Suds3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Suds3
Entrez Gene ID	71954
Full Name	suppressor of defective silencing 3 homolog (S. cerevisiae)
Synonyms	2400003N08Rik,2410008L21Rik,AU067672,mSds3
General protein information	Preferred Names suppressor of defective silencing 3 homolog (S. cerevisiae) Names sin3 histone deacetylase corepressor complex component SDS3 suppressor of defective silencing 3 protein homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 F

mRNA and Protein(s)

mRNA	Protein	Name
NM_001122666.2	NP_001116138.1	sin3 histone deacetylase corepressor complex component SDS3 isoform b
NM_178622.5	NP_848737.3	sin3 histone deacetylase corepressor complex component SDS3 isoform a

Pathways from BioSystems

Homologies

Homo sapiens (human)	SUDS3	NP_071936.2
Pan troglodytes (chimpanzee)	SUDS3	XP_509415.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000738	XP_559379.4
Rattus norvegicus (Norway rat)	Suds3	XP_341093.4
Gallus gallus (chicken)	SUDS3	NP_001026642.1
	SUDS3	XP_001084823.1
Mus musculus (house mouse)	Suds3	NP_848737.3
Drosophila melanogaster (fruit fly)	CG14220	NP_001245759.1
Xenopus tropicalis (tropical clawed frog)	suds3	XP_002938132.2
Bos taurus (cattle)	SUDS3	NP_001092361.1
Danio rerio (zebrafish)	suds3	NP_001003493.1
Canis lupus familiaris (dog)	SUDS3	XP_003639962.1

Gene Ontology
Bibliography

Related articles in PubMed

Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos.
Cui W, Dai X, Marcho C, Han Z, Zhang K, Tremblay KD, Mager J
Scientific reports637396(2016 Nov)

Depletion of Suds3 reveals an essential role in early lineage specification.
Zhang K, Dai X, Wallingford MC, Mager J
Developmental biology373(2)359-72(2013 Jan)

Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors.
Shi X, Seldin DC, Garry DJ
The Biochemical journal446(3)349-57(2012 Sep)

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.
Williams K, Christensen J, Pedersen MT, Johansen JV, Cloos PA, Rappsilber J, Helin K
Nature473(7347)343-8(2011 May)

Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53.
David G, Dannenberg JH, Simpson N, Finnerty PM, Miao L, Turner GM, Ding Z, Carrasco R, Depinho RA
Oncogene25(56)7354-60(2006 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data define a role for Suds3 in activation of FGF4/ERK signaling.
Title: Depletion of Suds3 reveals an essential role in early lineage specification.

the identification of Sds3 (suppressor of defective silencing 3) as an adaptor protein that recruits the Sin3 [SWI (switch)-independent 3]-HDAC (histone deacetylase) repression complex and binds Foxk1.
Title: Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors.

capacity of mSds3 to cooperate with p53 deficiency in cancer predisposition relates to its specific role in chromosome segregation, rather than its central role in maintaining a functional mSin3A complex
Title: Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53.

mSds3 and its associated mSin3/HDAC components play a central role in initiating the cascade of pericentric heterochromatin-specific modifications necessary for the proper distribution of chromosomes during cell division in mammalian cells.
Title: mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells.

The following Suds3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Suds3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05686	NM_001122666.2 Latest version!	Mus musculus suppressor of defective silencing 3 homolog (S. cerevisiae) (Suds3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OMu07420	NM_178622.5 Latest version!	Mus musculus suppressor of defective silencing 3 homolog (S. cerevisiae) (Suds3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Suds3 ( NM_001122666.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001116138.1 Mus musculus suppressor of defective silencing 3 homolog (S. cerevisiae) (Suds3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu05686
Clone ID Related Accession (Same CDS sequence)	NM_001122666.2
Accession Version	NM_001122666.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	sin3 histone deacetylase corepressor complex component SDS3 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ094124.1, BC062176.1, BC055764.1 and AV338433.1. On Oct 19, 2013 this sequence version replaced NM_001122666.1. Transcript Variant: This variant (2) represents the shorter transcript and encodes the longer isoform (b). ##Evidence-Data-START## Transcript exon combination :: BC062176.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGAGCGCCG CGGGGCTGCT GGCTCCGGCG CCGGCTCCGG CTGCAGCGCC GGCCGCCCCG 
GAGTACTACC CGGAGGACGA GGAGGAGTTG GAGAGCGCCG AGGACGACGA GCGCAGCTGC 
CGGGGCCGAG AGTCCGACGA AGACACCGAG GATGCCAGCG AGACTGACCT GGCGAAGCAC 
GATGAGGAAG ACTACGTGGA GATGAAGGAA CAGATGTATC AGGACAAACT GGCATCTTTG 
AAGAGGCAGC TGCAACAGCT TCAGGAAGGT ACGCTCCAGG AATATCAGAA ACGGATGAAG 
AAACTGGACC AGCAGTACCG AGAGCGGATC CGGAATGCAG AGCTCTTCCT CCAGCTGGAA 
ACGGAACAGG TGGAGAGGAA TTACATTAAA GAGAAGAAGG CGGCCGTGAA GGAGTTTGAA 
GACAAGAAGG TGGAGCTGAA GGAGAACCTG ATTGCCGAGC TGGAGGAGAA GAAGAAGATG 
ATCGAGAACG AGAAACTCAC CATGGAGCTG ACTGGAGATT CTATGGAAGT GAAACCCATC 
ATGACCAGAA AATTGCGGAG GCGACCAAAC GATCCTGTCC CCATTCCAGA CAAGAGGAGA 
AAACCGGCTC CTGCTCAGCT GAACTACTTG CTAACAGACG AGCAGATCAT GGAGGACCTG 
AGGACGCTGA ACAAGCTTAA GTCACCCAAG AGACCAGCTT CCCCATCCTC TCCTGAACAC 
TTGCCTGCCA CACCTGCAGA GTCTCCAGCC CAGAGGTTTG AGGCTCGGAT AGAAGATGGC 
AAACTGTACT ATGATAAGAG ATGGTACCAC AAGAGCCAGG CCATCTACCT GGAATCTAAG 
GACAACCAGA AGCTGAGCTG TGTGATCAGC TCAGTGGGAG CCAACGAGAT CTGGGTGAGG 
AAGACCAGCG ACAGCACCAA GATGCGGATC TACGTGGGCC AGCTGCAGCG TGGGCTCTTC 
GTGATCCGCC GGCGAAAATT CTTAACTTAC CGGGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116138.1
CDS	181..1179
Translation	MSAAGLLAPAPAPAAAPAAPEYYPEDEEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYRERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVRKTSDSTKMRIYVGQLQRGLFVIRRRKFLTYRD

