Cers6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cers6
Entrez Gene ID	241447
Full Name	ceramide synthase 6
Synonyms	4732462C07Rik,AW544719,Lass6,T1L
General protein information	Preferred Names ceramide synthase 6 Names ceramide synthase 6 LAG1 homolog, ceramide synthase 6 LAG1 longevity assurance homolog 6 longevity assurance homolog 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 C2

mRNA and Protein(s)

mRNA	Protein	Name
NM_172856.4	NP_766444.1	ceramide synthase 6 isoform 2
NM_172856.3	NP_766444.1	ceramide synthase 6
XM_017318074.1	XP_017173563.1	ceramide synthase 6 isoform X1
NM_001347161.1	NP_001334090.1	ceramide synthase 6 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CERS6	NP_982288.1
Rattus norvegicus (Norway rat)	Cers6	XP_006234370.1
Pan troglodytes (chimpanzee)	LASS6	XP_001154846.1
Bos taurus (cattle)	CERS6	NP_001180061.1
Arabidopsis thaliana (thale cress)	AT1G26200	NP_001154368.1
	LASS6	XP_001102489.1
Canis lupus familiaris (dog)	CERS6	XP_545509.3
Mus musculus (house mouse)	Cers6	NP_766444.1
Gallus gallus (chicken)	CERS6	XP_004942833.1
Danio rerio (zebrafish)	cers6	XP_693283.4
Xenopus tropicalis (tropical clawed frog)	cers6	XP_004917763.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis.
Williams B, Correnti J, Oranu A, Lin A, Scott V, Annoh M, Beck J, Furth E, Mitchell V, Senkal CE, Obeid L, Carr RM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology32(1)130-142(2018 Jan)

Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis.
Scheffel MJ, Helke K, Lu P, Bowers JS, Ogretmen B, Garrett-Mayer E, Paulos CM, Voelkel-Johnson C
Scientific reports7(1)15552(2017 Nov)

Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.
Li S, Teegarden A, Bauer EM, Choi J, Messaddeq N, Hendrix DA, Ganguli-Indra G, Leid M, Indra AK
Scientific reports7(1)13427(2017 Oct)

Ceramide synthesis regulates T cell activity and GVHD development.
Sofi MH, Heinrichs J, Dany M, Nguyen H, Dai M, Bastian D, Schutt S, Wu Y, Daenthanasanmak A, Gencer S, Zivkovic A, Szulc Z, Stark H, Liu C, Chang YJ, Ogretmen B, Yu XZ
JCI insight2(10)(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths.
Title: Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.

CerS1, -2, and -6 are hyperacetylated in the mitochondria of SIRT3-null mice.
Title: SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.

Data show that ceramide synthase 6 knockout (CerS6KO) experimental autoimmune encephalomyelitis (EAE) mice exhibit exacerbated progression of clinical symptoms.
Title: Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.

CerS6 deletion increases energy expenditure and improves glucose tolerance, not only in CerS6(Delta/Delta) mice, but also in brown adipose tissue- (CerS6(DeltaBAT)) and liver-specific (CerS6(DeltaLIVER)) CerS6 knockout mice.
Title: Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.

Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1-Cers6) activity in macrophages is responsible for the accumulation of ceramide.
Title: Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases.

