Pqbp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pqbp1
Entrez Gene ID	54633
Full Name	polyglutamine binding protein 1
Synonyms	PQBP-1,Sfc2,npw38
General protein information	Preferred Names polyglutamine binding protein 1 Names polyglutamine-binding protein 1 38 kDa nuclear protein containing a WW domain polyglutamine tract-binding protein 1 scurfy candidate 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X A1.1\|X 3.56 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006527654.1	XP_006527717.1	polyglutamine-binding protein 1 isoform X1
XM_006527654.2	XP_006527717.1	polyglutamine-binding protein 1 isoform X1
NM_019478.4	NP_062351.2	polyglutamine-binding protein 1 isoform 1
NM_001252529.1	NP_001239458.1	polyglutamine-binding protein 1 isoform 2
NM_001252528.1	NP_001239457.1	polyglutamine-binding protein 1 isoform 1

Pathways from BioSystems

Homologies

	PQBP1	XP_001104230.1
Caenorhabditis elegans (roundworm)	pqbp-1.2	NP_499914.1
Canis lupus familiaris (dog)	PQBP1	XP_851217.2
Rattus norvegicus (Norway rat)	Pqbp1	NP_001013979.1
Caenorhabditis elegans (roundworm)	pqbp-1.1	NP_499890.2
Mus musculus (house mouse)	Pqbp1	NP_001239457.1
Danio rerio (zebrafish)	pqbp1	NP_001002435.1
Pan troglodytes (chimpanzee)	PQBP1	XP_003954033.1
Bos taurus (cattle)	PQBP1	NP_001039854.1
Homo sapiens (human)	PQBP1	NP_001027554.1

Gene Ontology
Bibliography

Related articles in PubMed

In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.
Ito H, Shiwaku H, Yoshida C, Homma H, Luo H, Chen X, Fujita K, Musante L, Fischer U, Frints SG, Romano C, Ikeuchi Y, Shimamura T, Imoto S, Miyano S, Muramatsu SI, Kawauchi T, Hoshino M, Sudol M, Arumughan A, Wanker EE, Rich T, Schwartz C, Matsuzaki F, Bonni A, Kalscheuer VM, Okazawa H
Molecular psychiatry20(4)459-71(2015 Apr)

The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons.
Ikeuchi Y, de la Torre-Ubieta L, Matsuda T, Steen H, Okazawa H, Bonni A
Cell reports4(5)879-89(2013 Sep)

PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth.
Wang Q, Moore MJ, Adelmant G, Marto JA, Silver PA
Genes & development27(6)615-26(2013 Mar)

Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells.
Li C, Ito H, Fujita K, Shiwaku H, Qi Y, Tagawa K, Tamura T, Okazawa H
PloS one8(7)e68627(2013)

The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules.
Kunde SA, Musante L, Grimme A, Fischer U, M?ller E, Wanker EE, Kalscheuer VM
Human molecular genetics20(24)4916-31(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonstrated that in utero gene therapy for Pqbp1-cKO mice by intraperitoneal injection of the PQBP1-AAV vector at E10 successfully rescued microcephaly with preserved cortical structures and improved behavioral abnormalities in Pqbp1-cKO mice.
Title: In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.

These findings define PQBP1 and Dynamin 2 as components of a signaling pathway that orchestrates neuronal ciliary morphogenesis in the brain.
Title: The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons.

PQBP1 can affect the alternative splicing of multiple mRNAs and indicate specific affected targets whose splice site determination may contribute to the disease phenotype in PQBP1-linked neurological disorders
Title: PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth.

The results indicated that Sox2 regulated the transcription of PQBP1 in neural stem progenitor cells.
Title: Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells.

PQBP1 dysfunction in regulating gene expression underlies the abnormal behavior and cognition of PQBP1-Knock-down mice.
Title: Knock-down of PQBP1 impairs anxiety-related cognition in mouse.

