Klra16 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klra16
Entrez Gene ID	27424
Full Name	killer cell lectin-like receptor, subfamily A, member 16
Synonyms	Klra24,Ly-49P,Ly49P,Ly49x
General protein information	Preferred Names killer cell lectin-like receptor, subfamily A, member 16 Names killer cell lectin-like receptor, subfamily A, member 16 Ly49X receptor natural killer cell receptor Ly-49P3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_013794.4	NP_038822.3	killer cell lectin-like receptor, subfamily A, member 16

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

IFN-? modulates Ly-49 receptors on NK cells in IFN-?-induced pregnancy failure.
Li ZY, Song ZH, Meng CY, Yang DD, Yang Y, Peng JP
Scientific reports518159(2015 Dec)

Ly49 receptors: evolution, genetic diversity, and impact on immunity.
Rahim MM, Makrigiannis AP
Immunological reviews267(1)137-47(2015 Sep)

The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection.
Schenkel AR, Kingry LC, Slayden RA
Frontiers in immunology490(2013)

Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response.
Kielczewska A, Pyzik M, Sun T, Krmpotic A, Lodoen MB, Munks MW, Babic M, Hill AB, Koszinowski UH, Jonjic S, Lanier LL, Vidal SM
The Journal of experimental medicine206(3)515-23(2009 Mar)

Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection.
Desrosiers MP, Kielczewska A, Loredo-Osti JC, Adam SG, Makrigiannis AP, Lemieux S, Pham T, Lodoen MB, Morgan K, Lanier LL, Vidal SM
Nature genetics37(6)593-9(2005 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate deleterious effects of interferon gamma (IFN-gamma) in regulating NK cell Ly-49 receptors during pregnancy failure.
Title: IFN-? modulates Ly-49 receptors on NK cells in IFN-?-induced pregnancy failure.

The activating Ly49P receptor recognizes cells infected with mouse cytomegalovirus (MCMV) by a process that requires the presence of H2-D(k) and the MCMV m04 protein.
Title: Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response.

The following Klra16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klra16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu57871	NM_013794.4 Latest version!	Mus musculus killer cell lectin-like receptor, subfamily A, member 16 (Klra16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klra16 ( NM_013794.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038822.3 Mus musculus killer cell lectin-like receptor, subfamily A, member 16 (Klra16), mRNA.

Price & Availability↑

CloneID	OMu57871
Clone ID Related Accession (Same CDS sequence)	NM_013794.4
Accession Version	NM_013794.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-24
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor, subfamily A, member 16
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF146570.4. On Apr 5, 2007 this sequence version replaced NM_013794.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC119242.1, AY971807.1 [ECO:0000331] ##Evidence-Data-END##

ATGAGTGAGC AGGAGGTCAC CTTCTCAACT GTGAGATTCC AAAAGACTTC AGGGTTGCAG 
AACCGGGTGA GGCTTGAGGA GACGCTGAAG CCTAGAAAAG CTGGCCTCAG AGTGTGTTCA 
GTTTCCTGGC AGTTCATTGT GATAGCTCTC GGGATCCTCA TTTCCCTTCG ACTGGTAATT 
GTTGCAGTGC TTGTGACAAA CATTTTTCAG TATGGTCAAC AAAAACATGA ACTGCAGGAA 
TTTCTAAACC ACCACAATAA CTGCAGCATC ATGCAAAGTG ACATCAAATT GAAGAATGAA 
CTGCTGAAAA AGAAGTCTAT AGAGTGTAAT CTTCTGGAAT CCCTCAACAG GGATCAGAAC 
AGATTGTATA ATAAAACCAA GACTGTTTTA GATTTTTTAC AGCACACAGG CAGAGGTGAT 
AAAGTATACT GGTTTTGTTA TGGTATGAAA TGTTATTATT TCGTGATGGA CAGAAAACCA 
TGGAGTGGAT GTAAACAGAC CTGCCAGAGT TCCGGCTTAT CCCTTCTGAA GATAGATGAT 
GAGGATGAAC TGAAGTTCCT TCAGCTCGTG GTTCCTTCAG ACGTTTGCTG GATTGGATTG 
TCATATGATA ATAAGAAAAA AGATTGGTCA TGGGTTGACA ATGGCCCATC TAAACTTGCC 
TTGAACACAA GGAAATACAA TATAAGAGAT GGAGGATGTA TGTTGTTATC TAAAACAAGA 
CTAGACAATG GTAACTGTGA TCAAGTATTC ATCTGTATTT GTGCGAAGAG ACTGGATAAC 
TTCCCTCATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038822.3
CDS	106..897
Translation	MSEQEVTFSTVRFQKTSGLQNRVRLEETLKPRKAGLRVCSVSWQFIVIALGILISLRLVIVAVLVTNIFQYGQQKHELQEFLNHHNNCSIMQSDIKLKNELLKKKSIECNLLESLNRDQNRLYNKTKTVLDFLQHTGRGDKVYWFCYGMKCYYFVMDRKPWSGCKQTCQSSGLSLLKIDDEDELKFLQLVVPSDVCWIGLSYDNKKKDWSWVDNGPSKLALNTRKYNIRDGGCMLLSKTRLDNGNCDQVFICICAKRLDNFPH