Target ORF information:

RefSeq Version	NM_001122666.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus suppressor of defective silencing 3 homolog (S. cerevisiae) (Suds3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122666.2

ORF Insert Sequence:

ATGAGCGCCG CGGGGCTGCT GGCTCCGGCG CCGGCTCCGG CTGCAGCGCC GGCCGCCCCG 
GAGTACTACC CGGAGGACGA GGAGGAGTTG GAGAGCGCCG AGGACGACGA GCGCAGCTGC 
CGGGGCCGAG AGTCCGACGA AGACACCGAG GATGCCAGCG AGACTGACCT GGCGAAGCAC 
GATGAGGAAG ACTACGTGGA GATGAAGGAA CAGATGTATC AGGACAAACT GGCATCTTTG 
AAGAGGCAGC TGCAACAGCT TCAGGAAGGT ACGCTCCAGG AATATCAGAA ACGGATGAAG 
AAACTGGACC AGCAGTACCG AGAGCGGATC CGGAATGCAG AGCTCTTCCT CCAGCTGGAA 
ACGGAACAGG TGGAGAGGAA TTACATTAAA GAGAAGAAGG CGGCCGTGAA GGAGTTTGAA 
GACAAGAAGG TGGAGCTGAA GGAGAACCTG ATTGCCGAGC TGGAGGAGAA GAAGAAGATG 
ATCGAGAACG AGAAACTCAC CATGGAGCTG ACTGGAGATT CTATGGAAGT GAAACCCATC 
ATGACCAGAA AATTGCGGAG GCGACCAAAC GATCCTGTCC CCATTCCAGA CAAGAGGAGA 
AAACCGGCTC CTGCTCAGCT GAACTACTTG CTAACAGACG AGCAGATCAT GGAGGACCTG 
AGGACGCTGA ACAAGCTTAA GTCACCCAAG AGACCAGCTT CCCCATCCTC TCCTGAACAC 
TTGCCTGCCA CACCTGCAGA GTCTCCAGCC CAGAGGTTTG AGGCTCGGAT AGAAGATGGC 
AAACTGTACT ATGATAAGAG ATGGTACCAC AAGAGCCAGG CCATCTACCT GGAATCTAAG 
GACAACCAGA AGCTGAGCTG TGTGATCAGC TCAGTGGGAG CCAACGAGAT CTGGGTGAGG 
AAGACCAGCG ACAGCACCAA GATGCGGATC TACGTGGGCC AGCTGCAGCG TGGGCTCTTC 
GTGATCCGCC GGCGAAAATT CTTAACTTAC CGGGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Suds3 ( NM_178622.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_848737.3 Mus musculus suppressor of defective silencing 3 homolog (S. cerevisiae) (Suds3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu07420
Clone ID Related Accession (Same CDS sequence)	NM_178622.5
Accession Version	NM_178622.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	sin3 histone deacetylase corepressor complex component SDS3 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ094124.1, BC055764.1 and AV338433.1. On Oct 19, 2013 this sequence version replaced NM_178622.4. Transcript Variant: This variant (1) differs in the 3' coding region and the 3' UTR, compared to variant 2. It encodes isoform a, which has a shorter and distinct C-terminus, compared to isoform b. ##Evidence-Data-START## Transcript exon combination :: BC055764.1, AK045475.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGAGCGCCG CGGGGCTGCT GGCTCCGGCG CCGGCTCCGG CTGCAGCGCC GGCCGCCCCG 
GAGTACTACC CGGAGGACGA GGAGGAGTTG GAGAGCGCCG AGGACGACGA GCGCAGCTGC 
CGGGGCCGAG AGTCCGACGA AGACACCGAG GATGCCAGCG AGACTGACCT GGCGAAGCAC 
GATGAGGAAG ACTACGTGGA GATGAAGGAA CAGATGTATC AGGACAAACT GGCATCTTTG 
AAGAGGCAGC TGCAACAGCT TCAGGAAGGT ACGCTCCAGG AATATCAGAA ACGGATGAAG 
AAACTGGACC AGCAGTACCG AGAGCGGATC CGGAATGCAG AGCTCTTCCT CCAGCTGGAA 
ACGGAACAGG TGGAGAGGAA TTACATTAAA GAGAAGAAGG CGGCCGTGAA GGAGTTTGAA 
GACAAGAAGG TGGAGCTGAA GGAGAACCTG ATTGCCGAGC TGGAGGAGAA GAAGAAGATG 
ATCGAGAACG AGAAACTCAC CATGGAGCTG ACTGGAGATT CTATGGAAGT GAAACCCATC 
ATGACCAGAA AATTGCGGAG GCGACCAAAC GATCCTGTCC CCATTCCAGA CAAGAGGAGA 
AAACCGGCTC CTGCTCAGCT GAACTACTTG CTAACAGACG AGCAGATCAT GGAGGACCTG 
AGGACGCTGA ACAAGCTTAA GTCACCCAAG AGACCAGCTT CCCCATCCTC TCCTGAACAC 
TTGCCTGCCA CACCTGCAGA GTCTCCAGCC CAGAGGTTTG AGGCTCGGAT AGAAGATGGC 
AAACTGTACT ATGATAAGAG ATGGTACCAC AAGAGCCAGG CCATCTACCT GGAATCTAAG 
GACAACCAGA AGCTGAGCTG TGTGATCAGC TCAGTGGGAG CCAACGAGAT CTGGGTGAGG 
AAGACCAGCG ACAGCACCAA GATGCGGATC TACGTGGGCC AGCTGCAGCG TGGGCTCTTC 
GTGATCCGCC GGCGGTCAGC GGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848737.3
CDS	181..1167
Translation	MSAAGLLAPAPAPAAAPAAPEYYPEDEEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYRERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVRKTSDSTKMRIYVGQLQRGLFVIRRRSAA

