Capn10 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Capn10
Entrez Gene ID	23830
Full Name	calpain 10
Synonyms	AW049679,Capn8,mKIAA1845
General protein information	Preferred Names calpain 10 Names calpain-10 CANP 10 calcium-activated neutral proteinase 10 calpain 8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_011796.2	NP_035926.2	calpain-10

Pathways from BioSystems

Homologies

	CAPN10	XP_001107045.2
Rattus norvegicus (Norway rat)	Capn10	NP_113861.1
Danio rerio (zebrafish)	capn10	XP_698873.4
Homo sapiens (human)	CAPN10	NP_075571.1
Xenopus tropicalis (tropical clawed frog)	capn10	XP_004914447.1
Pan troglodytes (chimpanzee)	CAPN10	XP_003309611.1
Bos taurus (cattle)	LOC789674	XP_002686664.1
Canis lupus familiaris (dog)	CAPN10	XP_848308.1
Mus musculus (house mouse)	Capn10	NP_035926.2
Gallus gallus (chicken)	CAPN10	XP_004943444.1

Gene Ontology
Bibliography

Related articles in PubMed

Calpain-10 is a component of the obesity-related quantitative trait locus Adip1.
Cheverud JM, Fawcett GL, Jarvis JP, Norgard EA, Pavlicev M, Pletscher LS, Polonsky KS, Ye H, Bell GI, Semenkovich CF
Journal of lipid research51(5)907-13(2010 May)

Calpain 10 is required for cell viability and is decreased in the aging kidney.
Covington MD, Arrington DD, Schnellmann RG
American journal of physiology. Renal physiology296(3)F478-86(2009 Mar)

Mitochondrial calpain 10 activity and expression in the kidney of multiple species.
Giguere CJ, Covington MD, Schnellmann RG
Biochemical and biophysical research communications366(1)258-62(2008 Feb)

BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.
Goulley J, Dahl U, Baeza N, Mishina Y, Edlund H
Cell metabolism5(3)207-19(2007 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Capn10 plays an important role in regulating obesity and diabetes in mice.
Title: Calpain-10 is a component of the obesity-related quantitative trait locus Adip1.

Calpain 10 levels specifically decrease in kidney tissues when renal function decreases.
Title: Calpain 10 is required for cell viability and is decreased in the aging kidney.

These results provide evidence that several previously postulated splice variants of calpain 10 are localized to the mitochondria in kidneys of rabbits, rats, and mice.
Title: Mitochondrial calpain 10 activity and expression in the kidney of multiple species.

calpain-10 has a role in beta-cell survival and is suppressed by RyR2
Title: RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.

calpain-derived Htt fragmentation has a role in Huntington's disease and aberrant activation of calpains may play a role in HD pathogenesis
Title: Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.

The following Capn10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Capn10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08864	NM_011796.2 Latest version!	Mus musculus calpain 10 (Capn10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Capn10 ( NM_011796.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035926.2 Mus musculus calpain 10 (Capn10), mRNA.

Price & Availability↑

CloneID	OMu08864
Clone ID Related Accession (Same CDS sequence)	NM_011796.2
Accession Version	NM_011796.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2001bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	calpain-10
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI986964.1, BC010969.1 and BB747799.1. On Feb 9, 2006 this sequence version replaced NM_011796.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005681.1, AF089089.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCGGGCGG TCCGGGCCGA GACGCCGGCG CGGGAGCTCT TCCGGGACGC GGCATTCCCC 
GCCTCGGACT CCTCGCTCTT TTACAACTTG TCCACGCCTC TGGCCCAGTT TCGGGAGGAC 
ATCACTTGGA GACGACCCCA GGAAATCTGT GCCACACCTC AGCTGTTTCC AGATAACCCA 
TGGGAGGGAC AGGTGAAGCA AGGGCTGCTG GGAGATTGCT GGTTCCTGTG TGCCTGTGCC 
GCCCTTCAGA AGAGTCAACA CCTCCTGGAC CAGGTCTTCC CTCCAGGACA GCCAGGCTGG 
TCTGACCAGA AATACCAAGG CTTCTTCACC TGTCGGATTT GGCAGTTTGG ACACTGGGAG 
GAAGTGACCA TAGATGATCG TCTGCCTTGT CTTGCCGGGA GACTCTGCTT TTCCCGGTGC 
CAGAGAGAGG ATGTGTTCTG GCTTCCCTTA CTGGAAAAGG CCTATGCTAA GGTCCATGGA 
TCGTATGAGC ACCTGTGGGC AGGGCAAGTG GCAGATGCCT TAGTGGATCT CACTGGAAGC 
CTGGCAGAAA GGTGGAGCTT GAAGGATGTA ACGAAAGCCA GCGGCCAGCA GGACAGACCC 
AGTGGTGGGG AGCACAGAAC TTGTCGGCAG CTACTCCACC TGAAGGACCG GTGTCTAATC 
AGCTGCTCTG TGCTTAGCCC CAGAGCAGGT GCCAGGGAAC TCGGAGAGTT CCATGCCTTC 
ATCATCTCAG ATCTGCAGGA GCTCAGGAGT CAGACTGGCC AGGGTATCCT CCTGCTGCGG 
ATTCACAACC CCTGGGGCCG GCGTTGTTGG CAGGGCCTCT GGAGAGAAGG AGGTGAAGGG 
TGGAACCAGG TAGAGCCAGC TAAGGAGTCT GAGCTGCTGG CCCAACTCCA GGAAGGAGAG 
TTCTGGGTCG AGGAAGAGGA GTTCCTCAGG GAGTTTGATG AGGTCACCAT CGGCTACCCA 
GTCACAGAGG CCGGCCACCT ACAGAGTCTC CACACAGAGA GGGTGCTGTG CCATACGCGG 
ACACTGCCTG GTGCCTGGGT GACAGGGCAG TCAGCAGGAG GCTGCCGGAA CAACAGTTGC 
