Syce2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Syce2
Entrez Gene ID	71846
Full Name	synaptonemal complex central element protein 2
Synonyms	1700013H19Rik,AA407907,Cesc1
General protein information	Preferred Names synaptonemal complex central element protein 2 Names synaptonemal complex central element protein 2 central element synaptonemal complex 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001168244.1	NP_001161716.1	synaptonemal complex central element protein 2 isoform 3
NM_001168246.1	NP_001161718.1	synaptonemal complex central element protein 2 isoform 1
NM_027954.3	NP_082230.2	synaptonemal complex central element protein 2 isoform 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	SYCE2	XP_003643433.1
	LOC100431090	XP_002801138.1
Bos taurus (cattle)	SYCE2	XP_005208737.1
Mus musculus (house mouse)	Syce2	NP_001161718.1
Rattus norvegicus (Norway rat)	Syce2	NP_001178486.1
Homo sapiens (human)	SYCE2	NP_001099048.1
Pan troglodytes (chimpanzee)	SYCE2	XP_001155819.3
Canis lupus familiaris (dog)	SYCE2	XP_005632877.1

Gene Ontology
Bibliography

Related articles in PubMed

MEI4 ? a central player in the regulation of meiotic DNA double-strand break formation in the mouse.
Kumar R, Ghyselinck N, Ishiguro K, Watanabe Y, Kouznetsova A, H??g C, Strong E, Schimenti J, Daniel K, Toth A, de Massy B
Journal of cell science128(9)1800-11(2015 May)

Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution.
Sch?cker K, Holm T, Franke C, Sauer M, Benavente R
Proceedings of the National Academy of Sciences of the United States of America112(7)2029-33(2015 Feb)

STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis.
Fukuda T, Fukuda N, Agostinho A, Hern?ndez-Hern?ndez A, Kouznetsova A, H??g C
The EMBO journal33(11)1243-55(2014 Jun)

Phylogenies of central element proteins reveal the dynamic evolutionary history of the mammalian synaptonemal complex: ancient and recent components.
Fraune J, Brochier-Armanet C, Alsheimer M, Benavente R
Genetics195(3)781-93(2013 Nov)

SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.
Shi YQ, Zhuang XJ, Xu B, Hua J, Liao SY, Shi Q, Cooke HJ, Han C
Gene527(1)352-9(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SLX2 interacts with synaptonemal complex central element protein 2 (SYCE2), an important component of synaptonemal complex.
Title: SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.

Synaptonemal complex assembly is dependent on SYCE2.
Title: SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination.

The localisation of Syce1 and Cesc1 (Syce2) to the central element depends on recruitment by Sycp1.
Title: Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis.

The following Syce2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Syce2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu22923	NM_001168246.1 Latest version!	Mus musculus synaptonemal complex central element protein 2 (Syce2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu23200	NM_027954.3 Latest version!	Mus musculus synaptonemal complex central element protein 2 (Syce2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu23212	NM_001168244.1 Latest version!	Mus musculus synaptonemal complex central element protein 2 (Syce2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Syce2 ( NM_001168246.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001161718.1 Mus musculus synaptonemal complex central element protein 2 (Syce2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu22923
Clone ID Related Accession (Same CDS sequence)	NM_001168246.1
Accession Version	NM_001168246.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	synaptonemal complex central element protein 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC161765.5. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU961876.1, AW320188.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGCC ACGGAAGCTG GCTGCGCTCG CAGGTGGCCG CGCCTCCCGT GGAGTTAAAG 
GACCAGGAGC CGCCGGCGAT TGTGGAGAGC GGAGAGCATC GGCAGAGTGA GAACCACGAG 
GAGACGCCCG GCTCAGTGGC CCCGAGTGCC AGTTGCCAGC TGCCAGGACC CTTCTCCTCT 
CTGGACTCTA GCATTGAAAC CCTGAAGAAG AAAGCCCAGG AACTGATTGA AAACATCAAT 
GAAAGCAGGC AGAAGGACCA TGCACTTATG ACCAACTTCA GGGACAGCCT CAAGATGAAG 
GTCTCAGATC TGACAGAAAA GTTGGAGGAG AGGATGTACC AGGTGTACAG CCACCACAGC 
AAAATCATTC AGGAAAGACT ACAAGAATTT ACCCAGAAGA TGGCAAAGAT CAACCATCTG 
GAAATGGAGC TTAAACAAGT CTGCCAAACT GTGGAAACGG TGTACAAGGA CCTATGTGTC 
CAGTCTGAGG TTCCCACTTG CGAAGAACAG AATTACAAAG ATGGTGAATG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161718.1
CDS	129..662
Translation	MERHGSWLRSQVAAPPVELKDQEPPAIVESGEHRQSENHEETPGSVAPSASCQLPGPFSSLDSSIETLKKKAQELIENINESRQKDHALMTNFRDSLKMKVSDLTEKLEERMYQVYSHHSKIIQERLQEFTQKMAKINHLEMELKQVCQTVETVYKDLCVQSEVPTCEEQNYKDGEC

