Shb cDNA ORF clone, Mus musculus(house mouse)

Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity.
Galazo MJ, Emsley JG, Macklis JD
Neuron91(1)90-106(2016 Jul)

Shb deficiency in endothelium but not in leucocytes is responsible for impaired vascular performance during hindlimb ischaemia.
Nikpour M, Gustafsson K, V?gesj? E, Seignez C, Giraud A, Phillipson M, Welsh M
Acta physiologica (Oxford, England)214(2)200-9(2015 Jun)

Vascular dysfunction and increased metastasis of B16F10 melanomas in Shb deficient mice as compared with their wild type counterparts.
Zang G, Gustafsson K, Jamalpour M, Hong J, Genov? G, Welsh M
BMC cancer15234(2015 Apr)

The observed aberrations in myeloid cell properties in Shb-deficient mice are likely consequences of an abnormal vascular compartment and are not responsible for reduced muscle blood flow
Title: Shb deficiency in endothelium but not in leucocytes is responsible for impaired vascular performance during hindlimb ischaemia.

a unique combinatorial response of increased vascular permeability and reduced recruitment of cytotoxic CD8+ cells occurs as a consequence of Shb deficiency in B16F10 melanomas.
Title: Vascular dysfunction and increased metastasis of B16F10 melanomas in Shb deficient mice as compared with their wild type counterparts.

Data indicate that Src homology-2 domain containing protein B (SHB) deficiency causes a chronic increase in beta-cell focal adhesion kinase (FAK) activity that perturbs the normal insulin secretory characteristics of beta-cells.
Title: Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets.

loss of Shb alters TCR signalling ability, thereby favouring the development of Th2-driven inflammation and exacerbating symptoms of allergy
Title: Absence of the adaptor protein Shb potentiates the T helper type 2 response in a mouse model of atopic dermatitis.

Data suggest that absence of Src homology-2 protein Shb accelerates disease progression by exerting dual roles in BCR-ABL-induced leukemia: increased cell expansion due to elevated focal adhesion kinase (FAK) activity and neutrophilia in peripheral blood.
Title: The Src homology-2 protein Shb modulates focal adhesion kinase signaling in a BCR-ABL myeloproliferative disorder causing accelerated progression of disease.