Lrg1 cDNA ORF clone, Mus musculus(house mouse)

Leucine-rich ?2-glycoprotein overexpression in the brain contributes to memory impairment.
Akiba C, Nakajima M, Miyajima M, Ogino I, Miura M, Inoue R, Nakamura E, Kanai F, Tada N, Kunichika M, Yoshida M, Nishimura K, Kondo A, Sugano H, Arai H
Neurobiology of aging6011-19(2017 Dec)

Leucine-rich
Honda H, Fujimoto M, Serada S, Urushima H, Mishima T, Lee H, Ohkawara T, Kohno N, Hattori N, Yokoyama A, Naka T
Physiological reports5(24)(2017 12)

Hippocampal LRG overexpression contributes to synaptic dysfunction, which leads to memory impairment with advance of age.
Title: Leucine-rich ?2-glycoprotein overexpression in the brain contributes to memory impairment.

This study shows that TNF-alpha is the predominant proinflammatory cytokine that induces the secretion of LRG1. LRG1 contributes to angiogenesis-coupled de novo bone formation by increasing angiogenesis and recruiting MSCs in the subchondral bone of osteoarthritis joints.
Title: TNF-?-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis.

findings reveal a novel and essential role of Lrig1 in regulating morphogenic events that shape the hippocampal circuits and establish that the assembly of TrkB with Lrig1 represents a key mechanism for understanding how specific neuronal populations expand the repertoire of responses to BDNF during brain development
Title: Lrig1 is a cell-intrinsic modulator of hippocampal dendrite complexity and BDNF signaling.

Leucine-rich alpha2-glycoprotein signalling could be a therapeutic target against cardiovascular diseases
Title: Myeloid cell-derived LRG attenuates adverse cardiac remodelling after myocardial infarction.

Loss of LRG is associated with Lewis lung carcinoma.
Title: Leucine-rich ?-2-glycoprotein promotes TGF?1-mediated growth suppression in the Lewis lung carcinoma cell lines.