Eps8l2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Eps8l2
Entrez Gene ID	98845
Full Name	EPS8-like 2
Synonyms	AI042819,AW545405,Eps8r2
General protein information	Preferred Names EPS8-like 2 Names epidermal growth factor receptor kinase substrate 8-like protein 2 EPS8 related protein 2 EPS8-like protein 2 epidermal growth factor receptor pathway substrate 8-like protein 2 epidermal growth factor receptor pathway substrate 8-related protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 F5

mRNA and Protein(s)

mRNA	Protein	Name
NM_133191.2	NP_573454.2	epidermal growth factor receptor kinase substrate 8-like protein 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Eps8l2	NP_001101978.1
Gallus gallus (chicken)	LOC100859520	XP_003643217.2
Homo sapiens (human)	EPS8L2	NP_073609.2
	LOC720824	XP_001116697.2
Gallus gallus (chicken)	EPS8L2	XP_001232098.3
Danio rerio (zebrafish)	LOC798252	XP_002666818.2
Mus musculus (house mouse)	Eps8l2	NP_573454.2
Gallus gallus (chicken)	LOC100857614	XP_003643630.2
Xenopus tropicalis (tropical clawed frog)	eps8l2	XP_002937551.2

Gene Ontology
Bibliography

Related articles in PubMed

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.
Giese APJ, Tang YQ, Sinha GP, Bowl MR, Goldring AC, Parker A, Freeman MJ, Brown SDM, Riazuddin S, Fettiplace R, Schafer WR, Frolenkov GI, Ahmed ZM
Nature communications8(1)43(2017 06)

Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.
Furness DN, Johnson SL, Manor U, R?ttiger L, Tocchetti A, Offenhauser N, Olt J, Goodyear RJ, Vijayakumar S, Dai Y, Hackney CM, Franz C, Di Fiore PP, Masetto S, Jones SM, Knipper M, Holley MC, Richardson GP, Kachar B, Marcotti W
Proceedings of the National Academy of Sciences of the United States of America110(34)13898-903(2013 Aug)

Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.
Bell SM, Zhang L, Xu Y, Besnard V, Wert SE, Shroyer N, Whitsett JA
Developmental biology375(2)128-39(2013 Mar)

Eps8 controls actin-based motility by capping the barbed ends of actin filaments.
Disanza A, Carlier MF, Stradal TE, Didry D, Frittoli E, Confalonieri S, Croce A, Wehland J, Di Fiore PP, Scita G
Nature cell biology6(12)1180-8(2004 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Eps8L2 is required for the long-term maintenance of the staircase structure and mechanosensory function of auditory hair bundles.
Title: Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.

The following Eps8l2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eps8l2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14542	NM_133191.2 Latest version!	Mus musculus EPS8-like 2 (Eps8l2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$433.30 $619.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Eps8l2 ( NM_133191.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_573454.2 Mus musculus EPS8-like 2 (Eps8l2), mRNA.