The following Pqbp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pqbp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu13429	NM_001252529.1 Latest version!	Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu13632	NM_001252528.1 Latest version!	Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu13632	NM_019478.4 Latest version!	Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu13632	XM_006527654.2 Latest version!	Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu13632	XM_006527654.1	Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pqbp1 ( NM_001252529.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001239458.1 Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu13429
Clone ID Related Accession (Same CDS sequence)	NM_001252529.1
Accession Version	NM_001252529.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	polyglutamine-binding protein 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ550428.1, AK077652.1 and AW488646.1. Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an upstream, in-frame start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051673.1, AK077652.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGACCAG TTAATTGCAC CTGGGGAGAG TCGAGGAGCC TGTTGTGCTT TAAACCAAGA 
GCCCTTCGGT GTTGGTCTGG TCAGCTACCC ACTATGCCGC TTCCTGTTGC GCTGCAGACC 
CGCTTGGCGA AGAGGGGCAT CCTCAAACAT CTGGAGCCGG AGCCAGAGGA AGAGATTATT 
GCTGAAGACT ACGATGATGA TCCTGTTGAC TATGAGGCCA CCCGGATAGA GGGTCTGCCA 
CCGAGCTGGT ACAAGGTGTT TGACCCTTCT TGCGGACTCC CTTACTATTG GAATGTGGAG 
ACAGACCTTG TGTCGTGGCT CTCACCACAT GATCCTAACT TTGTCGTTAC CAAATCCGCC 
AAGAAAGTCA GGAACAATAA TGCAGATGCT GAGGACAAGT CGGACCGGAA TCTTGAAAAG 
GTGGACAGAA ATCATGAGAA GTCAGATCGT AGTCATGAGA AGCCAGACAG GAGCCACGAG 
AAGGCAGACC GAAACCACGA GAAGAATGAC AGAGAACGAG AGCGCAACTA CGACAAAGTG 
GATAGAGAGA GAGATCGGGA CAGGGAACGA GAGCGGGCAT TTGACAAGGC AGACCGGGAA 
GAGGGCAAAG ACCGACGCCA CCATCGCAGA GAGGAACTGG CTCCTTACCC CAAGAACAAG 
AAAGCGACGA GCCGCAAAGA TGAAGAATTA GACCCCATGG ACCCCAGCTC ATACTCAGAT 
GCACCCCGGG GCACATGGTC AACAGGACTC CCCAAGAGGA ACGAGGCCAA GACAGGTGCT 
GACACCACGG CAGCTGGGCC CCTCTTCCAG CAGCGCCCTT ACCCTTCCCC GGGCGCTGTG 
CTCCGCGCCA ATGCAGAAGC CTCCCGAACC AAACAGCAGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001239458.1
CDS	28..912
Translation	MRPVNCTWGESRSLLCFKPRALRCWSGQLPTMPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRIEGLPPSWYKVFDPSCGLPYYWNVETDLVSWLSPHDPNFVVTKSAKKVRNNNADAEDKSDRNLEKVDRNHEKSDRSHEKPDRSHEKADRNHEKNDRERERNYDKVDRERDRDRERERAFDKADREEGKDRRHHRREELAPYPKNKKATSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD

Target ORF information:

RefSeq Version	NM_001252529.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001252529.1

ORF Insert Sequence:

ATGCGACCAG TTAATTGCAC CTGGGGAGAG TCGAGGAGCC TGTTGTGCTT TAAACCAAGA 
GCCCTTCGGT GTTGGTCTGG TCAGCTACCC ACTATGCCGC TTCCTGTTGC GCTGCAGACC 
CGCTTGGCGA AGAGGGGCAT CCTCAAACAT CTGGAGCCGG AGCCAGAGGA AGAGATTATT 
GCTGAAGACT ACGATGATGA TCCTGTTGAC TATGAGGCCA CCCGGATAGA GGGTCTGCCA 
CCGAGCTGGT ACAAGGTGTT TGACCCTTCT TGCGGACTCC CTTACTATTG GAATGTGGAG 
ACAGACCTTG TGTCGTGGCT CTCACCACAT GATCCTAACT TTGTCGTTAC CAAATCCGCC 
AAGAAAGTCA GGAACAATAA TGCAGATGCT GAGGACAAGT CGGACCGGAA TCTTGAAAAG 
GTGGACAGAA ATCATGAGAA GTCAGATCGT AGTCATGAGA AGCCAGACAG GAGCCACGAG 
AAGGCAGACC GAAACCACGA GAAGAATGAC AGAGAACGAG AGCGCAACTA CGACAAAGTG 
GATAGAGAGA GAGATCGGGA CAGGGAACGA GAGCGGGCAT TTGACAAGGC AGACCGGGAA 
GAGGGCAAAG ACCGACGCCA CCATCGCAGA GAGGAACTGG CTCCTTACCC CAAGAACAAG 
AAAGCGACGA GCCGCAAAGA TGAAGAATTA GACCCCATGG ACCCCAGCTC ATACTCAGAT 
GCACCCCGGG GCACATGGTC AACAGGACTC CCCAAGAGGA ACGAGGCCAA GACAGGTGCT 
GACACCACGG CAGCTGGGCC CCTCTTCCAG CAGCGCCCTT ACCCTTCCCC GGGCGCTGTG 
CTCCGCGCCA ATGCAGAAGC CTCCCGAACC AAACAGCAGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pqbp1 ( NM_019478.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062351.2 Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13632
Clone ID Related Accession (Same CDS sequence)	XM_006527654.1 , XM_006527654.2 , NM_019478.4 , NM_001252528.1
Accession Version	NM_019478.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	polyglutamine-binding protein 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL671978.2, BC157976.1, AW456196.1 and AW488646.1. On Nov 18, 2011 this sequence version replaced NM_019478.3. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660821.363053.1, AW342125.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCTTC CTGTTGCGCT GCAGACCCGC TTGGCGAAGA GGGGCATCCT CAAACATCTG 
GAGCCGGAGC CAGAGGAAGA GATTATTGCT GAAGACTACG ATGATGATCC TGTTGACTAT 
GAGGCCACCC GGATAGAGGG TCTGCCACCG AGCTGGTACA AGGTGTTTGA CCCTTCTTGC 
GGACTCCCTT ACTATTGGAA TGTGGAGACA GACCTTGTGT CGTGGCTCTC ACCACATGAT 
CCTAACTTTG TCGTTACCAA ATCCGCCAAG AAAGTCAGGA ACAATAATGC AGATGCTGAG 
GACAAGTCGG ACCGGAATCT TGAAAAGGTG GACAGAAATC ATGAGAAGTC AGATCGTAGT 
CATGAGAAGC CAGACAGGAG CCACGAGAAG GCAGACCGAA ACCACGAGAA GAATGACAGA 
GAACGAGAGC GCAACTACGA CAAAGTGGAT AGAGAGAGAG ATCGGGACAG GGAACGAGAG 
CGGGCATTTG ACAAGGCAGA CCGGGAAGAG GGCAAAGACC GACGCCACCA TCGCAGAGAG 
GAACTGGCTC CTTACCCCAA GAACAAGAAA GCGACGAGCC GCAAAGATGA AGAATTAGAC 
CCCATGGACC CCAGCTCATA CTCAGATGCA CCCCGGGGCA CATGGTCAAC AGGACTCCCC 
AAGAGGAACG AGGCCAAGAC AGGTGCTGAC ACCACGGCAG CTGGGCCCCT CTTCCAGCAG 
CGCCCTTACC CTTCCCCGGG CGCTGTGCTC CGCGCCAATG CAGAAGCCTC CCGAACCAAA 
CAGCAGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062351.2
CDS	250..1041
Translation	MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRIEGLPPSWYKVFDPSCGLPYYWNVETDLVSWLSPHDPNFVVTKSAKKVRNNNADAEDKSDRNLEKVDRNHEKSDRSHEKPDRSHEKADRNHEKNDRERERNYDKVDRERDRDRERERAFDKADREEGKDRRHHRREELAPYPKNKKATSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD

Target ORF information:

RefSeq Version	NM_019478.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019478.4

ORF Insert Sequence:

ATGCCGCTTC CTGTTGCGCT GCAGACCCGC TTGGCGAAGA GGGGCATCCT CAAACATCTG 
GAGCCGGAGC CAGAGGAAGA GATTATTGCT GAAGACTACG ATGATGATCC TGTTGACTAT 
GAGGCCACCC GGATAGAGGG TCTGCCACCG AGCTGGTACA AGGTGTTTGA CCCTTCTTGC 
GGACTCCCTT ACTATTGGAA TGTGGAGACA GACCTTGTGT CGTGGCTCTC ACCACATGAT 
CCTAACTTTG TCGTTACCAA ATCCGCCAAG AAAGTCAGGA ACAATAATGC AGATGCTGAG 
GACAAGTCGG ACCGGAATCT TGAAAAGGTG GACAGAAATC ATGAGAAGTC AGATCGTAGT 
CATGAGAAGC CAGACAGGAG CCACGAGAAG GCAGACCGAA ACCACGAGAA GAATGACAGA 
GAACGAGAGC GCAACTACGA CAAAGTGGAT AGAGAGAGAG ATCGGGACAG GGAACGAGAG 
CGGGCATTTG ACAAGGCAGA CCGGGAAGAG GGCAAAGACC GACGCCACCA TCGCAGAGAG 
GAACTGGCTC CTTACCCCAA GAACAAGAAA GCGACGAGCC GCAAAGATGA AGAATTAGAC 
CCCATGGACC CCAGCTCATA CTCAGATGCA CCCCGGGGCA CATGGTCAAC AGGACTCCCC 
AAGAGGAACG AGGCCAAGAC AGGTGCTGAC ACCACGGCAG CTGGGCCCCT CTTCCAGCAG 
CGCCCTTACC CTTCCCCGGG CGCTGTGCTC CGCGCCAATG CAGAAGCCTC CCGAACCAAA 
CAGCAGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pqbp1 ( NM_001252528.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001239457.1 Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu13632
Clone ID Related Accession (Same CDS sequence)	XM_006527654.1 , XM_006527654.2 , NM_019478.4 , NM_001252528.1
Accession Version	NM_001252528.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Mus musculus(house mouse)
Product	polyglutamine-binding protein 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ143105.1, CN718083.1, CD741483.1 and AW488646.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC051673.1, BC009657.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCTTC CTGTTGCGCT GCAGACCCGC TTGGCGAAGA GGGGCATCCT CAAACATCTG 
GAGCCGGAGC CAGAGGAAGA GATTATTGCT GAAGACTACG ATGATGATCC TGTTGACTAT 
GAGGCCACCC GGATAGAGGG TCTGCCACCG AGCTGGTACA AGGTGTTTGA CCCTTCTTGC 
GGACTCCCTT ACTATTGGAA TGTGGAGACA GACCTTGTGT CGTGGCTCTC ACCACATGAT 
CCTAACTTTG TCGTTACCAA ATCCGCCAAG AAAGTCAGGA ACAATAATGC AGATGCTGAG 
GACAAGTCGG ACCGGAATCT TGAAAAGGTG GACAGAAATC ATGAGAAGTC AGATCGTAGT 
CATGAGAAGC CAGACAGGAG CCACGAGAAG GCAGACCGAA ACCACGAGAA GAATGACAGA 
GAACGAGAGC GCAACTACGA CAAAGTGGAT AGAGAGAGAG ATCGGGACAG GGAACGAGAG 
CGGGCATTTG ACAAGGCAGA CCGGGAAGAG GGCAAAGACC GACGCCACCA TCGCAGAGAG 
GAACTGGCTC CTTACCCCAA GAACAAGAAA GCGACGAGCC GCAAAGATGA AGAATTAGAC 
CCCATGGACC CCAGCTCATA CTCAGATGCA CCCCGGGGCA CATGGTCAAC AGGACTCCCC 
AAGAGGAACG AGGCCAAGAC AGGTGCTGAC ACCACGGCAG CTGGGCCCCT CTTCCAGCAG 
CGCCCTTACC CTTCCCCGGG CGCTGTGCTC CGCGCCAATG CAGAAGCCTC CCGAACCAAA 
CAGCAGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001239457.1
CDS	55..846
Translation	MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRIEGLPPSWYKVFDPSCGLPYYWNVETDLVSWLSPHDPNFVVTKSAKKVRNNNADAEDKSDRNLEKVDRNHEKSDRSHEKPDRSHEKADRNHEKNDRERERNYDKVDRERDRDRERERAFDKADREEGKDRRHHRREELAPYPKNKKATSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD

Target ORF information:

RefSeq Version	NM_001252528.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001252528.1

ORF Insert Sequence:

ATGCCGCTTC CTGTTGCGCT GCAGACCCGC TTGGCGAAGA GGGGCATCCT CAAACATCTG 
GAGCCGGAGC CAGAGGAAGA GATTATTGCT GAAGACTACG ATGATGATCC TGTTGACTAT 
GAGGCCACCC GGATAGAGGG TCTGCCACCG AGCTGGTACA AGGTGTTTGA CCCTTCTTGC 
GGACTCCCTT ACTATTGGAA TGTGGAGACA GACCTTGTGT CGTGGCTCTC ACCACATGAT 
CCTAACTTTG TCGTTACCAA ATCCGCCAAG AAAGTCAGGA ACAATAATGC AGATGCTGAG 
GACAAGTCGG ACCGGAATCT TGAAAAGGTG GACAGAAATC ATGAGAAGTC AGATCGTAGT 
CATGAGAAGC CAGACAGGAG CCACGAGAAG GCAGACCGAA ACCACGAGAA GAATGACAGA 
GAACGAGAGC GCAACTACGA CAAAGTGGAT AGAGAGAGAG ATCGGGACAG GGAACGAGAG 
CGGGCATTTG ACAAGGCAGA CCGGGAAGAG GGCAAAGACC GACGCCACCA TCGCAGAGAG 
GAACTGGCTC CTTACCCCAA GAACAAGAAA GCGACGAGCC GCAAAGATGA AGAATTAGAC 
CCCATGGACC CCAGCTCATA CTCAGATGCA CCCCGGGGCA CATGGTCAAC AGGACTCCCC 
AAGAGGAACG AGGCCAAGAC AGGTGCTGAC ACCACGGCAG CTGGGCCCCT CTTCCAGCAG 
CGCCCTTACC CTTCCCCGGG CGCTGTGCTC CGCGCCAATG CAGAAGCCTC CCGAACCAAA 
CAGCAGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pqbp1 ( XM_006527654.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006527717.1 Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu13632
Clone ID Related Accession (Same CDS sequence)	XM_006527654.1 , XM_006527654.2 , NM_019478.4 , NM_001252528.1
Accession Version	XM_006527654.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	polyglutamine-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGCTTC CTGTTGCGCT GCAGACCCGC TTGGCGAAGA GGGGCATCCT CAAACATCTG 
GAGCCGGAGC CAGAGGAAGA GATTATTGCT GAAGACTACG ATGATGATCC TGTTGACTAT 
GAGGCCACCC GGATAGAGGG TCTGCCACCG AGCTGGTACA AGGTGTTTGA CCCTTCTTGC 
GGACTCCCTT ACTATTGGAA TGTGGAGACA GACCTTGTGT CGTGGCTCTC ACCACATGAT 
CCTAACTTTG TCGTTACCAA ATCCGCCAAG AAAGTCAGGA ACAATAATGC AGATGCTGAG 
GACAAGTCGG ACCGGAATCT TGAAAAGGTG GACAGAAATC ATGAGAAGTC AGATCGTAGT 
CATGAGAAGC CAGACAGGAG CCACGAGAAG GCAGACCGAA ACCACGAGAA GAATGACAGA 
GAACGAGAGC GCAACTACGA CAAAGTGGAT AGAGAGAGAG ATCGGGACAG GGAACGAGAG 
CGGGCATTTG ACAAGGCAGA CCGGGAAGAG GGCAAAGACC GACGCCACCA TCGCAGAGAG 
GAACTGGCTC CTTACCCCAA GAACAAGAAA GCGACGAGCC GCAAAGATGA AGAATTAGAC 
CCCATGGACC CCAGCTCATA CTCAGATGCA CCCCGGGGCA CATGGTCAAC AGGACTCCCC 
AAGAGGAACG AGGCCAAGAC AGGTGCTGAC ACCACGGCAG CTGGGCCCCT CTTCCAGCAG 
CGCCCTTACC CTTCCCCGGG CGCTGTGCTC CGCGCCAATG CAGAAGCCTC CCGAACCAAA 
CAGCAGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006527717.1
CDS	200..991
Translation	MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRIEGLPPSWYKVFDPSCGLPYYWNVETDLVSWLSPHDPNFVVTKSAKKVRNNNADAEDKSDRNLEKVDRNHEKSDRSHEKPDRSHEKADRNHEKNDRERERNYDKVDRERDRDRERERAFDKADREEGKDRRHHRREELAPYPKNKKATSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD

Target ORF information:

RefSeq Version	XM_006527654.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006527654.1

ORF Insert Sequence:

ATGCCGCTTC CTGTTGCGCT GCAGACCCGC TTGGCGAAGA GGGGCATCCT CAAACATCTG 
GAGCCGGAGC CAGAGGAAGA GATTATTGCT GAAGACTACG ATGATGATCC TGTTGACTAT 
GAGGCCACCC GGATAGAGGG TCTGCCACCG AGCTGGTACA AGGTGTTTGA CCCTTCTTGC 
GGACTCCCTT ACTATTGGAA TGTGGAGACA GACCTTGTGT CGTGGCTCTC ACCACATGAT 
CCTAACTTTG TCGTTACCAA ATCCGCCAAG AAAGTCAGGA ACAATAATGC AGATGCTGAG 
GACAAGTCGG ACCGGAATCT TGAAAAGGTG GACAGAAATC ATGAGAAGTC AGATCGTAGT 
CATGAGAAGC CAGACAGGAG CCACGAGAAG GCAGACCGAA ACCACGAGAA GAATGACAGA 
GAACGAGAGC GCAACTACGA CAAAGTGGAT AGAGAGAGAG ATCGGGACAG GGAACGAGAG 
CGGGCATTTG ACAAGGCAGA CCGGGAAGAG GGCAAAGACC GACGCCACCA TCGCAGAGAG 
GAACTGGCTC CTTACCCCAA GAACAAGAAA GCGACGAGCC GCAAAGATGA AGAATTAGAC 
CCCATGGACC CCAGCTCATA CTCAGATGCA CCCCGGGGCA CATGGTCAAC AGGACTCCCC 
AAGAGGAACG AGGCCAAGAC AGGTGCTGAC ACCACGGCAG CTGGGCCCCT CTTCCAGCAG 
CGCCCTTACC CTTCCCCGGG CGCTGTGCTC CGCGCCAATG CAGAAGCCTC CCGAACCAAA 
CAGCAGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pqbp1 ( XM_006527654.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006527717.1 Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant X1, mRNA.

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CloneID	OMu13632
Clone ID Related Accession (Same CDS sequence)	XM_006527654.1 , XM_006527654.2 , NM_019478.4 , NM_001252528.1
Accession Version	XM_006527654.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	polyglutamine-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006527654.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGCTTC CTGTTGCGCT GCAGACCCGC TTGGCGAAGA GGGGCATCCT CAAACATCTG 
GAGCCGGAGC CAGAGGAAGA GATTATTGCT GAAGACTACG ATGATGATCC TGTTGACTAT 
GAGGCCACCC GGATAGAGGG TCTGCCACCG AGCTGGTACA AGGTGTTTGA CCCTTCTTGC 
GGACTCCCTT ACTATTGGAA TGTGGAGACA GACCTTGTGT CGTGGCTCTC ACCACATGAT 
CCTAACTTTG TCGTTACCAA ATCCGCCAAG AAAGTCAGGA ACAATAATGC AGATGCTGAG 
GACAAGTCGG ACCGGAATCT TGAAAAGGTG GACAGAAATC ATGAGAAGTC AGATCGTAGT 
CATGAGAAGC CAGACAGGAG CCACGAGAAG GCAGACCGAA ACCACGAGAA GAATGACAGA 
GAACGAGAGC GCAACTACGA CAAAGTGGAT AGAGAGAGAG ATCGGGACAG GGAACGAGAG 
CGGGCATTTG ACAAGGCAGA CCGGGAAGAG GGCAAAGACC GACGCCACCA TCGCAGAGAG 
GAACTGGCTC CTTACCCCAA GAACAAGAAA GCGACGAGCC GCAAAGATGA AGAATTAGAC 
CCCATGGACC CCAGCTCATA CTCAGATGCA CCCCGGGGCA CATGGTCAAC AGGACTCCCC 
AAGAGGAACG AGGCCAAGAC AGGTGCTGAC ACCACGGCAG CTGGGCCCCT CTTCCAGCAG 
CGCCCTTACC CTTCCCCGGG CGCTGTGCTC CGCGCCAATG CAGAAGCCTC CCGAACCAAA 
CAGCAGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006527717.1
CDS	212..1003
Translation	MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRIEGLPPSWYKVFDPSCGLPYYWNVETDLVSWLSPHDPNFVVTKSAKKVRNNNADAEDKSDRNLEKVDRNHEKSDRSHEKPDRSHEKADRNHEKNDRERERNYDKVDRERDRDRERERAFDKADREEGKDRRHHRREELAPYPKNKKATSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD

Target ORF information:

RefSeq Version	XM_006527654.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006527654.2

ORF Insert Sequence:

ATGCCGCTTC CTGTTGCGCT GCAGACCCGC TTGGCGAAGA GGGGCATCCT CAAACATCTG 
GAGCCGGAGC CAGAGGAAGA GATTATTGCT GAAGACTACG ATGATGATCC TGTTGACTAT 
GAGGCCACCC GGATAGAGGG TCTGCCACCG AGCTGGTACA AGGTGTTTGA CCCTTCTTGC 
GGACTCCCTT ACTATTGGAA TGTGGAGACA GACCTTGTGT CGTGGCTCTC ACCACATGAT 
CCTAACTTTG TCGTTACCAA ATCCGCCAAG AAAGTCAGGA ACAATAATGC AGATGCTGAG 
GACAAGTCGG ACCGGAATCT TGAAAAGGTG GACAGAAATC ATGAGAAGTC AGATCGTAGT 
CATGAGAAGC CAGACAGGAG CCACGAGAAG GCAGACCGAA ACCACGAGAA GAATGACAGA 
GAACGAGAGC GCAACTACGA CAAAGTGGAT AGAGAGAGAG ATCGGGACAG GGAACGAGAG 
CGGGCATTTG ACAAGGCAGA CCGGGAAGAG GGCAAAGACC GACGCCACCA TCGCAGAGAG 
GAACTGGCTC CTTACCCCAA GAACAAGAAA GCGACGAGCC GCAAAGATGA AGAATTAGAC 
CCCATGGACC CCAGCTCATA CTCAGATGCA CCCCGGGGCA CATGGTCAAC AGGACTCCCC 
AAGAGGAACG AGGCCAAGAC AGGTGCTGAC ACCACGGCAG CTGGGCCCCT CTTCCAGCAG 
CGCCCTTACC CTTCCCCGGG CGCTGTGCTC CGCGCCAATG CAGAAGCCTC CCGAACCAAA 
CAGCAGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.
Molecular psychiatry20(4)459-71(2015 Apr)
Ito H,Shiwaku H,Yoshida C,Homma H,Luo H,Chen X,Fujita K,Musante L,Fischer U,Frints SG,Romano C,Ikeuchi Y,Shimamura T,Imoto S,Miyano S,Muramatsu SI,Kawauchi T,Hoshino M,Sudol M,Arumughan A,Wanker EE,Rich T,Schwartz C,Matsuzaki F,Bonni A,Kalscheuer VM,Okazawa H

The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons.
Cell reports4(5)879-89(2013 Sep)
Ikeuchi Y,de la Torre-Ubieta L,Matsuda T,Steen H,Okazawa H,Bonni A

PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth.
Genes & development27(6)615-26(2013 Mar)
Wang Q,Moore MJ,Adelmant G,Marto JA,Silver PA

Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells.
PloS one8(7)e68627(2013)
Li C,Ito H,Fujita K,Shiwaku H,Qi Y,Tagawa K,Tamura T,Okazawa H

The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules.
Human molecular genetics20(24)4916-31(2011 Dec)
Kunde SA,Musante L,Grimme A,Fischer U,M?ller E,Wanker EE,Kalscheuer VM