The following Cers6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cers6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu30433	NM_001347161.1 Latest version!	Mus musculus ceramide synthase 6 (Cers6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu19574	NM_172856.4 Latest version!	Mus musculus ceramide synthase 6 (Cers6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu80248	XM_017318074.1 Latest version!	Mus musculus ceramide synthase 6 (Cers6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu19574	NM_172856.3	Mus musculus ceramide synthase 6 (Cers6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cers6 ( NM_001347161.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001334090.1 Mus musculus ceramide synthase 6 (Cers6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu30433
Clone ID Related Accession (Same CDS sequence)	NM_001347161.1
Accession Version	NM_001347161.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1179bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-13
Organism	Mus musculus(house mouse)
Product	ceramide synthase 6 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL929137.5 and AL929221.6. On Nov 17, 2016 this sequence version replaced XM_006499452.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.355702.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849385 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGGGA TCTTAGCCTG GTTCTGGAAC GAGCGGTTTT GGCTTCCGCA CAATGTCACC 
TGGGCAGACC TGAAGAACAC GGAGGAAGCC ACCTTTCCGC AGGCGGAGGA CCTCTACCTT 
GCCTTCCCCT TGGCCTTCTG CATCTTCATG GTGCGGCTCA TCTTCGAGAG ATTCATAGCC 
AAACCATGTG CCATAGCCCT CAACATCCAA GCCAATGGAC CACAAACTGC CCAGCCAAAT 
GCCATTCTGG AAAAGGTTTT CACTGCTATA ACAAAGCATC CTGATGAAAA GAGATTAGAA 
GGGCTCTCCA AGCAGCTGGA CTGGGATGTT CGGAGCATTC AACGCTGGTT TCGACAAAGA 
CGCAACCAGG AGAAACCCAG CACTCTGACC AGGTTCTGTG AGAGCATGTG GAGATTTTCC 
TTTTACCTCT ATGTATTTAG CTACGGAGTC CGGTTCTTGA AACAGACCCC TTGGTTGTGG 
AATACAAGAC ACTGCTGGTA TAACTACCCT TACCAGCCAC TCACAGCTGA CCTTCACTAC 
TATTACATCC TGGAGCTGTC ATTTTATTGG TCTTTAATGG TTTCCCAGTT CACAGATATC 
AAAAGGAAGG ACTTCGGCAT TATGTTCCTG CACCACCTTG CAACAATTTT CTTAATAACC 
TTTTCATATG TCAACAACAT GGCCCGAGTA GGAACCCTGG TCCTCTGTCT TCACGACTCA 
GCCGATGCTC TGCTAGAGGC TGCCAAAATG GCAAATTACG CCAAATTTCA GAAAATGTGT 
GATCTCCTGT TTGTCATGTT TGCCGTGGTT TTTATCACCA CACGGCTGGG CATATTTCCT 
CTCTGGGTGT TGAATACCAC ATTATTTGAA AGTTGGGAGA TCGTCGGACC CTACCCTTCC 
TGGTGGGTTT TTAACCTGCT GCTCTTGTTA CTACAAGGGT TGAACTGCTT CTGGTCTTAC 
CTGATTGTAA AAATAGCTTG CAAAACTGTT TCAAAAGGCA AGGCTGGGAA GTGGAACCCT 
TTGCATGTAT CCAAGGATGA CCGGAGTGAC ATTGAATCTA GCTCAGATGA TGAGGACTCA 
GAGCCTCCAG GGAAGAAACC ACACTCTTCA ACAACCACCA ACGGAACCAG CGGTACCAAT 
GGGTACCTCC TCACTGGTCC TTGTTCCGTG GATGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334090.1
CDS	196..1374
Translation	MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFIAKPCAIALNIQANGPQTAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFSYGVRFLKQTPWLWNTRHCWYNYPYQPLTADLHYYYILELSFYWSLMVSQFTDIKRKDFGIMFLHHLATIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLLQGLNCFWSYLIVKIACKTVSKGKAGKWNPLHVSKDDRSDIESSSDDEDSEPPGKKPHSSTTTNGTSGTNGYLLTGPCSVDD

Target ORF information:

RefSeq Version	NM_001347161.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ceramide synthase 6 (Cers6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347161.1

ORF Insert Sequence:

