Irf2bp2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Irf2bp2
Entrez Gene ID	270110
Full Name	interferon regulatory factor 2 binding protein 2
Synonyms	E130305N23Rik,IRF-2BP2
General protein information	Preferred Names interferon regulatory factor 2 binding protein 2 Names interferon regulatory factor 2-binding protein 2 IRF-2-binding protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001164598.1	NP_001158070.1	interferon regulatory factor 2-binding protein 2
NM_001164598.2	NP_001158070.1	interferon regulatory factor 2-binding protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	IRF2BP2	XP_005618905.1
Bos taurus (cattle)	IRF2BP2	XP_002698856.2
Mus musculus (house mouse)	Irf2bp2	NP_001158070.1
	LOC718705	XP_002808312.1
Rattus norvegicus (Norway rat)	Irf2bp2	XP_003751945.1
Homo sapiens (human)	IRF2BP2	NP_892017.2
Danio rerio (zebrafish)	irf2bp2b	NP_999917.1
Xenopus tropicalis (tropical clawed frog)	irf2bp2	NP_001001988.1
Pan troglodytes (chimpanzee)	IRF2BP2	XP_525097.2
Danio rerio (zebrafish)	irf2bp2a	NP_956275.1

Gene Ontology
Bibliography

Related articles in PubMed

Control of Pathological Cardiac Hypertrophy by Transcriptional Corepressor IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein 2).
Fang J, Li T, Zhu X, Deng KQ, Ji YX, Fang C, Zhang XJ, Guo JH, Zhang P, Li H, Wei X
Hypertension (Dallas, Tex. : 1979)70(3)515-523(2017 09)

IRF2BP2-deficient microglia block the anxiolytic effect of enhanced postnatal care.
Hari A, Cruz SA, Qin Z, Couture P, Vilmundarson RO, Huang H, Stewart AFR, Chen HH
Scientific reports7(1)9836(2017 Aug)

Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury.
Cruz SA, Hari A, Qin Z, Couture P, Huang H, Lagace DC, Stewart AFR, Chen HH
Frontiers in cellular neuroscience11201(2017)

IRF2BP2 transcriptional repressor restrains naive CD4 T cell activation and clonal expansion induced by TCR triggering.
S?cca C, Faget DV, Hanschke SC, Carneiro MS, Bonamino MH, de-Araujo-Souza PS, Viola JP
Journal of leukocyte biology100(5)1081-1091(2016 11)

Control of developmentally primed erythroid genes by combinatorial co-repressor actions.
Stadhouders R, Cico A, Stephen T, Thongjuea S, Kolovos P, Baymaz HI, Yu X, Demmers J, Bezstarosti K, Maas A, Barroca V, Kockx C, Ozgur Z, van Ijcken W, Arcangeli ML, Andrieu-Soler C, Lenhard B, Grosveld F, Soler E
Nature communications68893(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IRF2BP2 as a novel negative regulator in controlling pathological Cardiac Hypertrophy at the transcriptional level was defined.
Title: Control of Pathological Cardiac Hypertrophy by Transcriptional Corepressor IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein 2).

Irf2bp2 gene expression was decreased in CD4 T cells upon activation. Ectopic expression of IRF2BP2 led to a reduction in CD25 expression and STAT5 phosphorylation, along with an impaired proliferative capacity. IRF2BP2 overexpression in differentiated Th cells resulted in reduced IL-4 and pro-TGF-beta production in Th2 and iTregs but had no effect on IFN-gamma or IL-17 expression in Th1 and Th17 cells, respectively.
Title: IRF2BP2 transcriptional repressor restrains naive CD4 T cell activation and clonal expansion induced by TCR triggering.

Ablation of IRF2BP2 in macrophages worsens atherosclerosis in mice.
Title: IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis.

IRF2BP2 is a novel ischemia-induced coactivator of VEGFA expression that may contribute to revascularization of ischemic cardiac and skeletal muscles.
Title: IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression.

The following Irf2bp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Irf2bp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu09926	NM_001164598.2 Latest version!	Mus musculus interferon regulatory factor 2 binding protein 2 (Irf2bp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$335.30 $479.00
View Old Accession Versions >>
OMu09926	NM_001164598.1	Mus musculus interferon regulatory factor 2 binding protein 2 (Irf2bp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$335.30 $479.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Irf2bp2 ( NM_001164598.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001158070.1 Mus musculus interferon regulatory factor 2 binding protein 2 (Irf2bp2), mRNA.

