Hjv cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hjv
Entrez Gene ID	69585
Full Name	hemochromatosis type 2 (juvenile)
Synonyms	2310035L15Rik,5230400G09Rik,AI414844,AI789733,DL-M,HJV,Rgmc,hemojuvelin
General protein information	Preferred Names hemochromatosis type 2 (juvenile) Names hemojuvelin RGM domain family member C hemochromatosis type 2 (juvenile) (human homolog) hemochromatosis type 2 protein homolog repulsive guidance molecule C
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 F2.1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006502037.3	XP_006502100.1	hemojuvelin isoform X1
NM_027126.4	NP_081402.3	hemojuvelin precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	hfe2	XP_002938521.2
Homo sapiens (human)	HFE2	NP_998818.1
Canis lupus familiaris (dog)	HFE2	XP_859524.3
Bos taurus (cattle)	HFE2	NP_001193843.1
Mus musculus (house mouse)	Hfe2	NP_081402.3
Rattus norvegicus (Norway rat)	Hfe2	NP_001012080.1
Pan troglodytes (chimpanzee)	HFE2	XP_001163074.1
	HFE2	XP_001092987.1
Danio rerio (zebrafish)	hfe2	XP_005158349.1

Gene Ontology
Bibliography

Related articles in PubMed

Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway.
Wahedi M, Wortham AM, Kleven MD, Zhao N, Jue S, Enns CA, Zhang AS
The Journal of biological chemistry292(44)18354-18371(2017 11)

Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge.
Latour C, Besson-Fournier C, Gourbeyre O, Meynard D, Roth MP, Coppin H
Blood130(21)2339-2343(2017 11)

Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice.
Fr?dlov? J, Rychtar??kov? Z, Gurieva I, Vokurka M, Truksa J, Krijt J
PloS one12(10)e0186844(2017)

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA, Sundberg BA, Schofield PN, Pratt CH
PloS one12(7)e0180682(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest that, in Hjv(-/-) females, Bmp6 can provide a signal adequate to maintain hepcidin to a level sufficient to avoid extrahepatic iron loading.
Title: Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge.

The minor variant of the HJV polymorphic site rs16827043 is a significant factor associated with hypertension among 50 year-old individuals compared with the AA genotype carriers. For the other polymorphic variant rs7536827, association with hypertension was found only among normal or slightly overweight A-allele carriers. In conclusion, HJV genetic variants were associated with essential hypertension in Finnish subjects.
Title: Minor variant of rs 16827043 in the iron regulator hemojuvelin gene (HJV) contributes to hypertension: The TAMRISK study.

The results provide support for the interaction between TMPRSS6 and hemojuvelin in vivo; they also suggest that hemojuvelin could be cleaved by another as yet unknown protease in the absence of functional TMPRSS6.
Title: Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice.

The data demonstrate that endothelial cells are the predominant source of BMP6 in the liver and support a model in which endothelial cells BMP6 has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin transcription and maintain systemic iron homeostasis.
Title: Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice.

Hjv (--) and Hfe (C282YC282Y) transgenic mice displayed enhanced colonization of deep tissues by Yersinia pseudotuberculosis following oral inoculation, recapitulating enhanced susceptibility of humans with hemochromatosis to disseminated infection with enteropathogenic Yersinia.
Title: Hereditary Hemochromatosis Predisposes Mice to Yersinia pseudotuberculosis Infection Even in the Absence of the Type III Secretion System.

The following Hjv gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hjv cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22455	NM_027126.4 Latest version!	Mus musculus hemojuvelin BMP co-receptor (Hjv), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OMu22455	XM_006502037.3 Latest version!	Mus musculus hemojuvelin BMP co-receptor (Hjv), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hjv ( NM_027126.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081402.3 Mus musculus hemojuvelin BMP co-receptor (Hjv), mRNA.

