Mcpt4 cDNA ORF clone, Mus musculus(house mouse)

Mast cell chymase decreases the severity of group B Streptococcus infections.
Gendrin C, Shubin NJ, Boldenow E, Merillat S, Clauson M, Power D, Doran KS, Abrink M, Pejler G, Rajagopal L, Piliponsky AM
The Journal of allergy and clinical immunology(2017 Sep)

Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules.
Choi HW, Bowen SE, Miao Y, Chan CY, Miao EA, Abrink M, Moeser AJ, Abraham SN
Immunity45(6)1258-1269(2016 12)

Increased Bone Mass in Female Mice Lacking Mast Cell Chymase.
Lind T, Gustafson AM, Calounova G, Hu L, Rasmusson A, Jonsson KB, Wernersson S, ?brink M, Andersson G, Larsson S, Melhus H, Pejler G
PloS one11(12)e0167964(2016)

These results suggest that the inhibition of mMCP-4 reduces lesion spreading in the earlier phases of atherosclerosis development and can help stabilise the more advanced plaque
Title: Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice.

deletion of the gene encoding MMCP-4 (Mcpt4), markedly reduced late, but not early, infarct size by suppressing IGF-1 degradation and, consequently, diminished cardiac dysfunction and adverse structural remodeling
Title: IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction.

study supports a role for mMCP-4 in the early inflammatory phases of the disease in a mouse model of MS.
Title: Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis.

Results suggest that mouse mast cell proteases 4, 5, and 6 are mediators of the critical role mast cells play in microdeformational wound therapy in the proliferative phase of healing.
Title: The role of mouse mast cell proteases in the proliferative phase of wound healing in microdeformational wound therapy.

Data indicate that a second-degree burn injury can initiate an immediate novel zonal degranulation of mast cell throughout all skin layers and a disruption of the epidermal tight junctions dependent on the nonredundant presence of mMCP4 and mMCP5.
Title: Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions.