MX1 cDNA ORF clone, Ovis aries(sheep)

Gene
Clones
gRNAs

Summary

Gene Symbol	MX1
Entrez Gene ID	443146
Full Name	MX dynamin like GTPase 1
Synonyms	MX,OGTPBP,ONBP
Gene Type	protein-coding
Organism	Ovis aries(sheep)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001009753.1	NP_001009753.1	interferon-induced GTP-binding protein Mx1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

SNPs in candidate genes MX dynamin-like GTPase and chemokine (C-C motif) receptor-5 are associated with ovine pulmonary adenocarcinoma progression in Latxa sheep.
Larruskain A, Esparza-Baquer A, Minguij?n E, Juste RA, Jugo BM
Animal genetics46(6)666-75(2015 Dec)

The myxovirus-resistance protein, MX1, is a component of exosomes secreted by uterine epithelial cells.
Racicot K, Schmitt A, Ott T
American journal of reproductive immunology (New York, N.Y. : 1989)67(6)498-505(2012 Jun)

The myxovirus resistance protein, MX1, interacts with tubulin beta in uterine glandular epithelial cells.
Racicot K, Ott T
American journal of reproductive immunology (New York, N.Y. : 1989)65(1)44-53(2011 Jan)

Cellular localization and function of the antiviral protein, ovine Mx1 (oMx1): II. The oMx1 protein is a regulator of secretion in an ovine glandular epithelial cell line.
Toyokawa K, Leite F, Ott TL
American journal of reproductive immunology (New York, N.Y. : 1989)57(1)23-33(2007 Jan)

Cloning and characterizing of the ovine MX1 gene promoter/enhancer region.
Assiri AM, Ott TL
Developmental and comparative immunology31(8)847-57(2007)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Three SNPs analyzed in the MX1 locus showed a significant association with susceptibility to ovine pulmonary adenocarcinoma in Latxa sheep
Title: SNPs in candidate genes MX dynamin-like GTPase and chemokine (C-C motif) receptor-5 are associated with ovine pulmonary adenocarcinoma progression in Latxa sheep.

This study is the first to characterize MX1-associated exosomes, and we postulate that MX1 regulates secretion in epithelial cells by playing a role in exosome formation or trafficking
Title: The myxovirus-resistance protein, MX1, is a component of exosomes secreted by uterine epithelial cells.

MX1 was shown to interact with tubulin beta (TUBB) during interphase and mitosis and nocodazole disrupted this interaction
Title: The myxovirus resistance protein, MX1, interacts with tubulin beta in uterine glandular epithelial cells.

ovine Mx1 (oMx1) protein is secreted by oGE cells and that reduction in oMx1 protein levels by siRNA reduced secretion of interferon-stimulated gene 15.
Title: Cellular localization and function of the antiviral protein, ovine Mx1 (oMx1): II. The oMx1 protein is a regulator of secretion in an ovine glandular epithelial cell line.

cloning & characterization of the 5' flanking region of the MX1 gene; results contribute to understanding of the complex regulation of MX1 in the uterus & suggest the possibility that factors other than IFN-tau may regulate transcription of the MX1 gene
Title: Cloning and characterizing of the ovine MX1 gene promoter/enhancer region.

The following MX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSm00100	NM_001009753.1 Latest version!	Ovis aries MX dynamin like GTPase 1 (MX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MX1 ( NM_001009753.1 ) cDNA ORF clone, Ovis aries(sheep) -> NP_001009753.1 Ovis aries MX dynamin like GTPase 1 (MX1), mRNA.

Price & Availability↑

CloneID	OSm00100
Clone ID Related Accession (Same CDS sequence)	NM_001009753.1
Accession Version	NM_001009753.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1965bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Ovis aries(sheep)
Product	interferon-induced GTP-binding protein Mx1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF399856.1. ##Evidence-Data-START## Transcript exon combination :: X66093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA104494977, SAMEA104494983 [ECO:0000348] ##Evidence-Data-END##

