Elovl6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Elovl6
Entrez Gene ID	170439
Full Name	ELOVL family member 6, elongation of long chain fatty acids (yeast)
Synonyms	C77826,FAE,LCE
General protein information	Preferred Names ELOVL family member 6, elongation of long chain fatty acids (yeast) Names elongation of very long chain fatty acids protein 6 3-keto acyl-CoA synthase Elovl6 ELOVL FA elongase 6 ELOVL fatty acid elongase 6 fatty acyl-CoA elongase long chain fatty acid elongase long chain fatty acyl elongase myelin-associated SUR4 protein very long chain 3-ketoacyl-CoA synthase 6 very long chain 3-oxoacyl-CoA synthase 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 G3

mRNA and Protein(s)

mRNA	Protein	Name
NM_130450.2	NP_569717.1	elongation of very long chain fatty acids protein 6

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ELOVL6	NP_001026710.1
Danio rerio (zebrafish)	elovl6	NP_955826.1
Drosophila melanogaster (fruit fly)	Baldspot	NP_648909.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006520	XP_001237830.2
Caenorhabditis elegans (roundworm)	elo-3	NP_001255291.1
	ELOVL6	XP_001089527.1
Bos taurus (cattle)	ELOVL6	NP_001095625.1
Rattus norvegicus (Norway rat)	Elovl6	NP_599210.1
Homo sapiens (human)	ELOVL6	NP_001124193.1
Pan troglodytes (chimpanzee)	ELOVL6	XP_517396.1
Canis lupus familiaris (dog)	ELOVL6	XP_005639328.1
Mus musculus (house mouse)	Elovl6	NP_569717.1
Xenopus tropicalis (tropical clawed frog)	elovl6	NP_001017257.2
Rattus norvegicus (Norway rat)	LOC102549542	XP_006233363.1

Gene Ontology
Bibliography

Related articles in PubMed

Elovl6 Deficiency Improves Glycemic Control in Diabetic
Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, Okajima Y, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H
Diabetes66(7)1833-1846(2017 07)

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Elovl6 is a fundamental factor linking dysregulated lipid metabolism to beta-cell dysfunction, islet inflammation, and beta-cell apoptosis in T2D, highlighting oleate as the potential culprit of beta-cell lipotoxicity.
Title: Elovl6 Deficiency Improves Glycemic Control in Diabetic

the synergistic action of ChREBP and SREBP-1c is necessary for the maximal induction of Elovl6 expression in the liver.
Title: Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1c.

data suggest that Elovl6 plays a critical role for proper development of embryonic growth plate
Title: Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice.

Elongation of Very Long Chain fatty acids 6 (Elovl6) is necessary for the thermogenic action of brown adipose tissue
Title: Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6.

These findings suggest that Elovl6-mediated changes in hepatic FA composition, especially oleic acid (C18:1n-9), control handling of hepatic cholesterol and BA, which protects against hepatotoxicity and steatohepatitis
Title: Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model.

The following Elovl6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Elovl6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19394	NM_130450.2 Latest version!	Mus musculus ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Elovl6 ( NM_130450.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_569717.1 Mus musculus ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA.

