Dmgdh cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dmgdh
Entrez Gene ID	74129
Full Name	dimethylglycine dehydrogenase precursor
Synonyms	1200014D15Rik,AI787269
General protein information	Preferred Names dimethylglycine dehydrogenase precursor Names dimethylglycine dehydrogenase, mitochondrial ME2GLYDH
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 C3
Summary	This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. [provided by RefSeq, Jul 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_028772.3	NP_083048.1	dimethylglycine dehydrogenase, mitochondrial precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dmgdh	NP_083048.1
Danio rerio (zebrafish)	dmgdh	XP_002665871.2
Pan troglodytes (chimpanzee)	DMGDH	XP_526883.2
Canis lupus familiaris (dog)	DMGDH	XP_005618235.1
Gallus gallus (chicken)	DMGDH	XP_003643002.1
Caenorhabditis elegans (roundworm)	Y37E3.17	NP_001021746.1
Xenopus tropicalis (tropical clawed frog)	dmgdh	XP_002940239.2
Homo sapiens (human)	DMGDH	NP_037523.2
Rattus norvegicus (Norway rat)	Dmgdh	NP_620802.2
Bos taurus (cattle)	DMGDH	NP_001192474.1

Gene Ontology
Bibliography

Related articles in PubMed

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.
Tamplin OJ, Cox BJ, Rossant J
Developmental biology360(2)415-25(2011 Dec)

Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways.
Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor D, Tang DT, Grimmond SM, Little MH
PloS one6(2)e17286(2011 Feb)

Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice.
Pyo JO, Nah J, Kim HJ, Chang JW, Song YW, Yang DK, Jo DG, Kim HR, Chae HJ, Chae SW, Hwang SY, Kim SJ, Kim HJ, Cho C, Oh CG, Park WJ, Jung YK
The Journal of biological chemistry283(45)30707-14(2008 Nov)

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell115(5)629-40(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ARC may protect cardiomyocytes from hypoxic cell death by regulating its downstream, Drbp1 and pMe(2)GlyDH
Title: Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice.

The following Dmgdh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dmgdh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06102	NM_028772.3 Latest version!	Mus musculus dimethylglycine dehydrogenase precursor (Dmgdh), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dmgdh ( NM_028772.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083048.1 Mus musculus dimethylglycine dehydrogenase precursor (Dmgdh), mRNA.

