Arl6ip5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Arl6ip5
Entrez Gene ID	65106
Full Name	ADP-ribosylation factor-like 6 interacting protein 5
Synonyms	5930404D22Rik,AV001879,Aip-5,Gtrap3-18,addiscin
General protein information	Preferred Names ADP-ribosylation factor-like 6 interacting protein 5 Names PRA1 family protein 3 ADP-ribosylation factor-like protein 6-interacting protein 5 ADP-ribosylation-like factor 6 interacting protein 5 ARL-6-interacting protein 5 addicsin glutamate transporter EAAC1-interacting protein prenylated Rab acceptor protein 2 protein JWa
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 D3

mRNA and Protein(s)

mRNA	Protein	Name
NM_022992.2	NP_075368.1	PRA1 family protein 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ARL6IP5	XP_533764.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005121	XP_314002.4
	ARL6IP5	XP_001087809.1
Rattus norvegicus (Norway rat)	Arl6ip5	NP_076462.1
Danio rerio (zebrafish)	arl6ip5b	NP_001002517.1
Pan troglodytes (chimpanzee)	ARL6IP5	XP_003950188.1
Mus musculus (house mouse)	Arl6ip5	NP_075368.1
Caenorhabditis elegans (roundworm)	praf-3	NP_001023104.1
Xenopus tropicalis (tropical clawed frog)	arl6ip5	NP_001120902.1
Homo sapiens (human)	ARL6IP5	NP_006398.1
Bos taurus (cattle)	ARL6IP5	NP_001014891.1
Gallus gallus (chicken)	ARL6IP5	NP_001012623.1
Drosophila melanogaster (fruit fly)	Jwa	NP_609901.4
Danio rerio (zebrafish)	arl6ip5a	NP_001006096.1

Gene Ontology
Bibliography

Related articles in PubMed

GTRAP3-18 regulates food intake and body weight by interacting with pro-opiomelanocortin.
Aoyama K, Bhadhprasit W, Watabe M, Wang F, Matsumura N, Nakaki T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology32(1)330-341(2018 Jan)

JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.
Zhao X, Wang R, Xiong J, Yan D, Li A, Wang S, Xu J, Zhou J
Toxicology letters27732-40(2017 Aug)

Lack of JWA Enhances Neurogenesis and Long-Term Potentiation in Hippocampal Dentate Gyrus Leading to Spatial Cognitive Potentiation.
Sha S, Xu J, Lu ZH, Hong J, Qu WJ, Zhou JW, Chen L
Molecular neurobiology53(1)355-368(2016 Jan)

Overexpression of Arl6ip5 in osteoblast regulates RANKL subcellualr localization.
Wu Y, Wang M, Peng Y, Ding Y, Deng L, Fu Q
Biochemical and biophysical research communications464(4)1275-81(2015 Sep)

Deficiency of osteoblastic Arl6ip5 impaired osteoblast differentiation and enhanced osteoclastogenesis via disturbance of ER calcium homeostasis and induction of ER stress-mediated apoptosis.
Wu Y, Yang M, Fan J, Peng Y, Deng L, Ding Y, Yang R, Zhou J, Miao D, Fu Q
Cell death & disease5e1464(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Protective effect of JWA against paraquat neurotoxicity involves regulation of the MEK/PI3K-Nrf2 axis.
Title: JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.

the JWA deficiency through cascading FAK-PI3K-Akt-mTOR pathway increases the newborn neurons.
Title: Lack of JWA Enhances Neurogenesis and Long-Term Potentiation in Hippocampal Dentate Gyrus Leading to Spatial Cognitive Potentiation.

These findings indicated that Arl6ip5 was an anti-catabolic factor by binding with RANKL and disturbing its subcellular trafficking in osteoblast.
Title: Overexpression of Arl6ip5 in osteoblast regulates RANKL subcellualr localization.

Arl6ip5 is a novel regulator of bone formation in osteoblasts.
Title: Deficiency of osteoblastic Arl6ip5 impaired osteoblast differentiation and enhanced osteoclastogenesis via disturbance of ER calcium homeostasis and induction of ER stress-mediated apoptosis.

The double-fluorescent immunohistochemical analysis revealed that addicsin and TR1 were coexpressed in neurons
Title: Identification of tomoregulin-1 as a novel addicsin-associated factor.

The following Arl6ip5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Arl6ip5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00073	NM_022992.2 Latest version!	Mus musculus ADP-ribosylation factor-like 6 interacting protein 5 (Arl6ip5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Arl6ip5 ( NM_022992.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075368.1 Mus musculus ADP-ribosylation factor-like 6 interacting protein 5 (Arl6ip5), mRNA.