ATGGTTCTTT CTGACTTGGA TATCAAAGAA CCTGATTCCC CTGAATCCGG TCTAAATGGA 
AGTGACGATA TGGTGAGGGA ACATGAAACG GAGTCCAAGG GCAACCTGTA CAGCCAATAT 
GAGGAGAAGG TGCTGCCCTG CATTGACCTC ATCGACTCTC TGCGGGCCCT GGGCGTGGAG 
CAGGACCTGG CCCTGCCCGC CATCGCCGTT ATCGGGGACC AGAGCTCGGG CAAGAGCTCT 
GTGCTGGAGG CCCTGTCTGG GGTTGCCCTC CCCAGGGGCA GTGGTATTGT TACAAGATGT 
CCTCTCGTGC TGAGGCTGAA AAAACTTGAG AAGGAAGGCG AGTGGAAAGG CAAAGTCAGC 
TTCCTGGACA GAGAGATTGA GATTTCAGAT GCTTCACAGG TGGAAAAGGA AATCAGTGAA 
GCCCAGATTG CCATCGCTGG CGAAGGCATG GGGATCAGTC ATGAGCTGAT TAGTCTGGAG 
GTCAGCTCCC CTCACGTCCC AGATCTGACC CTGATAGACC TTCCTGGCAT CACCAGGGTT 
GCTGTGGGCA ACCAGCCACA CGACATTGAA TATCAGATCA AGTCTCTCAT CAGGAAGTAT 
ATCCTTAGGC AGGAGACCAT CAACTTGGTG GTGGTCCCTG CTAACGTGGA CATCGCCACC 
ACAGAGGCGC TGCGCATGGC TCAGGATGTG GATCCCCAAG GAGATAGGAC CATAGGAATC 
TTGACAAAGC CCGATCTGGT GGACAAAGGC ACGGAAGACA AGGTTGTAGA CGTGGTGAGA 
AACCTGGTCT TTCACCTGAA GAAGGGCTAC ATGATCGTCA AGTCGCGCGG CCAGCAGGAG 
ATCCAGCATC GGCTGAGCCT GGACAAGGCC CTACAGAGAG AGCGGATTAT CTTCGAGGAT 
CACACACATT TCAGGGACCT TCTGGAGGAA GGGAGGGCCA CTATCCCCTG CCTGGCAGAA 
AGACTCACCA ATGAACTCAT CATGCACATT TGTAAAACTC TGCCCCTGTT GGAAAATCAA 
ATAAAGGAGA CTCACCAGAG AATAACAGAG GAGTTCCAGA AGTATGGCAA GGACATCCCA 
GAAGAAGAAA GTGAGAAAAT GTTCTCTCTG ATAGAGAAAA TTGATACATT TAATAAAGAG 
ATCATCTCAA CAATAGAAGG GGAGGAACTC GTGGGGCAGT ATGACTCCCG ACTGTTTACC 
AAAGTACGAG CCGAATTCTG CAAATGGAGT GCTGTGGTTG AGAAAAATTT CGAAAAAGGT 
CATGAAGCCA TACGTAAAGA AATAAAGCAA TTTGAAAATC GGTATCGTGG CAGAGAGTTG 
CCAGGGTTTG TGAATTACAA GACATTTGAG ATCATCATAA AAAAGCAGGT CATAGTTCTG 
GAAGAGCCTG CTGTGGACAT GCTGCACACG GTGACAGATA TAATCCGGAA TACCTTCACA 
GAAGTTTCAG GAAAACACTT TAGTGAATTT TTCAACCTCC ACCGAACTGC CAAGTCCAAA 
ATTGAAGACA TTCGGTTAGA ACAAGAAAAT GAAGCTGAGA AATCCATCCG ACTACATTTC 
CAAATGGAGC AGTTGGTCTA CTGCCAGGAC CAGGTGTACC GACGTGCTTT GCAACAGGTC 
AGAGAGAAGG AGGCAGAAGA AGAAAAAAAA AAAAAAAAAA ACCATTATTA CCAATCTGAG 
GACTCAGAGC CCTCCACAGC TGAGATCTTT CAACACCTGA TGGCGTACCA CCAGGAAGTC 
AGCACCCGCA TCTCCAGCCA CATCCCCTTG ATCATCCAGT TCTTCGTGCT CCGGACGTAT 
GGGGAGCAGC TCAAGAAGAG CATGCTGCAG CTGCTGCAGG ACAAGGACCA GTACGACTGG 
CTGCTGAAGG AGCGCACCGA CACCAGAGAC AAGAGGAAGT TCCTGAAGGA GCGGCTGGAG 
CGGCTGTCCC GCGCTCGGCA GCGGCTCGCC AAGTTCCCGG GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001009753.1
CDS	122..2086
Translation	MVLSDLDIKEPDSPESGLNGSDDMVREHETESKGNLYSQYEEKVLPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLRLKKLEKEGEWKGKVSFLDREIEISDASQVEKEISEAQIAIAGEGMGISHELISLEVSSPHVPDLTLIDLPGITRVAVGNQPHDIEYQIKSLIRKYILRQETINLVVVPANVDIATTEALRMAQDVDPQGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKSRGQQEIQHRLSLDKALQRERIIFEDHTHFRDLLEEGRATIPCLAERLTNELIMHICKTLPLLENQIKETHQRITEEFQKYGKDIPEEESEKMFSLIEKIDTFNKEIISTIEGEELVGQYDSRLFTKVRAEFCKWSAVVEKNFEKGHEAIRKEIKQFENRYRGRELPGFVNYKTFEIIIKKQVIVLEEPAVDMLHTVTDIIRNTFTEVSGKHFSEFFNLHRTAKSKIEDIRLEQENEAEKSIRLHFQMEQLVYCQDQVYRRALQQVREKEAEEEKKKKKNHYYQSEDSEPSTAEIFQHLMAYHQEVSTRISSHIPLIIQFFVLRTYGEQLKKSMLQLLQDKDQYDWLLKERTDTRDKRKFLKERLERLSRARQRLAKFPG

