U2af1l4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	U2af1l4
Entrez Gene ID	233073
Full Name	U2 small nuclear RNA auxiliary factor 1-like 4
Synonyms	AA407033,AF419339,AI451269,AW553050,U2af26
General protein information	Preferred Names U2 small nuclear RNA auxiliary factor 1-like 4 Names splicing factor U2AF 26 kDa subunit U2 auxiliary factor 26 U2 small nuclear RNA auxiliary factor 1-like protein 4 U2AF1-like 4 auxiliary factor 26
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_170760.3	NP_739566.1	splicing factor U2AF 26 kDa subunit

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	U2af1l4	NP_001008775.1
Mus musculus (house mouse)	U2af1l4	NP_739566.1
Canis lupus familiaris (dog)	U2AF1L4	XP_005616750.1
Bos taurus (cattle)	U2AF1L4	NP_001029950.1

Gene Ontology
Bibliography

Related articles in PubMed

Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice.
Preu?ner M, Wilhelmi I, Schultz AS, Finkernagel F, Michel M, M?r?y T, Heyd F
Molecular cell54(4)651-62(2014 May)

Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26.
Heyd F, Carmo-Fonseca M, M?r?y T
The Journal of biological chemistry283(28)19636-45(2008 Jul)

Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing.
Heyd F, ten Dam G, M?r?y T
Nature immunology7(8)859-67(2006 Aug)

Characterization of U2AF(6), a splicing factor related to U2AF(35).
Shepard J, Reick M, Olson S, Graveley BR
Molecular and cellular biology22(1)221-30(2002 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest light-induced U2af26 alternative splicing to be a buffering mechanism that limits PERIOD1 induction, thus stabilizing the circadian clock against abnormal changes in light:dark conditions.
Title: Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice.

Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26
Title: Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26.

The following U2af1l4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the U2af1l4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03165	NM_170760.3 Latest version!	Mus musculus U2 small nuclear RNA auxiliary factor 1-like 4 (U2af1l4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

U2af1l4 ( NM_170760.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_739566.1 Mus musculus U2 small nuclear RNA auxiliary factor 1-like 4 (U2af1l4), mRNA.

Price & Availability↑

CloneID	OMu03165
Clone ID Related Accession (Same CDS sequence)	NM_170760.3
Accession Version	NM_170760.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	splicing factor U2AF 26 kDa subunit
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC167970.4. On Nov 17, 2006 this sequence version replaced NM_170760.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC060972.1, SRR1660811.89433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGAAT ATTTAGCTTC GATATTCGGG ACTGAGAAGG ACAAGGTTAA CTGCTCTTTT 
TACTTTAAGA TTGGAGCCTG CCGGCACGGG GACCGGTGCT CCCGACTTCA CAACAAACCG 
ACTTTCAGCC AGACCATAGT CCTGCTCAAC TTGTACCGGA ATCCACAGAA CACAGCCCAA 
ACTGCAGATG GATCACACTG TCACGTGAGC GACGTGGAGG TGCAAGAACA CTATGATAAC 
TTCTTTGAGG AGGTATTCAC AGAACTGCAG GAGAAGTATG GAGAGATTGA AGAGATGAAT 
GTGTGTGACA ACCTCGGGGA CCACCTCGTG GGCAATGTCT ACGTTAAGTT CCGGCGGGAG 
GAGGATGCAG AGCGGGCTGT AGCGGAACTC AATAACCGCT GGTTCAACGG GCAGGCTGTG 
CATGCCGAGC TGTCTCCTGT CACTGACTTC CGAGAGTCCT GCTGCCGGCA GTATGAGATG 
GGGGAATGCA CCCGAGGTGG CTTCTGCAAC TTTATGCACC TACGGCCCAT ATCTCGGAAC 
TTGCGCCGGC AGCTCTATGG GCGAGGACCC AGGCATAGGT CACCTCCAAG GTCCCACACA 
GGTCACCGTC CCCGAGAAAG GAACCGACGT CGTTCCCCAG ACCACCGGCA TGGTCGCTTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_739566.1
CDS	17..679
Translation	MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIVLLNLYRNPQNTAQTADGSHCHVSDVEVQEHYDNFFEEVFTELQEKYGEIEEMNVCDNLGDHLVGNVYVKFRREEDAERAVAELNNRWFNGQAVHAELSPVTDFRESCCRQYEMGECTRGGFCNFMHLRPISRNLRRQLYGRGPRHRSPPRSHTGHRPRERNRRRSPDHRHGRF

Target ORF information:

RefSeq Version	NM_170760.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus U2 small nuclear RNA auxiliary factor 1-like 4 (U2af1l4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_170760.3

ORF Insert Sequence:

ATGGCTGAAT ATTTAGCTTC GATATTCGGG ACTGAGAAGG ACAAGGTTAA CTGCTCTTTT 
TACTTTAAGA TTGGAGCCTG CCGGCACGGG GACCGGTGCT CCCGACTTCA CAACAAACCG 
ACTTTCAGCC AGACCATAGT CCTGCTCAAC TTGTACCGGA ATCCACAGAA CACAGCCCAA 
ACTGCAGATG GATCACACTG TCACGTGAGC GACGTGGAGG TGCAAGAACA CTATGATAAC 
TTCTTTGAGG AGGTATTCAC AGAACTGCAG GAGAAGTATG GAGAGATTGA AGAGATGAAT 
GTGTGTGACA ACCTCGGGGA CCACCTCGTG GGCAATGTCT ACGTTAAGTT CCGGCGGGAG 
GAGGATGCAG AGCGGGCTGT AGCGGAACTC AATAACCGCT GGTTCAACGG GCAGGCTGTG 
CATGCCGAGC TGTCTCCTGT CACTGACTTC CGAGAGTCCT GCTGCCGGCA GTATGAGATG 
GGGGAATGCA CCCGAGGTGG CTTCTGCAAC TTTATGCACC TACGGCCCAT ATCTCGGAAC 
TTGCGCCGGC AGCTCTATGG GCGAGGACCC AGGCATAGGT CACCTCCAAG GTCCCACACA 
GGTCACCGTC CCCGAGAAAG GAACCGACGT CGTTCCCCAG ACCACCGGCA TGGTCGCTTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice.
Molecular cell54(4)651-62(2014 May)
Preu?ner M,Wilhelmi I,Schultz AS,Finkernagel F,Michel M,M?r?y T,Heyd F

Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26.
The Journal of biological chemistry283(28)19636-45(2008 Jul)
Heyd F,Carmo-Fonseca M,M?r?y T

Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing.
Nature immunology7(8)859-67(2006 Aug)
Heyd F,ten Dam G,M?r?y T

Characterization of U2AF(6), a splicing factor related to U2AF(35).
Molecular and cellular biology22(1)221-30(2002 Jan)
Shepard J,Reick M,Olson S,Graveley BR