Klk1b24 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klk1b24
Entrez Gene ID	16617
Full Name	kallikrein 1-related peptidase b24
Synonyms	Klk24,mGk-24
General protein information	Preferred Names kallikrein 1-related peptidase b24 Names kallikrein 1-related peptidase b24 glandular kallikrein K24 tissue kallikrein 24
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B3\|7 28.7 cM
Summary	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010643.2	NP_034773.1	kallikrein 1-related peptidase b24 preproprotein
XM_006540674.3	XP_006540737.1	kallikrein 1-related peptidase b24 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Klk1b5	NP_032482.1
Mus musculus (house mouse)	Klk1b1	NP_034775.1
Mus musculus (house mouse)	Klk1b3	NP_032719.1
Mus musculus (house mouse)	Klk1b24	NP_034773.1
Mus musculus (house mouse)	Klk1b26	NP_034774.1
Mus musculus (house mouse)	Klk1b4	NP_035045.2
Mus musculus (house mouse)	Klk1b22	NP_034244.1
Mus musculus (house mouse)	Klk1b8	NP_032483.1
Mus musculus (house mouse)	Klk1b21	NP_034772.1
Mus musculus (house mouse)	Klk1b27	NP_064664.1
Homo sapiens (human)	KLK3	NP_001639.1
Mus musculus (house mouse)	Klk1b16	NP_032480.1
Mus musculus (house mouse)	Klk1b11	NP_034770.1
	KLK3	NP_001036241.1
Mus musculus (house mouse)	Klk1	NP_034769.4
Mus musculus (house mouse)	Klk1b9	NP_034246.1

Gene Ontology
Bibliography

Related articles in PubMed

Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome.
Isbel L, Srivastava R, Oey H, Spurling A, Daxinger L, Puthalakath H, Whitelaw E
PLoS genetics11(12)e1005693(2015 Dec)

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.
Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM
Biological chemistry387(6)637-41(2006 Jun)

Characterization of mouse glandular kallikrein 24 expressed in testicular Leydig cells.
Matsui H, Takano N, Takahashi T
The international journal of biochemistry & cell biology37(11)2333-43(2005 Nov)

Single-chain tissue-type plasminogen activator is a substrate of mouse glandular kallikrein 24.
Matsui H, Takano N, Moriyama A, Takahashi T
Zoological science22(10)1105-11(2005 Oct)

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.
Olsson AY, Lilja H, Lundwall A
Genomics84(1)147-56(2004 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that kallikrein 24 may play a role in the degradation of extracellular matrix proteins in the interstitial area surrounding the Leydig cells of the adult mouse testis.
Title: Characterization of mouse glandular kallikrein 24 expressed in testicular Leydig cells.

mK24 may play a role in the degradation of extracellular matrix proteins in the interstitial area surrounding the Leydig cells of the adult mouse testis.
Title: Single-chain tissue-type plasminogen activator is a substrate of mouse glandular kallikrein 24.

The following Klk1b24 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klk1b24 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06523	NM_010643.2 Latest version!	Mus musculus kallikrein 1-related peptidase b24 (Klk1b24), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu38709	XM_006540674.3 Latest version!	Mus musculus kallikrein 1-related peptidase b24 (Klk1b24), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klk1b24 ( NM_010643.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034773.1 Mus musculus kallikrein 1-related peptidase b24 (Klk1b24), mRNA.

Price & Availability↑

CloneID	OMu06523
Clone ID Related Accession (Same CDS sequence)	NM_010643.2
Accession Version	NM_010643.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	kallikrein 1-related peptidase b24 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC146019.1 and AB039277.1. On Feb 24, 2016 this sequence version replaced NM_010643.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC146015.1, BF540391.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGTTCC TGATCCTGTT CCTAGCCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
GTCCAGTCTC GTGTGGTTGG AGGATTCAAA TGTGAGAAGA ATTCCCAACC CTGGCATGTG 
GCTGTGTTCC GCTACAACAA ATATATATGC GGGGGAGTCC TGTTGAACCC CAACTGGGTT 
CTCACAGCTG CCCACTGCTA TGGCAATGCC ACCAGCCAGT ATAATGTTTG GCTGGGCAAA 
AACAAGCTAT TCCAACGTGA ACCCTCTGCT CAGCACCGAT GGGTCAGCAA AAGCTTCCCT 
CACCCTGACT ACAACATGAG CCTCCTGAAT GATGACATCC CGCAACCTAA GGACAAGAGC 
AATGACCTGA TGCTGCTCCG TCTCAGCGAG CCTGCTGACA TCACAGATGC TGTGAAGCCC 
ATCGACCTGC CCACTGAGGA GCCCAAGCTG GGGAGCACAT GCCTAGCCTC AGGCTGGGGC 
AGCATTACAC CCACGAAATG GCAAAAGCCA AATGACCTTC AGTGTGTGTT CATCAAGCTC 
CTGCCCAATG AGAACTGTAC CAAACCCTAC TTACATAAAG TCACAGATGT CATGCTGTGT 
GCAGGAGAGA TGGGTGGAGG CAAAGACACT TGTGCGGGTG ACTCAGGAGG CCCACTGATC 
TGTGATGGTA TTCTCCACGG TATCACATCA TGGGGTCCTG TCCCATGTGG TAAACCCAAT 
GCGCCGGCCA TCTACACCAA ACTTATTAAG TTTGCCTCCT GGATAAAAGA CACTATGGCC 
AAAAACCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034773.1
CDS	38..829
Translation	MWFLILFLALSLGGIDAAPPVQSRVVGGFKCEKNSQPWHVAVFRYNKYICGGVLLNPNWVLTAAHCYGNATSQYNVWLGKNKLFQREPSAQHRWVSKSFPHPDYNMSLLNDDIPQPKDKSNDLMLLRLSEPADITDAVKPIDLPTEEPKLGSTCLASGWGSITPTKWQKPNDLQCVFIKLLPNENCTKPYLHKVTDVMLCAGEMGGGKDTCAGDSGGPLICDGILHGITSWGPVPCGKPNAPAIYTKLIKFASWIKDTMAKNP