Price & Availability↑

CloneID	OMu09926
Clone ID Related Accession (Same CDS sequence)	NM_001164598.1 , NM_001164598.2
Accession Version	NM_001164598.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1713bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Mus musculus(house mouse)
Product	interferon regulatory factor 2-binding protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC118255.32. On or before Sep 9, 2009 this sequence version replaced XM_001002526.2, XM_284454.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.292210.1, SRR1660811.323596.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849390 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCGG CGGTGGCGGT GGCGGCCGCC TCTCGGCGCC AGTCGTGCTA TCTGTGTGAC 
CTGCCCCGCA TGCCCTGGGC CATGATCTGG GACTTCACGG AGCCCGTGTG CCGCGGCTGC 
GTCAACTACG AGGGAGCCGA CCGCGTGGAG TTCGTCATCG AGACGGCCCG CCAGCTGAAG 
CGTGCTCACG GCTGCTTCCC GGAGGGCCGC TCCCCGACCG GTGCACAGCC CGCAGCCGCC 
AAGCCACCGC CACTGTCGGC CAAGGACCTA CTGCTGCAGC CGCCGCCGCA GCTGGGCCAC 
GCGGGCGCCG AGGCCGCGCG CGCTCAGGCT ATGGAGCGCT ACCCGCTGGC GCCGGATCGT 
GCCCCGCGCC TGGCCTCCGA CTTCAGCACG CGTGCGGGTG CAGGCCTCCC ACAGTCGGCC 
GCGCAGCAGT CCGCGCCGGC GAACGGCATC CTGGTGCCCA ACGGGTTCTC CAAACTGGAG 
GAGCCGCCGG AGCTGAATCG CCAGAGCCCG AACCCTCGGC GTGCACACGC CGTTCCGCCC 
ACTCTGGTGC CTCTGGTCAA CGGTTCTGCC GCGCTGGGGT TGAGCGGCCG TGCTGCGGCC 
ACACTGGCCG CGGTGAGCGG AACACCGGGC CTGGGAGCTC AGCCCGCCGA GTTGGGCACC 
CACAAACGCC CGGCGTCTGT GTCGAGCGCG GCGGCGGAGC ACGAGGCGCG CGAGCCGAGC 
AAGGAGAAGG CGCAGCCCGC GCACCGGAGT CCGGCCGACA GCTTATCCAG CGCGGCCGGG 
GCCAGCGAGC TGAGCGCCGA GGGTGCAGGC AAAGGCCGCG CGCCCGGGGA GCAGGACTGG 
GCCAGCAGGC CTAAGACGGT GCGGGACACG CTCCTGGCGC TGCACCAGCA CGGCCACTCG 
GGGCCCTTCG AGAGCAAGTT CAAGAAGGAG CCGGCTCTGA CTGCAGCAGG CAGGTTGTTG 
GGTTTCGAGG CCAACGGGGC CAACGGGTCT AAAGCAGTTG CAAGGACAGC AAGGAAAAGG 
AAGCCTTCCC CAGAACCGGA AGGGGAAGTC GGGCCCCCTA AGATCAATGG TGAGACACAG 
CCTTGGCTGT CCACTTCCAC AGAAGGGCTC AAGATCCCCA TCACCCCTAC ATCCTCTTTT 
GTGTCTCCAC CACCCCCTAC TGCCTCTCCT CATTCCAACC GGACCACACC GCCTGAAGCG 
GCCCAGAATG GCCAGTCCCC AATGGCAGCC CTGATTTTAG TAGCAGACAA TGCCGGGGGC 
AGTCACGCCT CAAAAGATGC CACCCAGGTT CACTCCACCA CCAGGAGGAA CAGCAGCAGC 
CCGCCCTCTC CCTCCTCTAT GAACCAAAGA AGGCTTGGCC CCAGAGAGGT GGGGGGCCAG 
GCCACCGGCA GCACCGGAGG ACTGGAGCCG GTGCACCCTG CCAGCCTCCC AGACTCCTCT 
CTGGCAGCCA GCGCCCCCCT GTGCTGCACC CTCTGCCACG AGCGGCTGGA GGATACTCAC 
TTTGTGCAGT GCCCGTCTGT CCCTTCGCAC AAGTTCTGTT TCCCTTGCTC CAGACAAAGC 
ATTAAACAGC AGGGCGCTAG CGGAGAGGTC TATTGCCCAA GTGGAGAGAA GTGTCCTCTG 
GTGGGCTCCA ATGTCCCCTG GGCCTTCATG CAAGGAGAGA TTGCTACCAT CCTCGCCGGA 
GATGTGAAAG TGAAGAAGGA GAGAGACTCG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001158070.1
CDS	1..1713
Translation	MAAAVAVAAASRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLKRAHGCFPEGRSPTGAQPAAAKPPPLSAKDLLLQPPPQLGHAGAEAARAQAMERYPLAPDRAPRLASDFSTRAGAGLPQSAAQQSAPANGILVPNGFSKLEEPPELNRQSPNPRRAHAVPPTLVPLVNGSAALGLSGRAAATLAAVSGTPGLGAQPAELGTHKRPASVSSAAAEHEAREPSKEKAQPAHRSPADSLSSAAGASELSAEGAGKGRAPGEQDWASRPKTVRDTLLALHQHGHSGPFESKFKKEPALTAAGRLLGFEANGANGSKAVARTARKRKPSPEPEGEVGPPKINGETQPWLSTSTEGLKIPITPTSSFVSPPPPTASPHSNRTTPPEAAQNGQSPMAALILVADNAGGSHASKDATQVHSTTRRNSSSPPSPSSMNQRRLGPREVGGQATGSTGGLEPVHPASLPDSSLAASAPLCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGASGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDS

Target ORF information:

RefSeq Version	NM_001164598.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interferon regulatory factor 2 binding protein 2 (Irf2bp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001164598.1

ORF Insert Sequence:

ATGGCCGCGG CGGTGGCGGT GGCGGCCGCC TCTCGGCGCC AGTCGTGCTA TCTGTGTGAC 
CTGCCCCGCA TGCCCTGGGC CATGATCTGG GACTTCACGG AGCCCGTGTG CCGCGGCTGC 
GTCAACTACG AGGGAGCCGA CCGCGTGGAG TTCGTCATCG AGACGGCCCG CCAGCTGAAG 
CGTGCTCACG GCTGCTTCCC GGAGGGCCGC TCCCCGACCG GTGCACAGCC CGCAGCCGCC 
AAGCCACCGC CACTGTCGGC CAAGGACCTA CTGCTGCAGC CGCCGCCGCA GCTGGGCCAC 
GCGGGCGCCG AGGCCGCGCG CGCTCAGGCT ATGGAGCGCT ACCCGCTGGC GCCGGATCGT 
GCCCCGCGCC TGGCCTCCGA CTTCAGCACG CGTGCGGGTG CAGGCCTCCC ACAGTCGGCC 
GCGCAGCAGT CCGCGCCGGC GAACGGCATC CTGGTGCCCA ACGGGTTCTC CAAACTGGAG 
GAGCCGCCGG AGCTGAATCG CCAGAGCCCG AACCCTCGGC GTGCACACGC CGTTCCGCCC 
ACTCTGGTGC CTCTGGTCAA CGGTTCTGCC GCGCTGGGGT TGAGCGGCCG TGCTGCGGCC 
ACACTGGCCG CGGTGAGCGG AACACCGGGC CTGGGAGCTC AGCCCGCCGA GTTGGGCACC 
CACAAACGCC CGGCGTCTGT GTCGAGCGCG GCGGCGGAGC ACGAGGCGCG CGAGCCGAGC 
AAGGAGAAGG CGCAGCCCGC GCACCGGAGT CCGGCCGACA GCTTATCCAG CGCGGCCGGG 
GCCAGCGAGC TGAGCGCCGA GGGTGCAGGC AAAGGCCGCG CGCCCGGGGA GCAGGACTGG 
GCCAGCAGGC CTAAGACGGT GCGGGACACG CTCCTGGCGC TGCACCAGCA CGGCCACTCG 
GGGCCCTTCG AGAGCAAGTT CAAGAAGGAG CCGGCTCTGA CTGCAGCAGG CAGGTTGTTG 
GGTTTCGAGG CCAACGGGGC CAACGGGTCT AAAGCAGTTG CAAGGACAGC AAGGAAAAGG 
AAGCCTTCCC CAGAACCGGA AGGGGAAGTC GGGCCCCCTA AGATCAATGG TGAGACACAG 
CCTTGGCTGT CCACTTCCAC AGAAGGGCTC AAGATCCCCA TCACCCCTAC ATCCTCTTTT 
GTGTCTCCAC CACCCCCTAC TGCCTCTCCT CATTCCAACC GGACCACACC GCCTGAAGCG 
GCCCAGAATG GCCAGTCCCC AATGGCAGCC CTGATTTTAG TAGCAGACAA TGCCGGGGGC 
AGTCACGCCT CAAAAGATGC CACCCAGGTT CACTCCACCA CCAGGAGGAA CAGCAGCAGC 
CCGCCCTCTC CCTCCTCTAT GAACCAAAGA AGGCTTGGCC CCAGAGAGGT GGGGGGCCAG 
GCCACCGGCA GCACCGGAGG ACTGGAGCCG GTGCACCCTG CCAGCCTCCC AGACTCCTCT 
CTGGCAGCCA GCGCCCCCCT GTGCTGCACC CTCTGCCACG AGCGGCTGGA GGATACTCAC 
TTTGTGCAGT GCCCGTCTGT CCCTTCGCAC AAGTTCTGTT TCCCTTGCTC CAGACAAAGC 
ATTAAACAGC AGGGCGCTAG CGGAGAGGTC TATTGCCCAA GTGGAGAGAA GTGTCCTCTG 
GTGGGCTCCA ATGTCCCCTG GGCCTTCATG CAAGGAGAGA TTGCTACCAT CCTCGCCGGA 
GATGTGAAAG TGAAGAAGGA GAGAGACTCG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Irf2bp2 ( NM_001164598.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001158070.1 Mus musculus interferon regulatory factor 2 binding protein 2 (Irf2bp2), mRNA.