TTTCCCTGCA ACCCCAAGTT CTGGTTACGG CTCTTGGAAC CCAGCGAGGT GTGTGTGGCT 
GTTCTTCAGA GACCCCGGAG GCGCTTAGTG GGCCAGACTC GGGCACTGGC GGGTGCCAGT 
CCTGCACCGG TGAACCTCCC AGGCAAAGAC TACCAGGCTG TGGGCCTGCA CATCTGGAAG 
GTAGAGAAAC GGAAGATCAG CCTGCCCAGA GTCCTGTCTG CACCCCCTGT GGCTGGCACT 
GCATGCCATG CGTATGATCG TGAGATCCAC TTGCGTTGTG AGCTCTCACC AGGCTACTAC 
CTGGCCGTCC CTAGCACCTT TTTGAAGGAT GTGCCAGGGC AGTTCCTGCT CAGAGTCTTC 
TCCACTGGGA AAATCTCCCT CAGTGCCGTC AGGCTGGCCA CCAAGGGTGC ATCGCCTGGA 
ACAGCCCTGC CTGCAGGCGA GTGGGAGACT GTGCAGTTGC AGGGCTGCTG GAGAGCTGGC 
CAGACAGCTG GGGGCAGCAG GAACTTTGCC TCTTACCCCT GCAATCCCTG CCTCCCTTTC 
TCTGTTCCTG AGGGTGCTGG CCCCCGCTAC ATCCGTATCA CCCTACAGCA ACACTGCCGG 
CTCAGTGACA GCCAGCTGCA CCCCATTGGT TTCCATGTCT TTCAGGTTCC AGCAGACGGT 
GAGAACCAGG ACGCGTGTTC CCTGCTGCTC CAGGAGCCAC TGCTAAGCTG TGTACCACAT 
CGCTACGCCC AGGAAGTGAG CCGCCTCTGC CTCCTTTCTG TGGGGAACTA CAGGATTGTT 
CCCTCCACCT ACCTGCCAGA TACAGAGGGT ACCTTCACGG TAACCATAGC AACCAGAATC 
GATAGGCAGT CCATCCACAG CCAGGAGATG CTGGGCCAGC TGCTCCAGGA GGTCTCCTTT 
ATGGCAGTGA TGAAAGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035926.2
CDS	467..2467
Translation	MRAVRAETPARELFRDAAFPASDSSLFYNLSTPLAQFREDITWRRPQEICATPQLFPDNPWEGQVKQGLLGDCWFLCACAALQKSQHLLDQVFPPGQPGWSDQKYQGFFTCRIWQFGHWEEVTIDDRLPCLAGRLCFSRCQREDVFWLPLLEKAYAKVHGSYEHLWAGQVADALVDLTGSLAERWSLKDVTKASGQQDRPSGGEHRTCRQLLHLKDRCLISCSVLSPRAGARELGEFHAFIISDLQELRSQTGQGILLLRIHNPWGRRCWQGLWREGGEGWNQVEPAKESELLAQLQEGEFWVEEEEFLREFDEVTIGYPVTEAGHLQSLHTERVLCHTRTLPGAWVTGQSAGGCRNNSCFPCNPKFWLRLLEPSEVCVAVLQRPRRRLVGQTRALAGASPAPVNLPGKDYQAVGLHIWKVEKRKISLPRVLSAPPVAGTACHAYDREIHLRCELSPGYYLAVPSTFLKDVPGQFLLRVFSTGKISLSAVRLATKGASPGTALPAGEWETVQLQGCWRAGQTAGGSRNFASYPCNPCLPFSVPEGAGPRYIRITLQQHCRLSDSQLHPIGFHVFQVPADGENQDACSLLLQEPLLSCVPHRYAQEVSRLCLLSVGNYRIVPSTYLPDTEGTFTVTIATRIDRQSIHSQEMLGQLLQEVSFMAVMKA