ATGGCAGGGA TCTTAGCCTG GTTCTGGAAC GAGCGGTTTT GGCTTCCGCA CAATGTCACC 
TGGGCAGACC TGAAGAACAC GGAGGAAGCC ACCTTTCCGC AGGCGGAGGA CCTCTACCTT 
GCCTTCCCCT TGGCCTTCTG CATCTTCATG GTGCGGCTCA TCTTCGAGAG ATTCATAGCC 
AAACCATGTG CCATAGCCCT CAACATCCAA GCCAATGGAC CACAAACTGC CCAGCCAAAT 
GCCATTCTGG AAAAGGTTTT CACTGCTATA ACAAAGCATC CTGATGAAAA GAGATTAGAA 
GGGCTCTCCA AGCAGCTGGA CTGGGATGTT CGGAGCATTC AACGCTGGTT TCGACAAAGA 
CGCAACCAGG AGAAACCCAG CACTCTGACC AGGTTCTGTG AGAGCATGTG GAGATTTTCC 
TTTTACCTCT ATGTATTTAG CTACGGAGTC CGGTTCTTGA AACAGACCCC TTGGTTGTGG 
AATACAAGAC ACTGCTGGTA TAACTACCCT TACCAGCCAC TCACAGCTGA CCTTCACTAC 
TATTACATCC TGGAGCTGTC ATTTTATTGG TCTTTAATGG TTTCCCAGTT CACAGATATC 
AAAAGGAAGG ACTTCGGCAT TATGTTCCTG CACCACCTTG CAACAATTTT CTTAATAACC 
TTTTCATATG TCAACAACAT GGCCCGAGTA GGAACCCTGG TCCTCTGTCT TCACGACTCA 
GCCGATGCTC TGCTAGAGGC TGCCAAAATG GCAAATTACG CCAAATTTCA GAAAATGTGT 
GATCTCCTGT TTGTCATGTT TGCCGTGGTT TTTATCACCA CACGGCTGGG CATATTTCCT 
CTCTGGGTGT TGAATACCAC ATTATTTGAA AGTTGGGAGA TCGTCGGACC CTACCCTTCC 
TGGTGGGTTT TTAACCTGCT GCTCTTGTTA CTACAAGGGT TGAACTGCTT CTGGTCTTAC 
CTGATTGTAA AAATAGCTTG CAAAACTGTT TCAAAAGGCA AGGCTGGGAA GTGGAACCCT 
TTGCATGTAT CCAAGGATGA CCGGAGTGAC ATTGAATCTA GCTCAGATGA TGAGGACTCA 
GAGCCTCCAG GGAAGAAACC ACACTCTTCA ACAACCACCA ACGGAACCAG CGGTACCAAT 
GGGTACCTCC TCACTGGTCC TTGTTCCGTG GATGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cers6 ( NM_172856.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766444.1 Mus musculus ceramide synthase 6 (Cers6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu19574
Clone ID Related Accession (Same CDS sequence)	NM_172856.4 , NM_172856.3
Accession Version	NM_172856.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Mus musculus(house mouse)
Product	ceramide synthase 6 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL929137.5, AK028849.1 and AL929221.6. On Nov 17, 2016 this sequence version replaced NM_172856.3. Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028849.1, AK135798.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGGGA TCTTAGCCTG GTTCTGGAAC GAGCGGTTTT GGCTTCCGCA CAATGTCACC 
TGGGCAGACC TGAAGAACAC GGAGGAAGCC ACCTTTCCGC AGGCGGAGGA CCTCTACCTT 
GCCTTCCCCT TGGCCTTCTG CATCTTCATG GTGCGGCTCA TCTTCGAGAG ATTCATAGCC 
AAACCATGTG CCATAGCCCT CAACATCCAA GCCAATGGAC CACAAACTGC CCAGCCAAAT 
GCCATTCTGG AAAAGGTTTT CACTGCTATA ACAAAGCATC CTGATGAAAA GAGATTAGAA 
GGGCTCTCCA AGCAGCTGGA CTGGGATGTT CGGAGCATTC AACGCTGGTT TCGACAAAGA 
CGCAACCAGG AGAAACCCAG CACTCTGACC AGGTTCTGTG AGAGCATGTG GAGATTTTCC 
TTTTACCTCT ATGTATTTAG CTACGGAGTC CGGTTCTTGA AACAGACCCC TTGGTTGTGG 
AATACAAGAC ACTGCTGGTA TAACTACCCT TACCAGCCAC TCACAGCTGA CCTTCACTAC 
TATTACATCC TGGAGCTGTC ATTTTATTGG TCTTTAATGG TTTCCCAGTT CACAGATATC 
AAAAGGAAGG ACTTCGGCAT TATGTTCCTG CACCACCTTG CAACAATTTT CTTAATAACC 
TTTTCATATG TCAACAACAT GGCCCGAGTA GGAACCCTGG TCCTCTGTCT TCACGACTCA 
GCCGATGCTC TGCTAGAGGC TGCCAAAATG GCAAATTACG CCAAATTTCA GAAAATGTGT 
GATCTCCTGT TTGTCATGTT TGCCGTGGTT TTTATCACCA CACGGCTGGG CATATTTCCT 
CTCTGGGTGT TGAATACCAC ATTATTTGAA AGTTGGGAGA TCGTCGGACC CTACCCTTCC 
TGGTGGGTTT TTAACCTGCT GCTCTTGTTA CTACAAGGGT TGAACTGCTT CTGGTCTTAC 
CTGATTGTAA AAATAGCTTG CAAAACTGTT TCAAAAGGCA AGGTATCCAA GGATGACCGG 
AGTGACATTG AATCTAGCTC AGATGATGAG GACTCAGAGC CTCCAGGGAA GAAACCACAC 
TCTTCAACAA CCACCAACGG AACCAGCGGT ACCAATGGGT ACCTCCTCAC TGGTCCTTGT 
TCCGTGGATG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766444.1
CDS	196..1350
Translation	MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFIAKPCAIALNIQANGPQTAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFSYGVRFLKQTPWLWNTRHCWYNYPYQPLTADLHYYYILELSFYWSLMVSQFTDIKRKDFGIMFLHHLATIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLLQGLNCFWSYLIVKIACKTVSKGKVSKDDRSDIESSSDDEDSEPPGKKPHSSTTTNGTSGTNGYLLTGPCSVDD