Price & Availability↑

CloneID	OMu09926
Clone ID Related Accession (Same CDS sequence)	NM_001164598.1 , NM_001164598.2
Accession Version	NM_001164598.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1713bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Mus musculus(house mouse)
Product	interferon regulatory factor 2-binding protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC118255.32. On Jun 19, 2019 this sequence version replaced NM_001164598.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR6238556.2697749.1, SRR6238556.2697748.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849390 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCGCGG CGGTGGCGGT GGCGGCCGCC TCTCGGCGCC AGTCGTGCTA TCTGTGTGAC 
CTGCCCCGCA TGCCCTGGGC CATGATCTGG GACTTCACGG AGCCCGTGTG CCGCGGCTGC 
GTCAACTACG AGGGAGCCGA CCGCGTGGAG TTCGTCATCG AGACGGCCCG CCAGCTGAAG 
CGTGCTCACG GCTGCTTCCC GGAGGGCCGC TCCCCGACCG GTGCACAGCC CGCAGCCGCC 
AAGCCACCGC CACTGTCGGC CAAGGACCTA CTGCTGCAGC CGCCGCCGCA GCTGGGCCAC 
GCGGGCGCCG AGGCCGCGCG CGCTCAGGCT ATGGAGCGCT ACCCGCTGGC GCCGGATCGT 
GCCCCGCGCC TGGCCTCCGA CTTCAGCACG CGTGCGGGTG CAGGCCTCCC ACAGTCGGCC 
GCGCAGCAGT CCGCGCCGGC GAACGGCATC CTGGTGCCCA ACGGGTTCTC CAAACTGGAG 
GAGCCGCCGG AGCTGAATCG CCAGAGCCCG AACCCTCGGC GTGCACACGC CGTTCCGCCC 
ACTCTGGTGC CTCTGGTCAA CGGTTCTGCC GCGCTGGGGT TGAGCGGCCG TGCTGCGGCC 
ACACTGGCCG CGGTGAGCGG AACACCGGGC CTGGGAGCTC AGCCCGCCGA GTTGGGCACC 
CACAAACGCC CGGCGTCTGT GTCGAGCGCG GCGGCGGAGC ACGAGGCGCG CGAGCCGAGC 
AAGGAGAAGG CGCAGCCCGC GCACCGGAGT CCGGCCGACA GCTTATCCAG CGCGGCCGGG 
GCCAGCGAGC TGAGCGCCGA GGGTGCAGGC AAAGGCCGCG CGCCCGGGGA GCAGGACTGG 
GCCAGCAGGC CTAAGACGGT GCGGGACACG CTCCTGGCGC TGCACCAGCA CGGCCACTCG 
GGGCCCTTCG AGAGCAAGTT CAAGAAGGAG CCGGCTCTGA CTGCAGCAGG CAGGTTGTTG 
GGTTTCGAGG CCAACGGGGC CAACGGGTCT AAAGCAGTTG CAAGGACAGC AAGGAAAAGG 
AAGCCTTCCC CAGAACCGGA AGGGGAAGTC GGGCCCCCTA AGATCAATGG TGAGACACAG 
CCTTGGCTGT CCACTTCCAC AGAAGGGCTC AAGATCCCCA TCACCCCTAC ATCCTCTTTT 
GTGTCTCCAC CACCCCCTAC TGCCTCTCCT CATTCCAACC GGACCACACC GCCTGAAGCG 
GCCCAGAATG GCCAGTCCCC AATGGCAGCC CTGATTTTAG TAGCAGACAA TGCCGGGGGC 
AGTCACGCCT CAAAAGATGC CACCCAGGTT CACTCCACCA CCAGGAGGAA CAGCAGCAGC 
CCGCCCTCTC CCTCCTCTAT GAACCAAAGA AGGCTTGGCC CCAGAGAGGT GGGGGGCCAG 
GCCACCGGCA GCACCGGAGG ACTGGAGCCG GTGCACCCTG CCAGCCTCCC AGACTCCTCT 
CTGGCAGCCA GCGCCCCCCT GTGCTGCACC CTCTGCCACG AGCGGCTGGA GGATACTCAC 
TTTGTGCAGT GCCCGTCTGT CCCTTCGCAC AAGTTCTGTT TCCCTTGCTC CAGACAAAGC 
ATTAAACAGC AGGGCGCTAG CGGAGAGGTC TATTGCCCAA GTGGAGAGAA GTGTCCTCTG 
GTGGGCTCCA ATGTCCCCTG GGCCTTCATG CAAGGAGAGA TTGCTACCAT CCTCGCCGGA 
GATGTGAAAG TGAAGAAGGA GAGAGACTCG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001158070.1
CDS	551..2263
Translation	MAAAVAVAAASRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLKRAHGCFPEGRSPTGAQPAAAKPPPLSAKDLLLQPPPQLGHAGAEAARAQAMERYPLAPDRAPRLASDFSTRAGAGLPQSAAQQSAPANGILVPNGFSKLEEPPELNRQSPNPRRAHAVPPTLVPLVNGSAALGLSGRAAATLAAVSGTPGLGAQPAELGTHKRPASVSSAAAEHEAREPSKEKAQPAHRSPADSLSSAAGASELSAEGAGKGRAPGEQDWASRPKTVRDTLLALHQHGHSGPFESKFKKEPALTAAGRLLGFEANGANGSKAVARTARKRKPSPEPEGEVGPPKINGETQPWLSTSTEGLKIPITPTSSFVSPPPPTASPHSNRTTPPEAAQNGQSPMAALILVADNAGGSHASKDATQVHSTTRRNSSSPPSPSSMNQRRLGPREVGGQATGSTGGLEPVHPASLPDSSLAASAPLCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGASGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDS

Target ORF information:

RefSeq Version	NM_001164598.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus interferon regulatory factor 2 binding protein 2 (Irf2bp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001164598.2

ORF Insert Sequence:

ATGGCCGCGG CGGTGGCGGT GGCGGCCGCC TCTCGGCGCC AGTCGTGCTA TCTGTGTGAC 
CTGCCCCGCA TGCCCTGGGC CATGATCTGG GACTTCACGG AGCCCGTGTG CCGCGGCTGC 
GTCAACTACG AGGGAGCCGA CCGCGTGGAG TTCGTCATCG AGACGGCCCG CCAGCTGAAG 
CGTGCTCACG GCTGCTTCCC GGAGGGCCGC TCCCCGACCG GTGCACAGCC CGCAGCCGCC 
AAGCCACCGC CACTGTCGGC CAAGGACCTA CTGCTGCAGC CGCCGCCGCA GCTGGGCCAC 
GCGGGCGCCG AGGCCGCGCG CGCTCAGGCT ATGGAGCGCT ACCCGCTGGC GCCGGATCGT 
GCCCCGCGCC TGGCCTCCGA CTTCAGCACG CGTGCGGGTG CAGGCCTCCC ACAGTCGGCC 
GCGCAGCAGT CCGCGCCGGC GAACGGCATC CTGGTGCCCA ACGGGTTCTC CAAACTGGAG 
GAGCCGCCGG AGCTGAATCG CCAGAGCCCG AACCCTCGGC GTGCACACGC CGTTCCGCCC 
ACTCTGGTGC CTCTGGTCAA CGGTTCTGCC GCGCTGGGGT TGAGCGGCCG TGCTGCGGCC 
ACACTGGCCG CGGTGAGCGG AACACCGGGC CTGGGAGCTC AGCCCGCCGA GTTGGGCACC 
CACAAACGCC CGGCGTCTGT GTCGAGCGCG GCGGCGGAGC ACGAGGCGCG CGAGCCGAGC 
AAGGAGAAGG CGCAGCCCGC GCACCGGAGT CCGGCCGACA GCTTATCCAG CGCGGCCGGG 
GCCAGCGAGC TGAGCGCCGA GGGTGCAGGC AAAGGCCGCG CGCCCGGGGA GCAGGACTGG 
GCCAGCAGGC CTAAGACGGT GCGGGACACG CTCCTGGCGC TGCACCAGCA CGGCCACTCG 
GGGCCCTTCG AGAGCAAGTT CAAGAAGGAG CCGGCTCTGA CTGCAGCAGG CAGGTTGTTG 
GGTTTCGAGG CCAACGGGGC CAACGGGTCT AAAGCAGTTG CAAGGACAGC AAGGAAAAGG 
AAGCCTTCCC CAGAACCGGA AGGGGAAGTC GGGCCCCCTA AGATCAATGG TGAGACACAG 
CCTTGGCTGT CCACTTCCAC AGAAGGGCTC AAGATCCCCA TCACCCCTAC ATCCTCTTTT 
GTGTCTCCAC CACCCCCTAC TGCCTCTCCT CATTCCAACC GGACCACACC GCCTGAAGCG 
GCCCAGAATG GCCAGTCCCC AATGGCAGCC CTGATTTTAG TAGCAGACAA TGCCGGGGGC 
AGTCACGCCT CAAAAGATGC CACCCAGGTT CACTCCACCA CCAGGAGGAA CAGCAGCAGC 
CCGCCCTCTC CCTCCTCTAT GAACCAAAGA AGGCTTGGCC CCAGAGAGGT GGGGGGCCAG 