Target ORF information:

RefSeq Version	NM_013794.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor, subfamily A, member 16 (Klra16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013794.4

ORF Insert Sequence:

ATGAGTGAGC AGGAGGTCAC CTTCTCAACT GTGAGATTCC AAAAGACTTC AGGGTTGCAG 
AACCGGGTGA GGCTTGAGGA GACGCTGAAG CCTAGAAAAG CTGGCCTCAG AGTGTGTTCA 
GTTTCCTGGC AGTTCATTGT GATAGCTCTC GGGATCCTCA TTTCCCTTCG ACTGGTAATT 
GTTGCAGTGC TTGTGACAAA CATTTTTCAG TATGGTCAAC AAAAACATGA ACTGCAGGAA 
TTTCTAAACC ACCACAATAA CTGCAGCATC ATGCAAAGTG ACATCAAATT GAAGAATGAA 
CTGCTGAAAA AGAAGTCTAT AGAGTGTAAT CTTCTGGAAT CCCTCAACAG GGATCAGAAC 
AGATTGTATA ATAAAACCAA GACTGTTTTA GATTTTTTAC AGCACACAGG CAGAGGTGAT 
AAAGTATACT GGTTTTGTTA TGGTATGAAA TGTTATTATT TCGTGATGGA CAGAAAACCA 
TGGAGTGGAT GTAAACAGAC CTGCCAGAGT TCCGGCTTAT CCCTTCTGAA GATAGATGAT 
GAGGATGAAC TGAAGTTCCT TCAGCTCGTG GTTCCTTCAG ACGTTTGCTG GATTGGATTG 
TCATATGATA ATAAGAAAAA AGATTGGTCA TGGGTTGACA ATGGCCCATC TAAACTTGCC 
TTGAACACAA GGAAATACAA TATAAGAGAT GGAGGATGTA TGTTGTTATC TAAAACAAGA 
CTAGACAATG GTAACTGTGA TCAAGTATTC ATCTGTATTT GTGCGAAGAG ACTGGATAAC 
TTCCCTCATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IFN-? modulates Ly-49 receptors on NK cells in IFN-?-induced pregnancy failure.
Scientific reports518159(2015 Dec)
Li ZY,Song ZH,Meng CY,Yang DD,Yang Y,Peng JP

Ly49 receptors: evolution, genetic diversity, and impact on immunity.
Immunological reviews267(1)137-47(2015 Sep)
Rahim MM,Makrigiannis AP

The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection.
Frontiers in immunology490(2013)
Schenkel AR,Kingry LC,Slayden RA

Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response.
The Journal of experimental medicine206(3)515-23(2009 Mar)
Kielczewska A,Pyzik M,Sun T,Krmpotic A,Lodoen MB,Munks MW,Babic M,Hill AB,Koszinowski UH,Jonjic S,Lanier LL,Vidal SM

Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection.
Nature genetics37(6)593-9(2005 Jun)
Desrosiers MP,Kielczewska A,Loredo-Osti JC,Adam SG,Makrigiannis AP,Lemieux S,Pham T,Lodoen MB,Morgan K,Lanier LL,Vidal SM