Fosb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fosb
Entrez Gene ID	100360880
Full Name	FosB proto-oncogene, AP-1 transcription factor subunit
Synonyms	fra-2
General protein information	Preferred Names FosB proto-oncogene, AP-1 transcription factor subunit Names protein fosB FBJ osteosarcoma oncogene B FBJ osteosarcoma viral oncogene isoform deltaFosb-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256509.1	NP_001243438.1	protein fosB

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FOSB	NP_001013866.1
Bos taurus (cattle)	FOSB	NP_001095718.1
Rattus norvegicus (Norway rat)	Fosb	NP_001243438.1
Mus musculus (house mouse)	Fosb	NP_032062.1
Danio rerio (zebrafish)	fosb	NP_001007313.1
Xenopus tropicalis (tropical clawed frog)	LOC100490871	XP_002932681.2
Homo sapiens (human)	FOSB	NP_006723.2

Gene Ontology
Bibliography

Related articles in PubMed

Transcription factor ?FosB acts within the nucleus of the solitary tract to increase mean arterial pressure during exposures to intermittent hypoxia.
Wu Q, Cunningham JT, Mifflin SW
American journal of physiology. Heart and circulatory physiologyajpheart002682017(2017 Nov)

Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia.
Faulk K, Shell B, Nedungadi TP, Cunningham JT
American journal of physiology. Regulatory, integrative and comparative physiology312(2)R245-R252(2017 Feb)

Impact of repeated asenapine treatment on FosB/?FosB expression in the forebrain structures under normal conditions and mild stress preconditioning in the rat.
Majercikova Z, Horvathova L, Osacka J, Pecenak J, Kiss A
Brain research bulletin12729-37(2016 Oct)

Repeated forced swim stress affects the expression of pCREB and ?FosB and the acetylation of histone H3 in the rostral ventromedial medulla and locus coeruleus.
Imbe H, Kimura A
Brain research bulletin12711-22(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Chromatin immunoprecipitation (ChIP) assays demonstrated an increase in FosB/DeltaFosB association with the ACE1 gene within the MnPO following CIH. FosB/DeltaFosB may transcriptionally target ACE1 within the MnPO following CIH to affect the downstream PVN region, which may influence SNA and blood pressure.
Title: Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia.

Results show that repeated administration of asenapine may elici long-lasting FosB/DeltaFosB-like transcription factors that could mediate some of the persistent and region-specific changes in brain function, interconnected with chronic drug exposure. interconnected with chronic drug exposure. However, it cannot be excluded that the impact of repeated asenapine exposure might be influenced by an ambient stressogen leve...
Title: Impact of repeated asenapine treatment on FosB/?FosB expression in the forebrain structures under normal conditions and mild stress preconditioning in the rat.

Forced swim stress induced a significant increase in the expression of pCREB and DeltaFosB and the acetylation of histone H3 in the rostral ventromedial medulla, whereas the forced swim stress induced a significant increase only in the acetylation of histone H3 in the locus coeruleus.
Title: Repeated forced swim stress affects the expression of pCREB and ?FosB and the acetylation of histone H3 in the rostral ventromedial medulla and locus coeruleus.

Results show that FosB gene products are induced throughout the brain by chronic exposure to fluoxetine, and that the specific gene products expressed vary by brain region and between chronic stress and antidepressant treatment
Title: Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress.

Significant increase in FosB/DeltaFosB-like immunostaining was observed in the dentate gyrus, basolateral amygdala and medial prefrontal cortex of rats exposed to chronic variable stress-shock.
Title: History of chronic stress modifies acute stress-evoked fear memory and acoustic startle in male rats.

The following Fosb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fosb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09153	NM_001256509.1 Latest version!	Rattus norvegicus FosB proto-oncogene, AP-1 transcription factor subunit (Fosb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fosb ( NM_001256509.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001243438.1 Rattus norvegicus FosB proto-oncogene, AP-1 transcription factor subunit (Fosb), mRNA.

Price & Availability↑

CloneID	ORa09153
Clone ID Related Accession (Same CDS sequence)	NM_001256509.1
Accession Version	NM_001256509.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Rattus norvegicus(Norway rat)
Product	protein fosB
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473979.2. On or before Feb 5, 2012 this sequence version replaced XM_002725539.1, XM_002725540.1, XM_002728698.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END##

