Pmaip1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pmaip1
Entrez Gene ID	58801
Full Name	phorbol-12-myristate-13-acetate-induced protein 1
Synonyms	Noxa
General protein information	Preferred Names phorbol-12-myristate-13-acetate-induced protein 1 Names phorbol-12-myristate-13-acetate-induced protein 1 protein Noxa
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_021451.2	NP_067426.1	phorbol-12-myristate-13-acetate-induced protein 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Pmaip1	NP_001008386.1
Mus musculus (house mouse)	Pmaip1	NP_067426.1

Gene Ontology
Bibliography

Related articles in PubMed

The miR-183/ItgA3 axis is a key regulator of prosensory area during early inner ear development.
Van den Ackerveken P, Mounier A, Huyghe A, Sacheli R, Vanlerberghe PB, Volvert ML, Delacroix L, Nguyen L, Malgrange B
Cell death and differentiation24(12)2054-2065(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Noxa is involved in X-ray-induced lung injury.
Title: Pro-apoptotic Noxa is involved in ablative focal irradiation-induced lung injury.

In vivo upregulation of noxa was reduced by pifithrin-alpha, suggesting transcription may be partly p53-dependent.The present findings indicate Noxa does not serve as a proapoptotic BH3-only protein during seizure-induced neuronal death in vivo
Title: Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice.

knockdown of pmaip1 mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment.
Title: Plant Homeo Domain Finger Protein 8 Regulates Mesodermal and Cardiac Differentiation of Embryonic Stem Cells Through Mediating the Histone Demethylation of pmaip1.

Fluorizoline bind to prohibitin, inducing mitochondrial apoptotic pathway through NOXA and BIM upregulation.
Title: A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation.

In addition, studies in leukemia Jurkat T cells support the existence of the Sall2/Noxa axis, and the significance of this axis on the apoptotic response to doxorubicin in cancer cells.
Title: Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin.

The following Pmaip1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pmaip1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20604	NM_021451.2 Latest version!	Mus musculus phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pmaip1 ( NM_021451.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067426.1 Mus musculus phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1), mRNA.

Price & Availability↑

CloneID	OMu20604
Clone ID Related Accession (Same CDS sequence)	NM_021451.2
Accession Version	NM_021451.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	phorbol-12-myristate-13-acetate-induced protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC100212.8. On Nov 17, 2006 this sequence version replaced NM_021451.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB041230.1, AK169914.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCCCGGGA GAAAGGCGCG TCGGAACGCG CCAGTGAACC CAACGCGGGC AGAGCTACCA 
CCTGAGTTCG CAGCTCAACT CAGGAAGATC GGAGACAAAG TGTATTGCAC GTGGAGTGCA 
CCGGACATAA CTGTGGTTCT GGCGCAGATG CCTGGGAAGT CGCAAAAGAG CAGGATGAGG 
AGCCCAAGCC CAACCCGGGT GCCAGCAGAC TTGAAGGACG AGTGTGCTCA ACTCCGGAGG 
ATTGGAGACA AAGTGAATTT ACGGCAGAAA CTTCTGAATT TGATTTCCAA GCTCTTCAAT 
TTAGTAACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067426.1
CDS	158..469
Translation	MPGRKARRNAPVNPTRAELPPEFAAQLRKIGDKVYCTWSAPDITVVLAQMPGKSQKSRMRSPSPTRVPADLKDECAQLRRIGDKVNLRQKLLNLISKLFNLVT

Target ORF information:

RefSeq Version	NM_021451.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021451.2

ORF Insert Sequence:

ATGCCCGGGA GAAAGGCGCG TCGGAACGCG CCAGTGAACC CAACGCGGGC AGAGCTACCA 
CCTGAGTTCG CAGCTCAACT CAGGAAGATC GGAGACAAAG TGTATTGCAC GTGGAGTGCA 
CCGGACATAA CTGTGGTTCT GGCGCAGATG CCTGGGAAGT CGCAAAAGAG CAGGATGAGG 
AGCCCAAGCC CAACCCGGGT GCCAGCAGAC TTGAAGGACG AGTGTGCTCA ACTCCGGAGG 
ATTGGAGACA AAGTGAATTT ACGGCAGAAA CTTCTGAATT TGATTTCCAA GCTCTTCAAT 
TTAGTAACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The miR-183/ItgA3 axis is a key regulator of prosensory area during early inner ear development.
Cell death and differentiation24(12)2054-2065(2017 Dec)
Van den Ackerveken P,Mounier A,Huyghe A,Sacheli R,Vanlerberghe PB,Volvert ML,Delacroix L,Nguyen L,Malgrange B

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Pmaip1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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