Cd209d cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd209d
Entrez Gene ID	170779
Full Name	CD209d antigen
Synonyms	SIGN-R3,SIGNR3,mSIGNR3
General protein information	Preferred Names CD209d antigen Names CD209 antigen-like protein D DC-SIGN-related protein 3 DC-SIGNR3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 A1.1

mRNA and Protein(s)

mRNA	Protein	Name
XM_011242039.2	XP_011240341.1	CD209 antigen-like protein D isoform X1
XM_011242039.1	XP_011240341.1	CD209 antigen-like protein D isoform X1
NM_130904.2	NP_570974.1	CD209 antigen-like protein D

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CLEC4M	NP_001065255.1
Mus musculus (house mouse)	Cd209d	NP_570974.1
Rattus norvegicus (Norway rat)	Clec4m	NP_001102319.1

Gene Ontology
Bibliography

Related articles in PubMed

SIgA-Shigella Immune Complexes Interact with Dectin-1 and SIGNR3 to Differentially Regulate Mouse Peyer's Patch and Mesenteric Lymph Node Dendritic Cell's Responsiveness.
Mikulic J, Bioley G, Corth?sy B
Journal of molecular biology429(15)2387-2400(2017 Jul)

SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis.
Lightfoot YL, Selle K, Yang T, Goh YJ, Sahay B, Zadeh M, Owen JL, Colliou N, Li E, Johannssen T, Lepenies B, Klaenhammer TR, Mohamadzadeh M
The EMBO journal34(7)881-95(2015 Apr)

The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum.
Lef?vre L, Lugo-Villarino G, Meunier E, Valentin A, Olagnier D, Authier H, Duval C, Dardenne C, Bernad J, Lemesre JL, Auwerx J, Neyrolles O, Pipy B, Coste A
Immunity38(5)1038-49(2013 May)

A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins.
Orr SL, Le D, Long JM, Sobieszczuk P, Ma B, Tian H, Fang X, Paulson JC, Marth JD, Varki N
Glycobiology23(3)363-80(2013 Mar)

The C-Type Lectin Receptor SIGNR3 Binds to Fungi Present in Commensal Microbiota and Influences Immune Regulation in Experimental Colitis.
Eriksson M, Johannssen T, von Smolinski D, Gruber AD, Seeberger PH, Lepenies B
Frontiers in immunology4196(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The sum of the data suggests that in contrast to IgG-based immune complexes boosting immune reactivity of antigen-presenting cells, secretory IgA produced during an ongoing immune response can, in addition to its known function of immune exclusion, modulate mucosal dendritic cell conditioning via specific interaction with Dectin-1 and SIGNR3.
Title: SIgA-Shigella Immune Complexes Interact with Dectin-1 and SIGNR3 to Differentially Regulate Mouse Peyer's Patch and Mesenteric Lymph Node Dendritic Cell's Responsiveness.

the SlpA/SIGNR3 interaction plays a key regulatory role in colitis.
Title: SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis.

study reports the macrophage response against Leishmania infantum in vivo is characterized by an M2b-like phenotype and C-type lectin receptors signature composed of Dectin-1, mannose receptor (MR)and the DC-SIGN homolog SIGNR3 expression
Title: The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum.

SIGNR3 is a new differentiation marker for myeloid mononuclear cells and indicate that some dendritic cells may be replenished by monocytes.
Title: Expression of C-type lectin, SIGNR3, on subsets of dendritic cells, macrophages, and monocytes.