Target ORF information:

RefSeq Version	NM_001009753.1
Organism	Ovis aries(sheep)
Definition	Ovis aries MX dynamin like GTPase 1 (MX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001009753.1

ORF Insert Sequence:

ATGGTTCTTT CTGACTTGGA TATCAAAGAA CCTGATTCCC CTGAATCCGG TCTAAATGGA 
AGTGACGATA TGGTGAGGGA ACATGAAACG GAGTCCAAGG GCAACCTGTA CAGCCAATAT 
GAGGAGAAGG TGCTGCCCTG CATTGACCTC ATCGACTCTC TGCGGGCCCT GGGCGTGGAG 
CAGGACCTGG CCCTGCCCGC CATCGCCGTT ATCGGGGACC AGAGCTCGGG CAAGAGCTCT 
GTGCTGGAGG CCCTGTCTGG GGTTGCCCTC CCCAGGGGCA GTGGTATTGT TACAAGATGT 
CCTCTCGTGC TGAGGCTGAA AAAACTTGAG AAGGAAGGCG AGTGGAAAGG CAAAGTCAGC 
TTCCTGGACA GAGAGATTGA GATTTCAGAT GCTTCACAGG TGGAAAAGGA AATCAGTGAA 
GCCCAGATTG CCATCGCTGG CGAAGGCATG GGGATCAGTC ATGAGCTGAT TAGTCTGGAG 
GTCAGCTCCC CTCACGTCCC AGATCTGACC CTGATAGACC TTCCTGGCAT CACCAGGGTT 
GCTGTGGGCA ACCAGCCACA CGACATTGAA TATCAGATCA AGTCTCTCAT CAGGAAGTAT 
ATCCTTAGGC AGGAGACCAT CAACTTGGTG GTGGTCCCTG CTAACGTGGA CATCGCCACC 
ACAGAGGCGC TGCGCATGGC TCAGGATGTG GATCCCCAAG GAGATAGGAC CATAGGAATC 
TTGACAAAGC CCGATCTGGT GGACAAAGGC ACGGAAGACA AGGTTGTAGA CGTGGTGAGA 
AACCTGGTCT TTCACCTGAA GAAGGGCTAC ATGATCGTCA AGTCGCGCGG CCAGCAGGAG 
ATCCAGCATC GGCTGAGCCT GGACAAGGCC CTACAGAGAG AGCGGATTAT CTTCGAGGAT 
CACACACATT TCAGGGACCT TCTGGAGGAA GGGAGGGCCA CTATCCCCTG CCTGGCAGAA 
AGACTCACCA ATGAACTCAT CATGCACATT TGTAAAACTC TGCCCCTGTT GGAAAATCAA 
ATAAAGGAGA CTCACCAGAG AATAACAGAG GAGTTCCAGA AGTATGGCAA GGACATCCCA 
GAAGAAGAAA GTGAGAAAAT GTTCTCTCTG ATAGAGAAAA TTGATACATT TAATAAAGAG 
ATCATCTCAA CAATAGAAGG GGAGGAACTC GTGGGGCAGT ATGACTCCCG ACTGTTTACC 
AAAGTACGAG CCGAATTCTG CAAATGGAGT GCTGTGGTTG AGAAAAATTT CGAAAAAGGT 
CATGAAGCCA TACGTAAAGA AATAAAGCAA TTTGAAAATC GGTATCGTGG CAGAGAGTTG 
CCAGGGTTTG TGAATTACAA GACATTTGAG ATCATCATAA AAAAGCAGGT CATAGTTCTG 
GAAGAGCCTG CTGTGGACAT GCTGCACACG GTGACAGATA TAATCCGGAA TACCTTCACA 
GAAGTTTCAG GAAAACACTT TAGTGAATTT TTCAACCTCC ACCGAACTGC CAAGTCCAAA 
ATTGAAGACA TTCGGTTAGA ACAAGAAAAT GAAGCTGAGA AATCCATCCG ACTACATTTC 
CAAATGGAGC AGTTGGTCTA CTGCCAGGAC CAGGTGTACC GACGTGCTTT GCAACAGGTC 
AGAGAGAAGG AGGCAGAAGA AGAAAAAAAA AAAAAAAAAA ACCATTATTA CCAATCTGAG 
GACTCAGAGC CCTCCACAGC TGAGATCTTT CAACACCTGA TGGCGTACCA CCAGGAAGTC 
AGCACCCGCA TCTCCAGCCA CATCCCCTTG ATCATCCAGT TCTTCGTGCT CCGGACGTAT 
GGGGAGCAGC TCAAGAAGAG CATGCTGCAG CTGCTGCAGG ACAAGGACCA GTACGACTGG 
CTGCTGAAGG AGCGCACCGA CACCAGAGAC AAGAGGAAGT TCCTGAAGGA GCGGCTGGAG 
CGGCTGTCCC GCGCTCGGCA GCGGCTCGCC AAGTTCCCGG GCTGA