Klra4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klra4
Entrez Gene ID	16635
Full Name	killer cell lectin-like receptor, subfamily A, member 4
Synonyms	Chok,Klra32,Klra33,Ly-49d,Ly49d,ly49r<129>
General protein information	Preferred Names killer cell lectin-like receptor, subfamily A, member 4 Names killer cell lectin-like receptor 4 T-cell surface glycoprotein Ly-49D killer cell lectin-like receptor subfamily A member 32 killer cell lectin-like receptor subfamily A member 33 lymphocyte antigen 49d
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 F3\|6 63.44 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010649.3	NP_034779.1	killer cell lectin-like receptor 4 isoform 1
XM_006505646.2	XP_006505709.1	killer cell lectin-like receptor 4 isoform X1
XM_006505646.1	XP_006505709.1	killer cell lectin-like receptor 4 isoform X1
NM_001252577.1	NP_001239506.1	killer cell lectin-like receptor 4 isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Klra9	NP_034781.2
Mus musculus (house mouse)	Klra21	NP_444381.1
Mus musculus (house mouse)	Klra3	NP_034778.2
Mus musculus (house mouse)	Klra1	NP_057868.2
Mus musculus (house mouse)	Klra4	NP_034779.1
Mus musculus (house mouse)	Gm15854	XP_003688868.1
Mus musculus (house mouse)	Klra6	NP_032490.1
Mus musculus (house mouse)	Klra10	NP_032485.2
Mus musculus (house mouse)	Klra7	NP_001103793.1
Mus musculus (house mouse)	Klra5	NP_032489.1
Mus musculus (house mouse)	Klra8	NP_034780.1
Rattus norvegicus (Norway rat)	Klra2	NP_001009718.1

Gene Ontology
Bibliography

Related articles in PubMed

Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection.
Nabekura T, Lanier LL
Immunity45(1)74-82(2016 07)

Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation.
Liu J, Liu S, Xia M, Xu S, Wang C, Bao Y, Jiang M, Wu Y, Xu T, Cao X
Proceedings of the National Academy of Sciences of the United States of America110(19)7814-9(2013 May)

The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection.
Schenkel AR, Kingry LC, Slayden RA
Frontiers in immunology490(2013)

DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo.
Tassi I, Le Friec G, Gilfillan S, Takai T, Yokoyama WM, Colonna M
European journal of immunology39(4)1129-35(2009 Apr)

Ly49D engagement on T lymphocytes induces TCR-independent activation and CD8 effector functions that control tumor growth.
Merck E, Voyle RB, MacDonald HR
Journal of immunology (Baltimore, Md. : 1950)182(1)183-92(2009 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that after mouse cytomegalovirus infection, Ly49D augmented IFN-gamma production by virus-specific Ly49H(+) NK cells and preferentially promoted the generation of memory Ly49H(+) NK cells
Title: Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection.

these data demonstrate that DAP10 does associate with Ly49H and Ly49D in primary NK cells.
Title: DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo.

Ly49D stimulation triggers cellular activation of CD4 and CD8 populations; Ly49D recognizes the classical hamster class I molecule Hm1-C4 on CHO cells, as demonstrated by the killing of Hm1-C4-transfected thymoma cells by Ly49D cytotoxic T cells.
Title: Ly49D engagement on T lymphocytes induces TCR-independent activation and CD8 effector functions that control tumor growth.

The MHC class I receptor Ly49D expressed on immature B cells recognizes MHC class I on peripheral tissues, inducing secretion of low levels of IFN-gamma and thereby down-regulating immature B cell homing to the lymph nodes or to sites of inflammation.
Title: Ly49D receptor expressed on immature B cells regulates their IFN-gamma secretion, actin polymerization, and homing.

Glycosylation of Ly-49D at amino acid residues NTT221-23 reduces receptor binding to H-2Dd tetramers and may represent a mechanism by which natural killer cells regulate affinity for host class I ligands.
Title: Receptor glycosylation regulates Ly-49 binding to MHC class I.

