Nans cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nans
Entrez Gene ID	94181
Full Name	N-acetylneuraminic acid synthase (sialic acid synthase)
Synonyms	4632418E04Rik,BB056474,Sas
General protein information	Preferred Names N-acetylneuraminic acid synthase (sialic acid synthase) Names sialic acid synthase N-acetylneuraminate-9-phosphate synthase N-acetylneuraminic acid 9-phosphate synthetase N-acetylneuraminic acid phosphate synthase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_053179.3	NP_444409.1	sialic acid synthase

Pathways from BioSystems

Homologies

Homo sapiens (human)	NANS	NP_061819.2
Canis lupus familiaris (dog)	NANS	XP_538746.2
Mus musculus (house mouse)	Nans	NP_444409.1
Danio rerio (zebrafish)	nans	NP_996660.1
	LOC715459	XP_001113519.2
Bos taurus (cattle)	NANS	NP_001039947.1
Xenopus tropicalis (tropical clawed frog)	nans	XP_002935918.1
Drosophila melanogaster (fruit fly)	Sas	NP_650195.1
Pan troglodytes (chimpanzee)	NANS	XP_001157918.1
Rattus norvegicus (Norway rat)	Nans	NP_001100125.2
Gallus gallus (chicken)	NANS	NP_001007976.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004460	XP_313756.5

Gene Ontology
Bibliography

Related articles in PubMed

Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase.
Fujita A, Sato C, Kitajima K
Biochemical and biophysical research communications355(1)174-80(2007 Mar)

Transcription profile during maternal to zygotic transition in the mouse embryo.
Li XY, Cui XS, Kim NH
Reproduction, fertility, and development18(6)635-45(2006)

Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K
Biochemical and biophysical research communications273(2)642-8(2000 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Intracellular localization of this enzyme is regulated not only due to the nuclear localization signal but also two nuclear export signals.
Title: Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase.

The following Nans gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nans cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09304	NM_053179.3 Latest version!	Mus musculus N-acetylneuraminic acid synthase (sialic acid synthase) (Nans), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nans ( NM_053179.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444409.1 Mus musculus N-acetylneuraminic acid synthase (sialic acid synthase) (Nans), mRNA.

Price & Availability↑

CloneID	OMu09304
Clone ID Related Accession (Same CDS sequence)	NM_053179.3
Accession Version	NM_053179.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	sialic acid synthase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK076290.1. On Apr 5, 2007 this sequence version replaced NM_053179.2. ##Evidence-Data-START## Transcript exon combination :: AK076290.1, AK088912.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCCGCTGG AACTGGAGCT GTGTCCCGGG CGCTGGGTGG GTGGAAAGCA CCCGTGCTTC 
ATCATCGCGG AGATCGGCCA GAACCACCAA GGAGACATAG ATGTGGCCAA GCGCATGATC 
CGCACTGCCA AGGAGTGTGG GGCCGACTGC GCTAAGTTTC AGAAGAGCGA GTTGGAGTTC 
AAGTTTAACC GGAAGGCCCT GGAGAGACCA TATACTTCGA AGCATTCATG GGGGAAGACG 
TATGGGGAGC ACAAGCGGCA TCTGGAATTC AGCCACGACC AGTACAAGGA GCTGCAGAGC 
TATGCGCAGG AGATCGGCAT CTTCTTCACT GCCTCTGGCA TGGACGAGAT GGCAGTTGAG 
TTTCTGCACG AACTGAATGT TCCCTTTTTC AAAGTTGGAT CTGGGGACAC TAACAATTTT 
CCCTACCTGG AAAAGACAGC CAAGAAAGGT CGTCCTATGG TGATCTCCAG CGGGATGCAG 
TCAATGGACA CCATGAAGCA AGTCTATCAG ATCGTGAAGC CGCTGAATCC CAACTTCTGC 
TTCCTCCAAT GCACCAGCGC GTACCCACTA CAGCCCGAGG ATGCCAACCT GCGCGTCATC 
TCGGAATACC AGAAGCTCTT TCCCGACATT CCCATCGGGT ATTCCGGGCA CGAGACGGGC 
ATCGCCATAT CTGTGGCCGC CGTGGCTCTG GGGGCCAAGG TGTTGGAACG TCACATAACG 
TTGGACAAGA CCTGGAAGGG GAGTGACCAC TCAGCCTCGC TGGAGCCTGG GGAGCTGGCA 
GAGCTGGTGC GGTCTGTGCG CCTGGTGGAG CGGGCCCTGG GCTCCCCAAC CAAGCAGCTG 
CTGCCCTGTG AGATGGCCTG CAATGAGAAG CTCGGCAAGT CTGTGGTAGC CAAAGTGAAA 
ATCCCAGCAG GCACCACCCT GACCCTGGAC ATGCTCACTG TGAAGGTGGG GGAGCCCAAA 
GGCTATCCTC CTGAAGACAT CTTCAACCTA GCGGGCAAAA AGGTGCTGGT CACTATCGAA 
GAAGATGACA CGGTCATGGA AGAATCCGTG GAAAGTCACA GCAAGAAAAT CAAGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444409.1
CDS	31..1110
Translation	MPLELELCPGRWVGGKHPCFIIAEIGQNHQGDIDVAKRMIRTAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWGKTYGEHKRHLEFSHDQYKELQSYAQEIGIFFTASGMDEMAVEFLHELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFLQCTSAYPLQPEDANLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIPAGTTLTLDMLTVKVGEPKGYPPEDIFNLAGKKVLVTIEEDDTVMEESVESHSKKIKA

