Kctd12 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kctd12
Entrez Gene ID	239217
Full Name	potassium channel tetramerisation domain containing 12
Synonyms	AU046135,AW538430,Pfet1,Pfetin
General protein information	Preferred Names potassium channel tetramerisation domain containing 12 Names BTB/POZ domain-containing protein KCTD12 potassium channel tetramerization domain containing 12 predominantly fetal expressed T1 domain
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 E2.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_177715.4	NP_808383.3	BTB/POZ domain-containing protein KCTD12

Pathways from BioSystems

Homologies

Homo sapiens (human)	KCTD12	NP_612453.1
Pan troglodytes (chimpanzee)	KCTD12	XP_001137708.2
Bos taurus (cattle)	KCTD12	XP_005213929.1
Rattus norvegicus (Norway rat)	Kctd12	XP_006252482.1
Danio rerio (zebrafish)	kctd12.1	NP_919386.1
Canis lupus familiaris (dog)	KCTD12	XP_542614.3
	KCTD12	XP_001085454.1
Danio rerio (zebrafish)	kctd12.2	NP_001029191.1
Mus musculus (house mouse)	Kctd12	NP_808383.3
Xenopus tropicalis (tropical clawed frog)	kctd12	NP_001096456.1

Gene Ontology
Bibliography

Related articles in PubMed

Widespread and dynamic translational control of red blood cell development.
Alvarez-Dominguez JR, Zhang X, Hu W
Blood129(5)619-629(2017 02)

KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents.
Fritzius T, Turecek R, Seddik R, Kobayashi H, Tiao J, Rem PD, Metz M, Kralikova M, Bouvier M, Gassmann M, Bettler B
The Journal of neuroscience : the official journal of the Society for Neuroscience37(5)1162-1175(2017 Feb)

Altered emotionality and neuronal excitability in mice lacking KCTD12, an auxiliary subunit of GABAB receptors associated with mood disorders.
Cathomas F, Stegen M, Sigrist H, Schmid L, Seifritz E, Gassmann M, Bettler B, Pryce CR
Translational psychiatry5e510(2015 Feb)

GABAB receptor phosphorylation regulates KCTD12-induced K? current desensitization.
Adelfinger L, Turecek R, Ivankova K, Jensen AA, Moss SJ, Gassmann M, Bettler B
Biochemical pharmacology91(3)369-79(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

KCTD12 is involved in determining phenotypes of emotionality, behavioral activity and neuronal excitability.
Title: Altered emotionality and neuronal excitability in mice lacking KCTD12, an auxiliary subunit of GABAB receptors associated with mood disorders.

Serine-892 phosphorylation in GABAB receptor rearranges KCTD12 at the receptor and slows KCTD12-induced desensitization in neurons.
Title: GABAB receptor phosphorylation regulates KCTD12-induced K? current desensitization.

the up-regulation of functional GABA(B) receptors at the neuronal plasma membrane is an additional physiological role of the auxiliary subunit KCTD12.
Title: Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12).

Data suggest that the distinct spatial and temporal distribution patterns of KCTD8, 12, 12b, and 16 underlie functional differences in native GABA(B) responses.
Title: Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain.

new gene encoding 327 amino acids in mouse contains a voltage-gated potassium (K+) channel tetramerization (T1) domain.
Title: Isolation from cochlea of a novel human intronless gene with predominant fetal expression.

The following Kctd12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kctd12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16916	NM_177715.4 Latest version!	Mus musculus potassium channel tetramerisation domain containing 12 (Kctd12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kctd12 ( NM_177715.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_808383.3 Mus musculus potassium channel tetramerisation domain containing 12 (Kctd12), mRNA.