Target ORF information:

RefSeq Version	NM_001168246.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus synaptonemal complex central element protein 2 (Syce2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001168246.1

ORF Insert Sequence:

ATGGAGCGCC ACGGAAGCTG GCTGCGCTCG CAGGTGGCCG CGCCTCCCGT GGAGTTAAAG 
GACCAGGAGC CGCCGGCGAT TGTGGAGAGC GGAGAGCATC GGCAGAGTGA GAACCACGAG 
GAGACGCCCG GCTCAGTGGC CCCGAGTGCC AGTTGCCAGC TGCCAGGACC CTTCTCCTCT 
CTGGACTCTA GCATTGAAAC CCTGAAGAAG AAAGCCCAGG AACTGATTGA AAACATCAAT 
GAAAGCAGGC AGAAGGACCA TGCACTTATG ACCAACTTCA GGGACAGCCT CAAGATGAAG 
GTCTCAGATC TGACAGAAAA GTTGGAGGAG AGGATGTACC AGGTGTACAG CCACCACAGC 
AAAATCATTC AGGAAAGACT ACAAGAATTT ACCCAGAAGA TGGCAAAGAT CAACCATCTG 
GAAATGGAGC TTAAACAAGT CTGCCAAACT GTGGAAACGG TGTACAAGGA CCTATGTGTC 
CAGTCTGAGG TTCCCACTTG CGAAGAACAG AATTACAAAG ATGGTGAATG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Syce2 ( NM_027954.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082230.2 Mus musculus synaptonemal complex central element protein 2 (Syce2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu23200
Clone ID Related Accession (Same CDS sequence)	NM_027954.3
Accession Version	NM_027954.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Mus musculus(house mouse)
Product	synaptonemal complex central element protein 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC161765.5, BY246600.1, AK005954.1 and AK082833.1. On Dec 3, 2009 this sequence version replaced NM_027954.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK005954.1, DV660366.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGCC ACGGAGTGGC CGCGCCTCCC GTGGAGTTAA AGGACCAGGA GCCGCCGGCG 
ATTGTGGAGA GCGGAGAGCA TCGGCAGAGT GAGAACCACG AGGAGACGCC CGGCTCAGTG 
GCCCCGAGTG CCAGTTGCCA GCTGCCAGGA CCCTTCTCCT CTCTGGACTC TAGCATTGAA 
ACCCTGAAGA AGAAAGCCCA GGAACTGATT GAAAACATCA ATGAAAGCAG GCAGAAGGAC 
CATGCACTTA TGACCAACTT CAGGGACAGC CTCAAGATGA AGGTCTCAGA TCTGACAGAA 
AAGTTGGAGG AGAGGATGTA CCAGGTGTAC AGCCACCACA GCAAAATCAT TCAGGAAAGA 
CTACAAGAAT TTACCCAGAA GATGGCAAAG ATCAACCATC TGGAAATGGA GCTTAAACAA 
GTCTGCCAAA CTGTGGAAAC GGTGTACAAG GACCTATGTG TCCAGTCTGA GGTTCCCACT 
TGCGAAGAAC AGAATTACAA AGATGGTGAA TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082230.2
CDS	129..644
Translation	MERHGVAAPPVELKDQEPPAIVESGEHRQSENHEETPGSVAPSASCQLPGPFSSLDSSIETLKKKAQELIENINESRQKDHALMTNFRDSLKMKVSDLTEKLEERMYQVYSHHSKIIQERLQEFTQKMAKINHLEMELKQVCQTVETVYKDLCVQSEVPTCEEQNYKDGEC

Target ORF information:

RefSeq Version	NM_027954.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus synaptonemal complex central element protein 2 (Syce2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027954.3

ORF Insert Sequence:

ATGGAGCGCC ACGGAGTGGC CGCGCCTCCC GTGGAGTTAA AGGACCAGGA GCCGCCGGCG 
ATTGTGGAGA GCGGAGAGCA TCGGCAGAGT GAGAACCACG AGGAGACGCC CGGCTCAGTG 
GCCCCGAGTG CCAGTTGCCA GCTGCCAGGA CCCTTCTCCT CTCTGGACTC TAGCATTGAA 
ACCCTGAAGA AGAAAGCCCA GGAACTGATT GAAAACATCA ATGAAAGCAG GCAGAAGGAC 
CATGCACTTA TGACCAACTT CAGGGACAGC CTCAAGATGA AGGTCTCAGA TCTGACAGAA 
AAGTTGGAGG AGAGGATGTA CCAGGTGTAC AGCCACCACA GCAAAATCAT TCAGGAAAGA 
CTACAAGAAT TTACCCAGAA GATGGCAAAG ATCAACCATC TGGAAATGGA GCTTAAACAA 
GTCTGCCAAA CTGTGGAAAC GGTGTACAAG GACCTATGTG TCCAGTCTGA GGTTCCCACT 
TGCGAAGAAC AGAATTACAA AGATGGTGAA TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Syce2 ( NM_001168244.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001161716.1 Mus musculus synaptonemal complex central element protein 2 (Syce2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu23212
Clone ID Related Accession (Same CDS sequence)	NM_001168244.1
Accession Version	NM_001168244.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 267bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	synaptonemal complex central element protein 2 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC161765.5, AK167332.1 and AK082833.1. Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK167332.1, DV654070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCAACT TCAGGGACAG CCTCAAGATG AAGGTCTCAG ATCTGACAGA AAAGTTGGAG 
GAGAGGATGT ACCAGGTGTA CAGCCACCAC AGCAAAATCA TTCAGGAAAG ACTACAAGAA 
TTTACCCAGA AGATGGCAAA GATCAACCAT CTGGAAATGG AGCTTAAACA AGTCTGCCAA 
ACTGTGGAAA CGGTGTACAA GGACCTATGT GTCCAGTCTG AGGTTCCCAC TTGCGAAGAA 
CAGAATTACA AAGATGGTGA ATGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161716.1
CDS	697..963
Translation	MTNFRDSLKMKVSDLTEKLEERMYQVYSHHSKIIQERLQEFTQKMAKINHLEMELKQVCQTVETVYKDLCVQSEVPTCEEQNYKDGEC

Target ORF information:

RefSeq Version	NM_001168244.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus synaptonemal complex central element protein 2 (Syce2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001168244.1

ORF Insert Sequence:

ATGACCAACT TCAGGGACAG CCTCAAGATG AAGGTCTCAG ATCTGACAGA AAAGTTGGAG 
GAGAGGATGT ACCAGGTGTA CAGCCACCAC AGCAAAATCA TTCAGGAAAG ACTACAAGAA 
TTTACCCAGA AGATGGCAAA GATCAACCAT CTGGAAATGG AGCTTAAACA AGTCTGCCAA 
ACTGTGGAAA CGGTGTACAA GGACCTATGT GTCCAGTCTG AGGTTCCCAC TTGCGAAGAA 
CAGAATTACA AAGATGGTGA ATGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MEI4 ? a central player in the regulation of meiotic DNA double-strand break formation in the mouse.
Journal of cell science128(9)1800-11(2015 May)
Kumar R,Ghyselinck N,Ishiguro K,Watanabe Y,Kouznetsova A,H??g C,Strong E,Schimenti J,Daniel K,Toth A,de Massy B

Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution.
Proceedings of the National Academy of Sciences of the United States of America112(7)2029-33(2015 Feb)
Sch?cker K,Holm T,Franke C,Sauer M,Benavente R

STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis.
The EMBO journal33(11)1243-55(2014 Jun)
Fukuda T,Fukuda N,Agostinho A,Hern?ndez-Hern?ndez A,Kouznetsova A,H??g C

Phylogenies of central element proteins reveal the dynamic evolutionary history of the mammalian synaptonemal complex: ancient and recent components.
Genetics195(3)781-93(2013 Nov)
Fraune J,Brochier-Armanet C,Alsheimer M,Benavente R

SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.
Gene527(1)352-9(2013 Sep)
Shi YQ,Zhuang XJ,Xu B,Hua J,Liao SY,Shi Q,Cooke HJ,Han C