The following Klra4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klra4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18485	NM_001252577.1 Latest version!	Mus musculus killer cell lectin-like receptor, subfamily A, member 4 (Klra4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu18486	NM_010649.3 Latest version!	Mus musculus killer cell lectin-like receptor, subfamily A, member 4 (Klra4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu18485	XM_006505646.2 Latest version!	Mus musculus killer cell lectin-like receptor, subfamily A, member 4 (Klra4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu18485	XM_006505646.1	Mus musculus killer cell lectin-like receptor, subfamily A, member 4 (Klra4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klra4 ( NM_001252577.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001239506.1 Mus musculus killer cell lectin-like receptor, subfamily A, member 4 (Klra4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu18485
Clone ID Related Accession (Same CDS sequence)	XM_006505646.2 , XM_006505646.1 , NM_001252577.1
Accession Version	NM_001252577.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor 4 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK080171.1. On Apr 24, 2014 this sequence version replaced NM_001039118.1. Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK080171.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849381 [ECO:0000350] ##Evidence-Data-END##

ATGACTGAAC AGGAAGACAC TTTCTCAGCT GTGAGATTCC ATAAGTCTTC AGGGTTGCAG 
AACGAGATGA GGCTCAAGGA GACACGGAAG CCTGAAAAAG CTCGCCTCAG AGTGTGTTCA 
GTTCCCTGGC AGCTCATTGT GATAGCTCTC GGGATCCTCA TTTCCCTTCG ACTGGTAACT 
GTTGCAGTGC TTATGACAAA CATTTTTCAG TATGGTCAAC AAAAACATGA ACTGAAGGAA 
TTTCTAAAAC ACCACAATAA CTGCAGCATC ATGCAAAGTG ACATCAACTT GAAGGATGAA 
CTGCTGAAAA ATAAGTCTAT AGAGTGTAAT CTTCTGGAAT CCCTCAACAG GGATCAAAAC 
ATACTGTGTG ATAAAACCAG GACTGTTTTA GATTACTTAC AGCACACAGG CAGAGGTGTT 
AAAGTATACT GGTTCTGTTA TGGTATGAAA TGTTATTATT TCGTCATGGA CAGAAAACCA 
TGGAGTAGAT GTAAACAGAG CTGCCAGAAT TCCAGCTTAA CCCTTCTGAA GATAGATGAT 
GAGGATGAAC TGAAGTTCCT TCAGCTCGTG GTTCCTTCAG ACAGTTGCTG GATTGGATTG 
TCATATGATA ATAAGAAAAA AGATTGGGCA TGGATTGACA ATCGCCCATC TAAACTTGCC 
TTGAACACAA CGAAATACAA TATAAGAGAT GGAGGATGTA TGTTCTTATC TAAAACTAGA 
CTAGACAATA ATTACTGTGA TCAATCATTC ATCTGTATTT GTGGGAAGAG ATTGGACAAA 
TTCCCTCATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001239506.1
CDS	146..937
Translation	MTEQEDTFSAVRFHKSSGLQNEMRLKETRKPEKARLRVCSVPWQLIVIALGILISLRLVTVAVLMTNIFQYGQQKHELKEFLKHHNNCSIMQSDINLKDELLKNKSIECNLLESLNRDQNILCDKTRTVLDYLQHTGRGVKVYWFCYGMKCYYFVMDRKPWSRCKQSCQNSSLTLLKIDDEDELKFLQLVVPSDSCWIGLSYDNKKKDWAWIDNRPSKLALNTTKYNIRDGGCMFLSKTRLDNNYCDQSFICICGKRLDKFPH

Target ORF information:

RefSeq Version	NM_001252577.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor, subfamily A, member 4 (Klra4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001252577.1

ORF Insert Sequence:

ATGACTGAAC AGGAAGACAC TTTCTCAGCT GTGAGATTCC ATAAGTCTTC AGGGTTGCAG 
AACGAGATGA GGCTCAAGGA GACACGGAAG CCTGAAAAAG CTCGCCTCAG AGTGTGTTCA 
GTTCCCTGGC AGCTCATTGT GATAGCTCTC GGGATCCTCA TTTCCCTTCG ACTGGTAACT 
GTTGCAGTGC TTATGACAAA CATTTTTCAG TATGGTCAAC AAAAACATGA ACTGAAGGAA 
TTTCTAAAAC ACCACAATAA CTGCAGCATC ATGCAAAGTG ACATCAACTT GAAGGATGAA 
CTGCTGAAAA ATAAGTCTAT AGAGTGTAAT CTTCTGGAAT CCCTCAACAG GGATCAAAAC 
ATACTGTGTG ATAAAACCAG GACTGTTTTA GATTACTTAC AGCACACAGG CAGAGGTGTT 
AAAGTATACT GGTTCTGTTA TGGTATGAAA TGTTATTATT TCGTCATGGA CAGAAAACCA 
TGGAGTAGAT GTAAACAGAG CTGCCAGAAT TCCAGCTTAA CCCTTCTGAA GATAGATGAT 
GAGGATGAAC TGAAGTTCCT TCAGCTCGTG GTTCCTTCAG ACAGTTGCTG GATTGGATTG 
TCATATGATA ATAAGAAAAA AGATTGGGCA TGGATTGACA ATCGCCCATC TAAACTTGCC 
TTGAACACAA CGAAATACAA TATAAGAGAT GGAGGATGTA TGTTCTTATC TAAAACTAGA 
CTAGACAATA ATTACTGTGA TCAATCATTC ATCTGTATTT GTGGGAAGAG ATTGGACAAA 
TTCCCTCATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klra4 ( NM_010649.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034779.1 Mus musculus killer cell lectin-like receptor, subfamily A, member 4 (Klra4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18486
Clone ID Related Accession (Same CDS sequence)	NM_010649.3
Accession Version	NM_010649.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor 4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK080171.1, U10090.1 and AC090127.11. On Nov 19, 2011 this sequence version replaced NM_010649.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U10090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849388, SAMN01164133 [ECO:0000348] ##Evidence-Data-END##

ATGACTGAAC AGGAAGACAC TTTCTCAGCT GTGAGATTCC ATAAGTCTTC AGGGTTGCAG 
AACGAGATGA GGCTCAAGGA GACACGGAAG CCTGAAAAAG CTCGCCTCAG AGTTCCCTGG 
CAGCTCATTG TGATAGCTCT CGGGATCCTC ATTTCCCTTC GACTGGTAAC TGTTGCAGTG 
CTTATGACAA ACATTTTTCA GTATGGTCAA CAAAAACATG AACTGAAGGA ATTTCTAAAA 
CACCACAATA ACTGCAGCAT CATGCAAAGT GACATCAACT TGAAGGATGA ACTGCTGAAA 
AATAAGTCTA TAGAGTGTAA TCTTCTGGAA TCCCTCAACA GGGATCAAAA CATACTGTGT 
GATAAAACCA GGACTGTTTT AGATTACTTA CAGCACACAG GCAGAGGTGT TAAAGTATAC 
TGGTTCTGTT ATGGTATGAA ATGTTATTAT TTCGTCATGG ACAGAAAACC ATGGAGTAGA 
TGTAAACAGA GCTGCCAGAA TTCCAGCTTA ACCCTTCTGA AGATAGATGA TGAGGATGAA 
CTGAAGTTCC TTCAGCTCGT GGTTCCTTCA GACAGTTGCT GGATTGGATT GTCATATGAT 
AATAAGAAAA AAGATTGGGC ATGGATTGAC AATCGCCCAT CTAAACTTGC CTTGAACACA 
ACGAAATACA ATATAAGAGA TGGAGGATGT ATGTTCTTAT CTAAAACTAG ACTAGACAAT 
AATTACTGTG ATCAATCATT CATCTGTATT TGTGGGAAGA GATTGGACAA ATTCCCTCAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034779.1
CDS	158..940
Translation	MTEQEDTFSAVRFHKSSGLQNEMRLKETRKPEKARLRVPWQLIVIALGILISLRLVTVAVLMTNIFQYGQQKHELKEFLKHHNNCSIMQSDINLKDELLKNKSIECNLLESLNRDQNILCDKTRTVLDYLQHTGRGVKVYWFCYGMKCYYFVMDRKPWSRCKQSCQNSSLTLLKIDDEDELKFLQLVVPSDSCWIGLSYDNKKKDWAWIDNRPSKLALNTTKYNIRDGGCMFLSKTRLDNNYCDQSFICICGKRLDKFPH

Target ORF information:

RefSeq Version	NM_010649.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor, subfamily A, member 4 (Klra4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010649.3

ORF Insert Sequence:

ATGACTGAAC AGGAAGACAC TTTCTCAGCT GTGAGATTCC ATAAGTCTTC AGGGTTGCAG 
AACGAGATGA GGCTCAAGGA GACACGGAAG CCTGAAAAAG CTCGCCTCAG AGTTCCCTGG 
CAGCTCATTG TGATAGCTCT CGGGATCCTC ATTTCCCTTC GACTGGTAAC TGTTGCAGTG 
CTTATGACAA ACATTTTTCA GTATGGTCAA CAAAAACATG AACTGAAGGA ATTTCTAAAA 
CACCACAATA ACTGCAGCAT CATGCAAAGT GACATCAACT TGAAGGATGA ACTGCTGAAA 
AATAAGTCTA TAGAGTGTAA TCTTCTGGAA TCCCTCAACA GGGATCAAAA CATACTGTGT 
GATAAAACCA GGACTGTTTT AGATTACTTA CAGCACACAG GCAGAGGTGT TAAAGTATAC 
TGGTTCTGTT ATGGTATGAA ATGTTATTAT TTCGTCATGG ACAGAAAACC ATGGAGTAGA 
TGTAAACAGA GCTGCCAGAA TTCCAGCTTA ACCCTTCTGA AGATAGATGA TGAGGATGAA 
CTGAAGTTCC TTCAGCTCGT GGTTCCTTCA GACAGTTGCT GGATTGGATT GTCATATGAT 
AATAAGAAAA AAGATTGGGC ATGGATTGAC AATCGCCCAT CTAAACTTGC CTTGAACACA 
ACGAAATACA ATATAAGAGA TGGAGGATGT ATGTTCTTAT CTAAAACTAG ACTAGACAAT 
AATTACTGTG ATCAATCATT CATCTGTATT TGTGGGAAGA GATTGGACAA ATTCCCTCAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klra4 ( XM_006505646.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006505709.1 Mus musculus killer cell lectin-like receptor, subfamily A, member 4 (Klra4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu18485
Clone ID Related Accession (Same CDS sequence)	XM_006505646.2 , XM_006505646.1 , NM_001252577.1
Accession Version	XM_006505646.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTGAAC AGGAAGACAC TTTCTCAGCT GTGAGATTCC ATAAGTCTTC AGGGTTGCAG 
AACGAGATGA GGCTCAAGGA GACACGGAAG CCTGAAAAAG CTCGCCTCAG AGTGTGTTCA 
GTTCCCTGGC AGCTCATTGT GATAGCTCTC GGGATCCTCA TTTCCCTTCG ACTGGTAACT 
GTTGCAGTGC TTATGACAAA CATTTTTCAG TATGGTCAAC AAAAACATGA ACTGAAGGAA 
TTTCTAAAAC ACCACAATAA CTGCAGCATC ATGCAAAGTG ACATCAACTT GAAGGATGAA 
CTGCTGAAAA ATAAGTCTAT AGAGTGTAAT CTTCTGGAAT CCCTCAACAG GGATCAAAAC 
ATACTGTGTG ATAAAACCAG GACTGTTTTA GATTACTTAC AGCACACAGG CAGAGGTGTT 
AAAGTATACT GGTTCTGTTA TGGTATGAAA TGTTATTATT TCGTCATGGA CAGAAAACCA 
TGGAGTAGAT GTAAACAGAG CTGCCAGAAT TCCAGCTTAA CCCTTCTGAA GATAGATGAT 
GAGGATGAAC TGAAGTTCCT TCAGCTCGTG GTTCCTTCAG ACAGTTGCTG GATTGGATTG 
TCATATGATA ATAAGAAAAA AGATTGGGCA TGGATTGACA ATCGCCCATC TAAACTTGCC 
TTGAACACAA CGAAATACAA TATAAGAGAT GGAGGATGTA TGTTCTTATC TAAAACTAGA 
CTAGACAATA ATTACTGTGA TCAATCATTC ATCTGTATTT GTGGGAAGAG ATTGGACAAA 
TTCCCTCATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006505709.1
CDS	145..936
Translation	MTEQEDTFSAVRFHKSSGLQNEMRLKETRKPEKARLRVCSVPWQLIVIALGILISLRLVTVAVLMTNIFQYGQQKHELKEFLKHHNNCSIMQSDINLKDELLKNKSIECNLLESLNRDQNILCDKTRTVLDYLQHTGRGVKVYWFCYGMKCYYFVMDRKPWSRCKQSCQNSSLTLLKIDDEDELKFLQLVVPSDSCWIGLSYDNKKKDWAWIDNRPSKLALNTTKYNIRDGGCMFLSKTRLDNNYCDQSFICICGKRLDKFPH