Price & Availability↑

CloneID	OMu06102
Clone ID Related Accession (Same CDS sequence)	NM_028772.3
Accession Version	NM_028772.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2610bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Mus musculus(house mouse)
Product	dimethylglycine dehydrogenase, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT030023.15 and AC131739.3. On Apr 30, 2007 this sequence version replaced NM_028772.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK004755.1, BC089599.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGCTCCGCC CGGGCGCGCT GCGGCTGCGG GGCCTCGCGC TGCGGGGCTC CCCCAGGCGC 
CCAAGCTCCG CTGGCCTCCG GGAAGGACAG GAAAGCCCAG CCTCACCCCC AGAATGGAAG 
GACAGAGCAG AGACTGTGAT CATTGGAGGC GGCTGTGTGG GCGTGAGCCT GGCTTATCAT 
CTGGCCAAGG CTGGGATGAG AGATGTGGTC CTGATGGAGA AGTCGGAGCT CACCGCTGGC 
TCTACCTGGC ACGCAGCAGG TTTAACAACT TACTTTCACC CCGGGATAAA CTTGAAGAAA 
ATACATTATG ACAGCATCAA ACTTTACGAG AGGCTGGAAG AAGAAACCGG ACAGGTGGTG 
GGATTCCATC AACCAGGTAG TATCAGGCTT GCTACAACTC CTGTAAGGGT GGACGAATTT 
AAATACCAAA TGACGCGAAC CAACTGGCAC GCCACGGAAC AGTATATTAT TGAGCCTGAA 
AAAATCCACG AGCTGTTCCC TTTACTCAAC ATGAACAAGA TTTTAGCCGG ACTGTATAAC 
CCAGGAGATG GCCACATTGA TCCTTATTCT CTGACGATGG CCCTGGCTGC TGGTGCTAGG 
AAATATGGGG CCCTTCTAAA GTATCCAGCA CCAGTGACAT CTCTGAAGCC CAGGCCAGAT 
GGGACATGGG ATGTGGAGAC TCCACAAGGA TCTGTGAGAG CAAATAGGAT TGTGAATGCT 
GCAGGATTTT GGGCTCGTGA AGTGGGTAAA ATGATTGGAC TAGACCACCC CCTCATCCCC 
GTCCAACATC AATATGTCGT CACATCAACA ATCCCAGAAG TGAAGGCTTT GAAACGAGAG 
CTCCCCGTCC TCCGCGACCT GGAAGGATCC TACTACCTCC GACAGGAAAG GGATGGGCTT 
TTGTTTGGTC CCTATGAAAG TCAGGAGAAG ATGAAACTCC AAGCCTCCTG GGTCACTCAC 
GGAGTCCCTC CAGGCTTTGG AAAGGAGCTT TTTGAGTCTG ATTTAGATCG AATCTCAGAC 
CACCTGGAAG CTGCCATGGA GATGATTCCT GTCTTGAAGA AGGCGGACAT CATCAATGTC 
GTCAATGGCC CTATCACCTA CTCTCCCGAC ATTCTGCCTA TGGTGGGGCC CCATCAGGGG 
GTCAGAAACT ACTGGGTGGC GACTGGCTTT GGATACGGCA TAATCCATGC TGGTGGGGTA 
GGCAAGTTCC TCAGTGACTG GATCCTGCAT GGAGAACCTC CTTTTGACCT GATAGAACTG 
GATCCCAATC GCTACGGCAA ATGGACGACG ACACAGTACA CCGAGGCCAA AGCCCGAGAA 
TCATATGGGT TCAACAACAT TGTTGGTTAT CCTAAAGAAG AGCGGTTTGC TGGGAGGCCA 
ACCCAGAGAG TCAGTGGACT TTACAAAACC CTGAAGTCCA AGTGTTCCAT GGGCTTCCAT 
GCAGGCTGGG AACAGCCACA TTGGTTCTAT AAGCCTGGCC AGGACACTCA GTATAGGCCA 