Target ORF information:

RefSeq Version	NM_172856.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus ceramide synthase 6 (Cers6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172856.4

ORF Insert Sequence:

ATGGCAGGGA TCTTAGCCTG GTTCTGGAAC GAGCGGTTTT GGCTTCCGCA CAATGTCACC 
TGGGCAGACC TGAAGAACAC GGAGGAAGCC ACCTTTCCGC AGGCGGAGGA CCTCTACCTT 
GCCTTCCCCT TGGCCTTCTG CATCTTCATG GTGCGGCTCA TCTTCGAGAG ATTCATAGCC 
AAACCATGTG CCATAGCCCT CAACATCCAA GCCAATGGAC CACAAACTGC CCAGCCAAAT 
GCCATTCTGG AAAAGGTTTT CACTGCTATA ACAAAGCATC CTGATGAAAA GAGATTAGAA 
GGGCTCTCCA AGCAGCTGGA CTGGGATGTT CGGAGCATTC AACGCTGGTT TCGACAAAGA 
CGCAACCAGG AGAAACCCAG CACTCTGACC AGGTTCTGTG AGAGCATGTG GAGATTTTCC 
TTTTACCTCT ATGTATTTAG CTACGGAGTC CGGTTCTTGA AACAGACCCC TTGGTTGTGG 
AATACAAGAC ACTGCTGGTA TAACTACCCT TACCAGCCAC TCACAGCTGA CCTTCACTAC 
TATTACATCC TGGAGCTGTC ATTTTATTGG TCTTTAATGG TTTCCCAGTT CACAGATATC 
AAAAGGAAGG ACTTCGGCAT TATGTTCCTG CACCACCTTG CAACAATTTT CTTAATAACC 
TTTTCATATG TCAACAACAT GGCCCGAGTA GGAACCCTGG TCCTCTGTCT TCACGACTCA 
GCCGATGCTC TGCTAGAGGC TGCCAAAATG GCAAATTACG CCAAATTTCA GAAAATGTGT 
GATCTCCTGT TTGTCATGTT TGCCGTGGTT TTTATCACCA CACGGCTGGG CATATTTCCT 
CTCTGGGTGT TGAATACCAC ATTATTTGAA AGTTGGGAGA TCGTCGGACC CTACCCTTCC 
TGGTGGGTTT TTAACCTGCT GCTCTTGTTA CTACAAGGGT TGAACTGCTT CTGGTCTTAC 
CTGATTGTAA AAATAGCTTG CAAAACTGTT TCAAAAGGCA AGGTATCCAA GGATGACCGG 
AGTGACATTG AATCTAGCTC AGATGATGAG GACTCAGAGC CTCCAGGGAA GAAACCACAC 
TCTTCAACAA CCACCAACGG AACCAGCGGT ACCAATGGGT ACCTCCTCAC TGGTCCTTGT 
TCCGTGGATG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cers6 ( NM_172856.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766444.1 Mus musculus ceramide synthase 6 (Cers6), mRNA.

