Dram1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dram1
Entrez Gene ID	71712
Full Name	DNA-damage regulated autophagy modulator 1
Synonyms	1200002N14Rik,Dram
General protein information	Preferred Names DNA-damage regulated autophagy modulator 1 Names DNA damage-regulated autophagy modulator protein 1 damage-regulated autophagy modulator
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 C1

mRNA and Protein(s)

mRNA	Protein	Name
XM_011243576.1	XP_011241878.1	DNA damage-regulated autophagy modulator protein 1 isoform X1
NM_027878.2	NP_082154.2	DNA damage-regulated autophagy modulator protein 1
XM_017314100.1	XP_017169589.1	DNA damage-regulated autophagy modulator protein 1 isoform X1
XM_011243576.2	XP_011241878.1	DNA damage-regulated autophagy modulator protein 1 isoform X1

Pathways from BioSystems

Homologies

	DRAM1	XP_001093215.1
Mus musculus (house mouse)	Dram1	NP_082154.2
Danio rerio (zebrafish)	dram1	NP_001006049.1
Homo sapiens (human)	DRAM1	NP_060840.2
Rattus norvegicus (Norway rat)	Dram1	NP_001166898.1
Bos taurus (cattle)	DRAM1	NP_001026937.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000808	XP_311347.4
Pan troglodytes (chimpanzee)	DRAM1	XP_001155589.1
Canis lupus familiaris (dog)	DRAM1	XP_855009.1
Gallus gallus (chicken)	DRAM1	XP_001234899.2
Drosophila melanogaster (fruit fly)	CG4025	NP_569979.1
Xenopus tropicalis (tropical clawed frog)	dram1	NP_001015869.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.
Yu M, Jiang Y, Feng Q, Ouyang Y, Gan J
International journal of molecular sciences15(10)19253-64(2014 Oct)

Sin3a is essential for the genome integrity and viability of pluripotent cells.
McDonel P, Demmers J, Tan DW, Watt F, Hendrich BD
Developmental biology363(1)62-73(2012 Mar)

DRAM-1 encodes multiple isoforms that regulate autophagy.
Mah LY, O'Prey J, Baudot AD, Hoekstra A, Ryan KM
Autophagy8(1)18-28(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DRAM1 knockdown aggravates OGD/R-induced cell injury.
Title: DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.

DRAM-1 encodes not just one mRNA, but a series of p53-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines.
Title: DRAM-1 encodes multiple isoforms that regulate autophagy.

The following Dram1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dram1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu44843	XM_017314100.1 Latest version!	Mus musculus DNA-damage regulated autophagy modulator 1 (Dram1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu04711	NM_027878.2 Latest version!	Mus musculus DNA-damage regulated autophagy modulator 1 (Dram1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu44843	XM_011243576.2 Latest version!	Mus musculus DNA-damage regulated autophagy modulator 1 (Dram1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu44843	XM_011243576.1	Mus musculus DNA-damage regulated autophagy modulator 1 (Dram1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dram1 ( XM_011243576.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011241878.1 Mus musculus DNA-damage regulated autophagy modulator 1 (Dram1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu44843
Clone ID Related Accession (Same CDS sequence)	XM_011243576.1 , XM_017314100.1 , XM_011243576.2
Accession Version	XM_011243576.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	DNA damage-regulated autophagy modulator protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATAAACT TCTCTGCATT TCTTGGCGCA GCTACGATGT ACACAAGATA CAAGATAGTG 
GAGAAGCAGA ATGAGACCTG CTACTTCAGC ACTCCCGTTT TTAACTTGGT GTCCTTGGCG 
CTTGGATTGG TGGGATGCAT CGGAATGGGC ATCGTAGCCA ACTTCCAGGA GTTAGCCGTG 
CCTGTGGTCC ATGATGGCGG TGCGCTTCTG GCTTTCGTCT GCGGGGTGGT GTACACGCTC 
CTGCAATCGA TCATCTCCTA CAAATCCTGT CCCCAGTGGA ACAGTCTCAC CACGTGCCAT 
GTCAGGATGG CCATCTCCGC TGTTTCGTGC GCAGCTGTCG TCCCCATGAT TGCCTGTGCT 
TCACTCATTT CTATAACCAA GCTGGAATGG AATCCAAAAG AAAAGGATTA TATATATCAC 
GTGGTGAGCG CCATCTGTGA GTGGACCGTG GCTTTTGGTT TTATTTTCTA TTTCCTAACA 
TTCATCCAAG ATTTCCAGAG TGTCACTCTA AGGATATCCA CAGAAATCAA TGACGACTTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011241878.1
CDS	254..796
Translation	MINFSAFLGAATMYTRYKIVEKQNETCYFSTPVFNLVSLALGLVGCIGMGIVANFQELAVPVVHDGGALLAFVCGVVYTLLQSIISYKSCPQWNSLTTCHVRMAISAVSCAAVVPMIACASLISITKLEWNPKEKDYIYHVVSAICEWTVAFGFIFYFLTFIQDFQSVTLRISTEINDDF