Target ORF information:

RefSeq Version	NM_178622.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus suppressor of defective silencing 3 homolog (S. cerevisiae) (Suds3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178622.5

ORF Insert Sequence:

ATGAGCGCCG CGGGGCTGCT GGCTCCGGCG CCGGCTCCGG CTGCAGCGCC GGCCGCCCCG 
GAGTACTACC CGGAGGACGA GGAGGAGTTG GAGAGCGCCG AGGACGACGA GCGCAGCTGC 
CGGGGCCGAG AGTCCGACGA AGACACCGAG GATGCCAGCG AGACTGACCT GGCGAAGCAC 
GATGAGGAAG ACTACGTGGA GATGAAGGAA CAGATGTATC AGGACAAACT GGCATCTTTG 
AAGAGGCAGC TGCAACAGCT TCAGGAAGGT ACGCTCCAGG AATATCAGAA ACGGATGAAG 
AAACTGGACC AGCAGTACCG AGAGCGGATC CGGAATGCAG AGCTCTTCCT CCAGCTGGAA 
ACGGAACAGG TGGAGAGGAA TTACATTAAA GAGAAGAAGG CGGCCGTGAA GGAGTTTGAA 
GACAAGAAGG TGGAGCTGAA GGAGAACCTG ATTGCCGAGC TGGAGGAGAA GAAGAAGATG 
ATCGAGAACG AGAAACTCAC CATGGAGCTG ACTGGAGATT CTATGGAAGT GAAACCCATC 
ATGACCAGAA AATTGCGGAG GCGACCAAAC GATCCTGTCC CCATTCCAGA CAAGAGGAGA 
AAACCGGCTC CTGCTCAGCT GAACTACTTG CTAACAGACG AGCAGATCAT GGAGGACCTG 
AGGACGCTGA ACAAGCTTAA GTCACCCAAG AGACCAGCTT CCCCATCCTC TCCTGAACAC 
TTGCCTGCCA CACCTGCAGA GTCTCCAGCC CAGAGGTTTG AGGCTCGGAT AGAAGATGGC 
AAACTGTACT ATGATAAGAG ATGGTACCAC AAGAGCCAGG CCATCTACCT GGAATCTAAG 
GACAACCAGA AGCTGAGCTG TGTGATCAGC TCAGTGGGAG CCAACGAGAT CTGGGTGAGG 
AAGACCAGCG ACAGCACCAA GATGCGGATC TACGTGGGCC AGCTGCAGCG TGGGCTCTTC 
GTGATCCGCC GGCGGTCAGC GGCTTGA