Price & Availability↑

CloneID	OMu14542
Clone ID Related Accession (Same CDS sequence)	NM_133191.2
Accession Version	NM_133191.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-26
Organism	Mus musculus(house mouse)
Product	epidermal growth factor receptor kinase substrate 8-like protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC005492.1. On May 21, 2002 this sequence version replaced NM_133191.1. ##Evidence-Data-START## Transcript exon combination :: BC005492.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCAGT CAGCATCCAT GAGCTGCTGC CCAGGAGCTG CCAACGGCAG TCTGGGCCGG 
TCTGATGGTG TGCCCAGGAT GAGCGCAAAG GACCTGTTTG AGCAGAGGAA GAAGTACTCC 
AACTCCAACG TCATCATGCA TGAGACTTCA CAGTATCACG TGCAGCACCT GGCCACATTC 
ATCATGGACA AGAGTGAGGC TATTGCCTCC GTGGATGACG CCATCCGGAA GCTGGTACAG 
CTGAGCTCCA AGGAGAAGGT CTGGGCCCAG GAAGTCCTGC TGCAGGTGAA CGACAAGTCA 
CTGCGACTGC TGGATGTTGA GTCCCAGGAA GAGCTGGAGA ACTTTCCGCT GCCCACTGTG 
CAGCACAGCC AGACAGTGCT AAACCAGCTG CGCTACCCCT CTGTGCTGCT GCTGGTGTGC 
CAGGACTCAG ACCAGAACAA GCCCGACATC CACTTCTTTC ACTGTGACGA GGTGGAGGCG 
GAACTTGTGC AGGAAGACAT TGAGAGTGCT CTGGCTGACT ACCGGCTGGG GAAGAAGATG 
AGACCACAGA CCCTAAAGGG ACACCAGGAG AAGATCCGCC AGCGGCAGTC TATCTTACCC 
CCTCCACAGA GCCCAGCCCC CATTCCCTTC CAGCGACAGC CAGGAGATTC CCCTCAGGCC 
AAGAACCGTG TGGGCCTGCC CTTGCCAGTG CCATTCAGTG AACCAGGCTA TCGCAGGAGG 
GAATCCCAGG ACGAGGAGCC ACGGGCTGTG CTGGCTCAGA GAATAGAGAA GGAGACGCAA 
ATCCTTAACT GCACCCTGGA TGATATTGAA TGGTTCGTGG CCAGGCTGCA GAAGGCAGCT 
GAGGCTTTCA AGCAGTTGAA CCAGCGGAAA AAGGGGAAGA AGAAGAACAA GAAGGGGCCA 
GCAGAGGGTG TCCTTACACT TCGGGCACGC CCCCCCTCGG AGGGAGAGTT TGTTGACTGT 
TTCCAGAAAA CCAAGCTGGC CATCAACCTG CTGGCGAAGC TGCAGAAGCA CATCCAAAAC 
CCTAGTGCAG CCGAGCTGGT GCACTTCCTC TTCGGGCCTC TGGATCTGAT CATCAACACA 
TGTGGCAGCC CCGACATAGC ACGCTCTGTC TCCAGCCCTT TGCTGTCCAC TGACGCCGTG 
AGCTTCTTAC GTGGCCACTT GGTCCCCAAA GAGATGACAC TGTGGGAATC ACTGGGGGAG 
ACCTGGATGA GGCCTCGCTC TGAATGGCCC CGGGAGCCAC AGGTGCCACT CTATGTGCCC 
