Mapk8ip2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mapk8ip2
Entrez Gene ID	60597
Full Name	mitogen-activated protein kinase 8 interacting protein 2
Synonyms	3230402N03Rik,AI847694,AW049958,IB2,Jip2,R75148
General protein information	Preferred Names mitogen-activated protein kinase 8 interacting protein 2 Names C-Jun-amino-terminal kinase-interacting protein 2 IB-2 JIP-2 JNK MAP kinase scaffold protein 2 JNK-interacting protein 2 islet-brain-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_021921.3	NP_068740.3	C-Jun-amino-terminal kinase-interacting protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MAPK8IP2	XP_538304.2
Danio rerio (zebrafish)	mapk8ip2	XP_685086.6
Pan troglodytes (chimpanzee)	MAPK8IP2	XP_001142967.1
Mus musculus (house mouse)	Mapk8ip2	NP_068740.3
Rattus norvegicus (Norway rat)	Mapk8ip2	XP_235565.5
Homo sapiens (human)	MAPK8IP2	NP_036456.1
Xenopus tropicalis (tropical clawed frog)	mapk8ip2	NP_001090670.1
Bos taurus (cattle)	MAPK8IP2	NP_001180128.1

Gene Ontology
Bibliography

Related articles in PubMed

Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.
Osipovich AB, Long Q, Manduchi E, Gangula R, Hipkens SB, Schneider J, Okubo T, Stoeckert CJ Jr, Takada S, Magnuson MA
Development (Cambridge, England)141(15)2939-49(2014 Aug)

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity.
Ghosh AS, Wang B, Pozniak CD, Chen M, Watts RJ, Lewcock JW
The Journal of cell biology194(5)751-64(2011 Sep)

Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2.
Giza J, Urbanski MJ, Prestori F, Bandyopadhyay B, Yam A, Friedrich V, Kelley K, D'Angelo E, Goldfarb M
The Journal of neuroscience : the official journal of the Society for Neuroscience30(44)14805-16(2010 Nov)

Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain.
ElAli A, Hermann DM
Science signaling3(142)ra72(2010 Oct)

Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.
Standen CL, Kennedy NJ, Flavell RA, Davis RJ
Molecular and cellular biology29(17)4831-40(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data demonstrate that JIP-2 and -2 proteins can influence insulin-stimulated signal transduction mediated by insulin receptor substrate proteins.
Title: Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.

JIP scaffold proteins are critically required for normal NMDA receptor function.
Title: Requirement of JIP scaffold proteins for NMDA-mediated signal transduction.

there is a signaling module in which IB2 scaffolds a MLK3/MKK/p38delta kinase cascade.
Title: Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase.

JIP2 does not influence the processing of APP, although it is known that both JIP1b and JIP2 equally regulate the JNK signaling cascade
Title: Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism.

The following Mapk8ip2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mapk8ip2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12550	NM_021921.3 Latest version!	Mus musculus mitogen-activated protein kinase 8 interacting protein 2 (Mapk8ip2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$489.30 $699.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mapk8ip2 ( NM_021921.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_068740.3 Mus musculus mitogen-activated protein kinase 8 interacting protein 2 (Mapk8ip2), mRNA.

Price & Availability↑

CloneID	OMu12550
Clone ID Related Accession (Same CDS sequence)	NM_021921.3
Accession Version	NM_021921.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2493bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	C-Jun-amino-terminal kinase-interacting protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC137513.3, CA317486.1, AK158968.1 and BC029704.1. On Sep 2, 2009 this sequence version replaced NM_021921.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC029704.1, AK158968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849379, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGATC GCGCGGAGAT GTTTTCTCTC TCCACCTTTC ACTCGCTGTC GCCTCCCGGC 
TGCAGGCCTC CCCAGGACAT AAGCCTGGAA GAATTTGATG ATGAAGACCT GTCTGAGATC 
ACGGACGACT GTGGCCTGGG CCTTAGCTAC GACTCGGACC ACTGTGAGAA GGACAGTCTC 
TCTCTGGGCC GCTCGGAGCA GCCACACCCT ATTTGTTCCT TCCAAGATGA TTTCCAGGAG 
TTTGAGATGA TCGACGACAA CGAGGAGGAG GACGATGAGG AGGAGGAGGA AGAGGAGGAA 
GAGGAGGAAG ATGGAGATAG GCAGGGCAAA GCAGGGGGAG GGCCTGGTTC ACAGGCACTT 
GCTGGAGACT CCCTTATTCC CTCTCCTTCC CTAGAAGAGT CCCACAAGCT CCGACCCACC 
ACTCTCCATC TGACTACACT TGGAGCACAG GACTCTCTGA ATAACAACAA CGGAGGCTTT 
ACCTCTGCAC CCCCATCCTC CTGGCAGGAG ACTGTGCTGC GTTCGCCAGC CCAGGAGCCC 
CTTAAAGAGC TACCAGCCCC TCTCCTGCCA GCAGAAGAGG AGCGCCATGA AGTACAGTCC 
CTTGCACGCC CTGGTTGTGA CTGTGAAGGG AACCAGCCCC CAGAGCCACC AGCATCATCA 
GGTGGGGCCT CCCCTTCCTC GGATCCTGGT ATTGAGGCTG ACTTGAGAAG CCACTCTAGT 
GGAGGCCACG AGGGTCGGCG AAGCAGTCAG GAGCTCTCAT CACCAGGCTC GGACTCTGAG 
GATGCAGGCG GCGCTCGCCT AGGGCGCATG ATCTCGTCCA TTTCGGAGAC AGAGCTGGAA 
CTTAGCAGCG ACGGTGGCAG CAGCAGTGGC CGCTCATCAC ATCTCACCAA CTCCATCGAG 
GAGGCTTCGT CCCCAGCCTC GGAGCCTGAG CCGGAGCCCG AGCCACTACA TGAACCTCCC 
CGCCGCCCTG CCTTCCTGCC TGTGGGCCAG GATGACACCA ACAGCGAATA CGAGTCGGGC 
TCTGAGTCTG AGCCTGACCT GAGCGAGGAT GCTGACTCTC CCTGGCTGCT CAGCAACCTG 
GTGAGCCGCA TGATCTCTGA GGGCTCCTCG CCCATTCGTT GCCCTGGCCA GTGCTTATCT 
CCTGCCCCAC GCCTGCCAGA AGAGGCTGCG TCACAGGCCA ACTCGGTACC CCAGGACTGC 
CAAGACCCTG AGGCAGGGCC CCACGTGGAG TTGGTGGACA TGGACACTCT TTGCGGGCCA 
CCTCCGCCGG CGCCTGCCGC ACCTCGGCTT GGTCCCGCGC AGCCTGGGCC CTGCCTTTTC 
CTTAGTAACC CAACACGGGA TACCATCACC CCGCTTTGGG CCACACCGGG ACGCACTGCC 
