Atp6v1c1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atp6v1c1
Entrez Gene ID	66335
Full Name	ATPase, H+ transporting, lysosomal V1 subunit C1
Synonyms	1700025B18Rik,U13839
General protein information	Preferred Names ATPase, H+ transporting, lysosomal V1 subunit C1 Names V-type proton ATPase subunit C 1 ATPase, H+ transporting, V1 subunit C V-ATPase subunit C 1 vacuolar proton pump subunit C 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 B3.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_025494.3	NP_079770.2	V-type proton ATPase subunit C 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ATP6V1C1	XP_001155182.1
Canis lupus familiaris (dog)	ATP6V1C1	XP_005627900.1
Bos taurus (cattle)	ATP6V1C1	NP_788849.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005845	XP_315870.4
Schizosaccharomyces pombe (fission yeast)	vma5	NP_593891.1
Arabidopsis thaliana (thale cress)	DET3	NP_563916.1
Homo sapiens (human)	ATP6V1C1	NP_001686.1
Gallus gallus (chicken)	ATP6V1C1	XP_004940040.1
Danio rerio (zebrafish)	atp6v1c1a	NP_958479.1
Kluyveromyces lactis	KLLA0F26114g	XP_456243.1
	ATP6V1C1	XP_001083973.2
Mus musculus (house mouse)	Atp6v1c1	NP_079770.2
Rattus norvegicus (Norway rat)	Atp6v1c1	NP_001011992.1
Saccharomyces cerevisiae (baker's yeast)	VMA5	NP_012843.1
Neurospora crassa	NCU09897	XP_958622.1
Xenopus tropicalis (tropical clawed frog)	atp6v1c1	NP_989172.1
Drosophila melanogaster (fruit fly)	Vha44	NP_477266.1
Magnaporthe oryzae (rice blast fungus)	MGG_06349	XP_003717232.1
Oryza sativa (rice)	Os05g0593100	NP_001056500.1

Gene Ontology
Bibliography

Related articles in PubMed

Targeting Atp6v1c1 Prevents Inflammation and Bone Erosion Caused by Periodontitis and Reveals Its Critical Function in Osteoimmunology.
Li S, Hao L, Wang L, Lu Y, Li Q, Zhu Z, Shao JZ, Chen W
PloS one10(8)e0134903(2015)

Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity.
De Arras L, Laws R, Leach SM, Pontis K, Freedman JH, Schwartz DA, Alper S
Genetics197(2)485-96(2014 Jun)

Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.
Feng S, Zhu G, McConnell M, Deng L, Zhao Q, Wu M, Zhou Q, Wang J, Qi J, Li YP, Chen W
International journal of biological sciences9(8)853-62(2013)

Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts.
Feng S, Deng L, Chen W, Shao J, Xu G, Li YP
The Biochemical journal417(1)195-203(2009 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Atp6v1c1 RNAi knockdown gene therapy mediated by AAV-shRNA-Atp6v1c1 is a promising novel therapeutic approach for the treatment of bone erosion and inflammatory related diseases, such as periodontitis and rheumatoid arthritis.
Title: Targeting Atp6v1c1 Prevents Inflammation and Bone Erosion Caused by Periodontitis and Reveals Its Critical Function in Osteoimmunology.

Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.
Title: Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.

Study demonstrates that Atp6v1c1 is an essential component of the osteoclast proton pump at the osteoclast ruffled border and that it may regulate F-actin ring formation in osteoclast activation.
Title: Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts.

The following Atp6v1c1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atp6v1c1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22589	NM_025494.3 Latest version!	Mus musculus ATPase, H+ transporting, lysosomal V1 subunit C1 (Atp6v1c1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atp6v1c1 ( NM_025494.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079770.2 Mus musculus ATPase, H+ transporting, lysosomal V1 subunit C1 (Atp6v1c1), mRNA.

Price & Availability↑

CloneID	OMu22589
Clone ID Related Accession (Same CDS sequence)	NM_025494.3
Accession Version	NM_025494.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1149bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	V-type proton ATPase subunit C 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB869068.1, AK151237.1 and BQ746792.1. On Jun 4, 2008 this sequence version replaced NM_025494.2. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.133200.1, AK151237.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTGAGT TCTGGCTCAT ATCTGCTCCT GGGGAGAAAA CCTGTCAGCA AACATGGGAG 
AAACTACATG CAGCGACCAC CAAGAACAAT AATCTTGCCG TCTCTTCCAA GTTCAACATT 
CCTGACCTAA AGGTTGGCAC GTTGGATGTC TTGGTTGGCT TGTCGGATGA ACTGGCTAAA 
CTGGATGCAT TTGTAGAAGG TGTGGTCAAG AAAGTGGCTC AGTACATGGC TGATGTGCTG 
GAGGACAGCA AAGATAAAGT TCAGGAGAAC TTGCTGGCCA GCGGAGTTGA CTTGGTTACT 
TACATAACAA GGTTCCAGTG GGATATGGCT AAATATCCAA TCAAGCAGTC TCTGAAAAAT 
ATTTCTGAAA TAATTGCCAA GGGAGTGACT CAGATCGATA ATGACCTAAA GTCTCGGGCG 
TCTGCATACA ATAACCTGAA AGGGAATCTT CAGAATTTAG AGCGAAAGAA CGCGGGAAGT 
TTGCTAACGC GAAGCCTGGC GGAAATCGTG AAGAAAGATG ACTTTGTTCT TGATTCGGAG 
TATCTTGTCA CATTGCTGGT GGTAGTTCCC AAGCTGAACC ACAATGACTG GATTAAGCAG 
TATGAAACGC TCGCAGAAAT GGTAGTACCA AGGTCAAGCA ATGTTCTTTC AGAGGACCAA 
GACAGTTATC TTTGTAACGT CACCTTGTTT AGAAAAGCAG TTGATGATTT CAGACACAAA 
GCCAGAGAAA ACAAGTTCAT AGTTCGTGAC TTCCAGTATA ACGAGGAGGA GATGAAAGCA 
GATAAAGAAG AAATGACCAG GCTGTCTACT GACAAGAAGA AGCAGTTTGG ACCACTTGTG 
CGGTGGCTTA AAGTGAATTT CAGTGAGGCG TTTATTGCGT GGATTCATAT AAAAGCATTA 
CGGGTTTTTG TGGAGTCTGT TTTAAGGTAT GGCTTGCCGG TGAACTTCCA AGCAATGCTC 
CTTCAGCCGA ATAAGAAGTC AGTGAAGAAG CTAAGAGAAG TGCTGCACGA GTTGTACAAG 
CATCTGGACA GCAGTGCGGC TGCCATCATT GACGCTCCCA TGGATATCCC TGGCCTAAAC 
CTGAGTCAGC AGGAATACTA CCCCTATGTG TATTACAAGA TTGATTGCAA CTTGCTGGAA 
TTCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079770.2
CDS	213..1361
Translation	MTEFWLISAPGEKTCQQTWEKLHAATTKNNNLAVSSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLASGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADKEEMTRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAMLLQPNKKSVKKLREVLHELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK

Target ORF information:

RefSeq Version	NM_025494.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ATPase, H+ transporting, lysosomal V1 subunit C1 (Atp6v1c1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025494.3

ORF Insert Sequence:

ATGACTGAGT TCTGGCTCAT ATCTGCTCCT GGGGAGAAAA CCTGTCAGCA AACATGGGAG 
AAACTACATG CAGCGACCAC CAAGAACAAT AATCTTGCCG TCTCTTCCAA GTTCAACATT 
CCTGACCTAA AGGTTGGCAC GTTGGATGTC TTGGTTGGCT TGTCGGATGA ACTGGCTAAA 
CTGGATGCAT TTGTAGAAGG TGTGGTCAAG AAAGTGGCTC AGTACATGGC TGATGTGCTG 
GAGGACAGCA AAGATAAAGT TCAGGAGAAC TTGCTGGCCA GCGGAGTTGA CTTGGTTACT 
TACATAACAA GGTTCCAGTG GGATATGGCT AAATATCCAA TCAAGCAGTC TCTGAAAAAT 
ATTTCTGAAA TAATTGCCAA GGGAGTGACT CAGATCGATA ATGACCTAAA GTCTCGGGCG 
TCTGCATACA ATAACCTGAA AGGGAATCTT CAGAATTTAG AGCGAAAGAA CGCGGGAAGT 
TTGCTAACGC GAAGCCTGGC GGAAATCGTG AAGAAAGATG ACTTTGTTCT TGATTCGGAG 
TATCTTGTCA CATTGCTGGT GGTAGTTCCC AAGCTGAACC ACAATGACTG GATTAAGCAG 
TATGAAACGC TCGCAGAAAT GGTAGTACCA AGGTCAAGCA ATGTTCTTTC AGAGGACCAA 
GACAGTTATC TTTGTAACGT CACCTTGTTT AGAAAAGCAG TTGATGATTT CAGACACAAA 
GCCAGAGAAA ACAAGTTCAT AGTTCGTGAC TTCCAGTATA ACGAGGAGGA GATGAAAGCA 
GATAAAGAAG AAATGACCAG GCTGTCTACT GACAAGAAGA AGCAGTTTGG ACCACTTGTG 
CGGTGGCTTA AAGTGAATTT CAGTGAGGCG TTTATTGCGT GGATTCATAT AAAAGCATTA 
CGGGTTTTTG TGGAGTCTGT TTTAAGGTAT GGCTTGCCGG TGAACTTCCA AGCAATGCTC 
CTTCAGCCGA ATAAGAAGTC AGTGAAGAAG CTAAGAGAAG TGCTGCACGA GTTGTACAAG 
CATCTGGACA GCAGTGCGGC TGCCATCATT GACGCTCCCA TGGATATCCC TGGCCTAAAC 
CTGAGTCAGC AGGAATACTA CCCCTATGTG TATTACAAGA TTGATTGCAA CTTGCTGGAA 
TTCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Targeting Atp6v1c1 Prevents Inflammation and Bone Erosion Caused by Periodontitis and Reveals Its Critical Function in Osteoimmunology.
PloS one10(8)e0134903(2015)
Li S,Hao L,Wang L,Lu Y,Li Q,Zhu Z,Shao JZ,Chen W

Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity.
Genetics197(2)485-96(2014 Jun)
De Arras L,Laws R,Leach SM,Pontis K,Freedman JH,Schwartz DA,Alper S

Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.
International journal of biological sciences9(8)853-62(2013)
Feng S,Zhu G,McConnell M,Deng L,Zhao Q,Wu M,Zhou Q,Wang J,Qi J,Li YP,Chen W

Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts.
The Biochemical journal417(1)195-203(2009 Jan)
Feng S,Deng L,Chen W,Shao J,Xu G,Li YP