Price & Availability↑

CloneID	OMu19574
Clone ID Related Accession (Same CDS sequence)	NM_172856.4 , NM_172856.3
Accession Version	NM_172856.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	ceramide synthase 6
Comment

ATGGCAGGGA TCTTAGCCTG GTTCTGGAAC GAGCGGTTTT GGCTTCCGCA CAATGTCACC 
TGGGCAGACC TGAAGAACAC GGAGGAAGCC ACCTTTCCGC AGGCGGAGGA CCTCTACCTT 
GCCTTCCCCT TGGCCTTCTG CATCTTCATG GTGCGGCTCA TCTTCGAGAG ATTCATAGCC 
AAACCATGTG CCATAGCCCT CAACATCCAA GCCAATGGAC CACAAACTGC CCAGCCAAAT 
GCCATTCTGG AAAAGGTTTT CACTGCTATA ACAAAGCATC CTGATGAAAA GAGATTAGAA 
GGGCTCTCCA AGCAGCTGGA CTGGGATGTT CGGAGCATTC AACGCTGGTT TCGACAAAGA 
CGCAACCAGG AGAAACCCAG CACTCTGACC AGGTTCTGTG AGAGCATGTG GAGATTTTCC 
TTTTACCTCT ATGTATTTAG CTACGGAGTC CGGTTCTTGA AACAGACCCC TTGGTTGTGG 
AATACAAGAC ACTGCTGGTA TAACTACCCT TACCAGCCAC TCACAGCTGA CCTTCACTAC 
TATTACATCC TGGAGCTGTC ATTTTATTGG TCTTTAATGG TTTCCCAGTT CACAGATATC 
AAAAGGAAGG ACTTCGGCAT TATGTTCCTG CACCACCTTG CAACAATTTT CTTAATAACC 
TTTTCATATG TCAACAACAT GGCCCGAGTA GGAACCCTGG TCCTCTGTCT TCACGACTCA 
GCCGATGCTC TGCTAGAGGC TGCCAAAATG GCAAATTACG CCAAATTTCA GAAAATGTGT 
GATCTCCTGT TTGTCATGTT TGCCGTGGTT TTTATCACCA CACGGCTGGG CATATTTCCT 
CTCTGGGTGT TGAATACCAC ATTATTTGAA AGTTGGGAGA TCGTCGGACC CTACCCTTCC 
TGGTGGGTTT TTAACCTGCT GCTCTTGTTA CTACAAGGGT TGAACTGCTT CTGGTCTTAC 
CTGATTGTAA AAATAGCTTG CAAAACTGTT TCAAAAGGCA AGGTATCCAA GGATGACCGG 
AGTGACATTG AATCTAGCTC AGATGATGAG GACTCAGAGC CTCCAGGGAA GAAACCACAC 
TCTTCAACAA CCACCAACGG AACCAGCGGT ACCAATGGGT ACCTCCTCAC TGGTCCTTGT 
TCCGTGGATG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766444.1
Translation	MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFIAKPCAIALNIQANGPQTAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFSYGVRFLKQTPWLWNTRHCWYNYPYQPLTADLHYYYILELSFYWSLMVSQFTDIKRKDFGIMFLHHLATIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLLQGLNCFWSYLIVKIACKTVSKGKVSKDDRSDIESSSDDEDSEPPGKKPHSSTTTNGTSGTNGYLLTGPCSVDD

Target ORF information:

RefSeq Version	NM_172856.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus ceramide synthase 6 (Cers6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172856.3

ORF Insert Sequence:

ATGGCAGGGA TCTTAGCCTG GTTCTGGAAC GAGCGGTTTT GGCTTCCGCA CAATGTCACC 
TGGGCAGACC TGAAGAACAC GGAGGAAGCC ACCTTTCCGC AGGCGGAGGA CCTCTACCTT 
GCCTTCCCCT TGGCCTTCTG CATCTTCATG GTGCGGCTCA TCTTCGAGAG ATTCATAGCC 
AAACCATGTG CCATAGCCCT CAACATCCAA GCCAATGGAC CACAAACTGC CCAGCCAAAT 
GCCATTCTGG AAAAGGTTTT CACTGCTATA ACAAAGCATC CTGATGAAAA GAGATTAGAA 
GGGCTCTCCA AGCAGCTGGA CTGGGATGTT CGGAGCATTC AACGCTGGTT TCGACAAAGA 
CGCAACCAGG AGAAACCCAG CACTCTGACC AGGTTCTGTG AGAGCATGTG GAGATTTTCC 
TTTTACCTCT ATGTATTTAG CTACGGAGTC CGGTTCTTGA AACAGACCCC TTGGTTGTGG 
AATACAAGAC ACTGCTGGTA TAACTACCCT TACCAGCCAC TCACAGCTGA CCTTCACTAC 
TATTACATCC TGGAGCTGTC ATTTTATTGG TCTTTAATGG TTTCCCAGTT CACAGATATC 
AAAAGGAAGG ACTTCGGCAT TATGTTCCTG CACCACCTTG CAACAATTTT CTTAATAACC 
TTTTCATATG TCAACAACAT GGCCCGAGTA GGAACCCTGG TCCTCTGTCT TCACGACTCA 
GCCGATGCTC TGCTAGAGGC TGCCAAAATG GCAAATTACG CCAAATTTCA GAAAATGTGT 
GATCTCCTGT TTGTCATGTT TGCCGTGGTT TTTATCACCA CACGGCTGGG CATATTTCCT 
CTCTGGGTGT TGAATACCAC ATTATTTGAA AGTTGGGAGA TCGTCGGACC CTACCCTTCC 
TGGTGGGTTT TTAACCTGCT GCTCTTGTTA CTACAAGGGT TGAACTGCTT CTGGTCTTAC 
CTGATTGTAA AAATAGCTTG CAAAACTGTT TCAAAAGGCA AGGTATCCAA GGATGACCGG 
AGTGACATTG AATCTAGCTC AGATGATGAG GACTCAGAGC CTCCAGGGAA GAAACCACAC 
TCTTCAACAA CCACCAACGG AACCAGCGGT ACCAATGGGT ACCTCCTCAC TGGTCCTTGT 
TCCGTGGATG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cers6 ( XM_017318074.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017173563.1 Mus musculus ceramide synthase 6 (Cers6), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu80248
Clone ID Related Accession (Same CDS sequence)	XM_017318074.1
Accession Version	XM_017318074.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	ceramide synthase 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTGGCA CTTGGTGGAG ATTTTCCTTT TACCTCTATG TATTTAGCTA CGGAGTCCGG 
TTCTTGAAAC AGACCCCTTG GTTGTGGAAT ACAAGACACT GCTGGTATAA CTACCCTTAC 
CAGCCACTCA CAGCTGACCT TCACTACTAT TACATCCTGG AGCTGTCATT TTATTGGTCT 
TTAATGGTTT CCCAGTTCAC AGATATCAAA AGGAAGGACT TCGGCATTAT GTTCCTGCAC 
CACCTTGCAA CAATTTTCTT AATAACCTTT TCATATGTCA ACAACATGGC CCGAGTAGGA 
ACCCTGGTCC TCTGTCTTCA CGACTCAGCC GATGCTCTGC TAGAGGCTGC CAAAATGGCA 
AATTACGCCA AATTTCAGAA AATGTGTGAT CTCCTGTTTG TCATGTTTGC CGTGGTTTTT 
ATCACCACAC GGCTGGGCAT ATTTCCTCTC TGGGTGTTGA ATACCACATT ATTTGAAAGT 
TGGGAGATCG TCGGACCCTA CCCTTCCTGG TGGGTTTTTA ACCTGCTGCT CTTGTTACTA 
CAAGGGTTGA ACTGCTTCTG GTCTTACCTG ATTGTAAAAA TAGCTTGCAA AACTGTTTCA 
AAAGGCAAGG CTGGGAAGTG GAACCCTTTG CATGTATCCA AGGATGACCG GAGTGACATT 
GAATCTAGCT CAGATGATGA GGACTCAGAG CCTCCAGGGA AGAAACCACA CTCTTCAACA 
ACCACCAACG GAACCAGCGG TACCAATGGG TACCTCCTCA CTGGTCCTTG TTCCGTGGAT 
GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017173563.1
CDS	13130..13915
Translation	MPGTWWRFSFYLYVFSYGVRFLKQTPWLWNTRHCWYNYPYQPLTADLHYYYILELSFYWSLMVSQFTDIKRKDFGIMFLHHLATIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLLQGLNCFWSYLIVKIACKTVSKGKAGKWNPLHVSKDDRSDIESSSDDEDSEPPGKKPHSSTTTNGTSGTNGYLLTGPCSVDD

