Cables1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cables1
Entrez Gene ID	63955
Full Name	CDK5 and Abl enzyme substrate 1
Synonyms	Cables,ik3-1
General protein information	Preferred Names CDK5 and Abl enzyme substrate 1 Names CDK5 and ABL1 enzyme substrate 1 cdk3-binding protein ik3-1 interactor with CDK3 1 interactor-1 with cdk3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 A1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001146287.1	NP_001139759.1	CDK5 and ABL1 enzyme substrate 1 isoform 1
NM_022021.2	NP_071304.2	CDK5 and ABL1 enzyme substrate 1 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CABLES1	XP_003315866.1
Rattus norvegicus (Norway rat)	Cables1	NP_001100874.1
Canis lupus familiaris (dog)	CABLES1	XP_003435064.2
Bos taurus (cattle)	CABLES1	XP_002697772.3
Mus musculus (house mouse)	Cables1	NP_001139759.1
Xenopus tropicalis (tropical clawed frog)	cables1	XP_004915270.1
Danio rerio (zebrafish)	cables1	NP_001099135.1
Homo sapiens (human)	CABLES1	NP_001094089.1
Gallus gallus (chicken)	CABLES1	XP_001232075.3

Gene Ontology
Bibliography

Related articles in PubMed

Truncated Cables1 causes agenesis of the corpus callosum in mice.
Mizuno S, Tra DT, Mizobuchi A, Iseki H, Mizuno-Iijima S, Kim JD, Ishida J, Matsuda Y, Kunita S, Fukamizu A, Sugiyama F, Yagami K
Laboratory investigation; a journal of technical methods and pathology94(3)321-30(2014 Mar)

Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice.
Arnason T, Pino MS, Yilmaz O, Kirley SD, Rueda BR, Chung DC, Zukerberg LR
Cancer biology & therapy14(7)672-8(2013 Jul)

A novel locus on proximal chromosome 18 associated with agenesis of the corpus callosum in mice.
Mizuno S, Mizobuchi A, Iseki H, Iijima S, Matsuda Y, Kunita S, Sugiyama F, Yagami K
Mammalian genome : official journal of the International Mammalian Genome Society21(11-12)525-33(2010 Dec)

Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress.
Wang N, Guo L, Rueda BR, Tilly JL
EMBO reports11(8)633-9(2010 Aug)

Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female mice.
Lee HJ, Sakamoto H, Luo H, Skaznik-Wikiel ME, Friel AM, Niikura T, Tilly JC, Niikura Y, Klein R, Styer AK, Zukerberg LR, Tilly JL, Rueda BR
Cell cycle (Georgetown, Tex.)6(21)2678-84(2007 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Agenesis of the corpus callosum frequency in Cables1(+/TAS) mice was significantly lower than that in Cables1(-/TAS) mice, indicating that wild-type Cables1 interfered with the dominant negative effect of Cables1(TAS).
Title: Truncated Cables1 causes agenesis of the corpus callosum in mice.

Loss of Cables1 enhances tumor progression in the Apc(Min/+) mouse model and activates the Wnt/beta-catenin signaling pathway. Cables1 is a tumor suppressor gene on chromosome 18q in this in vivo mouse model.
Title: Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice.

Data show that oocytes lacking Cables1 exhibit lower basal levels of TAp63alpha and reduced accumulation of phosphorylated TAp63alpha in response to genotoxic stress.
Title: Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress.

Cables1 null mice exhibit a significant expansion of oocyte numbers at the expense of oocyte quality throughout adulthood.
Title: Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female mice.

Cables is a relevant target of the chromosome 18q deletions frequently seen in human colorectal cancer.
Title: The Cables gene on chromosome 18Q regulates colon cancer progression in vivo.

The following Cables1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cables1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19263	NM_001146287.1 Latest version!	Mus musculus CDK5 and Abl enzyme substrate 1 (Cables1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$349.30 $499.00
OMu19595	NM_022021.2 Latest version!	Mus musculus CDK5 and Abl enzyme substrate 1 (Cables1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$335.30 $479.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cables1 ( NM_001146287.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001139759.1 Mus musculus CDK5 and Abl enzyme substrate 1 (Cables1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19263
Clone ID Related Accession (Same CDS sequence)	NM_001146287.1
Accession Version	NM_001146287.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1785bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	CDK5 and ABL1 enzyme substrate 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC100751.6, AK158396.1, BQ917292.1, CX202925.1, CB205636.1 and CA751142.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK156273.1, AK158396.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGG CGACCGCCAC CGCGGGCACG GCCGCCTGCA GCAGCAGCAG CAGCAGTCGC 
GGCGGCAGCA CGGACGCCGC GGCCACCAGC GGGGTGCAGC CGCCGCCGCC TCCTCCGGCC 
ACCGCGCCGC CGGAACCTCT TCGTAAGCCG CGCATGGACC CGCGGCGCCG CCAGGCTGCC 
CTGTCCTTCC TCACCAACAT TTCTCTGGAC GGACGGCCTC CGCTGCAGGA CCACGAGTGG 
GGCGGCGGCG AGGAGGGCGG CGGGACCAAG CCCGGAGCAA GGGCTCGGCT CAGCCTGCTG 
GCCGCTGGCT GCAACGCGTT CTCGGCACCG GGCACCGCGG CCGCGCCGTG GACCGCCGGC 
TCGGGTTCCA GCCCTTGCCC GCTGCCGCCG TCTCTGGTCC CCCGGGTGTT GGGAGAGCCA 
TCTCAGCCGC CCCGTTCAGC TCCAGCTGTC ACCGGTGCTC AGCTGCAGTT GCCTGACGGG 
CCGGGAGGCG CCGGACAGGA GGAGCTGGAG GAGGACGATG CCTTCACCAA CGTGCAGGTG 
CCATCGGCCA GCTTTTTGGG CTCCGGGACC CCCGGGAGTA CGAGCGGCAG TCGGGGCCGC 
CTCAACTCGT TCACTCAGGG AATCCTGCCC ATCGCCTTCT CCAGGCAGAA CTCGCAGAAC 
TACTGCGCCT TGGAGCAGTC AGGCCAGGGC GGCAGCACCA GCGCCTTGGA GCAGCTGCAG 
AGGTCCAGAC GTCGCCTCAT CTCCCAGAGA TCATCTTTGG AGACCCTGGA AGATATTGAA 
GAGAATGCCC CTCTCCGGAG ATGTCGAACA CTCTCAGGTT CTCCCAGACC AAAGAATTTC 
AAGAAAATTC ATTTTATCAA GAATATGCGA CAGCACGATA CCAAGAATGG CAGAATAGTC 
CTTATCAGTG GCAGAAGATC CTTCTGTAGT ATATTTTCCG TGCTGCCGTA TCGAGACAGT 
ACCCAAGTCG GGGACCTGAA GTTGGATGGA GGGAGGCAGT CAGCAGGGGC CATGAGCCTG 
AAGGAGATCA TTGGCCTTGA AGGTGTGGAA CTGGGTGCCG ATGGGAAGAC AGTGTCTTAT 
ACCCAGTTTC TACTACCCAC AAATGCCTTT GGGAACCGTA GAAATACCAT AGACTCCACC 
GCCTCCTTCT CCCAGTTTCG GAGCCTGAGC CACCGAAGCC TCTCCATGGG CCGGGCTGGC 
AGCACCCAGG GGAGCCTTGA TGCAGGAAGT GACCTGGGAG ACTTTATGGA CTATGACCCA 
AACCTCCTGG ATGACCCCCA GTGGCCTTGC GGCAAGCACA AGCGAGTTCT GACCTTCCCT 
TCATACATGA CCACAGTGAT TGACTACGTG AAGCCCTCAG ATCTCAAGAA GGACATGAAT 
GAAACCTTCA AGGAGAAGTT TCCTCACATT AAATTAACAC TCAGCAAAAT CAGGAGCCTG 
AAAAGAGAGA TGCGGAAGCT TGCCCAGGAG GACTGTGGCT TTGAGGAGCC CACGGTGGCC 
ATGGCCTTTG TCTACTTTGA GAAGCTGGCC CTCAGGGGGA AGCTGAACAA GCAGAACCGG 
AAGCTCTGTG CGGGAGCCTG TGTGCTGCTA GCGGCCAAGG TCGGAAGTGA CCTCAGAAAG 
CACGAGGTCA AGCACCTGAT TGACAAACTG GAAGAGAAGT TCCGACTGAA CAGACGAGAA 
CTGATTGCCT TTGAATTCCC AGTGTTAGTG GCCTTGGAGT TTGCACTTCA CCTGCCAGAG 
CACGAAGTCA TGCCCCACTA TAGACGCCTG ATCCAGAGCT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139759.1
CDS	533..2317
Translation	MAAATATAGTAACSSSSSSRGGSTDAAATSGVQPPPPPPATAPPEPLRKPRMDPRRRQAALSFLTNISLDGRPPLQDHEWGGGEEGGGTKPGARARLSLLAAGCNAFSAPGTAAAPWTAGSGSSPCPLPPSLVPRVLGEPSQPPRSAPAVTGAQLQLPDGPGGAGQEELEEDDAFTNVQVPSASFLGSGTPGSTSGSRGRLNSFTQGILPIAFSRQNSQNYCALEQSGQGGSTSALEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTKNGRIVLISGRRSFCSIFSVLPYRDSTQVGDLKLDGGRQSAGAMSLKEIIGLEGVELGADGKTVSYTQFLLPTNAFGNRRNTIDSTASFSQFRSLSHRSLSMGRAGSTQGSLDAGSDLGDFMDYDPNLLDDPQWPCGKHKRVLTFPSYMTTVIDYVKPSDLKKDMNETFKEKFPHIKLTLSKIRSLKREMRKLAQEDCGFEEPTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHEVKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLIQSS

Target ORF information:

RefSeq Version	NM_001146287.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus CDK5 and Abl enzyme substrate 1 (Cables1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001146287.1

ORF Insert Sequence:

ATGGCGGCGG CGACCGCCAC CGCGGGCACG GCCGCCTGCA GCAGCAGCAG CAGCAGTCGC 
GGCGGCAGCA CGGACGCCGC GGCCACCAGC GGGGTGCAGC CGCCGCCGCC TCCTCCGGCC 
ACCGCGCCGC CGGAACCTCT TCGTAAGCCG CGCATGGACC CGCGGCGCCG CCAGGCTGCC 
CTGTCCTTCC TCACCAACAT TTCTCTGGAC GGACGGCCTC CGCTGCAGGA CCACGAGTGG 
GGCGGCGGCG AGGAGGGCGG CGGGACCAAG CCCGGAGCAA GGGCTCGGCT CAGCCTGCTG 
GCCGCTGGCT GCAACGCGTT CTCGGCACCG GGCACCGCGG CCGCGCCGTG GACCGCCGGC 
TCGGGTTCCA GCCCTTGCCC GCTGCCGCCG TCTCTGGTCC CCCGGGTGTT GGGAGAGCCA 
TCTCAGCCGC CCCGTTCAGC TCCAGCTGTC ACCGGTGCTC AGCTGCAGTT GCCTGACGGG 
CCGGGAGGCG CCGGACAGGA GGAGCTGGAG GAGGACGATG CCTTCACCAA CGTGCAGGTG 
CCATCGGCCA GCTTTTTGGG CTCCGGGACC CCCGGGAGTA CGAGCGGCAG TCGGGGCCGC 
CTCAACTCGT TCACTCAGGG AATCCTGCCC ATCGCCTTCT CCAGGCAGAA CTCGCAGAAC 
TACTGCGCCT TGGAGCAGTC AGGCCAGGGC GGCAGCACCA GCGCCTTGGA GCAGCTGCAG 
AGGTCCAGAC GTCGCCTCAT CTCCCAGAGA TCATCTTTGG AGACCCTGGA AGATATTGAA 
GAGAATGCCC CTCTCCGGAG ATGTCGAACA CTCTCAGGTT CTCCCAGACC AAAGAATTTC 
AAGAAAATTC ATTTTATCAA GAATATGCGA CAGCACGATA CCAAGAATGG CAGAATAGTC 
CTTATCAGTG GCAGAAGATC CTTCTGTAGT ATATTTTCCG TGCTGCCGTA TCGAGACAGT 
ACCCAAGTCG GGGACCTGAA GTTGGATGGA GGGAGGCAGT CAGCAGGGGC CATGAGCCTG 
AAGGAGATCA TTGGCCTTGA AGGTGTGGAA CTGGGTGCCG ATGGGAAGAC AGTGTCTTAT 
ACCCAGTTTC TACTACCCAC AAATGCCTTT GGGAACCGTA GAAATACCAT AGACTCCACC 
GCCTCCTTCT CCCAGTTTCG GAGCCTGAGC CACCGAAGCC TCTCCATGGG CCGGGCTGGC 
AGCACCCAGG GGAGCCTTGA TGCAGGAAGT GACCTGGGAG ACTTTATGGA CTATGACCCA 
AACCTCCTGG ATGACCCCCA GTGGCCTTGC GGCAAGCACA AGCGAGTTCT GACCTTCCCT 
TCATACATGA CCACAGTGAT TGACTACGTG AAGCCCTCAG ATCTCAAGAA GGACATGAAT 
GAAACCTTCA AGGAGAAGTT TCCTCACATT AAATTAACAC TCAGCAAAAT CAGGAGCCTG 
AAAAGAGAGA TGCGGAAGCT TGCCCAGGAG GACTGTGGCT TTGAGGAGCC CACGGTGGCC 
ATGGCCTTTG TCTACTTTGA GAAGCTGGCC CTCAGGGGGA AGCTGAACAA GCAGAACCGG 
AAGCTCTGTG CGGGAGCCTG TGTGCTGCTA GCGGCCAAGG TCGGAAGTGA CCTCAGAAAG 
CACGAGGTCA AGCACCTGAT TGACAAACTG GAAGAGAAGT TCCGACTGAA CAGACGAGAA 
CTGATTGCCT TTGAATTCCC AGTGTTAGTG GCCTTGGAGT TTGCACTTCA CCTGCCAGAG 
CACGAAGTCA TGCCCCACTA TAGACGCCTG ATCCAGAGCT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cables1 ( NM_022021.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_071304.2 Mus musculus CDK5 and Abl enzyme substrate 1 (Cables1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu19595
Clone ID Related Accession (Same CDS sequence)	NM_022021.2
Accession Version	NM_022021.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	CDK5 and ABL1 enzyme substrate 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC100751.6, CX213994.1, BQ917292.1, CX202925.1, CB205636.1 and CA751142.1. On Apr 4, 2009 this sequence version replaced NM_022021.1. Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. This difference results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF133208.1, AF328140.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGG CGACCGCCAC CGCGGGCACG GCCGCCTGCA GCAGCAGCAG CAGCAGTCGC 
GGCGGCAGCA CGGACGCCGC GGCCACCAGC GGGGTGCAGC CGCCGCCGCC TCCTCCGGCC 
ACCGCGCCGC CGGAACCTCT TCGTAAGCCG CGCATGGACC CGCGGCGCCG CCAGGCTGCC 
CTGTCCTTCC TCACCAACAT TTCTCTGGAC GGACGGCCTC CGCTGCAGGA CCACGAGTGG 
GGCGGCGGCG AGGAGGGCGG CGGGACCAAG CCCGGAGCAA GGGCTCGGCT CAGCCTGCTG 
GCCGCTGGCT GCAACGCGTT CTCGGCACCG GGCACCGCGG CCGCGCCGTG GACCGCCGGC 
TCGGGTTCCA GCCCTTGCCC GCTGCCGCCG TCTCTGGTCC CCCGGGTGTT GGGAGAGCCA 
TCTCAGCCGC CCCGTTCAGC TCCAGCTGTC ACCGGTGCTC AGCTGCAGTT GCCTGACGGG 
CCGGGAGGCG CCGGACAGGA GGAGCTGGAG GAGGACGATG CCTTCACCAA CGTGCAGGTG 
CCATCGGCCA GCTTTTTGGG CTCCGGGACC CCCGGGAGTA CGAGCGGCAG TCGGGGCCGC 
CTCAACTCGT TCACTCAGGG AATCCTGCCC ATCGCCTTCT CCAGGCAGAA CTCGCAGAAC 
TACTGCGCCT TGGAGCAGTC AGGCCAGGGC GGCAGCACCA GCGCCTTGGA GCAGCTGCAG 
AGGTCCAGAC GTCGCCTCAT CTCCCAGAGA TCATCTTTGG AGACCCTGGA AGATATTGAA 
GAGAATGCCC CTCTCCGGAG ATGTCGAACA CTCTCAGGTT CTCCCAGACC AAAGAATTTC 
AAGAAAATTC ATTTTATCAA GAATATGCGA CAGCACGATA CCAAGAATGG CAGGGACCTG 
AAGTTGGATG GAGGGAGGCA GTCAGCAGGG GCCATGAGCC TGAAGGAGAT CATTGGCCTT 
GAAGGTGTGG AACTGGGTGC CGATGGGAAG ACAGTGTCTT ATACCCAGTT TCTACTACCC 
ACAAATGCCT TTGGGAACCG TAGAAATACC ATAGACTCCA CCGCCTCCTT CTCCCAGTTT 
CGGAGCCTGA GCCACCGAAG CCTCTCCATG GGCCGGGCTG GCAGCACCCA GGGGAGCCTT 
GATGCAGGAA GTGACCTGGG AGACTTTATG GACTATGACC CAAACCTCCT GGATGACCCC 
CAGTGGCCTT GCGGCAAGCA CAAGCGAGTT CTGACCTTCC CTTCATACAT GACCACAGTG 
ATTGACTACG TGAAGCCCTC AGATCTCAAG AAGGACATGA ATGAAACCTT CAAGGAGAAG 
TTTCCTCACA TTAAATTAAC ACTCAGCAAA ATCAGGAGCC TGAAAAGAGA GATGCGGAAG 
CTTGCCCAGG AGGACTGTGG CTTTGAGGAG CCCACGGTGG CCATGGCCTT TGTCTACTTT 
GAGAAGCTGG CCCTCAGGGG GAAGCTGAAC AAGCAGAACC GGAAGCTCTG TGCGGGAGCC 
TGTGTGCTGC TAGCGGCCAA GGTCGGAAGT GACCTCAGAA AGCACGAGGT CAAGCACCTG 
ATTGACAAAC TGGAAGAGAA GTTCCGACTG AACAGACGAG AACTGATTGC CTTTGAATTC 
CCAGTGTTAG TGGCCTTGGA GTTTGCACTT CACCTGCCAG AGCACGAAGT CATGCCCCAC 
TATAGACGCC TGATCCAGAG CTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071304.2
CDS	533..2239
Translation	MAAATATAGTAACSSSSSSRGGSTDAAATSGVQPPPPPPATAPPEPLRKPRMDPRRRQAALSFLTNISLDGRPPLQDHEWGGGEEGGGTKPGARARLSLLAAGCNAFSAPGTAAAPWTAGSGSSPCPLPPSLVPRVLGEPSQPPRSAPAVTGAQLQLPDGPGGAGQEELEEDDAFTNVQVPSASFLGSGTPGSTSGSRGRLNSFTQGILPIAFSRQNSQNYCALEQSGQGGSTSALEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTKNGRDLKLDGGRQSAGAMSLKEIIGLEGVELGADGKTVSYTQFLLPTNAFGNRRNTIDSTASFSQFRSLSHRSLSMGRAGSTQGSLDAGSDLGDFMDYDPNLLDDPQWPCGKHKRVLTFPSYMTTVIDYVKPSDLKKDMNETFKEKFPHIKLTLSKIRSLKREMRKLAQEDCGFEEPTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHEVKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLIQSS

Target ORF information:

RefSeq Version	NM_022021.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus CDK5 and Abl enzyme substrate 1 (Cables1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022021.2

ORF Insert Sequence:

ATGGCGGCGG CGACCGCCAC CGCGGGCACG GCCGCCTGCA GCAGCAGCAG CAGCAGTCGC 
GGCGGCAGCA CGGACGCCGC GGCCACCAGC GGGGTGCAGC CGCCGCCGCC TCCTCCGGCC 
ACCGCGCCGC CGGAACCTCT TCGTAAGCCG CGCATGGACC CGCGGCGCCG CCAGGCTGCC 
CTGTCCTTCC TCACCAACAT TTCTCTGGAC GGACGGCCTC CGCTGCAGGA CCACGAGTGG 
GGCGGCGGCG AGGAGGGCGG CGGGACCAAG CCCGGAGCAA GGGCTCGGCT CAGCCTGCTG 
GCCGCTGGCT GCAACGCGTT CTCGGCACCG GGCACCGCGG CCGCGCCGTG GACCGCCGGC 
TCGGGTTCCA GCCCTTGCCC GCTGCCGCCG TCTCTGGTCC CCCGGGTGTT GGGAGAGCCA 
TCTCAGCCGC CCCGTTCAGC TCCAGCTGTC ACCGGTGCTC AGCTGCAGTT GCCTGACGGG 
CCGGGAGGCG CCGGACAGGA GGAGCTGGAG GAGGACGATG CCTTCACCAA CGTGCAGGTG 
CCATCGGCCA GCTTTTTGGG CTCCGGGACC CCCGGGAGTA CGAGCGGCAG TCGGGGCCGC 
CTCAACTCGT TCACTCAGGG AATCCTGCCC ATCGCCTTCT CCAGGCAGAA CTCGCAGAAC 
TACTGCGCCT TGGAGCAGTC AGGCCAGGGC GGCAGCACCA GCGCCTTGGA GCAGCTGCAG 
AGGTCCAGAC GTCGCCTCAT CTCCCAGAGA TCATCTTTGG AGACCCTGGA AGATATTGAA 
GAGAATGCCC CTCTCCGGAG ATGTCGAACA CTCTCAGGTT CTCCCAGACC AAAGAATTTC 
AAGAAAATTC ATTTTATCAA GAATATGCGA CAGCACGATA CCAAGAATGG CAGGGACCTG 
AAGTTGGATG GAGGGAGGCA GTCAGCAGGG GCCATGAGCC TGAAGGAGAT CATTGGCCTT 
GAAGGTGTGG AACTGGGTGC CGATGGGAAG ACAGTGTCTT ATACCCAGTT TCTACTACCC 
ACAAATGCCT TTGGGAACCG TAGAAATACC ATAGACTCCA CCGCCTCCTT CTCCCAGTTT 
CGGAGCCTGA GCCACCGAAG CCTCTCCATG GGCCGGGCTG GCAGCACCCA GGGGAGCCTT 
GATGCAGGAA GTGACCTGGG AGACTTTATG GACTATGACC CAAACCTCCT GGATGACCCC 
CAGTGGCCTT GCGGCAAGCA CAAGCGAGTT CTGACCTTCC CTTCATACAT GACCACAGTG 
ATTGACTACG TGAAGCCCTC AGATCTCAAG AAGGACATGA ATGAAACCTT CAAGGAGAAG 
TTTCCTCACA TTAAATTAAC ACTCAGCAAA ATCAGGAGCC TGAAAAGAGA GATGCGGAAG 
CTTGCCCAGG AGGACTGTGG CTTTGAGGAG CCCACGGTGG CCATGGCCTT TGTCTACTTT 
GAGAAGCTGG CCCTCAGGGG GAAGCTGAAC AAGCAGAACC GGAAGCTCTG TGCGGGAGCC 
TGTGTGCTGC TAGCGGCCAA GGTCGGAAGT GACCTCAGAA AGCACGAGGT CAAGCACCTG 
ATTGACAAAC TGGAAGAGAA GTTCCGACTG AACAGACGAG AACTGATTGC CTTTGAATTC 
CCAGTGTTAG TGGCCTTGGA GTTTGCACTT CACCTGCCAG AGCACGAAGT CATGCCCCAC 
TATAGACGCC TGATCCAGAG CTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Truncated Cables1 causes agenesis of the corpus callosum in mice.
Laboratory investigation; a journal of technical methods and pathology94(3)321-30(2014 Mar)
Mizuno S,Tra DT,Mizobuchi A,Iseki H,Mizuno-Iijima S,Kim JD,Ishida J,Matsuda Y,Kunita S,Fukamizu A,Sugiyama F,Yagami K

Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice.
Cancer biology & therapy14(7)672-8(2013 Jul)
Arnason T,Pino MS,Yilmaz O,Kirley SD,Rueda BR,Chung DC,Zukerberg LR

A novel locus on proximal chromosome 18 associated with agenesis of the corpus callosum in mice.
Mammalian genome : official journal of the International Mammalian Genome Society21(11-12)525-33(2010 Dec)
Mizuno S,Mizobuchi A,Iseki H,Iijima S,Matsuda Y,Kunita S,Sugiyama F,Yagami K

Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress.
EMBO reports11(8)633-9(2010 Aug)
Wang N,Guo L,Rueda BR,Tilly JL

Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female mice.
Cell cycle (Georgetown, Tex.)6(21)2678-84(2007 Nov)
Lee HJ,Sakamoto H,Luo H,Skaznik-Wikiel ME,Friel AM,Niikura T,Tilly JC,Niikura Y,Klein R,Styer AK,Zukerberg LR,Tilly JL,Rueda BR