CGCCCTGGCC GCTCCTGCTC TGCTGCCTGC TCGGAGGAGG AGGAGGAGGA TGAGGAAGAG 
GACGAGGAGG ATGAGGAGGA TGCGGAGGAC AGCGTGGTTC CCCCTGGCTC CAGGACTACA 
GGCTCTACTG CGCCGCTGGA TGCCTCGCTG GTGTACGATG CAGTTAAATA CACACTAGTG 
GTGGATGAGC ACACGCAGCT AGAGCTGGTG AGCCTGCGGC GCTGCGCAGG CCTGGGCAAC 
GACAGTGAAG AGGACAGCAG CTGCGAGGCC AGTGAGGAAG AGGCGGGAGC TACGTTACTA 
GGCAGTGACC AGGTGCCAGA GGATGCTTCT CCTGACAGTC CCGACCTCAC CTTCTCCAAG 
AAGTTCCTCA ATGTCTTTGT CAACAGCACG TCTCGATCCT CCAGCACTGA GTCCTTTGGT 
CTTTTTTCCT GTGTGGTGAA TGGGGAGGAG AGAGAGCAAA CGCACCGGGC TGTCTTCAGG 
TTCATCCCTC GACATCCGGA TGAGCTAGAA CTCGATGTGG ATGACCCTGT GCTGGTGGAA 
GCAGAAGAGG ATGACTTTTG GTTTCGTGGC TTCAACATGC GCACCGGCGA GCGTGGAGTG 
TTCCCTGCCT TCTATGCCCA TGCGGTACCG GGTCCTGCCA AGGACCTGCT GGGGAGCAAG 
CGGAGCCCGT GCTGGGTGGA TCGCTTCGAT GTGCAGTTCT TGGGCTCCGT GGAGGTACCG 
TGTCACCAGG GCAATGGGAT CCTGTGTGCA GCCATGCAAA AGATTGCCAC AGCCCGGAAA 
CTAACGGTCC ACCTGCGCCC TCCTGCCTCT TGTGACCTTG AGATCTCTCT GCGGGGGGTC 
AAGCTGAGTC TCAGTGGAGG AGGACCTGAG TTCCAGCGCT GCAGCCACTT CTTCCAGATG 
AAGAACATCT CATTCTGTGG CTGTCATCCC CGAAACAGCT GCTATTTTGG CTTCATCACC 
AAACACCCGC TGCTAAGCCG CTTTGCCTGC CACGTCTTTG TGTCCCAGGA GTCTATGAGA 
CCAGTGGCGC GGAGTGTGGG CCGGGCCTTC CTGGAGTACT ACCAGGAGCA CCTGGCGTTT 
GCCTGCCCTA CAGAGGATAT CTACCTGGAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068740.3
CDS	311..2803
Translation	MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSLSLGRSEQPHPICSFQDDFQEFEMIDDNEEEDDEEEEEEEEEEEDGDRQGKAGGGPGSQALAGDSLIPSPSLEESHKLRPTTLHLTTLGAQDSLNNNNGGFTSAPPSSWQETVLRSPAQEPLKELPAPLLPAEEERHEVQSLARPGCDCEGNQPPEPPASSGGASPSSDPGIEADLRSHSSGGHEGRRSSQELSSPGSDSEDAGGARLGRMISSISETELELSSDGGSSSGRSSHLTNSIEEASSPASEPEPEPEPLHEPPRRPAFLPVGQDDTNSEYESGSESEPDLSEDADSPWLLSNLVSRMISEGSSPIRCPGQCLSPAPRLPEEAASQANSVPQDCQDPEAGPHVELVDMDTLCGPPPPAPAAPRLGPAQPGPCLFLSNPTRDTITPLWATPGRTARPGRSCSAACSEEEEEDEEEDEEDEEDAEDSVVPPGSRTTGSTAPLDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLGNDSEEDSSCEASEEEAGATLLGSDQVPEDASPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCVVNGEEREQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDLLGSKRSPCWVDRFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCDLEISLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVFVSQESMRPVARSVGRAFLEYYQEHLAFACPTEDIYLE

