Ftmt cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ftmt
Entrez Gene ID	67634
Full Name	ferritin mitochondrial
Synonyms	4930447C24Rik,FerH,Fth3,MtF
General protein information	Preferred Names ferritin mitochondrial Names ferritin, mitochondrial ferritin H ferritin heavy chain 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_026286.3	NP_080562.2	ferritin, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FTMT	XP_526991.2
Danio rerio (zebrafish)	zgc:173593	XP_005164115.1
Danio rerio (zebrafish)	zgc:198419	NP_001107131.1
Canis lupus familiaris (dog)	LOC608550	XP_003431636.2
Bos taurus (cattle)	FTMT	NP_001069658.1
Rattus norvegicus (Norway rat)	Ftmt	NP_001099606.1
Danio rerio (zebrafish)	LOC100006428	XP_001921731.1
Homo sapiens (human)	FTMT	NP_803431.1
Canis lupus familiaris (dog)	LOC481426	XP_003431602.2
Mus musculus (house mouse)	Ftmt	NP_080562.2
Danio rerio (zebrafish)	zgc:173594	NP_001103324.1
Danio rerio (zebrafish)	LOC558816	XP_687175.1
Danio rerio (zebrafish)	zgc:109934	NP_001018367.1
	FTMT	XP_001088733.1
Danio rerio (zebrafish)	zgc:92066	NP_001002378.1
Danio rerio (zebrafish)	zgc:194125	NP_001124139.1
Drosophila melanogaster (fruit fly)	Fer3HCH	NP_572854.1

Gene Ontology
Bibliography

Related articles in PubMed

Lack of mitochondrial ferritin aggravated neurological deficits via enhancing oxidative stress in a traumatic brain injury murine model.
Wang L, Wang L, Dai Z, Wu P, Shi H, Zhao S
Bioscience reports37(6)(2017 Dec)

Mitochondrial ferritin affects mitochondria by stabilizing HIF-1? in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.
Wang X, Yang H, Yanagisawa D, Bellier JP, Morino K, Zhao S, Liu P, Vigers P, Tooyama I
Neurobiology of aging47168-179(2016 Nov)

Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage.
Darshan D, Vanoaica L, Richman L, Beermann F, K?hn LC
Hepatology (Baltimore, Md.)50(3)852-60(2009 Sep)

Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress.
MacKenzie EL, Ray PD, Tsuji Y
Free radical biology & medicine44(9)1762-71(2008 May)

Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post-transcriptional mechanism involving mRNA stabilization.
MacKenzie EL, Tsuji Y
The Biochemical journal411(1)107-13(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Age-related increase is found in FtMt and hypoxia-inducible factor-1a (HIF-1a) in murine retinal pigment epithelium (RPE).HIF-1alpha stabilization reduced the protein level of the mature, functional form of mitochondrial ferritin.
Title: Mitochondrial ferritin affects mitochondria by stabilizing HIF-1? in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.

Our results provide evidence that the iron storage function of ferritin plays a major role in preventing iron-mediated cell and tissue damage.
Title: Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage.

ferritin H transcription is activated by rotenone via an oxidative stress-mediated pathway leading to antioxidant-responsive element activation
Title: Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress.

ionomycin-mediated induction of ferritin H may occur in an NFAT-independent manner but through post-transcriptional stabilization of the ferritin H mRNA.
Title: Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post-transcriptional mechanism involving mRNA stabilization.

Its association with cell types characterized by high metabolic activity and oxygen consumption suggests a role in protecting mitochondria from iron-dependent oxidative damage.
Title: Mitochondrial ferritin expression in adult mouse tissues.

The following Ftmt gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ftmt cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58461	NM_026286.3 Latest version!	Mus musculus ferritin mitochondrial (Ftmt), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ftmt ( NM_026286.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080562.2 Mus musculus ferritin mitochondrial (Ftmt), mRNA.

Price & Availability↑

CloneID	OMu58461
Clone ID Related Accession (Same CDS sequence)	NM_026286.3
Accession Version	NM_026286.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	ferritin, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK015400.1 and AK133009.1. On Jul 2, 2009 this sequence version replaced NM_026286.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK133009.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGCTGTCCT GCTTTTGGTT CTTCTCCAAG CACATCAGCT CTGCACTGAT GTCCCTGCCC 
CGTGTGTTAC ACAGATTCAC TGCCCCACAG TGCTTGGCCT CCAGGTATCC TTTAGGTCCC 
CTACTGGCCT CCCCTCGACG CCTCCTGGCC TCGGTGGCTT CCTCTCAGGA CTCCACTAGA 
CCTTCCAGGG TCCGCCAGAA CTTTCACCCG GACTCGGAGG CTGCTATCAA CCGCCAAATC 
AACCTGGAGC TTTACGCATC CTACGTGTAC CTGTCCATGG CTTACTACTT CTCCAGGGAT 
GATGTGGCCT TGTATAACTT CTCCAAGTAT TTCCTTCGCC AGTCCCTGGA AGAGAGGGAA 
CATGCAGAGA AGCTAATGAA ACTGCAGAAC CAGCGAGGAG GCCGGATCTG CCTCCAGGAC 
ATCAAGAAGC CAGATAAAGA TGACTGGGAA TGCGGACTGC GGGCCATGGA ATGTGCCCTG 
CTCCTGGAAA AGAATGTAAA CCAGTCGCTG CTGGACTTAC ATACTCTGGC CTCAGAAAAA 
GGAGATCCTC ATTTGTGTGA CTTTCTGGAA ACTCACTACC TGCATGAGCA AGTGAAGTCT 
ATCAAAGAAT TAGGTGACCA CGTGCACAAC TTAGTCACCA TGGGGGCTCC AGCCGCGGGC 
TTAGCGGAAT ATCTTTTCGA CAAGCACACG CTTGGAAGCG AGAGCAAGCA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080562.2
CDS	79..792
Translation	MLSCFWFFSKHISSALMSLPRVLHRFTAPQCLASRYPLGPLLASPRRLLASVASSQDSTRPSRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALYNFSKYFLRQSLEEREHAEKLMKLQNQRGGRICLQDIKKPDKDDWECGLRAMECALLLEKNVNQSLLDLHTLASEKGDPHLCDFLETHYLHEQVKSIKELGDHVHNLVTMGAPAAGLAEYLFDKHTLGSESKH

Target ORF information:

RefSeq Version	NM_026286.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ferritin mitochondrial (Ftmt), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026286.3

ORF Insert Sequence:

ATGCTGTCCT GCTTTTGGTT CTTCTCCAAG CACATCAGCT CTGCACTGAT GTCCCTGCCC 
CGTGTGTTAC ACAGATTCAC TGCCCCACAG TGCTTGGCCT CCAGGTATCC TTTAGGTCCC 
CTACTGGCCT CCCCTCGACG CCTCCTGGCC TCGGTGGCTT CCTCTCAGGA CTCCACTAGA 
CCTTCCAGGG TCCGCCAGAA CTTTCACCCG GACTCGGAGG CTGCTATCAA CCGCCAAATC 
AACCTGGAGC TTTACGCATC CTACGTGTAC CTGTCCATGG CTTACTACTT CTCCAGGGAT 
GATGTGGCCT TGTATAACTT CTCCAAGTAT TTCCTTCGCC AGTCCCTGGA AGAGAGGGAA 
CATGCAGAGA AGCTAATGAA ACTGCAGAAC CAGCGAGGAG GCCGGATCTG CCTCCAGGAC 
ATCAAGAAGC CAGATAAAGA TGACTGGGAA TGCGGACTGC GGGCCATGGA ATGTGCCCTG 
CTCCTGGAAA AGAATGTAAA CCAGTCGCTG CTGGACTTAC ATACTCTGGC CTCAGAAAAA 
GGAGATCCTC ATTTGTGTGA CTTTCTGGAA ACTCACTACC TGCATGAGCA AGTGAAGTCT 
ATCAAAGAAT TAGGTGACCA CGTGCACAAC TTAGTCACCA TGGGGGCTCC AGCCGCGGGC 
TTAGCGGAAT ATCTTTTCGA CAAGCACACG CTTGGAAGCG AGAGCAAGCA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lack of mitochondrial ferritin aggravated neurological deficits via enhancing oxidative stress in a traumatic brain injury murine model.
Bioscience reports37(6)(2017 Dec)
Wang L,Wang L,Dai Z,Wu P,Shi H,Zhao S

Mitochondrial ferritin affects mitochondria by stabilizing HIF-1? in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.
Neurobiology of aging47168-179(2016 Nov)
Wang X,Yang H,Yanagisawa D,Bellier JP,Morino K,Zhao S,Liu P,Vigers P,Tooyama I

Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage.
Hepatology (Baltimore, Md.)50(3)852-60(2009 Sep)
Darshan D,Vanoaica L,Richman L,Beermann F,K?hn LC

Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress.
Free radical biology & medicine44(9)1762-71(2008 May)
MacKenzie EL,Ray PD,Tsuji Y

Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post-transcriptional mechanism involving mRNA stabilization.
The Biochemical journal411(1)107-13(2008 Apr)
MacKenzie EL,Tsuji Y