Enho cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Enho
Entrez Gene ID	100912292
Full Name	energy homeostasis associated
Synonyms	RGD1565232
General protein information	Preferred Names energy homeostasis associated Names adropin adropin-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001282336.1	NP_001269265.1	adropin precursor

Pathways from BioSystems

Homologies

	ENHO	XP_001097511.1
Rattus norvegicus (Norway rat)	LOC100912292	NP_001269265.1
Pan troglodytes (chimpanzee)	ENHO	XP_003312104.1
Canis lupus familiaris (dog)	ENHO	XP_003431614.1
Homo sapiens (human)	ENHO	NP_940975.2
Mus musculus (house mouse)	Enho	NP_081423.1

Gene Ontology
Bibliography

Related articles in PubMed

Neuroprotective effect of ischemic preconditioning via modulating the expression of adropin and oxidative markers against transient cerebral ischemia in diabetic rats.
Altintas O, Kumas M, Altintas MO
Peptides7931-8(2016 05)

Adropin is a brain membrane-bound protein regulating physical activity via the NB-3/Notch signaling pathway in mice.
Wong CM, Wang Y, Lee JT, Huang Z, Wu D, Xu A, Lam KS
The Journal of biological chemistry289(37)25976-86(2014 Sep)

Elevated adropin: a candidate diagnostic marker for myocardial infarction in conjunction with troponin-I.
Aydin S, Kuloglu T, Aydin S, Kalayci M, Yilmaz M, ?akmak T, Eren MN
Peptides5891-7(2014 Aug)

Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes.
Aydin S, Kuloglu T, Aydin S, Eren MN, Yilmaz M, Kalayci M, Sahin I, Kocaman N, Citil C, Kendir Y
Molecular and cellular biochemistry380(1-2)73-81(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The neuroprotective effects of ischemic preconditioning in middle cerebral artery infarcts correlated with the level of oxidative damage markers and adropin.
Title: Neuroprotective effect of ischemic preconditioning via modulating the expression of adropin and oxidative markers against transient cerebral ischemia in diabetic rats.

The findings elucidate the pathogenesis of MI, and the gradual increase in serum adropin could be a novel diagnostic marker and serve as an alternative to troponin-I measurement for diagnosing MI.
Title: Elevated adropin: a candidate diagnostic marker for myocardial infarction in conjunction with troponin-I.

Data show that adropin (ADR) is expressed in various tissues in the rats and its levels increased in STZ-induced diabetes.
Title: Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes.

The following Enho gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Enho cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11940	NM_001282336.1 Latest version!	Rattus norvegicus energy homeostasis associated (Enho), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Enho ( NM_001282336.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001269265.1 Rattus norvegicus energy homeostasis associated (Enho), mRNA.

Price & Availability↑

CloneID	ORa11940
Clone ID Related Accession (Same CDS sequence)	NM_001282336.1
Accession Version	NM_001282336.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 231bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-16
Organism	Rattus norvegicus(Norway rat)
Product	adropin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07048038.1. On or before Aug 30, 2013 this sequence version replaced XM_003749926.1, XM_003754007.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: EV779288.1, CB785460.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGCAG CCATCTCCCA GGGGGCTCTC ATTGCCATAG TCTGCAATGG CCTGGTAGGC 
TTCCTGCTGC TGCTGCTCTG GGTCATTCTC TGCTGGGCCT GCCACTCTCG CTCTGCTGAC 
GTCGACTCTC TCTCAGAATC CAGTCCCAAC TCCAGCCCTG GCCCCTGTCC TGAGAAGGCG 
CCGCCGCCCC AGAAGCCAAG CCATGAAGGC AGCTACCTGC TGCAGCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269265.1
CDS	309..539
Translation	MGAAISQGALIAIVCNGLVGFLLLLLWVILCWACHSRSADVDSLSESSPNSSPGPCPEKAPPPQKPSHEGSYLLQP

Target ORF information:

RefSeq Version	NM_001282336.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus energy homeostasis associated (Enho), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282336.1

ORF Insert Sequence:

ATGGGGGCAG CCATCTCCCA GGGGGCTCTC ATTGCCATAG TCTGCAATGG CCTGGTAGGC 
TTCCTGCTGC TGCTGCTCTG GGTCATTCTC TGCTGGGCCT GCCACTCTCG CTCTGCTGAC 
GTCGACTCTC TCTCAGAATC CAGTCCCAAC TCCAGCCCTG GCCCCTGTCC TGAGAAGGCG 
CCGCCGCCCC AGAAGCCAAG CCATGAAGGC AGCTACCTGC TGCAGCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neuroprotective effect of ischemic preconditioning via modulating the expression of adropin and oxidative markers against transient cerebral ischemia in diabetic rats.
Peptides7931-8(2016 05)
Altintas O,Kumas M,Altintas MO

Adropin is a brain membrane-bound protein regulating physical activity via the NB-3/Notch signaling pathway in mice.
The Journal of biological chemistry289(37)25976-86(2014 Sep)
Wong CM,Wang Y,Lee JT,Huang Z,Wu D,Xu A,Lam KS

Elevated adropin: a candidate diagnostic marker for myocardial infarction in conjunction with troponin-I.
Peptides5891-7(2014 Aug)
Aydin S,Kuloglu T,Aydin S,Kalayci M,Yilmaz M,?akmak T,Eren MN

Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes.
Molecular and cellular biochemistry380(1-2)73-81(2013 Aug)
Aydin S,Kuloglu T,Aydin S,Eren MN,Yilmaz M,Kalayci M,Sahin I,Kocaman N,Citil C,Kendir Y