Target ORF information:

RefSeq Version	XM_011243576.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus DNA-damage regulated autophagy modulator 1 (Dram1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011243576.1

ORF Insert Sequence:

ATGATAAACT TCTCTGCATT TCTTGGCGCA GCTACGATGT ACACAAGATA CAAGATAGTG 
GAGAAGCAGA ATGAGACCTG CTACTTCAGC ACTCCCGTTT TTAACTTGGT GTCCTTGGCG 
CTTGGATTGG TGGGATGCAT CGGAATGGGC ATCGTAGCCA ACTTCCAGGA GTTAGCCGTG 
CCTGTGGTCC ATGATGGCGG TGCGCTTCTG GCTTTCGTCT GCGGGGTGGT GTACACGCTC 
CTGCAATCGA TCATCTCCTA CAAATCCTGT CCCCAGTGGA ACAGTCTCAC CACGTGCCAT 
GTCAGGATGG CCATCTCCGC TGTTTCGTGC GCAGCTGTCG TCCCCATGAT TGCCTGTGCT 
TCACTCATTT CTATAACCAA GCTGGAATGG AATCCAAAAG AAAAGGATTA TATATATCAC 
GTGGTGAGCG CCATCTGTGA GTGGACCGTG GCTTTTGGTT TTATTTTCTA TTTCCTAACA 
TTCATCCAAG ATTTCCAGAG TGTCACTCTA AGGATATCCA CAGAAATCAA TGACGACTTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dram1 ( XM_017314100.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017169589.1 Mus musculus DNA-damage regulated autophagy modulator 1 (Dram1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu44843
Clone ID Related Accession (Same CDS sequence)	XM_011243576.1 , XM_017314100.1 , XM_011243576.2
Accession Version	XM_017314100.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	DNA damage-regulated autophagy modulator protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATAAACT TCTCTGCATT TCTTGGCGCA GCTACGATGT ACACAAGATA CAAGATAGTG 
GAGAAGCAGA ATGAGACCTG CTACTTCAGC ACTCCCGTTT TTAACTTGGT GTCCTTGGCG 
CTTGGATTGG TGGGATGCAT CGGAATGGGC ATCGTAGCCA ACTTCCAGGA GTTAGCCGTG 
CCTGTGGTCC ATGATGGCGG TGCGCTTCTG GCTTTCGTCT GCGGGGTGGT GTACACGCTC 
CTGCAATCGA TCATCTCCTA CAAATCCTGT CCCCAGTGGA ACAGTCTCAC CACGTGCCAT 
GTCAGGATGG CCATCTCCGC TGTTTCGTGC GCAGCTGTCG TCCCCATGAT TGCCTGTGCT 
TCACTCATTT CTATAACCAA GCTGGAATGG AATCCAAAAG AAAAGGATTA TATATATCAC 
GTGGTGAGCG CCATCTGTGA GTGGACCGTG GCTTTTGGTT TTATTTTCTA TTTCCTAACA 
TTCATCCAAG ATTTCCAGAG TGTCACTCTA AGGATATCCA CAGAAATCAA TGACGACTTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017169589.1
CDS	137..679
Translation	MINFSAFLGAATMYTRYKIVEKQNETCYFSTPVFNLVSLALGLVGCIGMGIVANFQELAVPVVHDGGALLAFVCGVVYTLLQSIISYKSCPQWNSLTTCHVRMAISAVSCAAVVPMIACASLISITKLEWNPKEKDYIYHVVSAICEWTVAFGFIFYFLTFIQDFQSVTLRISTEINDDF

Target ORF information:

RefSeq Version	XM_017314100.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus DNA-damage regulated autophagy modulator 1 (Dram1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017314100.1

ORF Insert Sequence:

ATGATAAACT TCTCTGCATT TCTTGGCGCA GCTACGATGT ACACAAGATA CAAGATAGTG 
GAGAAGCAGA ATGAGACCTG CTACTTCAGC ACTCCCGTTT TTAACTTGGT GTCCTTGGCG 
CTTGGATTGG TGGGATGCAT CGGAATGGGC ATCGTAGCCA ACTTCCAGGA GTTAGCCGTG 
CCTGTGGTCC ATGATGGCGG TGCGCTTCTG GCTTTCGTCT GCGGGGTGGT GTACACGCTC 
CTGCAATCGA TCATCTCCTA CAAATCCTGT CCCCAGTGGA ACAGTCTCAC CACGTGCCAT 
GTCAGGATGG CCATCTCCGC TGTTTCGTGC GCAGCTGTCG TCCCCATGAT TGCCTGTGCT 
TCACTCATTT CTATAACCAA GCTGGAATGG AATCCAAAAG AAAAGGATTA TATATATCAC 
GTGGTGAGCG CCATCTGTGA GTGGACCGTG GCTTTTGGTT TTATTTTCTA TTTCCTAACA 
TTCATCCAAG ATTTCCAGAG TGTCACTCTA AGGATATCCA CAGAAATCAA TGACGACTTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dram1 ( NM_027878.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082154.2 Mus musculus DNA-damage regulated autophagy modulator 1 (Dram1), mRNA.

Price & Availability↑

CloneID	OMu04711
Clone ID Related Accession (Same CDS sequence)	NM_027878.2
Accession Version	NM_027878.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	DNA damage-regulated autophagy modulator protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK004552.1. On Apr 6, 2007 this sequence version replaced NM_027878.1. ##Evidence-Data-START## Transcript exon combination :: AK004552.1, BY704777.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGCTGTGCT TCCTCAGGGG AATGGCTTTC GTCCCCTTCC TCCTGGTGAC TTGGTCGTCC 
GCAGCCTTCA TCATCTCCTA CGTGGTCGCG GTGCTCTCTG GGCACGTCAA CCCCTTTCTC 
CCCTATATCA GTGACACAGG AACAACTCCT CCAGAGAGTG GTATTTTTGG ATTCATGATA 
AACTTCTCTG CATTTCTTGG CGCAGCTACG ATGTACACAA GATACAAGAT AGTGGAGAAG 
CAGAATGAGA CCTGCTACTT CAGCACTCCC GTTTTTAACT TGGTGTCCTT GGCGCTTGGA 
TTGGTGGGAT GCATCGGAAT GGGCATCGTA GCCAACTTCC AGGAGTTAGC CGTGCCTGTG 
GTCCATGATG GCGGTGCGCT TCTGGCTTTC GTCTGCGGGG TGGTGTACAC GCTCCTGCAA 
TCGATCATCT CCTACAAATC CTGTCCCCAG TGGAACAGTC TCACCACGTG CCATGTCAGG 
ATGGCCATCT CCGCTGTTTC GTGCGCAGCT GTCGTCCCCA TGATTGCCTG TGCTTCACTC 
ATTTCTATAA CCAAGCTGGA ATGGAATCCA AAAGAAAAGG ATTATATATA TCACGTGGTG 
AGCGCCATCT GTGAGTGGAC CGTGGCTTTT GGTTTTATTT TCTATTTCCT AACATTCATC 
CAAGATTTCC AGAGTGTCAC TCTAAGGATA TCCACAGAAA TCAATGACGA CTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082154.2
CDS	154..870
Translation	MLCFLRGMAFVPFLLVTWSSAAFIISYVVAVLSGHVNPFLPYISDTGTTPPESGIFGFMINFSAFLGAATMYTRYKIVEKQNETCYFSTPVFNLVSLALGLVGCIGMGIVANFQELAVPVVHDGGALLAFVCGVVYTLLQSIISYKSCPQWNSLTTCHVRMAISAVSCAAVVPMIACASLISITKLEWNPKEKDYIYHVVSAICEWTVAFGFIFYFLTFIQDFQSVTLRISTEINDDF

Target ORF information:

RefSeq Version	NM_027878.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus DNA-damage regulated autophagy modulator 1 (Dram1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027878.2

ORF Insert Sequence:

ATGCTGTGCT TCCTCAGGGG AATGGCTTTC GTCCCCTTCC TCCTGGTGAC TTGGTCGTCC 
GCAGCCTTCA TCATCTCCTA CGTGGTCGCG GTGCTCTCTG GGCACGTCAA CCCCTTTCTC 
CCCTATATCA GTGACACAGG AACAACTCCT CCAGAGAGTG GTATTTTTGG ATTCATGATA 
AACTTCTCTG CATTTCTTGG CGCAGCTACG ATGTACACAA GATACAAGAT AGTGGAGAAG 
CAGAATGAGA CCTGCTACTT CAGCACTCCC GTTTTTAACT TGGTGTCCTT GGCGCTTGGA 
TTGGTGGGAT GCATCGGAAT GGGCATCGTA GCCAACTTCC AGGAGTTAGC CGTGCCTGTG 
GTCCATGATG GCGGTGCGCT TCTGGCTTTC GTCTGCGGGG TGGTGTACAC GCTCCTGCAA 
TCGATCATCT CCTACAAATC CTGTCCCCAG TGGAACAGTC TCACCACGTG CCATGTCAGG 
ATGGCCATCT CCGCTGTTTC GTGCGCAGCT GTCGTCCCCA TGATTGCCTG TGCTTCACTC 
ATTTCTATAA CCAAGCTGGA ATGGAATCCA AAAGAAAAGG ATTATATATA TCACGTGGTG 
AGCGCCATCT GTGAGTGGAC CGTGGCTTTT GGTTTTATTT TCTATTTCCT AACATTCATC 
CAAGATTTCC AGAGTGTCAC TCTAAGGATA TCCACAGAAA TCAATGACGA CTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dram1 ( XM_011243576.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011241878.1 Mus musculus DNA-damage regulated autophagy modulator 1 (Dram1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu44843
Clone ID Related Accession (Same CDS sequence)	XM_011243576.1 , XM_017314100.1 , XM_011243576.2
Accession Version	XM_011243576.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	DNA damage-regulated autophagy modulator protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011243576.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATAAACT TCTCTGCATT TCTTGGCGCA GCTACGATGT ACACAAGATA CAAGATAGTG 
GAGAAGCAGA ATGAGACCTG CTACTTCAGC ACTCCCGTTT TTAACTTGGT GTCCTTGGCG 
CTTGGATTGG TGGGATGCAT CGGAATGGGC ATCGTAGCCA ACTTCCAGGA GTTAGCCGTG 
CCTGTGGTCC ATGATGGCGG TGCGCTTCTG GCTTTCGTCT GCGGGGTGGT GTACACGCTC 
CTGCAATCGA TCATCTCCTA CAAATCCTGT CCCCAGTGGA ACAGTCTCAC CACGTGCCAT 
GTCAGGATGG CCATCTCCGC TGTTTCGTGC GCAGCTGTCG TCCCCATGAT TGCCTGTGCT 
TCACTCATTT CTATAACCAA GCTGGAATGG AATCCAAAAG AAAAGGATTA TATATATCAC 
GTGGTGAGCG CCATCTGTGA GTGGACCGTG GCTTTTGGTT TTATTTTCTA TTTCCTAACA 
TTCATCCAAG ATTTCCAGAG TGTCACTCTA AGGATATCCA CAGAAATCAA TGACGACTTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011241878.1
CDS	230..772
Translation	MINFSAFLGAATMYTRYKIVEKQNETCYFSTPVFNLVSLALGLVGCIGMGIVANFQELAVPVVHDGGALLAFVCGVVYTLLQSIISYKSCPQWNSLTTCHVRMAISAVSCAAVVPMIACASLISITKLEWNPKEKDYIYHVVSAICEWTVAFGFIFYFLTFIQDFQSVTLRISTEINDDF

Target ORF information:

RefSeq Version	XM_011243576.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus DNA-damage regulated autophagy modulator 1 (Dram1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011243576.2

ORF Insert Sequence:

ATGATAAACT TCTCTGCATT TCTTGGCGCA GCTACGATGT ACACAAGATA CAAGATAGTG 
GAGAAGCAGA ATGAGACCTG CTACTTCAGC ACTCCCGTTT TTAACTTGGT GTCCTTGGCG 
CTTGGATTGG TGGGATGCAT CGGAATGGGC ATCGTAGCCA ACTTCCAGGA GTTAGCCGTG 
CCTGTGGTCC ATGATGGCGG TGCGCTTCTG GCTTTCGTCT GCGGGGTGGT GTACACGCTC 
CTGCAATCGA TCATCTCCTA CAAATCCTGT CCCCAGTGGA ACAGTCTCAC CACGTGCCAT 
GTCAGGATGG CCATCTCCGC TGTTTCGTGC GCAGCTGTCG TCCCCATGAT TGCCTGTGCT 
TCACTCATTT CTATAACCAA GCTGGAATGG AATCCAAAAG AAAAGGATTA TATATATCAC 
GTGGTGAGCG CCATCTGTGA GTGGACCGTG GCTTTTGGTT TTATTTTCTA TTTCCTAACA 
TTCATCCAAG ATTTCCAGAG TGTCACTCTA AGGATATCCA CAGAAATCAA TGACGACTTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.
International journal of molecular sciences15(10)19253-64(2014 Oct)
Yu M,Jiang Y,Feng Q,Ouyang Y,Gan J

Sin3a is essential for the genome integrity and viability of pluripotent cells.
Developmental biology363(1)62-73(2012 Mar)
McDonel P,Demmers J,Tan DW,Watt F,Hendrich BD

DRAM-1 encodes multiple isoforms that regulate autophagy.
Autophagy8(1)18-28(2012 Jan)
Mah LY,O'Prey J,Baudot AD,Hoekstra A,Ryan KM

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Dram1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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