Ccl21c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccl21c
Entrez Gene ID	65956
Full Name	chemokine (C-C motif) ligand 21C (leucine)
Synonyms	6Ckine,CKb9,Ccl21b,SLC,Scya21,Scya21b,Scya21c,TCA4,exodus-2
General protein information	Preferred Names chemokine (C-C motif) ligand 21C (leucine) Names C-C motif chemokine 21c C-C motif chemokine 21b Ccl21-leu Small-inducible cytokine A21b beta-chemokine exodus-2 small inducible cytokine A21c thymus-derived chemotactic agent 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 A5\|4 22.54 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_023052.2	NP_075539.1	C-C motif chemokine 21c precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ccl21c	NP_075539.1
Pan troglodytes (chimpanzee)	CCL21	XP_001164162.1
Mus musculus (house mouse)	Gm13304	NP_001180595.1
Mus musculus (house mouse)	LOC100041593	XP_001473444.1
Mus musculus (house mouse)	Gm10591	NP_001180597.1
	CCL21	NP_001028027.1
Canis lupus familiaris (dog)	CCL21	NP_001005258.1
Mus musculus (house mouse)	Ccl21b	NP_035465.2
Mus musculus (house mouse)	Gm21541	NP_001257289.1
Mus musculus (house mouse)	Ccl21a	NP_035254.1
Homo sapiens (human)	CCL21	NP_002980.1
Bos taurus (cattle)	CCL21	NP_001033165.2
Mus musculus (house mouse)	LOC100041504	XP_001473308.1
Mus musculus (house mouse)	Gm1987	NP_001180596.1
Rattus norvegicus (Norway rat)	Ccl21	NP_001008513.1

Gene Ontology
Bibliography

Related articles in PubMed

CCR7 Is Important for Mesangial Cell Physiology and Repair.
Wurm S, Steege A, Rom-Jurek EM, van Roeyen CR, Kurtz A, Banas B, Banas MC
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society66(1)7-22(2018 Jan)

Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis.
Onder L, M?rbe U, Pikor N, Novkovic M, Cheng HW, Hehlgans T, Pfeffer K, Becher B, Waisman A, R?licke T, Gommerman J, Mueller CG, Sawa S, Scandella E, Ludewig B
Immunity47(1)80-92.e4(2017 07)

The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling.
Finsen AV, Ueland T, Sjaastad I, Ranheim T, Ahmed MS, Dahl CP, Askevold ET, Aakhus S, Husberg C, Fiane AE, Lipp M, Gullestad L, Christensen G, Aukrust P, Yndestad A
PloS one9(11)e112172(2014)

JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation.
Montresor A, Bolomini-Vittori M, Toffali L, Rossi B, Constantin G, Laudanna C
The Journal of cell biology203(6)1003-19(2013 Dec)

Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus.
Bryson JL, Griffith AV, Hughes B 3rd, Saito F, Takahama Y, Richie ER, Manley NR
PloS one8(6)e65196(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the CCR7/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1
Title: CCR7/CCL21 migration on fibronectin is mediated by phospholipase Cgamma1 and ERK1/2 in primary T lymphocytes.

CCL2 renders T cells defective in their ability to develop CCL21-triggered activation of LFA-1- and LFA-1-mediated adhesion strengthening to endothelial ICAM-1. CCL2 also attenuated lymphocyte chemotaxis toward lymph node chemokines.
Title: Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions.

CCL19/CCL21 act as regulatory chemokines for the control of airway allergic disease
Title: Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis.

The presence of CCL21 during the in vitro stimulation of CD4+ T cells with anti-CD3 plus anti-CD28 significantly enhanced in vitro AICD induction of the restimulated T cells, partially through enhancing expression of Fas ligand.
Title: Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells.

Results suggest that CCR7-positive fibrocytes infiltrate the kidney via CCL21-positive vessels, thereby contributing to the pathogenesis of renal fibrosis.
Title: Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis.

The following Ccl21c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccl21c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01544	NM_023052.2 Latest version!	Mus musculus chemokine (C-C motif) ligand 21C (leucine) (Ccl21c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccl21c ( NM_023052.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075539.1 Mus musculus chemokine (C-C motif) ligand 21C (leucine) (Ccl21c), mRNA.

Price & Availability↑

CloneID	OMu01544
Clone ID Related Accession (Same CDS sequence)	NM_023052.2
Accession Version	NM_023052.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	C-C motif chemokine 21c precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC087957.1. On Apr 11, 2007 this sequence version replaced NM_023052.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA494789.1, AI119340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCAGA TGATGACTCT GAGCCTCCTT AGCCTGGTCC TGGCTCTCTG CATCCCCTGG 
ACCCAAGGCA GTGATGGAGG GGGACAGGAC TGCTGCCTTA AGTACAGCCA GAAGAAAATT 
CCCTACAGTA TTGTCCGAGG CTATAGGAAG CAAGAACCAA GTTTAGGCTG TCCCATCCCG 
GCAATCCTGT TCTTACCCCG GAAGCACTCT AAGCCTGAGC TATGTGCAAA CCCTGAGGAA 
GGCTGGGTGC AGAACCTGAT GCGCCGCCTG GACCAGCCTC CAGCCCCAGG GAAACAAAGC 
CCCGGCTGCA GGAAGAACCG GGGAACCTCT AAGTCTGGAA AGAAAGGAAA GGGCTCCAAG 
GGCTGCAAGA GAACTGAACA GACACAGCCC TCAAGAGGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075539.1
CDS	73..474
Translation	MAQMMTLSLLSLVLALCIPWTQGSDGGGQDCCLKYSQKKIPYSIVRGYRKQEPSLGCPIPAILFLPRKHSKPELCANPEEGWVQNLMRRLDQPPAPGKQSPGCRKNRGTSKSGKKGKGSKGCKRTEQTQPSRG

Target ORF information:

RefSeq Version	NM_023052.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C-C motif) ligand 21C (leucine) (Ccl21c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023052.2

ORF Insert Sequence:

ATGGCTCAGA TGATGACTCT GAGCCTCCTT AGCCTGGTCC TGGCTCTCTG CATCCCCTGG 
ACCCAAGGCA GTGATGGAGG GGGACAGGAC TGCTGCCTTA AGTACAGCCA GAAGAAAATT 
CCCTACAGTA TTGTCCGAGG CTATAGGAAG CAAGAACCAA GTTTAGGCTG TCCCATCCCG 
GCAATCCTGT TCTTACCCCG GAAGCACTCT AAGCCTGAGC TATGTGCAAA CCCTGAGGAA 
GGCTGGGTGC AGAACCTGAT GCGCCGCCTG GACCAGCCTC CAGCCCCAGG GAAACAAAGC 
CCCGGCTGCA GGAAGAACCG GGGAACCTCT AAGTCTGGAA AGAAAGGAAA GGGCTCCAAG 
GGCTGCAAGA GAACTGAACA GACACAGCCC TCAAGAGGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CCR7 Is Important for Mesangial Cell Physiology and Repair.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society66(1)7-22(2018 Jan)
Wurm S,Steege A,Rom-Jurek EM,van Roeyen CR,Kurtz A,Banas B,Banas MC

Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis.
Immunity47(1)80-92.e4(2017 07)
Onder L,M?rbe U,Pikor N,Novkovic M,Cheng HW,Hehlgans T,Pfeffer K,Becher B,Waisman A,R?licke T,Gommerman J,Mueller CG,Sawa S,Scandella E,Ludewig B

The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling.
PloS one9(11)e112172(2014)
Finsen AV,Ueland T,Sjaastad I,Ranheim T,Ahmed MS,Dahl CP,Askevold ET,Aakhus S,Husberg C,Fiane AE,Lipp M,Gullestad L,Christensen G,Aukrust P,Yndestad A

JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation.
The Journal of cell biology203(6)1003-19(2013 Dec)
Montresor A,Bolomini-Vittori M,Toffali L,Rossi B,Constantin G,Laudanna C

Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus.
PloS one8(6)e65196(2013)
Bryson JL,Griffith AV,Hughes B 3rd,Saito F,Takahama Y,Richie ER,Manley NR