Gabarapl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gabarapl1
Entrez Gene ID	57436
Full Name	gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
Synonyms	3110025G09Rik,9130422N19Rik,AI196471,Apg8l,Atg8l,GECI,MNCb-0091
General protein information	Preferred Names gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 Names gamma-aminobutyric acid receptor-associated protein-like 1 GABA(A) receptor-associated protein like 1 GEC-1 glandular epithelial cell protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_020590.4	NP_065615.1	gamma-aminobutyric acid receptor-associated protein-like 1

Pathways from BioSystems

Homologies

	GABARAPL1	XP_001115102.1
Canis lupus familiaris (dog)	GABARAPL1	XP_005637218.1
Caenorhabditis elegans (roundworm)	lgg-1	NP_495277.1
Eremothecium gossypii	AGOS_AER396W	NP_985251.1
Homo sapiens (human)	GABARAPL1	NP_113600.1
Drosophila melanogaster (fruit fly)	Atg8a	NP_727447.1
Kluyveromyces lactis	KLLA0E20593g	XP_454881.1
Bos taurus (cattle)	GABARAPL1	NP_001028788.1
Mus musculus (house mouse)	Gabarapl1	NP_065615.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002685	XP_312238.3
Saccharomyces cerevisiae (baker's yeast)	ATG8	NP_009475.1
Schizosaccharomyces pombe (fission yeast)	atg8	NP_596531.1
Neurospora crassa	NCU01545	XP_956248.1
Arabidopsis thaliana (thale cress)	ATG8D	NP_178631.1
Pan troglodytes (chimpanzee)	GABARAPL1	XP_001146214.1
Rattus norvegicus (Norway rat)	Gabarapl1	NP_001037759.1
Gallus gallus (chicken)	GABARAPL1	XP_001231888.1
Danio rerio (zebrafish)	LOC793200	XP_003199067.2
Magnaporthe oryzae (rice blast fungus)	MGG_01062	XP_003717877.1
Xenopus tropicalis (tropical clawed frog)	gabarapl1	NP_001025652.1

Gene Ontology
Bibliography

Related articles in PubMed

Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, Yamamoto M
Nature immunology18(8)899-910(2017 Aug)

Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1.
Le Grand JN, Bon K, Fraichard A, Zhang J, Jouvenot M, Risold PY, Boyer-Guittaut M, Delage-Mourroux R
PloS one8(5)e63133(2013)

Identification of neuroglobin-interacting proteins using yeast two-hybrid screening.
Yu Z, Liu N, Wang Y, Li X, Wang X
Neuroscience20099-105(2012 Jan)

GABARAPL1 negatively regulates Wnt/?-catenin signaling by mediating Dvl2 degradation through the autophagy pathway.
Zhang Y, Wang F, Han L, Wu Y, Li S, Yang X, Wang Y, Ren F, Zhai Y, Wang D, Jia B, Xia Y, Chang Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology27(5)503-12(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cells that lacked GABARAPs and mice that lacked Gate-16 alone were defective in the IFN-gamma-induced clearance of vacuolar pathogens such as Toxoplasma. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases.
Title: Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.

study of cerebral GABARAPL1 protein expression provides insight into its role in the development and homeostasis of the mouse brain
Title: Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1.

analysis of specific functions of GABARAPL1 [review]
Title: GABARAPL1 (GEC1): original or copycat?

because of its stronger binding for hKOPR, GEC1 is able to be recruited by hKOPR sufficiently without membrane association via its C-terminal modification; however, du GABARAP appears to require C-terminal modifications to enhance KOPR expression.
Title: Effects of C-terminal modifications of GEC1 protein and gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein (GABARAP), two microtubule-associated proteins, on kappa opioid receptor expression.

GABARAPL1 negatively regulates Wnt/beta-catenin signaling by mediating Dvl2 degradation through the autophagy pathway.
Title: GABARAPL1 negatively regulates Wnt/?-catenin signaling by mediating Dvl2 degradation through the autophagy pathway.

The following Gabarapl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gabarapl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12104	NM_020590.4 Latest version!	Mus musculus gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 (Gabarapl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gabarapl1 ( NM_020590.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_065615.1 Mus musculus gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 (Gabarapl1), mRNA.

Price & Availability↑

CloneID	OMu12104
Clone ID Related Accession (Same CDS sequence)	NM_020590.4
Accession Version	NM_020590.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-20
Organism	Mus musculus(house mouse)
Product	gamma-aminobutyric acid receptor-associated protein-like 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK018687.1. On Apr 5, 2007 this sequence version replaced NM_020590.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024706.1, AK018687.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAAGTTCC AGTATAAGGA GGACCACCCC TTCGAGTATC GGAAAAAGGA AGGTGAAAAG 
ATTAGGAAGA AATACCCGGA CCGGGTGCCG GTCATCGTGG AGAAGGCTCC TAAAGCCAGG 
GTCCCTGATC TGGATAAGAG GAAGTACCTT GTGCCCTCCG ACCTCACTGT TGGCCAGTTC 
TACTTCTTAA TCCGGAAGAG GATCCACCTG AGACCTGAGG ACGCCTTATT CTTCTTTGTC 
AACAACACCA TCCCTCCCAC CAGTGCTACC ATGGGCCAGC TGTATGAGGA CAACCACGAG 
GAAGACTATT TTCTGTATGT GGCCTACAGT GATGAAAGTG TCTATGGAAA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065615.1
CDS	256..609
Translation	MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGK

Target ORF information:

RefSeq Version	NM_020590.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 (Gabarapl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020590.4

ORF Insert Sequence:

ATGAAGTTCC AGTATAAGGA GGACCACCCC TTCGAGTATC GGAAAAAGGA AGGTGAAAAG 
ATTAGGAAGA AATACCCGGA CCGGGTGCCG GTCATCGTGG AGAAGGCTCC TAAAGCCAGG 
GTCCCTGATC TGGATAAGAG GAAGTACCTT GTGCCCTCCG ACCTCACTGT TGGCCAGTTC 
TACTTCTTAA TCCGGAAGAG GATCCACCTG AGACCTGAGG ACGCCTTATT CTTCTTTGTC 
AACAACACCA TCCCTCCCAC CAGTGCTACC ATGGGCCAGC TGTATGAGGA CAACCACGAG 
GAAGACTATT TTCTGTATGT GGCCTACAGT GATGAAAGTG TCTATGGAAA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
Nature immunology18(8)899-910(2017 Aug)
Sasai M,Sakaguchi N,Ma JS,Nakamura S,Kawabata T,Bando H,Lee Y,Saitoh T,Akira S,Iwasaki A,Standley DM,Yoshimori T,Yamamoto M

Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1.
PloS one8(5)e63133(2013)
Le Grand JN,Bon K,Fraichard A,Zhang J,Jouvenot M,Risold PY,Boyer-Guittaut M,Delage-Mourroux R

Identification of neuroglobin-interacting proteins using yeast two-hybrid screening.
Neuroscience20099-105(2012 Jan)
Yu Z,Liu N,Wang Y,Li X,Wang X

GABARAPL1 negatively regulates Wnt/?-catenin signaling by mediating Dvl2 degradation through the autophagy pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology27(5)503-12(2011)
Zhang Y,Wang F,Han L,Wu Y,Li S,Yang X,Wang Y,Ren F,Zhai Y,Wang D,Jia B,Xia Y,Chang Z

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Gabarapl1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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