Price & Availability↑

CloneID	OMu22455
Clone ID Related Accession (Same CDS sequence)	XM_006502037.3 , NM_027126.4
Accession Version	NM_027126.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1263bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	hemojuvelin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ557515.1 and AI503400.1. On Jan 31, 2008 this sequence version replaced NM_027126.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ557515.1, AK014082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCAGT CCCCTAGTCC CCGGTCCCCC CACGGCAGCC CTCCAACTCT AAGCACCCTC 
ACTCTCCTGC TGCTCCTCTG TGGACAGGCT CACTCCCAGT GCAAGATCCT CCGCTGCAAT 
GCCGAGTATG TCTCGTCCAC TCTGAGTCTT CGGGGAGGTG GCTCACCGGA CACGCCGCGT 
GGAGGCGGCC GTGGTGGGCT GGCCTCAGGT GGCTTGTGTC GCGCCCTGCG CTCCTACGCT 
CTCTGCACGC GGCGCACGGC CCGCACCTGC CGCGGGGACC TTGCTTTCCA CTCTGCGGTG 
CATGGCATAG AGGACCTGAT GATCCAGCAC AACTGCTCAC GCCAGGGTCC CACGGCCCCG 
CCCCCGGCCC GGGGCCCCGC CCTGCCCGGG GCCGGGCCAG CGCCCCTGAC CCCAGATCCC 
TGTGACTATG AGGCCCGGTT TTCCAGGCTG CACGGTCGAG CCCCGGGCTT CTTGCATTGC 
GCATCCTTTG GAGATCCCCA TGTGCGCAGT TTCCACAACC AATTTCACAC ATGCCGTGTC 
CAAGGAGCTT GGCCCTTGCT AGATAACGAC TTCCTCTTTG TCCAGGCCAC CAGCTCCCCG 
GTTTCGTCGG GAGCCAACGC TACCACCATC CGGAAGATCA CTATCATATT TAAAAACATG 
CAGGAATGCA TTGACCAGAA AGTCTACCAG GCTGAGGTGG ACAATCTTCC TGCAGCCTTT 
GAAGATGGTT CTATCAATGG GGGCGACCGA CCTGGGGGCT CGAGTTTGTC CATTCAAACT 
GCTAACCTTG GGAGTCACGT GGAGATTCGA GCTGCCTACA TTGGAACAAC TATCATCATT 
CGACAGACAG CTGGGCAGCT CTCCTTCTCC ATCAGGGTAG CAGAGGATGT GGCGCGGGCC 
TTCTCCGCAG AGCAGGACCT ACAGCTGTGT GTTGGGGGAT GCCCTCCGAG CCAGCGACTC 
TCTCGCTCAG AGCGCAACCG CCGTGGGGCT ATAGCCATAG ATACTGCCAG AAGGCTGTGT 
AAGGAAGGGC TTCCGGTTGA AGATGCCTAC TTCCAATCCT GCGTCTTTGA TGTTTCAGTC 
TCCGGTGACC CCAACTTTAC TGTGGCAGCT CAGACAGCTC TGGACGATGC CCGAATCTTC 
TTGACGGATT TAGAGAACTT ACATCTCTTT CCCTCAGATG CGGGGCCTCC CCTCTCTCCT 
GCCATCTGCC TAGTCCCGCT TCTTTCGGCC CTCTTTGTTC TGTGGCTTTG CTTCAGTAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081402.3
CDS	233..1495
Translation	MGQSPSPRSPHGSPPTLSTLTLLLLLCGQAHSQCKILRCNAEYVSSTLSLRGGGSPDTPRGGGRGGLASGGLCRALRSYALCTRRTARTCRGDLAFHSAVHGIEDLMIQHNCSRQGPTAPPPARGPALPGAGPAPLTPDPCDYEARFSRLHGRAPGFLHCASFGDPHVRSFHNQFHTCRVQGAWPLLDNDFLFVQATSSPVSSGANATTIRKITIIFKNMQECIDQKVYQAEVDNLPAAFEDGSINGGDRPGGSSLSIQTANLGSHVEIRAAYIGTTIIIRQTAGQLSFSIRVAEDVARAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAIAIDTARRLCKEGLPVEDAYFQSCVFDVSVSGDPNFTVAAQTALDDARIFLTDLENLHLFPSDAGPPLSPAICLVPLLSALFVLWLCFSK

Target ORF information:

RefSeq Version	NM_027126.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus hemojuvelin BMP co-receptor (Hjv), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027126.4

ORF Insert Sequence:

ATGGGCCAGT CCCCTAGTCC CCGGTCCCCC CACGGCAGCC CTCCAACTCT AAGCACCCTC 
ACTCTCCTGC TGCTCCTCTG TGGACAGGCT CACTCCCAGT GCAAGATCCT CCGCTGCAAT 
GCCGAGTATG TCTCGTCCAC TCTGAGTCTT CGGGGAGGTG GCTCACCGGA CACGCCGCGT 
GGAGGCGGCC GTGGTGGGCT GGCCTCAGGT GGCTTGTGTC GCGCCCTGCG CTCCTACGCT 
CTCTGCACGC GGCGCACGGC CCGCACCTGC CGCGGGGACC TTGCTTTCCA CTCTGCGGTG 
CATGGCATAG AGGACCTGAT GATCCAGCAC AACTGCTCAC GCCAGGGTCC CACGGCCCCG 
CCCCCGGCCC GGGGCCCCGC CCTGCCCGGG GCCGGGCCAG CGCCCCTGAC CCCAGATCCC 
TGTGACTATG AGGCCCGGTT TTCCAGGCTG CACGGTCGAG CCCCGGGCTT CTTGCATTGC 
GCATCCTTTG GAGATCCCCA TGTGCGCAGT TTCCACAACC AATTTCACAC ATGCCGTGTC 
CAAGGAGCTT GGCCCTTGCT AGATAACGAC TTCCTCTTTG TCCAGGCCAC CAGCTCCCCG 
GTTTCGTCGG GAGCCAACGC TACCACCATC CGGAAGATCA CTATCATATT TAAAAACATG 
CAGGAATGCA TTGACCAGAA AGTCTACCAG GCTGAGGTGG ACAATCTTCC TGCAGCCTTT 
GAAGATGGTT CTATCAATGG GGGCGACCGA CCTGGGGGCT CGAGTTTGTC CATTCAAACT 
GCTAACCTTG GGAGTCACGT GGAGATTCGA GCTGCCTACA TTGGAACAAC TATCATCATT 
CGACAGACAG CTGGGCAGCT CTCCTTCTCC ATCAGGGTAG CAGAGGATGT GGCGCGGGCC 
TTCTCCGCAG AGCAGGACCT ACAGCTGTGT GTTGGGGGAT GCCCTCCGAG CCAGCGACTC 
TCTCGCTCAG AGCGCAACCG CCGTGGGGCT ATAGCCATAG ATACTGCCAG AAGGCTGTGT 
AAGGAAGGGC TTCCGGTTGA AGATGCCTAC TTCCAATCCT GCGTCTTTGA TGTTTCAGTC 
TCCGGTGACC CCAACTTTAC TGTGGCAGCT CAGACAGCTC TGGACGATGC CCGAATCTTC 
TTGACGGATT TAGAGAACTT ACATCTCTTT CCCTCAGATG CGGGGCCTCC CCTCTCTCCT 
GCCATCTGCC TAGTCCCGCT TCTTTCGGCC CTCTTTGTTC TGTGGCTTTG CTTCAGTAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hjv ( XM_006502037.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006502100.1 Mus musculus hemojuvelin BMP co-receptor (Hjv), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu22455
Clone ID Related Accession (Same CDS sequence)	XM_006502037.3 , NM_027126.4
Accession Version	XM_006502037.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1263bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	hemojuvelin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006502037.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCCAGT CCCCTAGTCC CCGGTCCCCC CACGGCAGCC CTCCAACTCT AAGCACCCTC 
ACTCTCCTGC TGCTCCTCTG TGGACAGGCT CACTCCCAGT GCAAGATCCT CCGCTGCAAT 
GCCGAGTATG TCTCGTCCAC TCTGAGTCTT CGGGGAGGTG GCTCACCGGA CACGCCGCGT 
GGAGGCGGCC GTGGTGGGCT GGCCTCAGGT GGCTTGTGTC GCGCCCTGCG CTCCTACGCT 
CTCTGCACGC GGCGCACGGC CCGCACCTGC CGCGGGGACC TTGCTTTCCA CTCTGCGGTG 
CATGGCATAG AGGACCTGAT GATCCAGCAC AACTGCTCAC GCCAGGGTCC CACGGCCCCG 
CCCCCGGCCC GGGGCCCCGC CCTGCCCGGG GCCGGGCCAG CGCCCCTGAC CCCAGATCCC 
TGTGACTATG AGGCCCGGTT TTCCAGGCTG CACGGTCGAG CCCCGGGCTT CTTGCATTGC 
GCATCCTTTG GAGATCCCCA TGTGCGCAGT TTCCACAACC AATTTCACAC ATGCCGTGTC 
CAAGGAGCTT GGCCCTTGCT AGATAACGAC TTCCTCTTTG TCCAGGCCAC CAGCTCCCCG 
GTTTCGTCGG GAGCCAACGC TACCACCATC CGGAAGATCA CTATCATATT TAAAAACATG 
CAGGAATGCA TTGACCAGAA AGTCTACCAG GCTGAGGTGG ACAATCTTCC TGCAGCCTTT 
GAAGATGGTT CTATCAATGG GGGCGACCGA CCTGGGGGCT CGAGTTTGTC CATTCAAACT 
GCTAACCTTG GGAGTCACGT GGAGATTCGA GCTGCCTACA TTGGAACAAC TATCATCATT 
CGACAGACAG CTGGGCAGCT CTCCTTCTCC ATCAGGGTAG CAGAGGATGT GGCGCGGGCC 
TTCTCCGCAG AGCAGGACCT ACAGCTGTGT GTTGGGGGAT GCCCTCCGAG CCAGCGACTC 
TCTCGCTCAG AGCGCAACCG CCGTGGGGCT ATAGCCATAG ATACTGCCAG AAGGCTGTGT 
AAGGAAGGGC TTCCGGTTGA AGATGCCTAC TTCCAATCCT GCGTCTTTGA TGTTTCAGTC 
TCCGGTGACC CCAACTTTAC TGTGGCAGCT CAGACAGCTC TGGACGATGC CCGAATCTTC 
TTGACGGATT TAGAGAACTT ACATCTCTTT CCCTCAGATG CGGGGCCTCC CCTCTCTCCT 
GCCATCTGCC TAGTCCCGCT TCTTTCGGCC CTCTTTGTTC TGTGGCTTTG CTTCAGTAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006502100.1
CDS	273..1535
Translation	MGQSPSPRSPHGSPPTLSTLTLLLLLCGQAHSQCKILRCNAEYVSSTLSLRGGGSPDTPRGGGRGGLASGGLCRALRSYALCTRRTARTCRGDLAFHSAVHGIEDLMIQHNCSRQGPTAPPPARGPALPGAGPAPLTPDPCDYEARFSRLHGRAPGFLHCASFGDPHVRSFHNQFHTCRVQGAWPLLDNDFLFVQATSSPVSSGANATTIRKITIIFKNMQECIDQKVYQAEVDNLPAAFEDGSINGGDRPGGSSLSIQTANLGSHVEIRAAYIGTTIIIRQTAGQLSFSIRVAEDVARAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAIAIDTARRLCKEGLPVEDAYFQSCVFDVSVSGDPNFTVAAQTALDDARIFLTDLENLHLFPSDAGPPLSPAICLVPLLSALFVLWLCFSK

Target ORF information:

RefSeq Version	XM_006502037.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus hemojuvelin BMP co-receptor (Hjv), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006502037.3

ORF Insert Sequence:

ATGGGCCAGT CCCCTAGTCC CCGGTCCCCC CACGGCAGCC CTCCAACTCT AAGCACCCTC 
ACTCTCCTGC TGCTCCTCTG TGGACAGGCT CACTCCCAGT GCAAGATCCT CCGCTGCAAT 
GCCGAGTATG TCTCGTCCAC TCTGAGTCTT CGGGGAGGTG GCTCACCGGA CACGCCGCGT 
GGAGGCGGCC GTGGTGGGCT GGCCTCAGGT GGCTTGTGTC GCGCCCTGCG CTCCTACGCT 
CTCTGCACGC GGCGCACGGC CCGCACCTGC CGCGGGGACC TTGCTTTCCA CTCTGCGGTG 
CATGGCATAG AGGACCTGAT GATCCAGCAC AACTGCTCAC GCCAGGGTCC CACGGCCCCG 
CCCCCGGCCC GGGGCCCCGC CCTGCCCGGG GCCGGGCCAG CGCCCCTGAC CCCAGATCCC 
TGTGACTATG AGGCCCGGTT TTCCAGGCTG CACGGTCGAG CCCCGGGCTT CTTGCATTGC 
GCATCCTTTG GAGATCCCCA TGTGCGCAGT TTCCACAACC AATTTCACAC ATGCCGTGTC 
CAAGGAGCTT GGCCCTTGCT AGATAACGAC TTCCTCTTTG TCCAGGCCAC CAGCTCCCCG 
GTTTCGTCGG GAGCCAACGC TACCACCATC CGGAAGATCA CTATCATATT TAAAAACATG 
CAGGAATGCA TTGACCAGAA AGTCTACCAG GCTGAGGTGG ACAATCTTCC TGCAGCCTTT 
GAAGATGGTT CTATCAATGG GGGCGACCGA CCTGGGGGCT CGAGTTTGTC CATTCAAACT 
GCTAACCTTG GGAGTCACGT GGAGATTCGA GCTGCCTACA TTGGAACAAC TATCATCATT 
CGACAGACAG CTGGGCAGCT CTCCTTCTCC ATCAGGGTAG CAGAGGATGT GGCGCGGGCC 
TTCTCCGCAG AGCAGGACCT ACAGCTGTGT GTTGGGGGAT GCCCTCCGAG CCAGCGACTC 
TCTCGCTCAG AGCGCAACCG CCGTGGGGCT ATAGCCATAG ATACTGCCAG AAGGCTGTGT 
AAGGAAGGGC TTCCGGTTGA AGATGCCTAC TTCCAATCCT GCGTCTTTGA TGTTTCAGTC 
TCCGGTGACC CCAACTTTAC TGTGGCAGCT CAGACAGCTC TGGACGATGC CCGAATCTTC 
TTGACGGATT TAGAGAACTT ACATCTCTTT CCCTCAGATG CGGGGCCTCC CCTCTCTCCT 
GCCATCTGCC TAGTCCCGCT TCTTTCGGCC CTCTTTGTTC TGTGGCTTTG CTTCAGTAAG 
TAG