Klf13 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klf13
Entrez Gene ID	50794
Full Name	Kruppel-like factor 13
Synonyms	0610043C13Rik,9430029L20Rik,Bteb3,FKLF-2,FKLF2,NSLP1,RFLAT-1,RFLAT1
General protein information	Preferred Names Kruppel-like factor 13 Names Krueppel-like factor 13 BTE-binding protein 3 C2-H2 zinc finger protein RANTES factor of late activated T-lymphocytes 1 basic transcription element-binding protein 3 erythroid transcription factor FKLF-2 transcription factor BTEB3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 C

mRNA and Protein(s)

mRNA	Protein	Name
NM_021366.3	NP_067341.2	Krueppel-like factor 13

Pathways from BioSystems

Homologies

Bos taurus (cattle)	KLF13	NP_001077002.1
Xenopus tropicalis (tropical clawed frog)	klf13	NP_001093690.1
Homo sapiens (human)	KLF13	NP_057079.2
Pan troglodytes (chimpanzee)	KLF13	XP_510269.2
Rattus norvegicus (Norway rat)	Klf13	NP_001102617.1
Gallus gallus (chicken)	KLF13	XP_425065.1
Danio rerio (zebrafish)	klf13	NP_001070240.1
Mus musculus (house mouse)	Klf13	NP_067341.2

Gene Ontology
Bibliography

Related articles in PubMed

A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes.
Bayoumi AS, Park KM, Wang Y, Teoh JP, Aonuma T, Tang Y, Su H, Weintraub NL, Kim IM
Journal of molecular and cellular cardiology11472-82(2017 Nov)

A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels.
Wiemerslage L, Islam R, van der Kamp C, Cao H, Olivo G, Ence-Eriksson F, Castillo S, Larsen AL, Bandstein M, Dahlberg LS, Perland E, Gustavsson V, Nilsson J, Vogel H, Sch?rmann A, Larsson EM, Rask-Andersen M, Benedict C, Schi?th HB
International journal of obesity (2005)41(6)990-994(2017 Jun)

KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.
Darwich R, Li W, Yamak A, Komati H, Andelfinger G, Sun K, Nemer M
Human molecular genetics26(5)942-954(2017 03)

Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice.
Hayashi S, Manabe I, Suzuki Y, Relaix F, Oishi Y
eLife5(2016 10)

Kr?ppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death.
Cruz-Topete D, He B, Xu X, Cidlowski JA
The Journal of biological chemistry291(37)19374-86(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data also suggest that, in human, KLF13 may be a genetic modifier of the Holt-Oram Syndrome gene TBX5.
Title: KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.

These results established a novel role for GR and KLF13 signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure.
Title: Kr?ppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death.

Results demonstrate lack of a causative relationship between endometrial KLF13 deficiency and lesion establishment in mice, and they support the broader participation of multiple signaling pathways in the pathology of endometriosis.
Title: Kr?ppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis.

KLF13 directly binds to IL-4 promoter regions and synergizes with c-Maf to positively regulate IL-4 expression.
Title: KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ T cells.

Fbw7 gamma - mediated ubiquitination of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.
Title: Fbw7?-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.

The following Klf13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klf13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12244	NM_021366.3 Latest version!	Mus musculus Kruppel-like factor 13 (Klf13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klf13 ( NM_021366.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067341.2 Mus musculus Kruppel-like factor 13 (Klf13), mRNA.

Price & Availability↑

CloneID	OMu12244
Clone ID Related Accession (Same CDS sequence)	NM_021366.3
Accession Version	NM_021366.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	Krueppel-like factor 13
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC148977.3 and AC127344.3. On Jul 28, 2009 this sequence version replaced NM_021366.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF251796.1, AF252285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGCCG CCGCCTATGT GGACCACTTT GCCGCCGAGT GCCTCGTGTC CATGTCCAGC 
CGCGCAGTCG TGCACGAGCC GCGGGAAGGA CCTGAACCCC GGCCCGAGGG CGCGGCCGCC 
GCCGCCCCCA CACTGCCCCG CGTTGACGAG CGCCGCGACG GCAAGGACAG CGCCTCGCTT 
TTCGTGGTGG CTCGGATCCT AGCGGACCTC AACCAGCAGG CGCCGGCGCC CGCCCCCGCG 
GAACGCAGAG AAGGGGCCGC TGCGCGCAAG GCGAGGACCC CCTGCCGCCT GCCGCCTGCG 
CCCCCTGCGC CGCCACCCGG CCCAGAGCCC GCCTCCCCGG GACAAGCAGG CGCGCCGGCC 
GCGCCCCCCA GCCCCGCGTG GAGCGAGCCG GAGGCGGCAT TGGAGCAGGA GCCCGGCCCC 
GCGGGGAGCG GCGAGCCTGG CCTCAGACAA AGGGGTCGGC GAGGCCGGAG CCGCGCGGAC 
CTCGAGTCCC CGCAGAGGAA GCACAAGTGC CACTACGCGG GCTGCGAGAA AGTTTACGGG 
AAATCTTCGC ACCTCAAGGC GCACCTGAGA ACTCACACAG GTGAGAGGCC TTTCGCCTGC 
AGCTGGCAGG AGTGCAACAA GAAGTTCGCA CGCTCGGACG AGCTGGCACG GCACTATCGC 
ACGCACACGG GCGAGAAGAA GTTCAGCTGC CCCATCTGTG AGAAGCGCTT CATGCGGAGC 
GACCACCTGA CGAAGCACGC ACGCCGCCAC GCCAACTTCC ACCCAGGCAT GCTGCAGCGG 
CGCGGCGGGG GCTCGAGGAC CGGCTCGCTC AGCGACTACA GCCGCTCCGA TGCCAGCAGC 
CCCACCATCA GCCCGGCCAG CTCACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067341.2
CDS	370..1239
Translation	MAAAAYVDHFAAECLVSMSSRAVVHEPREGPEPRPEGAAAAAPTLPRVDERRDGKDSASLFVVARILADLNQQAPAPAPAERREGAAARKARTPCRLPPAPPAPPPGPEPASPGQAGAPAAPPSPAWSEPEAALEQEPGPAGSGEPGLRQRGRRGRSRADLESPQRKHKCHYAGCEKVYGKSSHLKAHLRTHTGERPFACSWQECNKKFARSDELARHYRTHTGEKKFSCPICEKRFMRSDHLTKHARRHANFHPGMLQRRGGGSRTGSLSDYSRSDASSPTISPASSP

Target ORF information:

RefSeq Version	NM_021366.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus Kruppel-like factor 13 (Klf13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021366.3

ORF Insert Sequence:

ATGGCAGCCG CCGCCTATGT GGACCACTTT GCCGCCGAGT GCCTCGTGTC CATGTCCAGC 
CGCGCAGTCG TGCACGAGCC GCGGGAAGGA CCTGAACCCC GGCCCGAGGG CGCGGCCGCC 
GCCGCCCCCA CACTGCCCCG CGTTGACGAG CGCCGCGACG GCAAGGACAG CGCCTCGCTT 
TTCGTGGTGG CTCGGATCCT AGCGGACCTC AACCAGCAGG CGCCGGCGCC CGCCCCCGCG 
GAACGCAGAG AAGGGGCCGC TGCGCGCAAG GCGAGGACCC CCTGCCGCCT GCCGCCTGCG 
CCCCCTGCGC CGCCACCCGG CCCAGAGCCC GCCTCCCCGG GACAAGCAGG CGCGCCGGCC 
GCGCCCCCCA GCCCCGCGTG GAGCGAGCCG GAGGCGGCAT TGGAGCAGGA GCCCGGCCCC 
GCGGGGAGCG GCGAGCCTGG CCTCAGACAA AGGGGTCGGC GAGGCCGGAG CCGCGCGGAC 
CTCGAGTCCC CGCAGAGGAA GCACAAGTGC CACTACGCGG GCTGCGAGAA AGTTTACGGG 
AAATCTTCGC ACCTCAAGGC GCACCTGAGA ACTCACACAG GTGAGAGGCC TTTCGCCTGC 
AGCTGGCAGG AGTGCAACAA GAAGTTCGCA CGCTCGGACG AGCTGGCACG GCACTATCGC 
ACGCACACGG GCGAGAAGAA GTTCAGCTGC CCCATCTGTG AGAAGCGCTT CATGCGGAGC 
GACCACCTGA CGAAGCACGC ACGCCGCCAC GCCAACTTCC ACCCAGGCAT GCTGCAGCGG 
CGCGGCGGGG GCTCGAGGAC CGGCTCGCTC AGCGACTACA GCCGCTCCGA TGCCAGCAGC 
CCCACCATCA GCCCGGCCAG CTCACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes.
Journal of molecular and cellular cardiology11472-82(2017 Nov)
Bayoumi AS,Park KM,Wang Y,Teoh JP,Aonuma T,Tang Y,Su H,Weintraub NL,Kim IM

A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels.
International journal of obesity (2005)41(6)990-994(2017 Jun)
Wiemerslage L,Islam R,van der Kamp C,Cao H,Olivo G,Ence-Eriksson F,Castillo S,Larsen AL,Bandstein M,Dahlberg LS,Perland E,Gustavsson V,Nilsson J,Vogel H,Sch?rmann A,Larsson EM,Rask-Andersen M,Benedict C,Schi?th HB

KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.
Human molecular genetics26(5)942-954(2017 03)
Darwich R,Li W,Yamak A,Komati H,Andelfinger G,Sun K,Nemer M

Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice.
eLife5(2016 10)
Hayashi S,Manabe I,Suzuki Y,Relaix F,Oishi Y

Kr?ppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death.
The Journal of biological chemistry291(37)19374-86(2016 09)
Cruz-Topete D,He B,Xu X,Cidlowski JA