Target ORF information:

RefSeq Version	XM_006505646.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor, subfamily A, member 4 (Klra4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006505646.1

ORF Insert Sequence:

ATGACTGAAC AGGAAGACAC TTTCTCAGCT GTGAGATTCC ATAAGTCTTC AGGGTTGCAG 
AACGAGATGA GGCTCAAGGA GACACGGAAG CCTGAAAAAG CTCGCCTCAG AGTGTGTTCA 
GTTCCCTGGC AGCTCATTGT GATAGCTCTC GGGATCCTCA TTTCCCTTCG ACTGGTAACT 
GTTGCAGTGC TTATGACAAA CATTTTTCAG TATGGTCAAC AAAAACATGA ACTGAAGGAA 
TTTCTAAAAC ACCACAATAA CTGCAGCATC ATGCAAAGTG ACATCAACTT GAAGGATGAA 
CTGCTGAAAA ATAAGTCTAT AGAGTGTAAT CTTCTGGAAT CCCTCAACAG GGATCAAAAC 
ATACTGTGTG ATAAAACCAG GACTGTTTTA GATTACTTAC AGCACACAGG CAGAGGTGTT 
AAAGTATACT GGTTCTGTTA TGGTATGAAA TGTTATTATT TCGTCATGGA CAGAAAACCA 
TGGAGTAGAT GTAAACAGAG CTGCCAGAAT TCCAGCTTAA CCCTTCTGAA GATAGATGAT 
GAGGATGAAC TGAAGTTCCT TCAGCTCGTG GTTCCTTCAG ACAGTTGCTG GATTGGATTG 
TCATATGATA ATAAGAAAAA AGATTGGGCA TGGATTGACA ATCGCCCATC TAAACTTGCC 
TTGAACACAA CGAAATACAA TATAAGAGAT GGAGGATGTA TGTTCTTATC TAAAACTAGA 
CTAGACAATA ATTACTGTGA TCAATCATTC ATCTGTATTT GTGGGAAGAG ATTGGACAAA 
TTCCCTCATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klra4 ( XM_006505646.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006505709.1 Mus musculus killer cell lectin-like receptor, subfamily A, member 4 (Klra4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu18485
Clone ID Related Accession (Same CDS sequence)	XM_006505646.2 , XM_006505646.1 , NM_001252577.1
Accession Version	XM_006505646.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006505646.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTGAAC AGGAAGACAC TTTCTCAGCT GTGAGATTCC ATAAGTCTTC AGGGTTGCAG 
AACGAGATGA GGCTCAAGGA GACACGGAAG CCTGAAAAAG CTCGCCTCAG AGTGTGTTCA 
GTTCCCTGGC AGCTCATTGT GATAGCTCTC GGGATCCTCA TTTCCCTTCG ACTGGTAACT 
GTTGCAGTGC TTATGACAAA CATTTTTCAG TATGGTCAAC AAAAACATGA ACTGAAGGAA 
TTTCTAAAAC ACCACAATAA CTGCAGCATC ATGCAAAGTG ACATCAACTT GAAGGATGAA 
CTGCTGAAAA ATAAGTCTAT AGAGTGTAAT CTTCTGGAAT CCCTCAACAG GGATCAAAAC 
ATACTGTGTG ATAAAACCAG GACTGTTTTA GATTACTTAC AGCACACAGG CAGAGGTGTT 
AAAGTATACT GGTTCTGTTA TGGTATGAAA TGTTATTATT TCGTCATGGA CAGAAAACCA 
TGGAGTAGAT GTAAACAGAG CTGCCAGAAT TCCAGCTTAA CCCTTCTGAA GATAGATGAT 
GAGGATGAAC TGAAGTTCCT TCAGCTCGTG GTTCCTTCAG ACAGTTGCTG GATTGGATTG 
TCATATGATA ATAAGAAAAA AGATTGGGCA TGGATTGACA ATCGCCCATC TAAACTTGCC 
TTGAACACAA CGAAATACAA TATAAGAGAT GGAGGATGTA TGTTCTTATC TAAAACTAGA 
CTAGACAATA ATTACTGTGA TCAATCATTC ATCTGTATTT GTGGGAAGAG ATTGGACAAA 
TTCCCTCATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006505709.1
CDS	188..979
Translation	MTEQEDTFSAVRFHKSSGLQNEMRLKETRKPEKARLRVCSVPWQLIVIALGILISLRLVTVAVLMTNIFQYGQQKHELKEFLKHHNNCSIMQSDINLKDELLKNKSIECNLLESLNRDQNILCDKTRTVLDYLQHTGRGVKVYWFCYGMKCYYFVMDRKPWSRCKQSCQNSSLTLLKIDDEDELKFLQLVVPSDSCWIGLSYDNKKKDWAWIDNRPSKLALNTTKYNIRDGGCMFLSKTRLDNNYCDQSFICICGKRLDKFPH

Target ORF information:

RefSeq Version	XM_006505646.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor, subfamily A, member 4 (Klra4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006505646.2

ORF Insert Sequence:

ATGACTGAAC AGGAAGACAC TTTCTCAGCT GTGAGATTCC ATAAGTCTTC AGGGTTGCAG 
AACGAGATGA GGCTCAAGGA GACACGGAAG CCTGAAAAAG CTCGCCTCAG AGTGTGTTCA 
GTTCCCTGGC AGCTCATTGT GATAGCTCTC GGGATCCTCA TTTCCCTTCG ACTGGTAACT 
GTTGCAGTGC TTATGACAAA CATTTTTCAG TATGGTCAAC AAAAACATGA ACTGAAGGAA 
TTTCTAAAAC ACCACAATAA CTGCAGCATC ATGCAAAGTG ACATCAACTT GAAGGATGAA 
CTGCTGAAAA ATAAGTCTAT AGAGTGTAAT CTTCTGGAAT CCCTCAACAG GGATCAAAAC 
ATACTGTGTG ATAAAACCAG GACTGTTTTA GATTACTTAC AGCACACAGG CAGAGGTGTT 
AAAGTATACT GGTTCTGTTA TGGTATGAAA TGTTATTATT TCGTCATGGA CAGAAAACCA 
TGGAGTAGAT GTAAACAGAG CTGCCAGAAT TCCAGCTTAA CCCTTCTGAA GATAGATGAT 
GAGGATGAAC TGAAGTTCCT TCAGCTCGTG GTTCCTTCAG ACAGTTGCTG GATTGGATTG 
TCATATGATA ATAAGAAAAA AGATTGGGCA TGGATTGACA ATCGCCCATC TAAACTTGCC 
TTGAACACAA CGAAATACAA TATAAGAGAT GGAGGATGTA TGTTCTTATC TAAAACTAGA 
CTAGACAATA ATTACTGTGA TCAATCATTC ATCTGTATTT GTGGGAAGAG ATTGGACAAA 
TTCCCTCATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection.
Immunity45(1)74-82(2016 07)
Nabekura T,Lanier LL

Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation.
Proceedings of the National Academy of Sciences of the United States of America110(19)7814-9(2013 May)
Liu J,Liu S,Xia M,Xu S,Wang C,Bao Y,Jiang M,Wu Y,Xu T,Cao X

The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection.
Frontiers in immunology490(2013)
Schenkel AR,Kingry LC,Slayden RA

DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo.
European journal of immunology39(4)1129-35(2009 Apr)
Tassi I,Le Friec G,Gilfillan S,Takai T,Yokoyama WM,Colonna M

Ly49D engagement on T lymphocytes induces TCR-independent activation and CD8 effector functions that control tumor growth.
Journal of immunology (Baltimore, Md. : 1950)182(1)183-92(2009 Jan)
Merck E,Voyle RB,MacDonald HR