Mrm2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mrm2
Entrez Gene ID	68017
Full Name	mitochondrial rRNA methyltransferase 2
Synonyms	2310037B18Rik,Ftsj2
General protein information	Preferred Names mitochondrial rRNA methyltransferase 2 Names rRNA methyltransferase 2, mitochondrial 16S rRNA (uridine(1369)-2'-O)-methyltransferase 16S rRNA [Um1369] 2'-O-methyltransferase FtsJ RNA methyltransferase homolog 2 FtsJ homolog 2 protein ftsJ homolog 2 putative ribosomal RNA methyltransferase 2 rRNA (uridine-2'-O-)-methyltransferase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 G2

mRNA and Protein(s)

mRNA	Protein	Name
NM_026510.1	NP_080786.1	rRNA methyltransferase 2, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	FTSJ2	NP_037525.1
Danio rerio (zebrafish)	LOC555586	XP_683228.2
Saccharomyces cerevisiae (baker's yeast)	MRM2	NP_011379.1
Pan troglodytes (chimpanzee)	FTSJ2	XP_003318261.1
Bos taurus (cattle)	FTSJ2	NP_001178187.1
Rattus norvegicus (Norway rat)	Ftsj2	NP_001100595.1
Gallus gallus (chicken)	FTSJ2	NP_001264474.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP013223	XP_003436733.1
Caenorhabditis elegans (roundworm)	F45G2.9	NP_499776.1
Kluyveromyces lactis	KLLA0B01980g	XP_451619.1
Drosophila melanogaster (fruit fly)	CG11447	NP_650835.1
Eremothecium gossypii	AGOS_AFL117C	NP_985433.2
Magnaporthe oryzae (rice blast fungus)	MGG_04502	XP_003710953.1
Canis lupus familiaris (dog)	FTSJ2	XP_003434808.1
Xenopus tropicalis (tropical clawed frog)	ftsj2	XP_002944869.1
	FTSJ2	XP_001086161.1
Mus musculus (house mouse)	Ftsj2	NP_080786.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004177	XP_313065.4

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid.
Lee KW, Okot-Kotber C, LaComb JF, Bogenhagen DF
The Journal of biological chemistry288(43)31386-99(2013 Oct)

Characterization of a nucleolar 2'-O-methyltransferase and its involvement in the methylation of mouse precursor ribosomal RNA.
Eichler DC
Biochimie76(12)1115-22(1994)

A nucleolar 2'-O-methyltransferase. Specificity and evidence for its role in the methylation of mouse 28 S precursor ribosomal RNA.
Segal DM, Eichler DC
The Journal of biological chemistry266(36)24385-9(1991 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RNMTL1, MRM1, and MRM2 (FtsJ2) as members of the RNA methyltransferase family that may be responsible for the three known 2'-O-ribose modifications of the 16 S rRNA core of the large mitochondrial ribosome subunit.
Title: Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid.

The following Mrm2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mrm2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02466	NM_026510.1 Latest version!	Mus musculus mitochondrial rRNA methyltransferase 2 (Mrm2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mrm2 ( NM_026510.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080786.1 Mus musculus mitochondrial rRNA methyltransferase 2 (Mrm2), mRNA.