GCCACCGGCA GCACCGGAGG ACTGGAGCCG GTGCACCCTG CCAGCCTCCC AGACTCCTCT 
CTGGCAGCCA GCGCCCCCCT GTGCTGCACC CTCTGCCACG AGCGGCTGGA GGATACTCAC 
TTTGTGCAGT GCCCGTCTGT CCCTTCGCAC AAGTTCTGTT TCCCTTGCTC CAGACAAAGC 
ATTAAACAGC AGGGCGCTAG CGGAGAGGTC TATTGCCCAA GTGGAGAGAA GTGTCCTCTG 
GTGGGCTCCA ATGTCCCCTG GGCCTTCATG CAAGGAGAGA TTGCTACCAT CCTCGCCGGA 
GATGTGAAAG TGAAGAAGGA GAGAGACTCG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Control of Pathological Cardiac Hypertrophy by Transcriptional Corepressor IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein 2).
Hypertension (Dallas, Tex. : 1979)70(3)515-523(2017 09)
Fang J,Li T,Zhu X,Deng KQ,Ji YX,Fang C,Zhang XJ,Guo JH,Zhang P,Li H,Wei X

IRF2BP2-deficient microglia block the anxiolytic effect of enhanced postnatal care.
Scientific reports7(1)9836(2017 Aug)
Hari A,Cruz SA,Qin Z,Couture P,Vilmundarson RO,Huang H,Stewart AFR,Chen HH

Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury.
Frontiers in cellular neuroscience11201(2017)
Cruz SA,Hari A,Qin Z,Couture P,Huang H,Lagace DC,Stewart AFR,Chen HH

IRF2BP2 transcriptional repressor restrains naive CD4 T cell activation and clonal expansion induced by TCR triggering.
Journal of leukocyte biology100(5)1081-1091(2016 11)
S?cca C,Faget DV,Hanschke SC,Carneiro MS,Bonamino MH,de-Araujo-Souza PS,Viola JP

Control of developmentally primed erythroid genes by combinatorial co-repressor actions.
Nature communications68893(2015 Nov)
Stadhouders R,Cico A,Stephen T,Thongjuea S,Kolovos P,Baymaz HI,Yu X,Demmers J,Bezstarosti K,Maas A,Barroca V,Kockx C,Ozgur Z,van Ijcken W,Arcangeli ML,Andrieu-Soler C,Lenhard B,Grosveld F,Soler E

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Irf2bp2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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