IL1RN cDNA ORF clone, Oryctolagus cuniculus(rabbit)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL1RN
Entrez Gene ID	100009558
Full Name	interleukin 1 receptor antagonist
Synonyms	IL1RA,icIL-1ra
Gene Type	protein-coding
Organism	Oryctolagus cuniculus(rabbit)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001082770.1	NP_001076239.1	interleukin-1 receptor antagonist protein precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Correlation of neutrophil and monocyte derived interleukin-1 receptor antagonist and interleukin-8 with colitis severity in the rabbit.
Kaneda K, Saitoh F, Shibusawa H, Maegawa H, Saniabadi AR, Kashiwagi N, Matsukawa A
Cytokine56(2)508-14(2011 Nov)

Rabbit interleukin-1 receptor antagonist. Cloning, expression, functional characterization, and regulation during intestinal inflammation.
Cominelli F, Bortolami M, Pizarro TT, Monsacchi L, Ferretti M, Brewer MT, Eisenberg SP, Ng RK
The Journal of biological chemistry269(9)6962-71(1994 Mar)

Interleukin-1 receptor antagonist in inflammatory exudate cells of rabbits. Production, purification and determination of primary structure.
Goto F, Goto K, Miyata T, Ohkawara S, Takao T, Mori S, Furukawa S, Maeda T, Iwanaga S, Shimonishi Y
Immunology77(2)235-44(1992 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IL-8 and IL-1ra showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis
Title: Correlation of neutrophil and monocyte derived interleukin-1 receptor antagonist and interleukin-8 with colitis severity in the rabbit.

The following IL1RN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL1RN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OOb30114	NM_001082770.1 Latest version!	Oryctolagus cuniculus interleukin 1 receptor antagonist (IL1RN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL1RN ( NM_001082770.1 ) cDNA ORF clone, Oryctolagus cuniculus(rabbit) -> NP_001076239.1 Oryctolagus cuniculus interleukin 1 receptor antagonist (IL1RN), mRNA.

Price & Availability↑

CloneID	OOb30114
Clone ID Related Accession (Same CDS sequence)	NM_001082770.1
Accession Version	NM_001082770.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Oryctolagus cuniculus(rabbit)
Product	interleukin-1 receptor antagonist protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M57526.1. ##Evidence-Data-START## Transcript exon combination :: M57526.1, D21832.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3321799, SAMEA3321800 [ECO:0000348] ##Evidence-Data-END##

ATGAGACCCT CCAGGAGCAC CCGCAGGCAC CTAATCTCCC TCCTCCTCTT CCTGTTCCAT 
TCAGAGACAG CCTGCCGCCC TTCTGGGAAA AGACCTTGCA GGATGCAGGC CTTCAGAATC 
TGGGATGTTA ACCAGAAGAC CTTCTACTTG AGAAACAACC AACTAGTCGC TGGTTACTTG 
CAAGGCCCAA ATGCCAAATT AGAAGAAAGG ATAGATGTGG TGCCCCTTGA GCCTCAGCTC 
CTGTTCCTGG GCATCCAGAG GGGGAAGTTG TGCCTGTCTT GTGTGAAGTC TGGGGATAAG 
ATGAAGCTCC ATTTGGAGGC CGTTAACATC ACTGACCTGG GCAAGAACAA GGAGCAGGAC 
AAGCGCTTCA CCTTCATCCG CTCCAATAGC GGCCCTACCA CCACCTTCGA GTCTGCCTCC 
TGCCCGGGCT GGTTTCTCTG CACGGCCCTG GAGGCTGACC AGCCCGTCAG CCTCACCAAC 
ACGCCCGACG ACTCCATCGT GGTCACCAAG TTCTACTTCC AGGAGGACCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001076239.1
CDS	33..566
Translation	MRPSRSTRRHLISLLLFLFHSETACRPSGKRPCRMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNAKLEERIDVVPLEPQLLFLGIQRGKLCLSCVKSGDKMKLHLEAVNITDLGKNKEQDKRFTFIRSNSGPTTTFESASCPGWFLCTALEADQPVSLTNTPDDSIVVTKFYFQEDQ

Target ORF information:

RefSeq Version	NM_001082770.1
Organism	Oryctolagus cuniculus(rabbit)
Definition	Oryctolagus cuniculus interleukin 1 receptor antagonist (IL1RN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001082770.1

ORF Insert Sequence:

ATGAGACCCT CCAGGAGCAC CCGCAGGCAC CTAATCTCCC TCCTCCTCTT CCTGTTCCAT 
TCAGAGACAG CCTGCCGCCC TTCTGGGAAA AGACCTTGCA GGATGCAGGC CTTCAGAATC 
TGGGATGTTA ACCAGAAGAC CTTCTACTTG AGAAACAACC AACTAGTCGC TGGTTACTTG 
CAAGGCCCAA ATGCCAAATT AGAAGAAAGG ATAGATGTGG TGCCCCTTGA GCCTCAGCTC 
CTGTTCCTGG GCATCCAGAG GGGGAAGTTG TGCCTGTCTT GTGTGAAGTC TGGGGATAAG 
ATGAAGCTCC ATTTGGAGGC CGTTAACATC ACTGACCTGG GCAAGAACAA GGAGCAGGAC 
AAGCGCTTCA CCTTCATCCG CTCCAATAGC GGCCCTACCA CCACCTTCGA GTCTGCCTCC 
TGCCCGGGCT GGTTTCTCTG CACGGCCCTG GAGGCTGACC AGCCCGTCAG CCTCACCAAC 
ACGCCCGACG ACTCCATCGT GGTCACCAAG TTCTACTTCC AGGAGGACCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Correlation of neutrophil and monocyte derived interleukin-1 receptor antagonist and interleukin-8 with colitis severity in the rabbit.
Cytokine56(2)508-14(2011 Nov)
Kaneda K,Saitoh F,Shibusawa H,Maegawa H,Saniabadi AR,Kashiwagi N,Matsukawa A

Rabbit interleukin-1 receptor antagonist. Cloning, expression, functional characterization, and regulation during intestinal inflammation.
The Journal of biological chemistry269(9)6962-71(1994 Mar)
Cominelli F,Bortolami M,Pizarro TT,Monsacchi L,Ferretti M,Brewer MT,Eisenberg SP,Ng RK

Interleukin-1 receptor antagonist in inflammatory exudate cells of rabbits. Production, purification and determination of primary structure.
Immunology77(2)235-44(1992 Oct)
Goto F,Goto K,Miyata T,Ohkawara S,Takao T,Mori S,Furukawa S,Maeda T,Iwanaga S,Shimonishi Y