Price & Availability↑

CloneID	OMu16916
Clone ID Related Accession (Same CDS sequence)	NM_177715.4
Accession Version	NM_177715.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	BTB/POZ domain-containing protein KCTD12
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK087895.1, CF538046.1, AK173260.1 and BP753689.1. On Jan 20, 2007 this sequence version replaced NM_177715.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGCTCTGG CGGACAGCAC CCGAGGATTA CCCAACGGGG GCGGAGGCGG AGGTGGCAGC 
GGCTCGTCGT CGTCCTCGGC GGAGCCGCCG CTCTTCCCGG ACATCGTAGA GCTGAACGTG 
GGAGGGCAGG TGTATGTGAC CCGGCGCTGC ACCGTGGTGT CCGTGCCCGA CTCGCTGCTC 
TGGCGTATGT TCACGCAGCA GCAGCCGCAG GAGCTGGCCC GGGACAGCAA AGGCCGCTTC 
TTTCTGGACC GGGACGGCTT CCTCTTCCGC TACATCCTGG ATTACCTGCG GGACTTGCAG 
CTCGTGCTGC CCGACTACTT CCCGGAGCGC AGCCGGCTGC AGCGCGAGGC CGAGTACTTC 
GAGCTGCCGG AGCTCGTGCG TCGCCTCGGG GCGCCCCAGC AACCCGGTCC GGGGCCACCG 
CCGCCGCACT CGCGCCGCGG GGTGCACAAG GAGGGCTCTC TGGGCGATGA GCTGCTGCCG 
CTGGGCTACG CAGAGCCCGA GCCGCAGGAG GGCGCCTCGG CCGGGGCGCC TTCGCCCACG 
CTGGAGCTGG CTAGCCGCAG CCCGTCCGGG GGCGCGGCGG GGCCCCTGCT CACGCCGTCC 
CAGTCTTTGG ACGGCAGCCG GCGCTCCGGC TACATCACCA TCGGCTACCG CGGCTCCTAC 
ACCATCGGGC GCGACGCTCA GGCGGACGCC AAGTTCCGGC GGGTGGCGCG CATCACCGTG 
TGCGGCAAGA CGTCGCTGGC CAAGGAGGTG TTTGGGGACA CCCTGAATGA GAGCCGGGAC 
CCCGACCGGC CCCCGGAGCG CTACACCTCC CGCTATTACC TCAAGTTCAA CTTCCTAGAG 
CAGGCCTTCG ATAAGCTGTC CGAGTCGGGC TTCCACATGG TGGCGTGCAG CTCCACGGGC 
ACCTGCGCTT TTGCTAGCAG CACCGACCAG AGCGAGGACA AGATCTGGAC CAGCTACACC 
GAGTACGTCT TCTGCAGGGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808383.3
CDS	198..1181
Translation	MALADSTRGLPNGGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPPHSRRGVHKEGSLGDELLPLGYAEPEPQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFASSTDQSEDKIWTSYTEYVFCRE

Target ORF information:

RefSeq Version	NM_177715.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus potassium channel tetramerisation domain containing 12 (Kctd12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177715.4

ORF Insert Sequence:

ATGGCTCTGG CGGACAGCAC CCGAGGATTA CCCAACGGGG GCGGAGGCGG AGGTGGCAGC 
GGCTCGTCGT CGTCCTCGGC GGAGCCGCCG CTCTTCCCGG ACATCGTAGA GCTGAACGTG 
GGAGGGCAGG TGTATGTGAC CCGGCGCTGC ACCGTGGTGT CCGTGCCCGA CTCGCTGCTC 
TGGCGTATGT TCACGCAGCA GCAGCCGCAG GAGCTGGCCC GGGACAGCAA AGGCCGCTTC 
TTTCTGGACC GGGACGGCTT CCTCTTCCGC TACATCCTGG ATTACCTGCG GGACTTGCAG 
CTCGTGCTGC CCGACTACTT CCCGGAGCGC AGCCGGCTGC AGCGCGAGGC CGAGTACTTC 
GAGCTGCCGG AGCTCGTGCG TCGCCTCGGG GCGCCCCAGC AACCCGGTCC GGGGCCACCG 
CCGCCGCACT CGCGCCGCGG GGTGCACAAG GAGGGCTCTC TGGGCGATGA GCTGCTGCCG 
CTGGGCTACG CAGAGCCCGA GCCGCAGGAG GGCGCCTCGG CCGGGGCGCC TTCGCCCACG 
CTGGAGCTGG CTAGCCGCAG CCCGTCCGGG GGCGCGGCGG GGCCCCTGCT CACGCCGTCC 
CAGTCTTTGG ACGGCAGCCG GCGCTCCGGC TACATCACCA TCGGCTACCG CGGCTCCTAC 
ACCATCGGGC GCGACGCTCA GGCGGACGCC AAGTTCCGGC GGGTGGCGCG CATCACCGTG 
TGCGGCAAGA CGTCGCTGGC CAAGGAGGTG TTTGGGGACA CCCTGAATGA GAGCCGGGAC 
CCCGACCGGC CCCCGGAGCG CTACACCTCC CGCTATTACC TCAAGTTCAA CTTCCTAGAG 
CAGGCCTTCG ATAAGCTGTC CGAGTCGGGC TTCCACATGG TGGCGTGCAG CTCCACGGGC 
ACCTGCGCTT TTGCTAGCAG CACCGACCAG AGCGAGGACA AGATCTGGAC CAGCTACACC 
GAGTACGTCT TCTGCAGGGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread and dynamic translational control of red blood cell development.
Blood129(5)619-629(2017 02)
Alvarez-Dominguez JR,Zhang X,Hu W

KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(5)1162-1175(2017 Feb)
Fritzius T,Turecek R,Seddik R,Kobayashi H,Tiao J,Rem PD,Metz M,Kralikova M,Bouvier M,Gassmann M,Bettler B

Altered emotionality and neuronal excitability in mice lacking KCTD12, an auxiliary subunit of GABAB receptors associated with mood disorders.
Translational psychiatry5e510(2015 Feb)
Cathomas F,Stegen M,Sigrist H,Schmid L,Seifritz E,Gassmann M,Bettler B,Pryce CR

GABAB receptor phosphorylation regulates KCTD12-induced K? current desensitization.
Biochemical pharmacology91(3)369-79(2014 Oct)
Adelfinger L,Turecek R,Ivankova K,Jensen AA,Moss SJ,Gassmann M,Bettler B