Target ORF information:

RefSeq Version	NM_053179.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus N-acetylneuraminic acid synthase (sialic acid synthase) (Nans), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053179.3

ORF Insert Sequence:

ATGCCGCTGG AACTGGAGCT GTGTCCCGGG CGCTGGGTGG GTGGAAAGCA CCCGTGCTTC 
ATCATCGCGG AGATCGGCCA GAACCACCAA GGAGACATAG ATGTGGCCAA GCGCATGATC 
CGCACTGCCA AGGAGTGTGG GGCCGACTGC GCTAAGTTTC AGAAGAGCGA GTTGGAGTTC 
AAGTTTAACC GGAAGGCCCT GGAGAGACCA TATACTTCGA AGCATTCATG GGGGAAGACG 
TATGGGGAGC ACAAGCGGCA TCTGGAATTC AGCCACGACC AGTACAAGGA GCTGCAGAGC 
TATGCGCAGG AGATCGGCAT CTTCTTCACT GCCTCTGGCA TGGACGAGAT GGCAGTTGAG 
TTTCTGCACG AACTGAATGT TCCCTTTTTC AAAGTTGGAT CTGGGGACAC TAACAATTTT 
CCCTACCTGG AAAAGACAGC CAAGAAAGGT CGTCCTATGG TGATCTCCAG CGGGATGCAG 
TCAATGGACA CCATGAAGCA AGTCTATCAG ATCGTGAAGC CGCTGAATCC CAACTTCTGC 
TTCCTCCAAT GCACCAGCGC GTACCCACTA CAGCCCGAGG ATGCCAACCT GCGCGTCATC 
TCGGAATACC AGAAGCTCTT TCCCGACATT CCCATCGGGT ATTCCGGGCA CGAGACGGGC 
ATCGCCATAT CTGTGGCCGC CGTGGCTCTG GGGGCCAAGG TGTTGGAACG TCACATAACG 
TTGGACAAGA CCTGGAAGGG GAGTGACCAC TCAGCCTCGC TGGAGCCTGG GGAGCTGGCA 
GAGCTGGTGC GGTCTGTGCG CCTGGTGGAG CGGGCCCTGG GCTCCCCAAC CAAGCAGCTG 
CTGCCCTGTG AGATGGCCTG CAATGAGAAG CTCGGCAAGT CTGTGGTAGC CAAAGTGAAA 
ATCCCAGCAG GCACCACCCT GACCCTGGAC ATGCTCACTG TGAAGGTGGG GGAGCCCAAA 
GGCTATCCTC CTGAAGACAT CTTCAACCTA GCGGGCAAAA AGGTGCTGGT CACTATCGAA 
GAAGATGACA CGGTCATGGA AGAATCCGTG GAAAGTCACA GCAAGAAAAT CAAGGCTTAA