Target ORF information:

RefSeq Version	NM_011796.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus calpain 10 (Capn10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011796.2

ORF Insert Sequence:

ATGCGGGCGG TCCGGGCCGA GACGCCGGCG CGGGAGCTCT TCCGGGACGC GGCATTCCCC 
GCCTCGGACT CCTCGCTCTT TTACAACTTG TCCACGCCTC TGGCCCAGTT TCGGGAGGAC 
ATCACTTGGA GACGACCCCA GGAAATCTGT GCCACACCTC AGCTGTTTCC AGATAACCCA 
TGGGAGGGAC AGGTGAAGCA AGGGCTGCTG GGAGATTGCT GGTTCCTGTG TGCCTGTGCC 
GCCCTTCAGA AGAGTCAACA CCTCCTGGAC CAGGTCTTCC CTCCAGGACA GCCAGGCTGG 
TCTGACCAGA AATACCAAGG CTTCTTCACC TGTCGGATTT GGCAGTTTGG ACACTGGGAG 
GAAGTGACCA TAGATGATCG TCTGCCTTGT CTTGCCGGGA GACTCTGCTT TTCCCGGTGC 
CAGAGAGAGG ATGTGTTCTG GCTTCCCTTA CTGGAAAAGG CCTATGCTAA GGTCCATGGA 
TCGTATGAGC ACCTGTGGGC AGGGCAAGTG GCAGATGCCT TAGTGGATCT CACTGGAAGC 
CTGGCAGAAA GGTGGAGCTT GAAGGATGTA ACGAAAGCCA GCGGCCAGCA GGACAGACCC 
AGTGGTGGGG AGCACAGAAC TTGTCGGCAG CTACTCCACC TGAAGGACCG GTGTCTAATC 
AGCTGCTCTG TGCTTAGCCC CAGAGCAGGT GCCAGGGAAC TCGGAGAGTT CCATGCCTTC 
ATCATCTCAG ATCTGCAGGA GCTCAGGAGT CAGACTGGCC AGGGTATCCT CCTGCTGCGG 
ATTCACAACC CCTGGGGCCG GCGTTGTTGG CAGGGCCTCT GGAGAGAAGG AGGTGAAGGG 
TGGAACCAGG TAGAGCCAGC TAAGGAGTCT GAGCTGCTGG CCCAACTCCA GGAAGGAGAG 
TTCTGGGTCG AGGAAGAGGA GTTCCTCAGG GAGTTTGATG AGGTCACCAT CGGCTACCCA 
GTCACAGAGG CCGGCCACCT ACAGAGTCTC CACACAGAGA GGGTGCTGTG CCATACGCGG 
ACACTGCCTG GTGCCTGGGT GACAGGGCAG TCAGCAGGAG GCTGCCGGAA CAACAGTTGC 
TTTCCCTGCA ACCCCAAGTT CTGGTTACGG CTCTTGGAAC CCAGCGAGGT GTGTGTGGCT 
GTTCTTCAGA GACCCCGGAG GCGCTTAGTG GGCCAGACTC GGGCACTGGC GGGTGCCAGT 
CCTGCACCGG TGAACCTCCC AGGCAAAGAC TACCAGGCTG TGGGCCTGCA CATCTGGAAG 
GTAGAGAAAC GGAAGATCAG CCTGCCCAGA GTCCTGTCTG CACCCCCTGT GGCTGGCACT 
GCATGCCATG CGTATGATCG TGAGATCCAC TTGCGTTGTG AGCTCTCACC AGGCTACTAC 
CTGGCCGTCC CTAGCACCTT TTTGAAGGAT GTGCCAGGGC AGTTCCTGCT CAGAGTCTTC 
TCCACTGGGA AAATCTCCCT CAGTGCCGTC AGGCTGGCCA CCAAGGGTGC ATCGCCTGGA 
ACAGCCCTGC CTGCAGGCGA GTGGGAGACT GTGCAGTTGC AGGGCTGCTG GAGAGCTGGC 
CAGACAGCTG GGGGCAGCAG GAACTTTGCC TCTTACCCCT GCAATCCCTG CCTCCCTTTC 
TCTGTTCCTG AGGGTGCTGG CCCCCGCTAC ATCCGTATCA CCCTACAGCA ACACTGCCGG 
CTCAGTGACA GCCAGCTGCA CCCCATTGGT TTCCATGTCT TTCAGGTTCC AGCAGACGGT 
GAGAACCAGG ACGCGTGTTC CCTGCTGCTC CAGGAGCCAC TGCTAAGCTG TGTACCACAT 
CGCTACGCCC AGGAAGTGAG CCGCCTCTGC CTCCTTTCTG TGGGGAACTA CAGGATTGTT 
CCCTCCACCT ACCTGCCAGA TACAGAGGGT ACCTTCACGG TAACCATAGC AACCAGAATC 
GATAGGCAGT CCATCCACAG CCAGGAGATG CTGGGCCAGC TGCTCCAGGA GGTCTCCTTT 
ATGGCAGTGA TGAAAGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Calpain-10 is a component of the obesity-related quantitative trait locus Adip1.
Journal of lipid research51(5)907-13(2010 May)
Cheverud JM,Fawcett GL,Jarvis JP,Norgard EA,Pavlicev M,Pletscher LS,Polonsky KS,Ye H,Bell GI,Semenkovich CF

Calpain 10 is required for cell viability and is decreased in the aging kidney.
American journal of physiology. Renal physiology296(3)F478-86(2009 Mar)
Covington MD,Arrington DD,Schnellmann RG

Mitochondrial calpain 10 activity and expression in the kidney of multiple species.
Biochemical and biophysical research communications366(1)258-62(2008 Feb)
Giguere CJ,Covington MD,Schnellmann RG

BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.
Cell metabolism5(3)207-19(2007 Mar)
Goulley J,Dahl U,Baeza N,Mishina Y,Edlund H