AAGTTCCGCA GCGGCTGGGA ACCACCCCTG GATGTCCTAC AGGAGGCTCC CTGGGAGGTA 
GAAGGACTGG CATCTGTGCC CAGTGATCAG CTGACCCCCA AGAATCGACT ATCTGTACGA 
CATTCCCCAA AGCACAGCCT CTCCTCCGAG TCCCAAGCCC CAGAGGACAT TGCACCACCA 
GGCAGCTCCC CACATGCTAA CAGGGGCTAC CAGCCAACAC CAGCCATGAC CAAGTACGTC 
AAGATCCTCT ATGATTTCAC AGCGCGAAAC GCCAATGAGC TATCTGTGCT CAAGGACGAG 
GTCCTAGAGG TGCTGGAGGA CGGCCGGCAG TGGTGGAAGC TACGAAATCG CAGTGGCCAG 
GCGGGCTATG TGCCCTGCAA CATCCTGGCT GAAGCTCGGC AGGAGGACGT GGGTGCCCCC 
TTGGAACAGT CTGGCCAGAA ATACTGGGGT CCAGCCAGCC CCACCCACAA ACTGCCCCCA 
ATTTTCGCAG GGAACAAAGA AGAGCTAATC CACCACATGG ACGAGGTCAA TGACGAGCTC 
ATGAAAAAGA TCAGCCACAT CAAGACACAG CCGCAGCGCA ACTTCCGCGT GGAGCGCAGC 
CAGCCAGTGC ACCTGCCGCT TACCTTCGAG TCAGGTCCGG ATGAGGTCCG CGCCTGGCTG 
GAAGCCAAGG CCTTCAGTGC CAGGATCGTG GAGAACCTGG GCATCTTAAC TGGACCCCAG 
CTCTTCTCCC TCAACAAGGA GGAACTGAAA AAAGTGTGCG GGGAAGAGGG CAGTCGCGTG 
TACAGCCAGC TCACGGTTCA GAAGGCCTTC CTGGAGAAAC AACAAAGTGG GTCAGAACTG 
GAGAAGCTCA TGAGCAAGAT CAGGAGGGCC GAGGACAGCT ATACCAGCCA ACACACTTCA 
CCAGAGTCAG AGGGGGCGCC GCACCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573454.2
CDS	96..2285
Translation	MSQSASMSCCPGAANGSLGRSDGVPRMSAKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAIASVDDAIRKLVQLSSKEKVWAQEVLLQVNDKSLRLLDVESQEELENFPLPTVQHSQTVLNQLRYPSVLLLVCQDSDQNKPDIHFFHCDEVEAELVQEDIESALADYRLGKKMRPQTLKGHQEKIRQRQSILPPPQSPAPIPFQRQPGDSPQAKNRVGLPLPVPFSEPGYRRRESQDEEPRAVLAQRIEKETQILNCTLDDIEWFVARLQKAAEAFKQLNQRKKGKKKNKKGPAEGVLTLRARPPSEGEFVDCFQKTKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIINTCGSPDIARSVSSPLLSTDAVSFLRGHLVPKEMTLWESLGETWMRPRSEWPREPQVPLYVPKFRSGWEPPLDVLQEAPWEVEGLASVPSDQLTPKNRLSVRHSPKHSLSSESQAPEDIAPPGSSPHANRGYQPTPAMTKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRNRSGQAGYVPCNILAEARQEDVGAPLEQSGQKYWGPASPTHKLPPIFAGNKEELIHHMDEVNDELMKKISHIKTQPQRNFRVERSQPVHLPLTFESGPDEVRAWLEAKAFSARIVENLGILTGPQLFSLNKEELKKVCGEEGSRVYSQLTVQKAFLEKQQSGSELEKLMSKIRRAEDSYTSQHTSPESEGAPHL

