Setd7 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Setd7
Entrez Gene ID	73251
Full Name	SET domain containing (lysine methyltransferase) 7
Synonyms	1600028F23Rik,H3K4MT,KMT7,Set7,Set7/9,mKIAA1717
General protein information	Preferred Names SET domain containing (lysine methyltransferase) 7 Names histone-lysine N-methyltransferase SETD7 H3-K4 methyltransferase H3-K4-HMTase SETD7 SET domain-containing protein 7 histone H3-K4 methyltransferase SETD7
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 C

mRNA and Protein(s)

mRNA	Protein	Name
NM_080793.5	NP_542983.3	histone-lysine N-methyltransferase SETD7

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SETD7	XP_005217639.1
	SETD7	XP_001088778.2
Rattus norvegicus (Norway rat)	Setd7	NP_001103028.1
Danio rerio (zebrafish)	setd7	NP_001002456.1
Homo sapiens (human)	SETD7	NP_085151.1
Gallus gallus (chicken)	SETD7	XP_420409.2
Pan troglodytes (chimpanzee)	SETD7	XP_001138145.2
Mus musculus (house mouse)	Setd7	NP_542983.3
Xenopus tropicalis (tropical clawed frog)	setd7	NP_001027510.1

Gene Ontology
Bibliography

Related articles in PubMed

Spinal SET7/9 may contribute to the maintenance of cancer-induced bone pain in mice.
Hang LH, Xu ZK, Wei SY, Shu WW, Luo H, Chen J
Clinical and experimental pharmacology & physiology44(10)1001-1007(2017 Oct)

Set7 mediated interactions regulate transcriptional networks in embryonic stem cells.
Tuano NK, Okabe J, Ziemann M, Cooper ME, El-Osta A
Nucleic acids research44(19)9206-9217(2016 Nov)

Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.
Oudhoff MJ, Antignano F, Chenery AL, Burrows K, Redpath SA, Braam MJ, Perona-Wright G, Zaph C
PLoS pathogens12(9)e1005876(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We observe Set7-mediated modification of serum response factor (SRF) and mono-methylation of histone H4 lysine 4 (H3K4me1) regulate gene expression. We conclude the broad substrate specificity of Set7 serves to control key transcriptional networks in embryonic stem cells.
Title: Set7 mediated interactions regulate transcriptional networks in embryonic stem cells.

SETD7 plays an important role in intestinal epithelial cell (IEC) biology during infection.
Title: Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.

the methyltransferase Set9 potentiates TGF-beta signaling by targeting Smad7, an inhibitory downstream effector.
Title: SET9-Mediated Regulation of TGF-? Signaling Links Protein Methylation to Pulmonary Fibrosis.

SETD7 is required for Wnt-driven intestinal tumorigenesis and regeneration. SETD7-dependent methylation of YAP facilitates Wnt-induced nuclear accumulation of beta-catenin.
Title: SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/?-Catenin and Hippo/YAP Signaling.

SET7/9 regulates Nos2 expression through methylation of H3K4 in beta cells.
Title: SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet ? Cell.

The following Setd7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Setd7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09747	NM_080793.5 Latest version!	Mus musculus SET domain containing (lysine methyltransferase) 7 (Setd7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Setd7 ( NM_080793.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_542983.3 Mus musculus SET domain containing (lysine methyltransferase) 7 (Setd7), mRNA.