ATGTTTCAAG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGTAGCTC ATCACCCTCC 
GCCGAGTCTC AGTACCTGTC TTCGGTGGAC TCCTTCGGCA GTCCACCCAC CGCCGCCGCC 
TCCCAGGAGT GCGCCGGTCT CGGGGAAATG CCCGGCTCCT TCGTGCCAAC GGTCACCGCA 
ATCACAACCA GCCAGGACCT TCAGTGGCTC GTGCAGCCCA CCCTCATCTC TTCCATGGCC 
CAGTCCCAGG GGCAGCCACT GGCCTCCCAG CCTCCAGCTG TTGACCCTTA TGACATGCCT 
GGAACCAGCT ACTCAACCCC GGGCCTGAGT GCCTACAGCA CTGGTGGGGC AAGCGGAAGT 
GGTGGGCCTT CAACTAGCAC AAGCACCAGT GGACCCGTGT CTGCCCGCCC AGCCAGAGCC 
AGGCCTAGAA GACCCCGAGA AGAAACACTT ACCCCAGAAG AAGAAGAAAA ACGAAGGGTT 
CGCAGAGAGC GGAACAAGCT GGCTGCAGCT AAATGCAGAA ACCGTCGGAG GGAGCTGACA 
GACCGACTCC AGGCGGAAAC GGATCAGCTC GAAGAGGAAA AGGCAGAGCT GGAGTCGGAG 
ATCGCCGAGC TGCAAAAAGA GAAGGAACGC CTGGAGTTTG TCCTGGTGGC CCACAAACCG 
GGCTGCAAGA TCCCTTACGA AGAGGGGCCG GGGCCAGGCC CGCTGGCCGA GGTGAGAGAT 
TTGCCAGGGT CAACATCCGC TAAGGAAGAC GGCTTCGGCT GGCTGCTGCC GCCCCCTCCA 
CCACCGCCCC TGCCCTTCCA GAGCAGCCGA GACGCACCCC CCAACCTGAC GGCTTCTCTC 
TTTACACACA GTGAAGTTCA AGTCCTCGGC GACCCCTTCC CCGTTGTTAG CCCTTCGTAC 
ACTTCCTCGT TTGTCCTCAC CTGCCCGGAG GTCTCCGCGT TCGCCGGCTC CCAACGCACC 
AGCGGCAGCG AGCAGCCGTC CGACCCCCTG AACTCGCCCT CCCTTCTTGC TCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243438.1
CDS	325..1341
Translation	MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPAVDPYDMPGTSYSTPGLSAYSTGGASGSGGPSTSTSTSGPVSARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSTSAKEDGFGWLLPPPPPPPLPFQSSRDAPPNLTASLFTHSEVQVLGDPFPVVSPSYTSSFVLTCPEVSAFAGSQRTSGSEQPSDPLNSPSLLAL

Target ORF information:

RefSeq Version	NM_001256509.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FosB proto-oncogene, AP-1 transcription factor subunit (Fosb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256509.1

ORF Insert Sequence:

ATGTTTCAAG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGTAGCTC ATCACCCTCC 
GCCGAGTCTC AGTACCTGTC TTCGGTGGAC TCCTTCGGCA GTCCACCCAC CGCCGCCGCC 
TCCCAGGAGT GCGCCGGTCT CGGGGAAATG CCCGGCTCCT TCGTGCCAAC GGTCACCGCA 
ATCACAACCA GCCAGGACCT TCAGTGGCTC GTGCAGCCCA CCCTCATCTC TTCCATGGCC 
CAGTCCCAGG GGCAGCCACT GGCCTCCCAG CCTCCAGCTG TTGACCCTTA TGACATGCCT 
GGAACCAGCT ACTCAACCCC GGGCCTGAGT GCCTACAGCA CTGGTGGGGC AAGCGGAAGT 
GGTGGGCCTT CAACTAGCAC AAGCACCAGT GGACCCGTGT CTGCCCGCCC AGCCAGAGCC 
AGGCCTAGAA GACCCCGAGA AGAAACACTT ACCCCAGAAG AAGAAGAAAA ACGAAGGGTT 
CGCAGAGAGC GGAACAAGCT GGCTGCAGCT AAATGCAGAA ACCGTCGGAG GGAGCTGACA 
GACCGACTCC AGGCGGAAAC GGATCAGCTC GAAGAGGAAA AGGCAGAGCT GGAGTCGGAG 
ATCGCCGAGC TGCAAAAAGA GAAGGAACGC CTGGAGTTTG TCCTGGTGGC CCACAAACCG 
GGCTGCAAGA TCCCTTACGA AGAGGGGCCG GGGCCAGGCC CGCTGGCCGA GGTGAGAGAT 
TTGCCAGGGT CAACATCCGC TAAGGAAGAC GGCTTCGGCT GGCTGCTGCC GCCCCCTCCA 
CCACCGCCCC TGCCCTTCCA GAGCAGCCGA GACGCACCCC CCAACCTGAC GGCTTCTCTC 
TTTACACACA GTGAAGTTCA AGTCCTCGGC GACCCCTTCC CCGTTGTTAG CCCTTCGTAC 
ACTTCCTCGT TTGTCCTCAC CTGCCCGGAG GTCTCCGCGT TCGCCGGCTC CCAACGCACC 
AGCGGCAGCG AGCAGCCGTC CGACCCCCTG AACTCGCCCT CCCTTCTTGC TCTGTAA