The following Cd209d gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd209d cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu09856	NM_130904.2 Latest version!	Mus musculus CD209d antigen (Cd209d), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu72517	XM_011242039.2 Latest version!	Mus musculus CD209d antigen (Cd209d), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu72517	XM_011242039.1	Mus musculus CD209d antigen (Cd209d), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd209d ( XM_011242039.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011240341.1 Mus musculus CD209d antigen (Cd209d), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu72517
Clone ID Related Accession (Same CDS sequence)	XM_011242039.2 , XM_011242039.1
Accession Version	XM_011242039.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	CD209 antigen-like protein D isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTGACT CCATGGAATC AAAGACACAG CAAGTGGTCA TTCCAGAGGA TGAAGAGTGT 
TTGATGAGTG GCACCAGGTA TTCTGATATC AGCTCCCGAT TACAAACAAA ATTTGGAATC 
AAGAGTTTGG CAGAGTATAC GAAGCAGAGC CGCAACCCCT TGGTCCTGCA GCTGCTTTCC 
TTCCTGTTCT TGGCTGGGCT TCTGCTGATC ATTCTGATCC TAGTGTCAAA GGTCCCCAGC 
TCAGAGGTTC AGAACAAAAT CTACCAGGAG CTCATGCAAC TGAAGGCTGA AGTTCATGAT 
GGCTTGTGCC AACCCTGCGC CAGGGACTGG ACATTCTTCA ATGGAAGCTG TTACTTCTTC 
TCCAAGTCCC AAAGAAATTG GCACAACTCC ACCACTGCCT GCCAGGAACT GGGGGCCCAA 
CTGGTCATCA TAGAGACTGA TGAGGAGCAG ACTTTCCTGC AGCAGACTTC TAAGGCTAGA 
GGACCAACCT GGATGGGTCT CTCAGACATG CATAATGAAG CCACATGGCA CTGGGTGGAT 
GGCTCACCTC TGTCACCCAG ACATATCCAC AGGCCAGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011240341.1
CDS	66..647
Translation	MSDSMESKTQQVVIPEDEECLMSGTRYSDISSRLQTKFGIKSLAEYTKQSRNPLVLQLLSFLFLAGLLLIILILVSKVPSSEVQNKIYQELMQLKAEVHDGLCQPCARDWTFFNGSCYFFSKSQRNWHNSTTACQELGAQLVIIETDEEQTFLQQTSKARGPTWMGLSDMHNEATWHWVDGSPLSPRHIHRPA

Target ORF information:

RefSeq Version	XM_011242039.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD209d antigen (Cd209d), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011242039.1

ORF Insert Sequence:

ATGAGTGACT CCATGGAATC AAAGACACAG CAAGTGGTCA TTCCAGAGGA TGAAGAGTGT 
TTGATGAGTG GCACCAGGTA TTCTGATATC AGCTCCCGAT TACAAACAAA ATTTGGAATC 
AAGAGTTTGG CAGAGTATAC GAAGCAGAGC CGCAACCCCT TGGTCCTGCA GCTGCTTTCC 
TTCCTGTTCT TGGCTGGGCT TCTGCTGATC ATTCTGATCC TAGTGTCAAA GGTCCCCAGC 
TCAGAGGTTC AGAACAAAAT CTACCAGGAG CTCATGCAAC TGAAGGCTGA AGTTCATGAT 
GGCTTGTGCC AACCCTGCGC CAGGGACTGG ACATTCTTCA ATGGAAGCTG TTACTTCTTC 
TCCAAGTCCC AAAGAAATTG GCACAACTCC ACCACTGCCT GCCAGGAACT GGGGGCCCAA 
CTGGTCATCA TAGAGACTGA TGAGGAGCAG ACTTTCCTGC AGCAGACTTC TAAGGCTAGA 
GGACCAACCT GGATGGGTCT CTCAGACATG CATAATGAAG CCACATGGCA CTGGGTGGAT 
GGCTCACCTC TGTCACCCAG ACATATCCAC AGGCCAGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cd209d ( NM_130904.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_570974.1 Mus musculus CD209d antigen (Cd209d), mRNA.

Price & Availability↑

CloneID	OMu09856
Clone ID Related Accession (Same CDS sequence)	NM_130904.2
Accession Version	NM_130904.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	CD209 antigen-like protein D
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF373411.1. On Nov 2, 2002 this sequence version replaced NM_130904.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF373411.1, AK136586.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382 [ECO:0000348] ##Evidence-Data-END##