Price & Availability↑

CloneID	OMu02466
Clone ID Related Accession (Same CDS sequence)	NM_026510.1
Accession Version	NM_026510.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	rRNA methyltransferase 2, mitochondrial
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK009656.1. ##Evidence-Data-START## Transcript exon combination :: AK009656.1, AK145808.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCCGGGC ATCTGAAGCT GGTAGGCGTT CCCCTTAAGG TTCGGAGGTT ACACACAGCA 
GTGTGTCACT ACAGGGGCCG GACCGGCGCT GAGCACCTGT GGCTCACGCG GCATCTAAAG 
GATCCGTTTG TGAAGGCCGC AAAGGTGGAG AGTTACCGCT GCCGCAGTGC CTTCAAACTC 
CTGGAGATGA ATGAGAAGCA TCAGATCCTG AGGCCCGGTC TCCGGGTGCT GGACTGCGGG 
GCAGCTCCGG GAGCCTGGAG TCAGGTGGCA GTGCAGCGCG TCAATGCCAC AGGCGCAGAT 
TCCAGCTCTC CTGTGGGCTT TGTGCTTGGG GTCGATCTCC TTCACATATT CCCTTTGGCG 
GGAGCAACTT TTCTATGCCC TGCTGATGTG ACTGACCCCA GAACTTTCCA GAAGATTCTA 
GAACTGCTTC CCAGCAGGAG AGCAGATGTG ATTCTGAGTG ACATGGCACC GAATGCCACT 
GGGATCAGAG ACCTCGATCA CGATAAGCTC ATCAGCTTGT GCCTTACCCT TGTGGACATG 
GCTGTGGACA TCCTGCATCC CGGAGGGACA CTGCTGTGTA AAACCTGGGC CGGAAGTAAA 
AGCCACCTGC TGCAGAAGAG ACTGACCCAG GAATTCCAGA GCACAAGGGT GGTGAAACCG 
GAGGCCAGCA GGAAAGAGTC TTCGGAGGTG TACCTGTTAG CCACCCAGTA CCGTGGGGGG 
AAGGGCACCA GGAGGCCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080786.1
CDS	39..779
Translation	MAGHLKLVGVPLKVRRLHTAVCHYRGRTGAEHLWLTRHLKDPFVKAAKVESYRCRSAFKLLEMNEKHQILRPGLRVLDCGAAPGAWSQVAVQRVNATGADSSSPVGFVLGVDLLHIFPLAGATFLCPADVTDPRTFQKILELLPSRRADVILSDMAPNATGIRDLDHDKLISLCLTLVDMAVDILHPGGTLLCKTWAGSKSHLLQKRLTQEFQSTRVVKPEASRKESSEVYLLATQYRGGKGTRRP

Target ORF information:

RefSeq Version	NM_026510.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitochondrial rRNA methyltransferase 2 (Mrm2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026510.1

ORF Insert Sequence:

ATGGCCGGGC ATCTGAAGCT GGTAGGCGTT CCCCTTAAGG TTCGGAGGTT ACACACAGCA 
GTGTGTCACT ACAGGGGCCG GACCGGCGCT GAGCACCTGT GGCTCACGCG GCATCTAAAG 
GATCCGTTTG TGAAGGCCGC AAAGGTGGAG AGTTACCGCT GCCGCAGTGC CTTCAAACTC 
CTGGAGATGA ATGAGAAGCA TCAGATCCTG AGGCCCGGTC TCCGGGTGCT GGACTGCGGG 
GCAGCTCCGG GAGCCTGGAG TCAGGTGGCA GTGCAGCGCG TCAATGCCAC AGGCGCAGAT 
TCCAGCTCTC CTGTGGGCTT TGTGCTTGGG GTCGATCTCC TTCACATATT CCCTTTGGCG 
GGAGCAACTT TTCTATGCCC TGCTGATGTG ACTGACCCCA GAACTTTCCA GAAGATTCTA 
GAACTGCTTC CCAGCAGGAG AGCAGATGTG ATTCTGAGTG ACATGGCACC GAATGCCACT 
GGGATCAGAG ACCTCGATCA CGATAAGCTC ATCAGCTTGT GCCTTACCCT TGTGGACATG 
GCTGTGGACA TCCTGCATCC CGGAGGGACA CTGCTGTGTA AAACCTGGGC CGGAAGTAAA 
AGCCACCTGC TGCAGAAGAG ACTGACCCAG GAATTCCAGA GCACAAGGGT GGTGAAACCG 
GAGGCCAGCA GGAAAGAGTC TTCGGAGGTG TACCTGTTAG CCACCCAGTA CCGTGGGGGG 
AAGGGCACCA GGAGGCCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid.
The Journal of biological chemistry288(43)31386-99(2013 Oct)
Lee KW,Okot-Kotber C,LaComb JF,Bogenhagen DF

Characterization of a nucleolar 2'-O-methyltransferase and its involvement in the methylation of mouse precursor ribosomal RNA.
Biochimie76(12)1115-22(1994)
Eichler DC

A nucleolar 2'-O-methyltransferase. Specificity and evidence for its role in the methylation of mouse 28 S precursor ribosomal RNA.
The Journal of biological chemistry266(36)24385-9(1991 Dec)
Segal DM,Eichler DC