Target ORF information:

RefSeq Version	XM_017318074.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ceramide synthase 6 (Cers6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017318074.1

ORF Insert Sequence:

ATGCCTGGCA CTTGGTGGAG ATTTTCCTTT TACCTCTATG TATTTAGCTA CGGAGTCCGG 
TTCTTGAAAC AGACCCCTTG GTTGTGGAAT ACAAGACACT GCTGGTATAA CTACCCTTAC 
CAGCCACTCA CAGCTGACCT TCACTACTAT TACATCCTGG AGCTGTCATT TTATTGGTCT 
TTAATGGTTT CCCAGTTCAC AGATATCAAA AGGAAGGACT TCGGCATTAT GTTCCTGCAC 
CACCTTGCAA CAATTTTCTT AATAACCTTT TCATATGTCA ACAACATGGC CCGAGTAGGA 
ACCCTGGTCC TCTGTCTTCA CGACTCAGCC GATGCTCTGC TAGAGGCTGC CAAAATGGCA 
AATTACGCCA AATTTCAGAA AATGTGTGAT CTCCTGTTTG TCATGTTTGC CGTGGTTTTT 
ATCACCACAC GGCTGGGCAT ATTTCCTCTC TGGGTGTTGA ATACCACATT ATTTGAAAGT 
TGGGAGATCG TCGGACCCTA CCCTTCCTGG TGGGTTTTTA ACCTGCTGCT CTTGTTACTA 
CAAGGGTTGA ACTGCTTCTG GTCTTACCTG ATTGTAAAAA TAGCTTGCAA AACTGTTTCA 
AAAGGCAAGG CTGGGAAGTG GAACCCTTTG CATGTATCCA AGGATGACCG GAGTGACATT 
GAATCTAGCT CAGATGATGA GGACTCAGAG CCTCCAGGGA AGAAACCACA CTCTTCAACA 
ACCACCAACG GAACCAGCGG TACCAATGGG TACCTCCTCA CTGGTCCTTG TTCCGTGGAT 
GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology32(1)130-142(2018 Jan)
Williams B,Correnti J,Oranu A,Lin A,Scott V,Annoh M,Beck J,Furth E,Mitchell V,Senkal CE,Obeid L,Carr RM

Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis.
Scientific reports7(1)15552(2017 Nov)
Scheffel MJ,Helke K,Lu P,Bowers JS,Ogretmen B,Garrett-Mayer E,Paulos CM,Voelkel-Johnson C

Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.
Scientific reports7(1)13427(2017 Oct)
Li S,Teegarden A,Bauer EM,Choi J,Messaddeq N,Hendrix DA,Ganguli-Indra G,Leid M,Indra AK

Ceramide synthesis regulates T cell activity and GVHD development.
JCI insight2(10)(2017 May)
Sofi MH,Heinrichs J,Dany M,Nguyen H,Dai M,Bastian D,Schutt S,Wu Y,Daenthanasanmak A,Gencer S,Zivkovic A,Szulc Z,Stark H,Liu C,Chang YJ,Ogretmen B,Yu XZ

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Cers6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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