ATGAGTGACT CCATGGAATC AAAGACACAG CAAGTGGTCA TTCCAGAGGA TGAAGAGTGT 
TTGATGAGTG GCACCAGGTA TTCTGATATC AGCTCCCGAT TACAAACAAA ATTTGGAATC 
AAGAGTTTGG CAGAGTATAC GAAGCAGAGC CGCAACCCCT TGGTCCTGCA GCTGCTTTCC 
TTCCTGTTCT TGGCTGGGCT TCTGCTGATC ATTCTGATCC TAGTGTCAAA GGTCCCCAGC 
TCAGAGGTTC AGAACAAAAT CTACCAGGAG CTCATGCAAC TGAAGGCTGA AGTTCATGAT 
GGCTTGTGCC AACCCTGCGC CAGGGACTGG ACATTCTTCA ATGGAAGCTG TTACTTCTTC 
TCCAAGTCCC AAAGAAATTG GCACAACTCC ACCACTGCCT GCCAGGAACT GGGGGCCCAA 
CTGGTCATCA TAGAGACTGA TGAGGAGCAG ACTTTCCTGC AGCAGACTTC TAAGGCTAGA 
GGACCAACCT GGATGGGTCT CTCAGACATG CATAATGAAG CCACATGGCA CTGGGTGGAT 
GGCTCACCTC TGTCACCCAG CTTTACACGC TATTGGAATA GAGGGGAGCC CAACAATGTC 
GGTGATGAAG ATTGTGCAGA GTTCTCTGGG GATGGCTGGA ATGATCTCAG TTGTGATAAA 
CTACTTTTCT GGATCTGTAA GAAAGTTTCA ACCTCATCAT GCACCACCAA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570974.1
CDS	17..730
Translation	MSDSMESKTQQVVIPEDEECLMSGTRYSDISSRLQTKFGIKSLAEYTKQSRNPLVLQLLSFLFLAGLLLIILILVSKVPSSEVQNKIYQELMQLKAEVHDGLCQPCARDWTFFNGSCYFFSKSQRNWHNSTTACQELGAQLVIIETDEEQTFLQQTSKARGPTWMGLSDMHNEATWHWVDGSPLSPSFTRYWNRGEPNNVGDEDCAEFSGDGWNDLSCDKLLFWICKKVSTSSCTTK

Target ORF information:

RefSeq Version	NM_130904.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD209d antigen (Cd209d), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130904.2

ORF Insert Sequence:

ATGAGTGACT CCATGGAATC AAAGACACAG CAAGTGGTCA TTCCAGAGGA TGAAGAGTGT 
TTGATGAGTG GCACCAGGTA TTCTGATATC AGCTCCCGAT TACAAACAAA ATTTGGAATC 
AAGAGTTTGG CAGAGTATAC GAAGCAGAGC CGCAACCCCT TGGTCCTGCA GCTGCTTTCC 
TTCCTGTTCT TGGCTGGGCT TCTGCTGATC ATTCTGATCC TAGTGTCAAA GGTCCCCAGC 
TCAGAGGTTC AGAACAAAAT CTACCAGGAG CTCATGCAAC TGAAGGCTGA AGTTCATGAT 
GGCTTGTGCC AACCCTGCGC CAGGGACTGG ACATTCTTCA ATGGAAGCTG TTACTTCTTC 
TCCAAGTCCC AAAGAAATTG GCACAACTCC ACCACTGCCT GCCAGGAACT GGGGGCCCAA 
CTGGTCATCA TAGAGACTGA TGAGGAGCAG ACTTTCCTGC AGCAGACTTC TAAGGCTAGA 
GGACCAACCT GGATGGGTCT CTCAGACATG CATAATGAAG CCACATGGCA CTGGGTGGAT 
GGCTCACCTC TGTCACCCAG CTTTACACGC TATTGGAATA GAGGGGAGCC CAACAATGTC 
GGTGATGAAG ATTGTGCAGA GTTCTCTGGG GATGGCTGGA ATGATCTCAG TTGTGATAAA 
CTACTTTTCT GGATCTGTAA GAAAGTTTCA ACCTCATCAT GCACCACCAA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cd209d ( XM_011242039.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011240341.1 Mus musculus CD209d antigen (Cd209d), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu72517
Clone ID Related Accession (Same CDS sequence)	XM_011242039.2 , XM_011242039.1
Accession Version	XM_011242039.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	CD209 antigen-like protein D isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011242039.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTGACT CCATGGAATC AAAGACACAG CAAGTGGTCA TTCCAGAGGA TGAAGAGTGT 
TTGATGAGTG GCACCAGGTA TTCTGATATC AGCTCCCGAT TACAAACAAA ATTTGGAATC 
AAGAGTTTGG CAGAGTATAC GAAGCAGAGC CGCAACCCCT TGGTCCTGCA GCTGCTTTCC 
TTCCTGTTCT TGGCTGGGCT TCTGCTGATC ATTCTGATCC TAGTGTCAAA GGTCCCCAGC 
TCAGAGGTTC AGAACAAAAT CTACCAGGAG CTCATGCAAC TGAAGGCTGA AGTTCATGAT 
GGCTTGTGCC AACCCTGCGC CAGGGACTGG ACATTCTTCA ATGGAAGCTG TTACTTCTTC 
TCCAAGTCCC AAAGAAATTG GCACAACTCC ACCACTGCCT GCCAGGAACT GGGGGCCCAA 
CTGGTCATCA TAGAGACTGA TGAGGAGCAG ACTTTCCTGC AGCAGACTTC TAAGGCTAGA 
GGACCAACCT GGATGGGTCT CTCAGACATG CATAATGAAG CCACATGGCA CTGGGTGGAT 
GGCTCACCTC TGTCACCCAG ACATATCCAC AGGCCAGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011240341.1
CDS	66..647
Translation	MSDSMESKTQQVVIPEDEECLMSGTRYSDISSRLQTKFGIKSLAEYTKQSRNPLVLQLLSFLFLAGLLLIILILVSKVPSSEVQNKIYQELMQLKAEVHDGLCQPCARDWTFFNGSCYFFSKSQRNWHNSTTACQELGAQLVIIETDEEQTFLQQTSKARGPTWMGLSDMHNEATWHWVDGSPLSPRHIHRPA

