Slco1a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slco1a1
Entrez Gene ID	28248
Full Name	solute carrier organic anion transporter family, member 1a1
Synonyms	A530084B21,OATP-1,Oatp1,Oatp1a1,Slc21a1
General protein information	Preferred Names solute carrier organic anion transporter family, member 1a1 Names solute carrier organic anion transporter family member 1A1 sodium-independent organic anion-transporting polypeptide 1 solute carrier family 21 (organic anion transporter), member 1 solute carrier family 21 member 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 G2

mRNA and Protein(s)

mRNA	Protein	Name
NM_013797.5	NP_038825.1	solute carrier organic anion transporter family member 1A1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Slco1a1	NP_058807.1
Mus musculus (house mouse)	Slco1a1	NP_038825.1

Gene Ontology
Bibliography

Related articles in PubMed

Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.
Lee HH, Leake BF, Kim RB, Ho RH
Molecular pharmacology91(1)14-24(2017 Jan)

The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice.
Durmus S, van Hoppe S, Schinkel AH
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy2772-88(2016 Jul)

OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.
Iusuf D, Ludwig M, Elbatsh A, van Esch A, van de Steeg E, Wagenaar E, van der Valk M, Lin F, van Tellingen O, Schinkel AH
Molecular cancer therapeutics13(2)492-503(2014 Feb)

Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins.
Wang WJ, Murray JW, Wolkoff AW
Drug metabolism and disposition: the biological fate of chemicals42(1)62-9(2014 Jan)

Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice.
Zhang Y, Limaye PB, Lehman-McKeeman LD, Klaassen CD
PloS one7(4)e34522(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

important roles for OATP1A/1B in transporter-mediated uptake and disposition of doxorubicin, are reported.
Title: Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.

Organic anion-transporting polypeptides exert strong impact on disposition and toxicity of antitumor drugs. (Review)
Title: The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice.

Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses.
Title: OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.

PDZK1 regulates intracellular trafficking of Oatp1a1.
Title: Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins.

Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism.
Title: Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice.

The following Slco1a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slco1a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09991	NM_013797.5 Latest version!	Mus musculus solute carrier organic anion transporter family, member 1a1 (Slco1a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slco1a1 ( NM_013797.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038825.1 Mus musculus solute carrier organic anion transporter family, member 1a1 (Slco1a1), mRNA.

