Reg2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Reg2
Entrez Gene ID	19693
Full Name	regenerating islet-derived 2
Synonyms	RegII
General protein information	Preferred Names regenerating islet-derived 2 Names lithostathine-2 PSP PTP REG-2 islet of Langerhans regenerating protein 2 pancreatic stone protein 2 pancreatic thread protein 2 regenerating islet-derived, mouse homolog 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_009043.2	NP_033069.1	lithostathine-2 precursor
NM_009043.1	NP_033069.1	lithostathine-2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	REG1B	XP_001163951.2
Mus musculus (house mouse)	Reg2	NP_033069.1
Homo sapiens (human)	REG1B	NP_006498.1
	REG1B	XP_001112647.1

Gene Ontology
Bibliography

Related articles in PubMed

Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet-Induced Obesity.
Li Q, Li B, Miao X, Ramgattie C, Gao ZH, Liu JL
Endocrinology158(6)1634-1644(2017 Jun)

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.
Aden K, Rehman A, Falk-Paulsen M, Secher T, Kuiper J, Tran F, Pfeuffer S, Sheibani-Tezerji R, Breuer A, Luzius A, Jentzsch M, H?sler R, Billmann-Born S, Will O, Lipinski S, Bharti R, Adolph T, Iovanna JL, Kempster SL, Blumberg RS, Schreiber S, Becher B, Chamaillard M, Kaser A, Rosenstiel P
Cell reports16(8)2208-2218(2016 Aug)

mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells.
Liu L, Chowdhury S, Uppal S, Fang X, Liu JL, Srikant CB
Growth factors (Chur, Switzerland)33(1)1-7(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Normal expression of Reg2 gene is required for appropriate compensations in pancreatic islet proliferation and expansion in response to obesity and aging.
Title: Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet-Induced Obesity.

mReg2 inhibits AIF-mediated apoptosis by promoting the nuclear presence of Scythe and inducing hsp70.
Title: mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells.

Reg2 induces glucose-regulated peptide 78 (GRP78) expression via the Akt-mTORC1 axis.
Title: Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells.

Direct stimulation of Reg2 and Reg3beta genes by glucocorticoids.
Title: Transcriptional activation of Reg2 and Reg3? genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells.

Reg2, Reg3alpha, and Reg3beta were abundantly expressed in most acinar cells of the pancreas with clear age-dependent and isoform-specific patterns.
Title: Coordinated age-dependent and pancreatic-specific expression of mouse Reg2Reg3?, and Reg3? genes.

The following Reg2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Reg2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu03408	NM_009043.2 Latest version!	Mus musculus regenerating islet-derived 2 (Reg2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu03408	NM_009043.1	Mus musculus regenerating islet-derived 2 (Reg2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Reg2 ( NM_009043.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033069.1 Mus musculus regenerating islet-derived 2 (Reg2), mRNA.

Price & Availability↑

CloneID	OMu03408
Clone ID Related Accession (Same CDS sequence)	NM_009043.2 , NM_009043.1
Accession Version	NM_009043.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	lithostathine-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113058.6, AK008196.1 and BC098503.1. On Feb 24, 2018 this sequence version replaced NM_009043.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF580998.1, AK008196.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCAGA ACAATGTATA CCTTATCCTG TTCTTATGCC TGATGTTCCT GTCATACAGC 
CAAGGCCAGG TAGCTGAAGA AGACTTCCCC TTGGCTGAAA AAGACCTTCC TTCTGCCAAA 
ATCAACTGCC CAGAGGGTGC CAACGCCTAT GGTTCCTACT GTTATTATCT AATTGAAGAC 
CGTTTGACCT GGGGGGAGGC TGATCTCTTT TGCCAGAACA TGAATGCAGG TCACCTGGTG 
TCAATACTCA GCCAGGCTGA GAGCAACTTT GTGGCCTCGC TGGTTAAGGA GAGTGGTACT 
ACAGCTTCCA ATGTCTGGAC TGGACTTCAT GACCCTAAAA GTAACCGTCG TTGGCACTGG 
AGCAGTGGCT CCCTATTTCT CTTCAAGTCA TGGGCCACTG GAGCTCCAAG CACTGCCAAC 
CGTGGTTATT GTGTATCGCT GACTTCAAAC ACAGCATACA AAAAATGGAA GGACGAAAAC 
TGTGAGGCAC AGTACTCCTT TGTCTGCAAG TTCAGAGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033069.1
CDS	72..593
Translation	MAQNNVYLILFLCLMFLSYSQGQVAEEDFPLAEKDLPSAKINCPEGANAYGSYCYYLIEDRLTWGEADLFCQNMNAGHLVSILSQAESNFVASLVKESGTTASNVWTGLHDPKSNRRWHWSSGSLFLFKSWATGAPSTANRGYCVSLTSNTAYKKWKDENCEAQYSFVCKFRA

Target ORF information:

RefSeq Version	NM_009043.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus regenerating islet-derived 2 (Reg2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009043.2

ORF Insert Sequence:

ATGGCTCAGA ACAATGTATA CCTTATCCTG TTCTTATGCC TGATGTTCCT GTCATACAGC 
CAAGGCCAGG TAGCTGAAGA AGACTTCCCC TTGGCTGAAA AAGACCTTCC TTCTGCCAAA 
ATCAACTGCC CAGAGGGTGC CAACGCCTAT GGTTCCTACT GTTATTATCT AATTGAAGAC 
CGTTTGACCT GGGGGGAGGC TGATCTCTTT TGCCAGAACA TGAATGCAGG TCACCTGGTG 
TCAATACTCA GCCAGGCTGA GAGCAACTTT GTGGCCTCGC TGGTTAAGGA GAGTGGTACT 
ACAGCTTCCA ATGTCTGGAC TGGACTTCAT GACCCTAAAA GTAACCGTCG TTGGCACTGG 
AGCAGTGGCT CCCTATTTCT CTTCAAGTCA TGGGCCACTG GAGCTCCAAG CACTGCCAAC 
CGTGGTTATT GTGTATCGCT GACTTCAAAC ACAGCATACA AAAAATGGAA GGACGAAAAC 
TGTGAGGCAC AGTACTCCTT TGTCTGCAAG TTCAGAGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Reg2 ( NM_009043.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033069.1 Mus musculus regenerating islet-derived 2 (Reg2), mRNA.

Price & Availability↑

CloneID	OMu03408
Clone ID Related Accession (Same CDS sequence)	NM_009043.2 , NM_009043.1
Accession Version	NM_009043.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Mus musculus(house mouse)
Product	lithostathine-2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D14011.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK008196.1, CF580998.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCAGA ACAATGTATA CCTTATCCTG TTCTTATGCC TGATGTTCCT GTCATACAGC 
CAAGGCCAGG TAGCTGAAGA AGACTTCCCC TTGGCTGAAA AAGACCTTCC TTCTGCCAAA 
ATCAACTGCC CAGAGGGTGC CAACGCCTAT GGTTCCTACT GTTATTATCT AATTGAAGAC 
CGTTTGACCT GGGGGGAGGC TGATCTCTTT TGCCAGAACA TGAATGCAGG TCACCTGGTG 
TCAATACTCA GCCAGGCTGA GAGCAACTTT GTGGCCTCGC TGGTTAAGGA GAGTGGTACT 
ACAGCTTCCA ATGTCTGGAC TGGACTTCAT GACCCTAAAA GTAACCGTCG TTGGCACTGG 
AGCAGTGGCT CCCTATTTCT CTTCAAGTCA TGGGCCACTG GAGCTCCAAG CACTGCCAAC 
CGTGGTTATT GTGTATCGCT GACTTCAAAC ACAGCATACA AAAAATGGAA GGACGAAAAC 
TGTGAGGCAC AGTACTCCTT TGTCTGCAAG TTCAGAGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033069.1
CDS	72..593
Translation	MAQNNVYLILFLCLMFLSYSQGQVAEEDFPLAEKDLPSAKINCPEGANAYGSYCYYLIEDRLTWGEADLFCQNMNAGHLVSILSQAESNFVASLVKESGTTASNVWTGLHDPKSNRRWHWSSGSLFLFKSWATGAPSTANRGYCVSLTSNTAYKKWKDENCEAQYSFVCKFRA

Target ORF information:

RefSeq Version	NM_009043.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus regenerating islet-derived 2 (Reg2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009043.1

ORF Insert Sequence:

ATGGCTCAGA ACAATGTATA CCTTATCCTG TTCTTATGCC TGATGTTCCT GTCATACAGC 
CAAGGCCAGG TAGCTGAAGA AGACTTCCCC TTGGCTGAAA AAGACCTTCC TTCTGCCAAA 
ATCAACTGCC CAGAGGGTGC CAACGCCTAT GGTTCCTACT GTTATTATCT AATTGAAGAC 
CGTTTGACCT GGGGGGAGGC TGATCTCTTT TGCCAGAACA TGAATGCAGG TCACCTGGTG 
TCAATACTCA GCCAGGCTGA GAGCAACTTT GTGGCCTCGC TGGTTAAGGA GAGTGGTACT 
ACAGCTTCCA ATGTCTGGAC TGGACTTCAT GACCCTAAAA GTAACCGTCG TTGGCACTGG 
AGCAGTGGCT CCCTATTTCT CTTCAAGTCA TGGGCCACTG GAGCTCCAAG CACTGCCAAC 
CGTGGTTATT GTGTATCGCT GACTTCAAAC ACAGCATACA AAAAATGGAA GGACGAAAAC 
TGTGAGGCAC AGTACTCCTT TGTCTGCAAG TTCAGAGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet-Induced Obesity.
Endocrinology158(6)1634-1644(2017 Jun)
Li Q,Li B,Miao X,Ramgattie C,Gao ZH,Liu JL

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.
Cell reports16(8)2208-2218(2016 Aug)
Aden K,Rehman A,Falk-Paulsen M,Secher T,Kuiper J,Tran F,Pfeuffer S,Sheibani-Tezerji R,Breuer A,Luzius A,Jentzsch M,H?sler R,Billmann-Born S,Will O,Lipinski S,Bharti R,Adolph T,Iovanna JL,Kempster SL,Blumberg RS,Schreiber S,Becher B,Chamaillard M,Kaser A,Rosenstiel P

mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells.
Growth factors (Chur, Switzerland)33(1)1-7(2015 Feb)
Liu L,Chowdhury S,Uppal S,Fang X,Liu JL,Srikant CB

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Reg2 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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