Target ORF information:

RefSeq Version	NM_021921.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitogen-activated protein kinase 8 interacting protein 2 (Mapk8ip2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021921.3

ORF Insert Sequence:

ATGGCGGATC GCGCGGAGAT GTTTTCTCTC TCCACCTTTC ACTCGCTGTC GCCTCCCGGC 
TGCAGGCCTC CCCAGGACAT AAGCCTGGAA GAATTTGATG ATGAAGACCT GTCTGAGATC 
ACGGACGACT GTGGCCTGGG CCTTAGCTAC GACTCGGACC ACTGTGAGAA GGACAGTCTC 
TCTCTGGGCC GCTCGGAGCA GCCACACCCT ATTTGTTCCT TCCAAGATGA TTTCCAGGAG 
TTTGAGATGA TCGACGACAA CGAGGAGGAG GACGATGAGG AGGAGGAGGA AGAGGAGGAA 
GAGGAGGAAG ATGGAGATAG GCAGGGCAAA GCAGGGGGAG GGCCTGGTTC ACAGGCACTT 
GCTGGAGACT CCCTTATTCC CTCTCCTTCC CTAGAAGAGT CCCACAAGCT CCGACCCACC 
ACTCTCCATC TGACTACACT TGGAGCACAG GACTCTCTGA ATAACAACAA CGGAGGCTTT 
ACCTCTGCAC CCCCATCCTC CTGGCAGGAG ACTGTGCTGC GTTCGCCAGC CCAGGAGCCC 
CTTAAAGAGC TACCAGCCCC TCTCCTGCCA GCAGAAGAGG AGCGCCATGA AGTACAGTCC 
CTTGCACGCC CTGGTTGTGA CTGTGAAGGG AACCAGCCCC CAGAGCCACC AGCATCATCA 
GGTGGGGCCT CCCCTTCCTC GGATCCTGGT ATTGAGGCTG ACTTGAGAAG CCACTCTAGT 
GGAGGCCACG AGGGTCGGCG AAGCAGTCAG GAGCTCTCAT CACCAGGCTC GGACTCTGAG 
GATGCAGGCG GCGCTCGCCT AGGGCGCATG ATCTCGTCCA TTTCGGAGAC AGAGCTGGAA 
CTTAGCAGCG ACGGTGGCAG CAGCAGTGGC CGCTCATCAC ATCTCACCAA CTCCATCGAG 
GAGGCTTCGT CCCCAGCCTC GGAGCCTGAG CCGGAGCCCG AGCCACTACA TGAACCTCCC 
CGCCGCCCTG CCTTCCTGCC TGTGGGCCAG GATGACACCA ACAGCGAATA CGAGTCGGGC 
TCTGAGTCTG AGCCTGACCT GAGCGAGGAT GCTGACTCTC CCTGGCTGCT CAGCAACCTG 
GTGAGCCGCA TGATCTCTGA GGGCTCCTCG CCCATTCGTT GCCCTGGCCA GTGCTTATCT 
CCTGCCCCAC GCCTGCCAGA AGAGGCTGCG TCACAGGCCA ACTCGGTACC CCAGGACTGC 
CAAGACCCTG AGGCAGGGCC CCACGTGGAG TTGGTGGACA TGGACACTCT TTGCGGGCCA 
CCTCCGCCGG CGCCTGCCGC ACCTCGGCTT GGTCCCGCGC AGCCTGGGCC CTGCCTTTTC 
CTTAGTAACC CAACACGGGA TACCATCACC CCGCTTTGGG CCACACCGGG ACGCACTGCC 
CGCCCTGGCC GCTCCTGCTC TGCTGCCTGC TCGGAGGAGG AGGAGGAGGA TGAGGAAGAG 
GACGAGGAGG ATGAGGAGGA TGCGGAGGAC AGCGTGGTTC CCCCTGGCTC CAGGACTACA 
GGCTCTACTG CGCCGCTGGA TGCCTCGCTG GTGTACGATG CAGTTAAATA CACACTAGTG 
GTGGATGAGC ACACGCAGCT AGAGCTGGTG AGCCTGCGGC GCTGCGCAGG CCTGGGCAAC 
GACAGTGAAG AGGACAGCAG CTGCGAGGCC AGTGAGGAAG AGGCGGGAGC TACGTTACTA 
GGCAGTGACC AGGTGCCAGA GGATGCTTCT CCTGACAGTC CCGACCTCAC CTTCTCCAAG 
AAGTTCCTCA ATGTCTTTGT CAACAGCACG TCTCGATCCT CCAGCACTGA GTCCTTTGGT 
CTTTTTTCCT GTGTGGTGAA TGGGGAGGAG AGAGAGCAAA CGCACCGGGC TGTCTTCAGG 
TTCATCCCTC GACATCCGGA TGAGCTAGAA CTCGATGTGG ATGACCCTGT GCTGGTGGAA 
GCAGAAGAGG ATGACTTTTG GTTTCGTGGC TTCAACATGC GCACCGGCGA GCGTGGAGTG 
TTCCCTGCCT TCTATGCCCA TGCGGTACCG GGTCCTGCCA AGGACCTGCT GGGGAGCAAG 
CGGAGCCCGT GCTGGGTGGA TCGCTTCGAT GTGCAGTTCT TGGGCTCCGT GGAGGTACCG 
TGTCACCAGG GCAATGGGAT CCTGTGTGCA GCCATGCAAA AGATTGCCAC AGCCCGGAAA 
CTAACGGTCC ACCTGCGCCC TCCTGCCTCT TGTGACCTTG AGATCTCTCT GCGGGGGGTC 
AAGCTGAGTC TCAGTGGAGG AGGACCTGAG TTCCAGCGCT GCAGCCACTT CTTCCAGATG 
AAGAACATCT CATTCTGTGG CTGTCATCCC CGAAACAGCT GCTATTTTGG CTTCATCACC 
AAACACCCGC TGCTAAGCCG CTTTGCCTGC CACGTCTTTG TGTCCCAGGA GTCTATGAGA 
CCAGTGGCGC GGAGTGTGGG CCGGGCCTTC CTGGAGTACT ACCAGGAGCA CCTGGCGTTT 
GCCTGCCCTA CAGAGGATAT CTACCTGGAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.
Development (Cambridge, England)141(15)2939-49(2014 Aug)
Osipovich AB,Long Q,Manduchi E,Gangula R,Hipkens SB,Schneider J,Okubo T,Stoeckert CJ Jr,Takada S,Magnuson MA

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity.
The Journal of cell biology194(5)751-64(2011 Sep)
Ghosh AS,Wang B,Pozniak CD,Chen M,Watts RJ,Lewcock JW

Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2.
The Journal of neuroscience : the official journal of the Society for Neuroscience30(44)14805-16(2010 Nov)
Giza J,Urbanski MJ,Prestori F,Bandyopadhyay B,Yam A,Friedrich V,Kelley K,D'Angelo E,Goldfarb M

Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain.
Science signaling3(142)ra72(2010 Oct)
ElAli A,Hermann DM

Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.
Molecular and cellular biology29(17)4831-40(2009 Sep)
Standen CL,Kennedy NJ,Flavell RA,Davis RJ