Price & Availability↑

CloneID	OMu19394
Clone ID Related Accession (Same CDS sequence)	NM_130450.2
Accession Version	NM_130450.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	elongation of very long chain fatty acids protein 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK029029.1 and AC098732.3. On Apr 8, 2006 this sequence version replaced NM_130450.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY053453.1, AB072039.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACATGT CAGTGTTGAC TTTACAAGAA TATGAATTCG AAAAGCAGTT CAACGAGAAC 
GAAGCCATCC AATGGATGCA GGAAAACTGG AAGAAGTCTT TCCTGTTTTC TGCGCTGTAC 
GCTGCCTTTA TCTTTGGTGG TCGGCATCTG ATGAACAAGC GAGCCAAGTT TGAACTTCGG 
AAGCCGCTCG TGCTCTGGTC GCTGACTCTT GCCGTCTTCA GTATATTCGG TGCTCTTCGA 
ACTGGTGCTT ACATGCTGTA CATTCTGATG ACCAAAGGCC TGAAGCAGTC AGTTTGTGAC 
CAGAGTTTTT ACAATGGACC TGTCAGCAAA TTCTGGGCTT ATGCATTTGT GCTCAGCAAA 
GCACCCGAAC TAGGTGACAC GATATTCATC ATTCTGAGGA AACAGAAACT GATCTTCCTG 
CACTGGTACC ACCACATCAC TGTGCTCCTG TACTCCTGGT ACTCCTACAA AGACATGGTC 
GCTGGGGGTG GTTGGTTCAT GACTATGAAC TATGGCGTGC ATGCCGTCAT GTACTCTTAC 
TACGCCTTGC GGGCTGCGGG TTTCCGAGTC TCCCGGAAGT TTGCCATGTT CATCACCTTG 
TCCCAGATCA CTCAGATGCT GATGGGCTGT GTCATTAACT ACCTGGTCTT CAACTGGATG 
CAGCATGACA ACGACCAGTG CTACTCCCAC TTTCAGAACA TCTTCTGGTC CTCGCTCATG 
TACCTCAGCT ACCTTGTGCT CTTCTGCCAT TTCTTCTTTG AGGCCTACAT CGGCAAAGTG 
AAGAAAGCCA CGAAGGCTGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_569717.1
CDS	143..946
Translation	MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMLYILMTKGLKQSVCDQSFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVINYLVFNWMQHDNDQCYSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKVKKATKAE

Target ORF information:

RefSeq Version	NM_130450.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130450.2

ORF Insert Sequence:

ATGAACATGT CAGTGTTGAC TTTACAAGAA TATGAATTCG AAAAGCAGTT CAACGAGAAC 
GAAGCCATCC AATGGATGCA GGAAAACTGG AAGAAGTCTT TCCTGTTTTC TGCGCTGTAC 
GCTGCCTTTA TCTTTGGTGG TCGGCATCTG ATGAACAAGC GAGCCAAGTT TGAACTTCGG 
AAGCCGCTCG TGCTCTGGTC GCTGACTCTT GCCGTCTTCA GTATATTCGG TGCTCTTCGA 
ACTGGTGCTT ACATGCTGTA CATTCTGATG ACCAAAGGCC TGAAGCAGTC AGTTTGTGAC 
CAGAGTTTTT ACAATGGACC TGTCAGCAAA TTCTGGGCTT ATGCATTTGT GCTCAGCAAA 
GCACCCGAAC TAGGTGACAC GATATTCATC ATTCTGAGGA AACAGAAACT GATCTTCCTG 
CACTGGTACC ACCACATCAC TGTGCTCCTG TACTCCTGGT ACTCCTACAA AGACATGGTC 
GCTGGGGGTG GTTGGTTCAT GACTATGAAC TATGGCGTGC ATGCCGTCAT GTACTCTTAC 
TACGCCTTGC GGGCTGCGGG TTTCCGAGTC TCCCGGAAGT TTGCCATGTT CATCACCTTG 
TCCCAGATCA CTCAGATGCT GATGGGCTGT GTCATTAACT ACCTGGTCTT CAACTGGATG 
CAGCATGACA ACGACCAGTG CTACTCCCAC TTTCAGAACA TCTTCTGGTC CTCGCTCATG 
TACCTCAGCT ACCTTGTGCT CTTCTGCCAT TTCTTCTTTG AGGCCTACAT CGGCAAAGTG 
AAGAAAGCCA CGAAGGCTGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Elovl6 Deficiency Improves Glycemic Control in Diabetic
Diabetes66(7)1833-1846(2017 07)
Zhao H,Matsuzaka T,Nakano Y,Motomura K,Tang N,Yokoo T,Okajima Y,Han SI,Takeuchi Y,Aita Y,Iwasaki H,Yatoh S,Suzuki H,Sekiya M,Yahagi N,Nakagawa Y,Sone H,Yamada N,Shimano H

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
PLoS genetics12(9)e1006355(2016 Sep)
Wu Y,Wei FY,Kawarada L,Suzuki T,Araki K,Komohara Y,Fujimura A,Kaitsuka T,Takeya M,Oike Y,Suzuki T,Tomizawa K