AGTTTCCGCC GCACAAACTG GTTTGAGCCG GTGGGCTCTG AGTACAAACA GGTTATGCAA 
AGAGTTGGTG TGATTGACCT GTCTCCATTT GGCAAGTTCA ACATCAAAGG CCGAGATTCT 
ACCCAACTTC TGGACCATCT CTTTGCTAAT GTCATTCCCA AGGTGGGTTT TACAAACATA 
AGTCACATGT TGACGCCCAG AGGTCGGGTG TATGCTGAGC TGACTGTTTC CCAGCAGTCT 
CCTGGGGAGT TCCTGTTGAT CACTGGCTCC GGGTCGGAGC TTCACGACCT TAGATGGATT 
GAAGAAGCAG CCTTCAGAGG TGGATATGAT GTGGAAATTC AAAACATAAC CGATGAGTTT 
GGGGTCCTGG GAGTTGCAGG GCCATATGCA AGAAGAGTCC TTCAGAAGCT GACCTCAGAA 
GATCTCAGCG ATGATGCATT CAAGTTTCTT CAAACCAAAT CTTTTAACAT CTCAGACATT 
CCAGTCACTG CTATCAGAAT CTCCTATACT GGTGAGCTGG GCTGGGAGCT GTACCACAGA 
CGAGAAGATT CTGCGACGCT TTATGAGCGC ATCATGAGTG CCGGCCAGGA GGAGGGCATC 
GGCGACTTTG GAACTTACGC CCTGAACGCT TTGAGACTGG AGAAGGCTTT CCGAGCCTGG 
GGCTCCGAGA TGAACTGTGA CACAAACCCC TTGGAAGCTG GGCTGGAATA TTTCGTGAAG 
CTGAATAAGC CCGCTGACTT CATAGGGAAG CAGGCCCTGA AGCAGATTAA AACCGAGGGG 
CTAAAGCGGA GACTGGTCTG CCTCACCGTG GCAACGGACG ATGTGGATCC AGAGGGAAAT 
GAAAGCATTT GGTACAAGGG CAAGGTGGTT GGCAACACAA CATCTGGAAG CTACAGTTAC 
AGCATTCAGA AGAGCCTGGC TTTTGCTTAT GTCCCAGTCC AGCTCAGTGA AGTGGGACAG 
CAAGTGGAGG TTGAACTACT GGGTAAAAAT TACCCAGCCA CCATTATACA AGAACCCCTG 
GTACTCACGG AGCCTGCCCG AGCCAGGCTT CAGAAAGACG GTAAAAAGAC AAATCTTGAG 
AAAGGCCCAT CCCGGACAAC CAAGTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083048.1
CDS	12..2621
Translation	MLRPGALRLRGLALRGSPRRPSSAGLREGQESPASPPEWKDRAETVIIGGGCVGVSLAYHLAKAGMRDVVLMEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYERLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTNWHATEQYIIEPEKIHELFPLLNMNKILAGLYNPGDGHIDPYSLTMALAAGARKYGALLKYPAPVTSLKPRPDGTWDVETPQGSVRANRIVNAAGFWAREVGKMIGLDHPLIPVQHQYVVTSTIPEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKLQASWVTHGVPPGFGKELFESDLDRISDHLEAAMEMIPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVATGFGYGIIHAGGVGKFLSDWILHGEPPFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYKTLKSKCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVGVIDLSPFGKFNIKGRDSTQLLDHLFANVIPKVGFTNISHMLTPRGRVYAELTVSQQSPGEFLLITGSGSELHDLRWIEEAAFRGGYDVEIQNITDEFGVLGVAGPYARRVLQKLTSEDLSDDAFKFLQTKSFNISDIPVTAIRISYTGELGWELYHRREDSATLYERIMSAGQEEGIGDFGTYALNALRLEKAFRAWGSEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKTEGLKRRLVCLTVATDDVDPEGNESIWYKGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGKNYPATIIQEPLVLTEPARARLQKDGKKTNLEKGPSRTTKL

Target ORF information:

RefSeq Version	NM_028772.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus dimethylglycine dehydrogenase precursor (Dmgdh), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028772.3

ORF Insert Sequence:

ATGCTCCGCC CGGGCGCGCT GCGGCTGCGG GGCCTCGCGC TGCGGGGCTC CCCCAGGCGC 
CCAAGCTCCG CTGGCCTCCG GGAAGGACAG GAAAGCCCAG CCTCACCCCC AGAATGGAAG 
GACAGAGCAG AGACTGTGAT CATTGGAGGC GGCTGTGTGG GCGTGAGCCT GGCTTATCAT 
CTGGCCAAGG CTGGGATGAG AGATGTGGTC CTGATGGAGA AGTCGGAGCT CACCGCTGGC 
TCTACCTGGC ACGCAGCAGG TTTAACAACT TACTTTCACC CCGGGATAAA CTTGAAGAAA 
ATACATTATG ACAGCATCAA ACTTTACGAG AGGCTGGAAG AAGAAACCGG ACAGGTGGTG 
GGATTCCATC AACCAGGTAG TATCAGGCTT GCTACAACTC CTGTAAGGGT GGACGAATTT 
AAATACCAAA TGACGCGAAC CAACTGGCAC GCCACGGAAC AGTATATTAT TGAGCCTGAA 
AAAATCCACG AGCTGTTCCC TTTACTCAAC ATGAACAAGA TTTTAGCCGG ACTGTATAAC 
CCAGGAGATG GCCACATTGA TCCTTATTCT CTGACGATGG CCCTGGCTGC TGGTGCTAGG 
AAATATGGGG CCCTTCTAAA GTATCCAGCA CCAGTGACAT CTCTGAAGCC CAGGCCAGAT 
GGGACATGGG ATGTGGAGAC TCCACAAGGA TCTGTGAGAG CAAATAGGAT TGTGAATGCT 
GCAGGATTTT GGGCTCGTGA AGTGGGTAAA ATGATTGGAC TAGACCACCC CCTCATCCCC 
GTCCAACATC AATATGTCGT CACATCAACA ATCCCAGAAG TGAAGGCTTT GAAACGAGAG 
CTCCCCGTCC TCCGCGACCT GGAAGGATCC TACTACCTCC GACAGGAAAG GGATGGGCTT 
TTGTTTGGTC CCTATGAAAG TCAGGAGAAG ATGAAACTCC AAGCCTCCTG GGTCACTCAC 
GGAGTCCCTC CAGGCTTTGG AAAGGAGCTT TTTGAGTCTG ATTTAGATCG AATCTCAGAC 
CACCTGGAAG CTGCCATGGA GATGATTCCT GTCTTGAAGA AGGCGGACAT CATCAATGTC 
GTCAATGGCC CTATCACCTA CTCTCCCGAC ATTCTGCCTA TGGTGGGGCC CCATCAGGGG 
GTCAGAAACT ACTGGGTGGC GACTGGCTTT GGATACGGCA TAATCCATGC TGGTGGGGTA 
GGCAAGTTCC TCAGTGACTG GATCCTGCAT GGAGAACCTC CTTTTGACCT GATAGAACTG 
GATCCCAATC GCTACGGCAA ATGGACGACG ACACAGTACA CCGAGGCCAA AGCCCGAGAA 
TCATATGGGT TCAACAACAT TGTTGGTTAT CCTAAAGAAG AGCGGTTTGC TGGGAGGCCA 
ACCCAGAGAG TCAGTGGACT TTACAAAACC CTGAAGTCCA AGTGTTCCAT GGGCTTCCAT 
GCAGGCTGGG AACAGCCACA TTGGTTCTAT AAGCCTGGCC AGGACACTCA GTATAGGCCA 
AGTTTCCGCC GCACAAACTG GTTTGAGCCG GTGGGCTCTG AGTACAAACA GGTTATGCAA 
AGAGTTGGTG TGATTGACCT GTCTCCATTT GGCAAGTTCA ACATCAAAGG CCGAGATTCT 
ACCCAACTTC TGGACCATCT CTTTGCTAAT GTCATTCCCA AGGTGGGTTT TACAAACATA 
AGTCACATGT TGACGCCCAG AGGTCGGGTG TATGCTGAGC TGACTGTTTC CCAGCAGTCT 
CCTGGGGAGT TCCTGTTGAT CACTGGCTCC GGGTCGGAGC TTCACGACCT TAGATGGATT 
GAAGAAGCAG CCTTCAGAGG TGGATATGAT GTGGAAATTC AAAACATAAC CGATGAGTTT 
GGGGTCCTGG GAGTTGCAGG GCCATATGCA AGAAGAGTCC TTCAGAAGCT GACCTCAGAA 
GATCTCAGCG ATGATGCATT CAAGTTTCTT CAAACCAAAT CTTTTAACAT CTCAGACATT 
CCAGTCACTG CTATCAGAAT CTCCTATACT GGTGAGCTGG GCTGGGAGCT GTACCACAGA 
CGAGAAGATT CTGCGACGCT TTATGAGCGC ATCATGAGTG CCGGCCAGGA GGAGGGCATC 
GGCGACTTTG GAACTTACGC CCTGAACGCT TTGAGACTGG AGAAGGCTTT CCGAGCCTGG 
GGCTCCGAGA TGAACTGTGA CACAAACCCC TTGGAAGCTG GGCTGGAATA TTTCGTGAAG 
CTGAATAAGC CCGCTGACTT CATAGGGAAG CAGGCCCTGA AGCAGATTAA AACCGAGGGG 
CTAAAGCGGA GACTGGTCTG CCTCACCGTG GCAACGGACG ATGTGGATCC AGAGGGAAAT 
GAAAGCATTT GGTACAAGGG CAAGGTGGTT GGCAACACAA CATCTGGAAG CTACAGTTAC 
AGCATTCAGA AGAGCCTGGC TTTTGCTTAT GTCCCAGTCC AGCTCAGTGA AGTGGGACAG 
CAAGTGGAGG TTGAACTACT GGGTAAAAAT TACCCAGCCA CCATTATACA AGAACCCCTG 
GTACTCACGG AGCCTGCCCG AGCCAGGCTT CAGAAAGACG GTAAAAAGAC AAATCTTGAG 
AAAGGCCCAT CCCGGACAAC CAAGTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.
Developmental biology360(2)415-25(2011 Dec)
Tamplin OJ,Cox BJ,Rossant J

Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways.
PloS one6(2)e17286(2011 Feb)
Thiagarajan RD,Georgas KM,Rumballe BA,Lesieur E,Chiu HS,Taylor D,Tang DT,Grimmond SM,Little MH

Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice.
The Journal of biological chemistry283(45)30707-14(2008 Nov)
Pyo JO,Nah J,Kim HJ,Chang JW,Song YW,Yang DK,Jo DG,Kim HR,Chae HJ,Chae SW,Hwang SY,Kim SJ,Kim HJ,Cho C,Oh CG,Park WJ,Jung YK

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Cell115(5)629-40(2003 Nov)
Mootha VK,Bunkenborg J,Olsen JV,Hjerrild M,Wisniewski JR,Stahl E,Bolouri MS,Ray HN,Sihag S,Kamal M,Patterson N,Lander ES,Mann M

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Dmgdh cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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