Plp2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Plp2
Entrez Gene ID	18824
Full Name	proteolipid protein 2
Synonyms	mIMA4
General protein information	Preferred Names proteolipid protein 2 Names proteolipid protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X A1.1\|X 3.45 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_019755.5	NP_062729.1	proteolipid protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PLP2	NP_002659.1
Bos taurus (cattle)	PLP2	NP_976239.1
Xenopus tropicalis (tropical clawed frog)	plp2	NP_001037892.1
	PLP2	XP_001106080.1
Canis lupus familiaris (dog)	PLP2	XP_005642144.1
Mus musculus (house mouse)	Plp2	NP_062729.1
Danio rerio (zebrafish)	plp2	NP_001154917.1
Rattus norvegicus (Norway rat)	Plp2	NP_997484.1

Gene Ontology
Bibliography

Related articles in PubMed

Reduced PLP2 expression increases ER-stress-induced neuronal apoptosis and risk for adverse neurological outcomes after hypoxia ischemia injury.
Zhang L, Wang T, Valle D
Human molecular genetics24(25)7221-6(2015 Dec)

Proteolipid protein 2 is associated with melanoma metastasis.
Sonoda Y, Warita M, Suzuki T, Ozawa H, Fukuda Y, Funakoshi-Tago M, Kasahara T
Oncology reports23(2)371-6(2010 Feb)

Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.
Chen YT, Hims MM, Shetty RS, Mull J, Liu L, Leyne M, Slaugenhaupt SA
Molecular and cellular biology29(3)736-44(2009 Feb)

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Piao Y, Ko NT, Lim MK, Ko MS
Genome research11(9)1553-8(2001 Sep)

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F
Nature genetics27(1)68-73(2001 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PLP2 enhanced proliferation, adhesion, invasion, and MMP-2 secretion in vitro, and tumor metastasis in vivo.
Title: Proteolipid protein 2 is associated with melanoma metastasis.

The following Plp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11245	NM_019755.5 Latest version!	Mus musculus proteolipid protein 2 (Plp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Plp2 ( NM_019755.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062729.1 Mus musculus proteolipid protein 2 (Plp2), mRNA.

Price & Availability↑

CloneID	OMu11245
Clone ID Related Accession (Same CDS sequence)	NM_019755.5
Accession Version	NM_019755.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Mus musculus(house mouse)
Product	proteolipid protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY254069.1, AK003522.1 and AI595418.1. On Aug 25, 2015 this sequence version replaced NM_019755.4. ##Evidence-Data-START## Transcript exon combination :: BC092095.1, SRR1660813.336029.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGATT CTGAGCGTCT CTCGGCCCCC GGCTGCTGGT TAGCCTGCAC CAGCTTCTCG 
CGCACCAAAA AGGGAATTCT CCTGTTTGCT GAGATTATAC TGTGCCTGGT GATCTTGATT 
TGCTTCAGTG CATCTACAAC ATCGGCCTAC TCCTCCCTGT CGGTGATTGA GATGATCTGT 
GCTGCTGTCT TACTTGTCTT CTACACGTGT GACCTGCACT CCAAGATATC ATTCATCAAC 
TGGCCTTGGA CTGACTTCTT CAGATCCCTC ATAGCAACCA TCCTGTACCT GATCACCTCC 
ATTGTTGTCC TTGTAGAAGG AAGAGGCAGC TCCAGAGTTG TCGCTGGGAT ACTGGGCTTA 
CTTGCTACGT TGCTCTTTGG CTACGATGCA TACATCACCT TCCCTCTAAA GCAGCAAAGA 
CATACAGCAG CTCCCACTGA CCCCACTGAT GGCCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062729.1
CDS	153..611
Translation	MADSERLSAPGCWLACTSFSRTKKGILLFAEIILCLVILICFSASTTSAYSSLSVIEMICAAVLLVFYTCDLHSKISFINWPWTDFFRSLIATILYLITSIVVLVEGRGSSRVVAGILGLLATLLFGYDAYITFPLKQQRHTAAPTDPTDGP

Target ORF information:

RefSeq Version	NM_019755.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus proteolipid protein 2 (Plp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019755.5

ORF Insert Sequence:

ATGGCGGATT CTGAGCGTCT CTCGGCCCCC GGCTGCTGGT TAGCCTGCAC CAGCTTCTCG 
CGCACCAAAA AGGGAATTCT CCTGTTTGCT GAGATTATAC TGTGCCTGGT GATCTTGATT 
TGCTTCAGTG CATCTACAAC ATCGGCCTAC TCCTCCCTGT CGGTGATTGA GATGATCTGT 
GCTGCTGTCT TACTTGTCTT CTACACGTGT GACCTGCACT CCAAGATATC ATTCATCAAC 
TGGCCTTGGA CTGACTTCTT CAGATCCCTC ATAGCAACCA TCCTGTACCT GATCACCTCC 
ATTGTTGTCC TTGTAGAAGG AAGAGGCAGC TCCAGAGTTG TCGCTGGGAT ACTGGGCTTA 
CTTGCTACGT TGCTCTTTGG CTACGATGCA TACATCACCT TCCCTCTAAA GCAGCAAAGA 
CATACAGCAG CTCCCACTGA CCCCACTGAT GGCCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reduced PLP2 expression increases ER-stress-induced neuronal apoptosis and risk for adverse neurological outcomes after hypoxia ischemia injury.
Human molecular genetics24(25)7221-6(2015 Dec)
Zhang L,Wang T,Valle D

Proteolipid protein 2 is associated with melanoma metastasis.
Oncology reports23(2)371-6(2010 Feb)
Sonoda Y,Warita M,Suzuki T,Ozawa H,Fukuda Y,Funakoshi-Tago M,Kasahara T

Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.
Molecular and cellular biology29(3)736-44(2009 Feb)
Chen YT,Hims MM,Shetty RS,Mull J,Liu L,Leyne M,Slaugenhaupt SA

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Genome research11(9)1553-8(2001 Sep)
Piao Y,Ko NT,Lim MK,Ko MS

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
Nature genetics27(1)68-73(2001 Jan)
Brunkow ME,Jeffery EW,Hjerrild KA,Paeper B,Clark LB,Yasayko SA,Wilkinson JE,Galas D,Ziegler SF,Ramsdell F