Target ORF information:

RefSeq Version	XM_011242039.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD209d antigen (Cd209d), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011242039.2

ORF Insert Sequence:

ATGAGTGACT CCATGGAATC AAAGACACAG CAAGTGGTCA TTCCAGAGGA TGAAGAGTGT 
TTGATGAGTG GCACCAGGTA TTCTGATATC AGCTCCCGAT TACAAACAAA ATTTGGAATC 
AAGAGTTTGG CAGAGTATAC GAAGCAGAGC CGCAACCCCT TGGTCCTGCA GCTGCTTTCC 
TTCCTGTTCT TGGCTGGGCT TCTGCTGATC ATTCTGATCC TAGTGTCAAA GGTCCCCAGC 
TCAGAGGTTC AGAACAAAAT CTACCAGGAG CTCATGCAAC TGAAGGCTGA AGTTCATGAT 
GGCTTGTGCC AACCCTGCGC CAGGGACTGG ACATTCTTCA ATGGAAGCTG TTACTTCTTC 
TCCAAGTCCC AAAGAAATTG GCACAACTCC ACCACTGCCT GCCAGGAACT GGGGGCCCAA 
CTGGTCATCA TAGAGACTGA TGAGGAGCAG ACTTTCCTGC AGCAGACTTC TAAGGCTAGA 
GGACCAACCT GGATGGGTCT CTCAGACATG CATAATGAAG CCACATGGCA CTGGGTGGAT 
GGCTCACCTC TGTCACCCAG ACATATCCAC AGGCCAGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SIgA-Shigella Immune Complexes Interact with Dectin-1 and SIGNR3 to Differentially Regulate Mouse Peyer's Patch and Mesenteric Lymph Node Dendritic Cell's Responsiveness.
Journal of molecular biology429(15)2387-2400(2017 Jul)
Mikulic J,Bioley G,Corth?sy B

SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis.
The EMBO journal34(7)881-95(2015 Apr)
Lightfoot YL,Selle K,Yang T,Goh YJ,Sahay B,Zadeh M,Owen JL,Colliou N,Li E,Johannssen T,Lepenies B,Klaenhammer TR,Mohamadzadeh M

The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum.
Immunity38(5)1038-49(2013 May)
Lef?vre L,Lugo-Villarino G,Meunier E,Valentin A,Olagnier D,Authier H,Duval C,Dardenne C,Bernad J,Lemesre JL,Auwerx J,Neyrolles O,Pipy B,Coste A

A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins.
Glycobiology23(3)363-80(2013 Mar)
Orr SL,Le D,Long JM,Sobieszczuk P,Ma B,Tian H,Fang X,Paulson JC,Marth JD,Varki N

The C-Type Lectin Receptor SIGNR3 Binds to Fungi Present in Commensal Microbiota and Influences Immune Regulation in Experimental Colitis.
Frontiers in immunology4196(2013)
Eriksson M,Johannssen T,von Smolinski D,Gruber AD,Seeberger PH,Lepenies B