Price & Availability↑

CloneID	OMu09991
Clone ID Related Accession (Same CDS sequence)	NM_013797.5
Accession Version	NM_013797.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2013bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	solute carrier organic anion transporter family member 1A1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB848260.1, AF223067.1 and AC156277.6. On Apr 16, 2010 this sequence version replaced NM_013797.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY195868.1, AY195869.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGAAA CAGAGAAAAA GGTTGCAACA CAAGAAGGCA GATTCTTCTC CAAGATGAAG 
GTGTTTCTGA TGTCATTAAC ATGTGCATAC CTAGCCAAAT CACTATCAGG AGTTTATATG 
AATTCCATGC TCACACAAAT AGAGAGACAA TTTGGTATCC CTACATCTGT AGTTGGATTT 
ATCACTGGGA GCTTTGAGAT AGGAAACCTT TTGTTGATTG TATTCGTGAG TTATTTTGGA 
AGGAAACTGC ACAGACCTAT CATTATTGGT GTTGGATGTG TGGTTATGGG CCTGGGGTGT 
TTCTTAATGG CATCACCTCA TTTCCTCATG GGCAGATACA AATATGAAAC AACAATATCA 
CCTACAAGCA ACTTGTCCTC AAACAGCTTC TTGTGTATAG AAAACAGAAC ACAGACCTTA 
AAGCCAACGC AAGATCCAAC AGAGTGTGTA AAAGAAATAA AATCATTAAT GTGGATATAT 
GTACTAATAG GAAATACTAT GCGTGGAATT GGTGAAACTC CCATAATGCC CTTGGGTATT 
TCTTACATCG AAGACTTTGC CAAATCAGAA AACTCTCCTT TATATATTGG GATTTTAGAA 
ATGGGGAAGA TTGTTGGCCC GATTATTGGA CTTTTGTTGG GATCTTTCTT TGCACGTGTT 
TATGTAGACA TTGGGTCTGT GAATACAGAT GACCTGACCA TAACTCCCAC TGATACACGC 
TGGGTCGGTG CTTGGTGGAT TGGCTTTTTG GTCTGTGCAG GAGTGAATAT CCTGACCAGC 
ATCCCCTTTT TCTTCTTTCC AAAGACACTG CCAAAGAAAG AACTACAGGA TAATGTGGAT 
GTGACTAAAT ATGAGAAAGT TGAAAAACAT AGAGAAAGAG CCAAAAAGGA AAACCTTGGA 
ATCACTAAAG ATTTCTTGCC ATTCATGAAG AGCCTCTGCT GCAATCCTAT TTATATGCTG 
TTCAGTCTTA CGAGTGTGCT CCAGATAAAT GGATTTGCCA GTACATTTAC CTTCTTGCCC 
AAATACCTGG AGCAGCAATA TGGAAAATCC ACTTCAGAGG CAGTATTCCT CATAGGTGTT 
TATAGCTTGC CTCCAGTATG CCTTGGATAT TTAATCAGTG GCTTTATTAT GAAGAAGTTT 
AAGATCACTG TCAAGAAAGC TGCATACATA GCATTTGGCC TGTCCTTATC TGAATATTTT 
ATTTTTCTCT GTAACTATTT GTTGACCTGT GATAATTTCC CAGTTGCTGG ATTAACCACC 
TCTTATAAAG GAGTTCAGCA CCCTCTATAT GGGGAGAAAA ATGTCCTTGC TGACTGCAAC 
ACAAGGTGCA GCTGCTTAAC GGACACATGG GATCCAGTGT GTGGGGACAA TGGCCTAGCT 
TACATGTCAG CCTGCCTCGC AGGCTGTGAG AAGTCTGTTG GAACTGGAAC CAACATGGTG 
TTTCAAAATT GCAGCTGCAT TGGGTCATCA GGAAACTCAT CTGCAGTCCT GGGGCTGTGT 
AAGAAAGGCC CTGAGTGTGA CAACAAGCTG CAGTACTTTT TAATCAAGTC AGTATTTTCC 
AGTTTCATCT TCTCACTCGC AGCCATCCCT GGATACATGG TTCTTCTGAG GTGTGTCAAA 
TCTGAAGAGA AGTCAATTGG AGTTGGATTA CATGCATTTT TCATAAGACT ATTAGCTGGC 
ATTCCGGCAC CTGTTTACTT TGGCGCTTTG ATAGACAGAA CCTGTTTACA TTGGGGAACT 
CTGAAATGTG GTCAACCAGG GGCATGCAGG ATGTATGATA TAAACAGATT CAGGCACATT 
TACCTGGGGT TGCCTGCAGC AGTGAGAGGA TCAAGCTTTC TCCCCGCAGT CTTCATTCTA 
ATCCTTATGA GGAAATTCCA TTTCCCTGGC GACATCCACT CTCCAGACAC TGAACTTGCA 
GAGATGAAGC TCACAGAGAA GGAAAGCGAG TGCACAGATG TGTGCAGAAG TCCTAAGGTC 
GAGAACGATG GAGAACTGAA AACTAAGCTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038825.1
CDS	325..2337
Translation	MEETEKKVATQEGRFFSKMKVFLMSLTCAYLAKSLSGVYMNSMLTQIERQFGIPTSVVGFITGSFEIGNLLLIVFVSYFGRKLHRPIIIGVGCVVMGLGCFLMASPHFLMGRYKYETTISPTSNLSSNSFLCIENRTQTLKPTQDPTECVKEIKSLMWIYVLIGNTMRGIGETPIMPLGISYIEDFAKSENSPLYIGILEMGKIVGPIIGLLLGSFFARVYVDIGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLPKKELQDNVDVTKYEKVEKHRERAKKENLGITKDFLPFMKSLCCNPIYMLFSLTSVLQINGFASTFTFLPKYLEQQYGKSTSEAVFLIGVYSLPPVCLGYLISGFIMKKFKITVKKAAYIAFGLSLSEYFIFLCNYLLTCDNFPVAGLTTSYKGVQHPLYGEKNVLADCNTRCSCLTDTWDPVCGDNGLAYMSACLAGCEKSVGTGTNMVFQNCSCIGSSGNSSAVLGLCKKGPECDNKLQYFLIKSVFSSFIFSLAAIPGYMVLLRCVKSEEKSIGVGLHAFFIRLLAGIPAPVYFGALIDRTCLHWGTLKCGQPGACRMYDINRFRHIYLGLPAAVRGSSFLPAVFILILMRKFHFPGDIHSPDTELAEMKLTEKESECTDVCRSPKVENDGELKTKL

Target ORF information:

RefSeq Version	NM_013797.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier organic anion transporter family, member 1a1 (Slco1a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013797.5

ORF Insert Sequence:

ATGGAAGAAA CAGAGAAAAA GGTTGCAACA CAAGAAGGCA GATTCTTCTC CAAGATGAAG 
GTGTTTCTGA TGTCATTAAC ATGTGCATAC CTAGCCAAAT CACTATCAGG AGTTTATATG 
AATTCCATGC TCACACAAAT AGAGAGACAA TTTGGTATCC CTACATCTGT AGTTGGATTT 
ATCACTGGGA GCTTTGAGAT AGGAAACCTT TTGTTGATTG TATTCGTGAG TTATTTTGGA 
AGGAAACTGC ACAGACCTAT CATTATTGGT GTTGGATGTG TGGTTATGGG CCTGGGGTGT 
TTCTTAATGG CATCACCTCA TTTCCTCATG GGCAGATACA AATATGAAAC AACAATATCA 
CCTACAAGCA ACTTGTCCTC AAACAGCTTC TTGTGTATAG AAAACAGAAC ACAGACCTTA 
AAGCCAACGC AAGATCCAAC AGAGTGTGTA AAAGAAATAA AATCATTAAT GTGGATATAT 
GTACTAATAG GAAATACTAT GCGTGGAATT GGTGAAACTC CCATAATGCC CTTGGGTATT 
TCTTACATCG AAGACTTTGC CAAATCAGAA AACTCTCCTT TATATATTGG GATTTTAGAA 
ATGGGGAAGA TTGTTGGCCC GATTATTGGA CTTTTGTTGG GATCTTTCTT TGCACGTGTT 
TATGTAGACA TTGGGTCTGT GAATACAGAT GACCTGACCA TAACTCCCAC TGATACACGC 
TGGGTCGGTG CTTGGTGGAT TGGCTTTTTG GTCTGTGCAG GAGTGAATAT CCTGACCAGC 
ATCCCCTTTT TCTTCTTTCC AAAGACACTG CCAAAGAAAG AACTACAGGA TAATGTGGAT 
GTGACTAAAT ATGAGAAAGT TGAAAAACAT AGAGAAAGAG CCAAAAAGGA AAACCTTGGA 
ATCACTAAAG ATTTCTTGCC ATTCATGAAG AGCCTCTGCT GCAATCCTAT TTATATGCTG 
TTCAGTCTTA CGAGTGTGCT CCAGATAAAT GGATTTGCCA GTACATTTAC CTTCTTGCCC 
AAATACCTGG AGCAGCAATA TGGAAAATCC ACTTCAGAGG CAGTATTCCT CATAGGTGTT 
TATAGCTTGC CTCCAGTATG CCTTGGATAT TTAATCAGTG GCTTTATTAT GAAGAAGTTT 
AAGATCACTG TCAAGAAAGC TGCATACATA GCATTTGGCC TGTCCTTATC TGAATATTTT 
ATTTTTCTCT GTAACTATTT GTTGACCTGT GATAATTTCC CAGTTGCTGG ATTAACCACC 
TCTTATAAAG GAGTTCAGCA CCCTCTATAT GGGGAGAAAA ATGTCCTTGC TGACTGCAAC 
ACAAGGTGCA GCTGCTTAAC GGACACATGG GATCCAGTGT GTGGGGACAA TGGCCTAGCT 
TACATGTCAG CCTGCCTCGC AGGCTGTGAG AAGTCTGTTG GAACTGGAAC CAACATGGTG 
TTTCAAAATT GCAGCTGCAT TGGGTCATCA GGAAACTCAT CTGCAGTCCT GGGGCTGTGT 
AAGAAAGGCC CTGAGTGTGA CAACAAGCTG CAGTACTTTT TAATCAAGTC AGTATTTTCC 
AGTTTCATCT TCTCACTCGC AGCCATCCCT GGATACATGG TTCTTCTGAG GTGTGTCAAA 
TCTGAAGAGA AGTCAATTGG AGTTGGATTA CATGCATTTT TCATAAGACT ATTAGCTGGC 
ATTCCGGCAC CTGTTTACTT TGGCGCTTTG ATAGACAGAA CCTGTTTACA TTGGGGAACT 
CTGAAATGTG GTCAACCAGG GGCATGCAGG ATGTATGATA TAAACAGATT CAGGCACATT 
TACCTGGGGT TGCCTGCAGC AGTGAGAGGA TCAAGCTTTC TCCCCGCAGT CTTCATTCTA 
ATCCTTATGA GGAAATTCCA TTTCCCTGGC GACATCCACT CTCCAGACAC TGAACTTGCA 
GAGATGAAGC TCACAGAGAA GGAAAGCGAG TGCACAGATG TGTGCAGAAG TCCTAAGGTC 
GAGAACGATG GAGAACTGAA AACTAAGCTG TAA