OAZ1 cDNA ORF clone, Python bivittatus(Burmese python)

Gene
Clones
gRNAs

Summary

Gene Symbol	OAZ1
Entrez Gene ID	103062016
Full Name	ornithine decarboxylase antizyme 1
Gene Type	protein-coding
Organism	Python bivittatus(Burmese python)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). [provided by RefSeq, Feb 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001305094.1	NP_001292023.1	ornithine decarboxylase antizyme 1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Ivanov IP, Atkins JF
Nucleic acids research35(6)1842-58(2007)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following OAZ1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OPy96680	NM_001305094.1 Latest version!	Python bivittatus ornithine decarboxylase antizyme 1 (OAZ1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OAZ1 ( NM_001305094.1 ) cDNA ORF clone, Python bivittatus(Burmese python) -> NP_001292023.1 Python bivittatus ornithine decarboxylase antizyme 1 (OAZ1), mRNA.

Price & Availability↑

CloneID	OPy96680
Clone ID Related Accession (Same CDS sequence)	NM_001305094.1
Accession Version	NM_001305094.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-17
Organism	Python bivittatus(Burmese python)
Product	ornithine decarboxylase antizyme 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AEQU02201510.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN03263920, SAMN03263922 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END##

ATGGTGAAAT CCTCCCTGCA GCGGATCCTC AACAGTCACT GCTTTGCCCG CGAGAAGGAA 
GGAAATAAAA AGACCAGTAT CGCCACCATG CCCACCCTGC CCACCAACGC CGCTTTGAGG 
AGTTCCAGGG TGTCTTTCAG TTGCTGTAGT AACCTGGGTC CAGGGCCTCG GTGGTGCTCC 
GATGTCCCTC ACCCACCCCT GAAGATCCCA GGTGGGCGAG GGAATAGTCG GAGGGATCAC 
AATCTTTCAG CTAACTTATT TTACTCTGAT AATCGGCTGA ATGTAACAGA GGAAATAACA 
TCAAGTAACA GGACAAGAAT TCTGAACATC CAGTCCAGGC TGACGGATGC CAAACACATC 
AGTTGGAGAA CTGTGTTGAA TAACAGCAAT TTGTATATTG AACTTCCCAA TGGCGCTTTG 
CCGGAAGGGA GCAAAGACAG TTTTGCAGTT CTTCTTGAGT TTGCGGAAGA GCAGCTTCAA 
GTAGAGCACG TGTTCATTTG TTTCCACAAG AACAGAGATG ACAGAGCTTC GCTGCTCCGT 
ACCTTCAGCT TCTTGGGCTT TGAGATTGTG AGACCAGGGC ATCCCCTTGT CCCCAAGAGA 
CCTGACGCTT GCTTTATGGC GTACACATTT GAACGAGACT CTTCTGAAGA AGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001292023.1
CDS	join(3..182,184..660)
Translation	MVKSSLQRILNSHCFAREKEGNKKTSIATMPTLPTNAALRSSRVSFSCCSNLGPGPRWCSDVPHPPLKIPGGRGNSRRDHNLSANLFYSDNRLNVTEEITSSNRTRILNIQSRLTDAKHISWRTVLNNSNLYIELPNGALPEGSKDSFAVLLEFAEEQLQVEHVFICFHKNRDDRASLLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERDSSEED

Target ORF information:

RefSeq Version	NM_001305094.1
Organism	Python bivittatus(Burmese python)
Definition	Python bivittatus ornithine decarboxylase antizyme 1 (OAZ1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305094.1

ORF Insert Sequence:

ATGGTGAAAT CCTCCCTGCA GCGGATCCTC AACAGTCACT GCTTTGCCCG CGAGAAGGAA 
GGAAATAAAA AGACCAGTAT CGCCACCATG CCCACCCTGC CCACCAACGC CGCTTTGAGG 
AGTTCCAGGG TGTCTTTCAG TTGCTGTAGT AACCTGGGTC CAGGGCCTCG GTGGTGCTCC 
GATGTCCCTC ACCCACCCCT GAAGATCCCA GGTGGGCGAG GGAATAGTCG GAGGGATCAC 
AATCTTTCAG CTAACTTATT TTACTCTGAT AATCGGCTGA ATGTAACAGA GGAAATAACA 
TCAAGTAACA GGACAAGAAT TCTGAACATC CAGTCCAGGC TGACGGATGC CAAACACATC 
AGTTGGAGAA CTGTGTTGAA TAACAGCAAT TTGTATATTG AACTTCCCAA TGGCGCTTTG 
CCGGAAGGGA GCAAAGACAG TTTTGCAGTT CTTCTTGAGT TTGCGGAAGA GCAGCTTCAA 
GTAGAGCACG TGTTCATTTG TTTCCACAAG AACAGAGATG ACAGAGCTTC GCTGCTCCGT 
ACCTTCAGCT TCTTGGGCTT TGAGATTGTG AGACCAGGGC ATCCCCTTGT CCCCAAGAGA 
CCTGACGCTT GCTTTATGGC GTACACATTT GAACGAGACT CTTCTGAAGA AGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF