Dact3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dact3
Entrez Gene ID	629378
Full Name	dishevelled-binding antagonist of beta-catenin 3
Synonyms	EG666671,naa-3
General protein information	Preferred Names dishevelled-binding antagonist of beta-catenin 3 Names dapper homolog 3 dact 3 dapper antagonist of catenin 3 dapper homolog 3, antagonist of beta-catenin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 A2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001081655.1	NP_001075124.1	dapper homolog 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	DACT3	NP_659493.2
Canis lupus familiaris (dog)	DACT3	XP_005616925.1
Bos taurus (cattle)	DACT3	XP_003587345.1
Mus musculus (house mouse)	Dact3	NP_001075124.1
Pan troglodytes (chimpanzee)	DACT3	XP_001151829.2
Rattus norvegicus (Norway rat)	Dact3	NP_001178876.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/?-catenin signaling.
Xue H, Xiao Z, Zhang J, Wen J, Wang Y, Chang Z, Zhao J, Gao X, Du J, Chen YG
The Journal of biological chemistry288(21)15006-14(2013 May)

All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.
Kivim?e S, Yang XY, Cheyette BN
BMC biochemistry1233(2011 Jun)

Dact1-3 mRNAs exhibit distinct expression domains during tooth development.
Kettunen P, Kivim?e S, Keshari P, Klein OD, Cheyette BN, Luukko K
Gene expression patterns : GEP10(2-3)140-3(2010 Feb-Mar)

Three Dact gene family members are expressed during embryonic development and in the adult brains of mice.
Fisher DA, Kivim?e S, Hoshino J, Suriben R, Martin PM, Baxter N, Cheyette BN
Developmental dynamics : an official publication of the American Association of Anatomists235(9)2620-30(2006 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dapper3 antagonizes the fibrotic actions of Wnt signaling in kidney.
Title: Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/?-catenin signaling.

conserved role for Dact3 protein in kinase-regulated biochemistry involving Vangl and Dvl.
Title: All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.

Dact3 may contribute to early tooth formation by modulation of Wnt signaling pathways in the mesenchyme, including preodontoblasts
Title: Dact1-3 mRNAs exhibit distinct expression domains during tooth development.

Dact3, not previously described in any organism, is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, and in the embryonic CNS
Title: Three Dact gene family members are expressed during embryonic development and in the adult brains of mice.

The following Dact3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dact3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01138	NM_001081655.1 Latest version!	Mus musculus dishevelled-binding antagonist of beta-catenin 3 (Dact3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dact3 ( NM_001081655.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001075124.1 Mus musculus dishevelled-binding antagonist of beta-catenin 3 (Dact3), mRNA.

Price & Availability↑

CloneID	OMu01138
Clone ID Related Accession (Same CDS sequence)	NM_001081655.1
Accession Version	NM_001081655.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1833bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	dapper homolog 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DQ832319.1 and AC148981.7. On or before Feb 24, 2007 this sequence version replaced XM_985316.1, XM_914665.2, XM_984413.1. ##Evidence-Data-START## Transcript exon combination :: DQ832319.1, AB073971.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGATCCGGG CCTTCTCGTT CCCGGTGAGC CCGGAGCGGG GTCGGCTGCG GGGATGGTTG 
GAAGGCAGCC TGGCCGGGCT CTGCGAGTTG CATTGGCTCC GAGAGAGGCA GGAGTACCGC 
GTGCAGCAGG CGCTGCGGCT GGCCCAGCCC GGGATGGGGG GCGCCGAGGC TGAGGACGAG 
GAGGACGCCG AGGAGGACGA GGATGCGGCA GCGGCGCGCA GGGCCGCAGC AGCCCTGGAG 
GAGCAGCTGG AGGCCCTGCC TGGGCTCATC TGGGACCTGG GCCAGCAGCT GGGAGACCTG 
AGTCTGGAGT CTGGTGGCCT GGACCAGGAG AGTGGGCGCA GCTCAGGCTT CTATGAAGAC 
CCCAGTTCTA CTGGAGGCCC AGATTCACCA CCCTCCACCT TCTGCGGGGA CAGTGGCTTC 
TCCGGATCTG GCTCCTATGG ACGCCTGGGT CCCTCGGACC CCCGGGGCAT CTATGCCAGT 
GAGAGACCCA AGTCCTTAGG CGACGCCAGT CCCAGCGCCC CAGAGTCGGT GGGTGCCCGG 
GTTGCAGTGC CTCGATCCTT CTCAGCTCCC TATCCGACGG CAGCAGCCGG AGCTGAGACC 
TGCTCATCCG CGGAACGGCG GGCTCGTGCC GGGCCCTTCC TGACACCTAG CCCACTGCAC 
GCGGTGGCTC TGCGCAGCCC AAGGCCAAGT GGACGCGTAC CGTGCGGCTC GCCGGACGGG 
GCGGCCAGCC GGCCCCTTGA CGGCTACATC TCGGCGCTCC TGCGCAGGCG CCGCCGCCGG 
GGGGCGGGCC AACCGCGCAC AAGTCCCGGG GGCGCGGACG GGGGCGCGCG GCGCCAGAAC 
GGCGCGCGCC CGCGGCCGCC TGAAGCGTCC CCGCCCCCCG GAGGCGCGCG ACCCGCGCGG 
GAACCGTCGA CAGAGCGCGC CTGGGCTGCG GCGTGGGAGG CGGAGGTTCC ACCCGAACCC 
GCGCCTCCGG CCGCCGCGTC GCCGCCCTCC AGTCCGGCAG AGGGCCGCCT CGTGAAGGCA 
CAGTACATCC CGGGCGCGCC CGCGGCCTCC AGGGGCCTCC CGGGCCGCGC CGCGCGCCGC 
CGGGCTCCGC CGCTTACGCG AGGTCGCAGT GTGGAGCAGT CCCCGCCAAG GGAACGGCCG 
CGCGCTGCGG GCCGTCGGGG CCGCCTGGCA GAGCCGTCGG GGCGTCGGGG ATCGCCGAGG 
GCGCGCAAAG CGGCGCGCTC GCAGTCTGAG ACCAGTCTAC TGGGCCGCGC GCACGCCGCT 
CCGCCACCCA AGTACCCCAC GGCCGAGCGA GACGAACCCC GACCGCCCCG GCCCCGTCGT 
GGCCCAGCGC CCACGCCGAC GGTCCAGGCC TGCCGTCGGT GGCGTTCCAC CGCTGAGATC 
GACGCACCGG ATGGCCGCCG CCCCCGAGCC CGCGTGCCCG CGCCACGAGG CCCCGCACCC 
TCGCCATCTG CGCCCCCGCG CCGGCTGTTG TACGGTTGCG CAGGCAGCGA CTCCGAGTGC 
TCAGCGGTAG GGCGGCCGGT GCCGCTCGGC CGTCGGATGC CGTCTGGATG CGCTCCAGGA 
GGCTATGGCG AAAGCGAGTC GAGCGCCAGC GAGGGCGAGT CGCCCGCCTT CAGCTCTGCC 
TCTAGCGACT CCGACGGCAG CGGAGGCCTC GTGTGGCCGC AGCAACTGGT GGCGGCCGCC 
GGGGCCTCGC CGTCGGGGCC CGGGGGTGCT GCTGGTGGAG GGACGCCTGC GGGCCCCGCC 
AAGGTCTTCG TGAAGATCAA GGCATCGCAC GCGCTGAAGA AAAAGATCCT TCGTTTTCGG 
TCGGGTTCTC TGAAGGTCAT GACGACTGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001075124.1
CDS	109..1941
Translation	MIRAFSFPVSPERGRLRGWLEGSLAGLCELHWLRERQEYRVQQALRLAQPGMGGAEAEDEEDAEEDEDAAAARRAAAALEEQLEALPGLIWDLGQQLGDLSLESGGLDQESGRSSGFYEDPSSTGGPDSPPSTFCGDSGFSGSGSYGRLGPSDPRGIYASERPKSLGDASPSAPESVGARVAVPRSFSAPYPTAAAGAETCSSAERRARAGPFLTPSPLHAVALRSPRPSGRVPCGSPDGAASRPLDGYISALLRRRRRRGAGQPRTSPGGADGGARRQNGARPRPPEASPPPGGARPAREPSTERAWAAAWEAEVPPEPAPPAAASPPSSPAEGRLVKAQYIPGAPAASRGLPGRAARRRAPPLTRGRSVEQSPPRERPRAAGRRGRLAEPSGRRGSPRARKAARSQSETSLLGRAHAAPPPKYPTAERDEPRPPRPRRGPAPTPTVQACRRWRSTAEIDAPDGRRPRARVPAPRGPAPSPSAPPRRLLYGCAGSDSECSAVGRPVPLGRRMPSGCAPGGYGESESSASEGESPAFSSASSDSDGSGGLVWPQQLVAAAGASPSGPGGAAGGGTPAGPAKVFVKIKASHALKKKILRFRSGSLKVMTTV

Target ORF information:

RefSeq Version	NM_001081655.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dishevelled-binding antagonist of beta-catenin 3 (Dact3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001081655.1

ORF Insert Sequence:

ATGATCCGGG CCTTCTCGTT CCCGGTGAGC CCGGAGCGGG GTCGGCTGCG GGGATGGTTG 
GAAGGCAGCC TGGCCGGGCT CTGCGAGTTG CATTGGCTCC GAGAGAGGCA GGAGTACCGC 
GTGCAGCAGG CGCTGCGGCT GGCCCAGCCC GGGATGGGGG GCGCCGAGGC TGAGGACGAG 
GAGGACGCCG AGGAGGACGA GGATGCGGCA GCGGCGCGCA GGGCCGCAGC AGCCCTGGAG 
GAGCAGCTGG AGGCCCTGCC TGGGCTCATC TGGGACCTGG GCCAGCAGCT GGGAGACCTG 
AGTCTGGAGT CTGGTGGCCT GGACCAGGAG AGTGGGCGCA GCTCAGGCTT CTATGAAGAC 
CCCAGTTCTA CTGGAGGCCC AGATTCACCA CCCTCCACCT TCTGCGGGGA CAGTGGCTTC 
TCCGGATCTG GCTCCTATGG ACGCCTGGGT CCCTCGGACC CCCGGGGCAT CTATGCCAGT 
GAGAGACCCA AGTCCTTAGG CGACGCCAGT CCCAGCGCCC CAGAGTCGGT GGGTGCCCGG 
GTTGCAGTGC CTCGATCCTT CTCAGCTCCC TATCCGACGG CAGCAGCCGG AGCTGAGACC 
TGCTCATCCG CGGAACGGCG GGCTCGTGCC GGGCCCTTCC TGACACCTAG CCCACTGCAC 
GCGGTGGCTC TGCGCAGCCC AAGGCCAAGT GGACGCGTAC CGTGCGGCTC GCCGGACGGG 
GCGGCCAGCC GGCCCCTTGA CGGCTACATC TCGGCGCTCC TGCGCAGGCG CCGCCGCCGG 
GGGGCGGGCC AACCGCGCAC AAGTCCCGGG GGCGCGGACG GGGGCGCGCG GCGCCAGAAC 
GGCGCGCGCC CGCGGCCGCC TGAAGCGTCC CCGCCCCCCG GAGGCGCGCG ACCCGCGCGG 
GAACCGTCGA CAGAGCGCGC CTGGGCTGCG GCGTGGGAGG CGGAGGTTCC ACCCGAACCC 
GCGCCTCCGG CCGCCGCGTC GCCGCCCTCC AGTCCGGCAG AGGGCCGCCT CGTGAAGGCA 
CAGTACATCC CGGGCGCGCC CGCGGCCTCC AGGGGCCTCC CGGGCCGCGC CGCGCGCCGC 
CGGGCTCCGC CGCTTACGCG AGGTCGCAGT GTGGAGCAGT CCCCGCCAAG GGAACGGCCG 
CGCGCTGCGG GCCGTCGGGG CCGCCTGGCA GAGCCGTCGG GGCGTCGGGG ATCGCCGAGG 
GCGCGCAAAG CGGCGCGCTC GCAGTCTGAG ACCAGTCTAC TGGGCCGCGC GCACGCCGCT 
CCGCCACCCA AGTACCCCAC GGCCGAGCGA GACGAACCCC GACCGCCCCG GCCCCGTCGT 
GGCCCAGCGC CCACGCCGAC GGTCCAGGCC TGCCGTCGGT GGCGTTCCAC CGCTGAGATC 
GACGCACCGG ATGGCCGCCG CCCCCGAGCC CGCGTGCCCG CGCCACGAGG CCCCGCACCC 
TCGCCATCTG CGCCCCCGCG CCGGCTGTTG TACGGTTGCG CAGGCAGCGA CTCCGAGTGC 
TCAGCGGTAG GGCGGCCGGT GCCGCTCGGC CGTCGGATGC CGTCTGGATG CGCTCCAGGA 
GGCTATGGCG AAAGCGAGTC GAGCGCCAGC GAGGGCGAGT CGCCCGCCTT CAGCTCTGCC 
TCTAGCGACT CCGACGGCAG CGGAGGCCTC GTGTGGCCGC AGCAACTGGT GGCGGCCGCC 
GGGGCCTCGC CGTCGGGGCC CGGGGGTGCT GCTGGTGGAG GGACGCCTGC GGGCCCCGCC 
AAGGTCTTCG TGAAGATCAA GGCATCGCAC GCGCTGAAGA AAAAGATCCT TCGTTTTCGG 
TCGGGTTCTC TGAAGGTCAT GACGACTGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/?-catenin signaling.
The Journal of biological chemistry288(21)15006-14(2013 May)
Xue H,Xiao Z,Zhang J,Wen J,Wang Y,Chang Z,Zhao J,Gao X,Du J,Chen YG

All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.
BMC biochemistry1233(2011 Jun)
Kivim?e S,Yang XY,Cheyette BN

Dact1-3 mRNAs exhibit distinct expression domains during tooth development.
Gene expression patterns : GEP10(2-3)140-3(2010 Feb-Mar)
Kettunen P,Kivim?e S,Keshari P,Klein OD,Cheyette BN,Luukko K

Three Dact gene family members are expressed during embryonic development and in the adult brains of mice.
Developmental dynamics : an official publication of the American Association of Anatomists235(9)2620-30(2006 Sep)
Fisher DA,Kivim?e S,Hoshino J,Suriben R,Martin PM,Baxter N,Cheyette BN

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Dact3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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