Target ORF information:

RefSeq Version	NM_133191.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus EPS8-like 2 (Eps8l2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133191.2

ORF Insert Sequence:

ATGAGCCAGT CAGCATCCAT GAGCTGCTGC CCAGGAGCTG CCAACGGCAG TCTGGGCCGG 
TCTGATGGTG TGCCCAGGAT GAGCGCAAAG GACCTGTTTG AGCAGAGGAA GAAGTACTCC 
AACTCCAACG TCATCATGCA TGAGACTTCA CAGTATCACG TGCAGCACCT GGCCACATTC 
ATCATGGACA AGAGTGAGGC TATTGCCTCC GTGGATGACG CCATCCGGAA GCTGGTACAG 
CTGAGCTCCA AGGAGAAGGT CTGGGCCCAG GAAGTCCTGC TGCAGGTGAA CGACAAGTCA 
CTGCGACTGC TGGATGTTGA GTCCCAGGAA GAGCTGGAGA ACTTTCCGCT GCCCACTGTG 
CAGCACAGCC AGACAGTGCT AAACCAGCTG CGCTACCCCT CTGTGCTGCT GCTGGTGTGC 
CAGGACTCAG ACCAGAACAA GCCCGACATC CACTTCTTTC ACTGTGACGA GGTGGAGGCG 
GAACTTGTGC AGGAAGACAT TGAGAGTGCT CTGGCTGACT ACCGGCTGGG GAAGAAGATG 
AGACCACAGA CCCTAAAGGG ACACCAGGAG AAGATCCGCC AGCGGCAGTC TATCTTACCC 
CCTCCACAGA GCCCAGCCCC CATTCCCTTC CAGCGACAGC CAGGAGATTC CCCTCAGGCC 
AAGAACCGTG TGGGCCTGCC CTTGCCAGTG CCATTCAGTG AACCAGGCTA TCGCAGGAGG 
GAATCCCAGG ACGAGGAGCC ACGGGCTGTG CTGGCTCAGA GAATAGAGAA GGAGACGCAA 
ATCCTTAACT GCACCCTGGA TGATATTGAA TGGTTCGTGG CCAGGCTGCA GAAGGCAGCT 
GAGGCTTTCA AGCAGTTGAA CCAGCGGAAA AAGGGGAAGA AGAAGAACAA GAAGGGGCCA 
GCAGAGGGTG TCCTTACACT TCGGGCACGC CCCCCCTCGG AGGGAGAGTT TGTTGACTGT 
TTCCAGAAAA CCAAGCTGGC CATCAACCTG CTGGCGAAGC TGCAGAAGCA CATCCAAAAC 
CCTAGTGCAG CCGAGCTGGT GCACTTCCTC TTCGGGCCTC TGGATCTGAT CATCAACACA 
TGTGGCAGCC CCGACATAGC ACGCTCTGTC TCCAGCCCTT TGCTGTCCAC TGACGCCGTG 
AGCTTCTTAC GTGGCCACTT GGTCCCCAAA GAGATGACAC TGTGGGAATC ACTGGGGGAG 
ACCTGGATGA GGCCTCGCTC TGAATGGCCC CGGGAGCCAC AGGTGCCACT CTATGTGCCC 
AAGTTCCGCA GCGGCTGGGA ACCACCCCTG GATGTCCTAC AGGAGGCTCC CTGGGAGGTA 
GAAGGACTGG CATCTGTGCC CAGTGATCAG CTGACCCCCA AGAATCGACT ATCTGTACGA 
CATTCCCCAA AGCACAGCCT CTCCTCCGAG TCCCAAGCCC CAGAGGACAT TGCACCACCA 
GGCAGCTCCC CACATGCTAA CAGGGGCTAC CAGCCAACAC CAGCCATGAC CAAGTACGTC 
AAGATCCTCT ATGATTTCAC AGCGCGAAAC GCCAATGAGC TATCTGTGCT CAAGGACGAG 
GTCCTAGAGG TGCTGGAGGA CGGCCGGCAG TGGTGGAAGC TACGAAATCG CAGTGGCCAG 
GCGGGCTATG TGCCCTGCAA CATCCTGGCT GAAGCTCGGC AGGAGGACGT GGGTGCCCCC 
TTGGAACAGT CTGGCCAGAA ATACTGGGGT CCAGCCAGCC CCACCCACAA ACTGCCCCCA 
ATTTTCGCAG GGAACAAAGA AGAGCTAATC CACCACATGG ACGAGGTCAA TGACGAGCTC 
ATGAAAAAGA TCAGCCACAT CAAGACACAG CCGCAGCGCA ACTTCCGCGT GGAGCGCAGC 
CAGCCAGTGC ACCTGCCGCT TACCTTCGAG TCAGGTCCGG ATGAGGTCCG CGCCTGGCTG 
GAAGCCAAGG CCTTCAGTGC CAGGATCGTG GAGAACCTGG GCATCTTAAC TGGACCCCAG 
CTCTTCTCCC TCAACAAGGA GGAACTGAAA AAAGTGTGCG GGGAAGAGGG CAGTCGCGTG 
TACAGCCAGC TCACGGTTCA GAAGGCCTTC CTGGAGAAAC AACAAAGTGG GTCAGAACTG 
GAGAAGCTCA TGAGCAAGAT CAGGAGGGCC GAGGACAGCT ATACCAGCCA ACACACTTCA 
CCAGAGTCAG AGGGGGCGCC GCACCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.
Nature communications8(1)43(2017 06)
Giese APJ,Tang YQ,Sinha GP,Bowl MR,Goldring AC,Parker A,Freeman MJ,Brown SDM,Riazuddin S,Fettiplace R,Schafer WR,Frolenkov GI,Ahmed ZM

Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.
Proceedings of the National Academy of Sciences of the United States of America110(34)13898-903(2013 Aug)
Furness DN,Johnson SL,Manor U,R?ttiger L,Tocchetti A,Offenhauser N,Olt J,Goodyear RJ,Vijayakumar S,Dai Y,Hackney CM,Franz C,Di Fiore PP,Masetto S,Jones SM,Knipper M,Holley MC,Richardson GP,Kachar B,Marcotti W

Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.
Developmental biology375(2)128-39(2013 Mar)
Bell SM,Zhang L,Xu Y,Besnard V,Wert SE,Shroyer N,Whitsett JA

Eps8 controls actin-based motility by capping the barbed ends of actin filaments.
Nature cell biology6(12)1180-8(2004 Dec)
Disanza A,Carlier MF,Stradal TE,Didry D,Frittoli E,Confalonieri S,Croce A,Wehland J,Di Fiore PP,Scita G

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Eps8l2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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