Price & Availability↑

CloneID	OMu00073
Clone ID Related Accession (Same CDS sequence)	NM_022992.2
Accession Version	NM_022992.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	PRA1 family protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC155724.8. On Nov 17, 2006 this sequence version replaced NM_022992.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003897.1, AK077826.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGACGTGA ACCTCGCCCC GCTCCGTGCC TGGGACGATT TCTTCCCGGG CTCTGATCGT 
TTCGCCCGGC CGGACTTCAG GGACATTTCC AAATGGAACA ACCGTGTAGT GAGCAATCTG 
CTCTATTACC AGACCAACTA CCTGGTGGTG GCTGCCATGA TGATTTCGGT TGTTGGGTTT 
CTGAGCCCCT TCAACATGAT CCTCGGAGGA GTCATTGTGG TGCTGGTGTT CATGGGGTTC 
GTGTGGGCAG CGCACAATAA AGACATCCTC CGCCGGATGA AGAAGCAGTA CCCAACGGCC 
TTCGTGATGG TGGTCATGCT AGCCAGCTAC TTCCTCATAT CCATGTTCGG GGGTGTCATG 
GTCTTTGTGT TCGGCATCAC TCTTCCTTTG CTGTTGATGT TCATCCACGC ATCCCTGAGA 
CTTCGCAACC TCAAGAACAA GCTGGAAAAT AAAATGGAGG GAATCGGCCT GAAGAAAACT 
CCGATGGGCA TTATCCTGGA TGCCTTGGAA CAGCAGGAAG ATAACATCAA CAAATTTGCT 
GACTACATCA GCAAAGCGAG GGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075368.1
CDS	30..596
Translation	MDVNLAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISVVGFLSPFNMILGGVIVVLVFMGFVWAAHNKDILRRMKKQYPTAFVMVVMLASYFLISMFGGVMVFVFGITLPLLLMFIHASLRLRNLKNKLENKMEGIGLKKTPMGIILDALEQQEDNINKFADYISKARE

Target ORF information:

RefSeq Version	NM_022992.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ADP-ribosylation factor-like 6 interacting protein 5 (Arl6ip5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022992.2

ORF Insert Sequence:

ATGGACGTGA ACCTCGCCCC GCTCCGTGCC TGGGACGATT TCTTCCCGGG CTCTGATCGT 
TTCGCCCGGC CGGACTTCAG GGACATTTCC AAATGGAACA ACCGTGTAGT GAGCAATCTG 
CTCTATTACC AGACCAACTA CCTGGTGGTG GCTGCCATGA TGATTTCGGT TGTTGGGTTT 
CTGAGCCCCT TCAACATGAT CCTCGGAGGA GTCATTGTGG TGCTGGTGTT CATGGGGTTC 
GTGTGGGCAG CGCACAATAA AGACATCCTC CGCCGGATGA AGAAGCAGTA CCCAACGGCC 
TTCGTGATGG TGGTCATGCT AGCCAGCTAC TTCCTCATAT CCATGTTCGG GGGTGTCATG 
GTCTTTGTGT TCGGCATCAC TCTTCCTTTG CTGTTGATGT TCATCCACGC ATCCCTGAGA 
CTTCGCAACC TCAAGAACAA GCTGGAAAAT AAAATGGAGG GAATCGGCCT GAAGAAAACT 
CCGATGGGCA TTATCCTGGA TGCCTTGGAA CAGCAGGAAG ATAACATCAA CAAATTTGCT 
GACTACATCA GCAAAGCGAG GGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GTRAP3-18 regulates food intake and body weight by interacting with pro-opiomelanocortin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology32(1)330-341(2018 Jan)
Aoyama K,Bhadhprasit W,Watabe M,Wang F,Matsumura N,Nakaki T

JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.
Toxicology letters27732-40(2017 Aug)
Zhao X,Wang R,Xiong J,Yan D,Li A,Wang S,Xu J,Zhou J

Lack of JWA Enhances Neurogenesis and Long-Term Potentiation in Hippocampal Dentate Gyrus Leading to Spatial Cognitive Potentiation.
Molecular neurobiology53(1)355-368(2016 Jan)
Sha S,Xu J,Lu ZH,Hong J,Qu WJ,Zhou JW,Chen L

Overexpression of Arl6ip5 in osteoblast regulates RANKL subcellualr localization.
Biochemical and biophysical research communications464(4)1275-81(2015 Sep)
Wu Y,Wang M,Peng Y,Ding Y,Deng L,Fu Q

Deficiency of osteoblastic Arl6ip5 impaired osteoblast differentiation and enhanced osteoclastogenesis via disturbance of ER calcium homeostasis and induction of ER stress-mediated apoptosis.
Cell death & disease5e1464(2014 Oct)
Wu Y,Yang M,Fan J,Peng Y,Deng L,Ding Y,Yang R,Zhou J,Miao D,Fu Q