYRRPCTNRLKHCDPGLSFSEEVCRCVPSYWKRPHLN

Target ORF information:

RefSeq Version	NM_053653.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus vascular endothelial growth factor C (Vegfc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053653.1

ORF Insert Sequence:

ATGCACTTGC TGTGCTTCTT GTCTCTGGCG TGTTCCTTGC TCGCCGCTGC GCTGATCCCC 
GGTCCGCGCG AGGCGCCCGC CACCGTCGCC GCCTTCGAGT CGGGACTGGG CTTCTCGGAA 
GCAGAGCCGG ACGGGGGCGA GGTCAAGGGT TTCGAAGGCA AAGACCTGGA GGAGCAGTTG 
CGGTCTGTGT CCAGTGTAGA TGAGCTCATG TCTGTCCTGT ACCCAGACTA CTGGAAAATG 
TACAAGTGCC AGCTAAGGAA AGGCGGCTGG CAGCAGCCCT CCCTCAACAT GAGGACAGGG 
GACACTGTAA AACTTGCTGC TGCACATTAC AACACTGAGA TCCTGAAAAG TATTGATAAT 
GAGTGGAGAA AGACTCAATG CATGCCACGT GAGGTGTGTA TAGATGTGGG GAAGGAGTTT 
GGAGCAGCCA CAAACACCTT CTTTAAACCT CCATGTGTGT CCGTCTACAG ATGTGGGGGT 
TGCTGCAACA GTGAAGGGCT GCAATGCATG AACACCAGCA CAGGTTACCT CAGCAAGACG 
TTGTTTGAAA TTACAGTGCC TCTCTCTCAA GGCCCCAAAC CAGTCACAAT CAGTTTTGCC 
AATCACACTT CCTGCCGGTG CATGTCTAAA CTGGATGTTT ACAGACAAGT TCATTCAATT 
ATTAGACGTT CTCTGCCAGC AACATTACCA CAGTGTCAGG CAGCTAACAA GACTTGTCCA 
GCAAACTACG TGTGGAATAA CTACATGTGT CAATGCCTGG CTCAGCAGGA TTTTATCTTT 
TATTCAAATG TTGAGGATGA CTCATCCAAT GGATTCCATG ATGTCTGTGG ACCCAACAAG 
GAGTTGGATG AAGACACCTG CCAGTGTGTC TGCAAGGGGG GGCTTCGACC ATCCAGCTGT 
GGACCCCACA AAGAGCTAGA TAGAGACTCA TGCCAGTGTG TCTGTAAAAA CAAACTTTTC 
CTTAATTCAT GTGGAGCCAA CAGGGAATTT GATGAGAACA CATGCCAGTG TGTCTGCAAG 
AGAACATGTC CAAGAAATCA ACCCCTGAAT CCTGGAAAAT GTGCCTGTGA ATGTACAGAA 
AACACACAGA AGTGCTTCCT AAAAGGGAAG AAATTCCACC ATCAAACATG CAGCTGTTAC 
AGACGACCAT GTACAAATCG ACTGAAGCAT TGTGATCCGG GACTGTCATT TAGTGAAGAG 
GTGTGTCGCT GTGTCCCATC ATATTGGAAA AGACCACATC TGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Developmental expression of vascular endothelial growth factor receptor 3 and vascular endothelial growth factor C in forebrain.
Neuroscience303544-57(2015 Sep)
Ward MC,Cunningham AM

VEGF-C induces lymphangiogenesis and angiogenesis in the rat mesentery culture model.
Microcirculation (New York, N.Y. : 1994)21(6)532-40(2014 Aug)
Sweat RS,Sloas DC,Murfee WL

Novel DOX-MTX nanoparticles improve oral SCC clinical outcome by down regulation of lymph dissemination factor VEGF-C expression in vivo: oral and IV modalities.
Asian Pacific journal of cancer prevention : APJCP15(15)6227-32(2014)
Abbasi MM,Monfaredan A,Hamishehkar H,Seidi K,Jahanban- Esfahlan R

Expression of vascular endothelial growth factor family messenger RNA in diseased thyroid tissues.
Surgery today32(9)761-8(2002)
Tanaka K,Kurebayashi J,Sonoo H,Otsuki T,Yamamoto Y,Ohkubo S,Yamamoto S,Shimozuma K

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Vegfc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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