Price & Availability↑

CloneID	OMu09747
Clone ID Related Accession (Same CDS sequence)	NM_080793.5
Accession Version	NM_080793.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1101bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	histone-lysine N-methyltransferase SETD7
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC102860.13. On May 1, 2007 this sequence version replaced NM_080793.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147422.1, AK147667.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGGATAGCG ACGATGAGGT GGTGGAGGAA GCCGTGGAAG GGCACCTGGA CGATGACGGA 
TTACCACACG GGTTCTGCAC TGTCACCTAC TCCTCCACGG ACAGATTTGA GGGCAACTTT 
GTGCATGGAG AAAAGAATGG GCGTGGGAAA TTCTTCTTCT TTGACGGCAG CACCCTGGAG 
GGATATTACG TGGACGATGC CCTGCAGGGC CAGGGCGTTT ACACCTATGA GGATGGAGGT 
GTTCTCCAAG GCACCTATGT GGATGGAGAG CTGAATGGAC CGGCCCAGGA GTACGACTCT 
GACGGGAGGC TGATCTTCAA GGGACAGTAC AAAGACAACA ATCGACACGG AGTGTGTTGG 
ATCCATTACC CGGATGGAGG CAGCCTCGTC GGGGAAGTCA ATGAAGATGG AGAGATGACG 
GGAGAAAAGA TCGCCTATGT GTACCCTGAC CAGAGGACTG CGCTCTATGG GAAGTTCATT 
GACGGAGAGA TGCTCGAAGG GAAACTGGCC ACCCTCATGG CCACCGAAGA AGGGAGGCCA 
CACTTTGAAG TGACGTCGGG AAGTTCCGTG TACCACTTTG ATAAATCGAC TTCCTCCTGC 
ATCTCCAGCG ATGCTCTCCT TCCAGACCCT TATGAGTCTG AGAGGGTTTA TGTTGCCGAC 
TCTCTCATCT CCAGTGCTGG AGAAGGGCTG TTTTCCAAGG TAGCAGTTGG ACCTAATACT 
GTTATGTCGT TTTATAATGG AGTCCGAATT ACACACCAAG AGGTTGACAG CAGGGATTGG 
GCCCTAAATG GGAACACTCT CTCCCTGGAC GAGGAGACAG TCATTGATGT GCCCGAGCCC 
TACAACCACG TGTCCAAGTA CTGTGCCTCC TTGGGACACA AGGCCAATCA CTCCTTCACT 
CCGAACTGCG TCTATGACCT GTTTGTCCAC CCCCGTTTCG GGCCGATCAA GTGCATCCGC 
ACCCTGCGAG CTGTGGAGGC CGAGGAAGAG CTGACCGTTG CCTACGGCTA TGACCACAGC 
CCCCCGGGGA AGAGTGGGCC TGAAGCCCCC GAGTGGTATC AAGTGGAGCT GAAGGCCTTC 
CAGGCCACCC AGCAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542983.3
CDS	267..1367
Translation	MDSDDEVVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDSDGRLIFKGQYKDNNRHGVCWIHYPDGGSLVGEVNEDGEMTGEKIAYVYPDQRTALYGKFIDGEMLEGKLATLMATEEGRPHFEVTSGSSVYHFDKSTSSCISSDALLPDPYESERVYVADSLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCVYDLFVHPRFGPIKCIRTLRAVEAEEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK

Target ORF information:

RefSeq Version	NM_080793.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus SET domain containing (lysine methyltransferase) 7 (Setd7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080793.5

ORF Insert Sequence:

ATGGATAGCG ACGATGAGGT GGTGGAGGAA GCCGTGGAAG GGCACCTGGA CGATGACGGA 
TTACCACACG GGTTCTGCAC TGTCACCTAC TCCTCCACGG ACAGATTTGA GGGCAACTTT 
GTGCATGGAG AAAAGAATGG GCGTGGGAAA TTCTTCTTCT TTGACGGCAG CACCCTGGAG 
GGATATTACG TGGACGATGC CCTGCAGGGC CAGGGCGTTT ACACCTATGA GGATGGAGGT 
GTTCTCCAAG GCACCTATGT GGATGGAGAG CTGAATGGAC CGGCCCAGGA GTACGACTCT 
GACGGGAGGC TGATCTTCAA GGGACAGTAC AAAGACAACA ATCGACACGG AGTGTGTTGG 
ATCCATTACC CGGATGGAGG CAGCCTCGTC GGGGAAGTCA ATGAAGATGG AGAGATGACG 
GGAGAAAAGA TCGCCTATGT GTACCCTGAC CAGAGGACTG CGCTCTATGG GAAGTTCATT 
GACGGAGAGA TGCTCGAAGG GAAACTGGCC ACCCTCATGG CCACCGAAGA AGGGAGGCCA 
CACTTTGAAG TGACGTCGGG AAGTTCCGTG TACCACTTTG ATAAATCGAC TTCCTCCTGC 
ATCTCCAGCG ATGCTCTCCT TCCAGACCCT TATGAGTCTG AGAGGGTTTA TGTTGCCGAC 
TCTCTCATCT CCAGTGCTGG AGAAGGGCTG TTTTCCAAGG TAGCAGTTGG ACCTAATACT 
GTTATGTCGT TTTATAATGG AGTCCGAATT ACACACCAAG AGGTTGACAG CAGGGATTGG 
GCCCTAAATG GGAACACTCT CTCCCTGGAC GAGGAGACAG TCATTGATGT GCCCGAGCCC 
TACAACCACG TGTCCAAGTA CTGTGCCTCC TTGGGACACA AGGCCAATCA CTCCTTCACT 
CCGAACTGCG TCTATGACCT GTTTGTCCAC CCCCGTTTCG GGCCGATCAA GTGCATCCGC 
ACCCTGCGAG CTGTGGAGGC CGAGGAAGAG CTGACCGTTG CCTACGGCTA TGACCACAGC 
CCCCCGGGGA AGAGTGGGCC TGAAGCCCCC GAGTGGTATC AAGTGGAGCT GAAGGCCTTC 
CAGGCCACCC AGCAGAAGTG A