Target ORF information:

RefSeq Version	NM_010643.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus kallikrein 1-related peptidase b24 (Klk1b24), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010643.2

ORF Insert Sequence:

ATGTGGTTCC TGATCCTGTT CCTAGCCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
GTCCAGTCTC GTGTGGTTGG AGGATTCAAA TGTGAGAAGA ATTCCCAACC CTGGCATGTG 
GCTGTGTTCC GCTACAACAA ATATATATGC GGGGGAGTCC TGTTGAACCC CAACTGGGTT 
CTCACAGCTG CCCACTGCTA TGGCAATGCC ACCAGCCAGT ATAATGTTTG GCTGGGCAAA 
AACAAGCTAT TCCAACGTGA ACCCTCTGCT CAGCACCGAT GGGTCAGCAA AAGCTTCCCT 
CACCCTGACT ACAACATGAG CCTCCTGAAT GATGACATCC CGCAACCTAA GGACAAGAGC 
AATGACCTGA TGCTGCTCCG TCTCAGCGAG CCTGCTGACA TCACAGATGC TGTGAAGCCC 
ATCGACCTGC CCACTGAGGA GCCCAAGCTG GGGAGCACAT GCCTAGCCTC AGGCTGGGGC 
AGCATTACAC CCACGAAATG GCAAAAGCCA AATGACCTTC AGTGTGTGTT CATCAAGCTC 
CTGCCCAATG AGAACTGTAC CAAACCCTAC TTACATAAAG TCACAGATGT CATGCTGTGT 
GCAGGAGAGA TGGGTGGAGG CAAAGACACT TGTGCGGGTG ACTCAGGAGG CCCACTGATC 
TGTGATGGTA TTCTCCACGG TATCACATCA TGGGGTCCTG TCCCATGTGG TAAACCCAAT 
GCGCCGGCCA TCTACACCAA ACTTATTAAG TTTGCCTCCT GGATAAAAGA CACTATGGCC 
AAAAACCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klk1b24 ( XM_006540674.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006540737.1 Mus musculus kallikrein 1-related peptidase b24 (Klk1b24), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu38709
Clone ID Related Accession (Same CDS sequence)	XM_006540674.3
Accession Version	XM_006540674.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	kallikrein 1-related peptidase b24 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006540674.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGTTCC TGATCCTGTT CCTAGCCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
GTCCAGTCTC GTGTGGTTGG AGGATTCAAA TGTGAGAAGA ATTCCCAACC CTGGCATGTG 
GCTGTGTTCC GCTACAACAA ATATATATGC GGGGGAGTCC TGTTGAACCC CAACTGGGTT 
CTCACAGCTG CCCACTGCTA TGGCAACCAG TATAATGTTT GGCTGGGCAA AAACAAGCTA 
TTCCAACGTG AACCCTCTGC TCAGCACCGA TGGGTCAGCA AAAGCTTCCC TCACCCTGAC 
TACAACATGA GCCTCCTGAA TGATGACATC CCGCAACCTA AGGACAAGAG CAATGACCTG 
ATGCTGCTCC GTCTCAGCGA GCCTGCTGAC ATCACAGATG CTGTGAAGCC CATCGACCTG 
CCCACTGAGG AGCCCAAGCT GGGGAGCACA TGCCTAGCCT CAGGCTGGGG CAGCATTACA 
CCCACGAAAT GGCAAAAGCC AAATGACCTT CAGTGTGTGT TCATCAAGCT CCTGCCCAAT 
GAGAACTGTA CCAAACCCTA CTTACATAAA GTCACAGATG TCATGCTGTG TGCAGGAGAG 
ATGGGTGGAG GCAAAGACAC TTGTGCGGGT GACTCAGGAG GCCCACTGAT CTGTGATGGT 
ATTCTCCACG GTATCACATC ATGGGGTCCT GTCCCATGTG GTAAACCCAA TGCGCCGGCC 
ATCTACACCA AACTTATTAA GTTTGCCTCC TGGATAAAAG ACACTATGGC CAAAAACCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006540737.1
CDS	40..822
Translation	MWFLILFLALSLGGIDAAPPVQSRVVGGFKCEKNSQPWHVAVFRYNKYICGGVLLNPNWVLTAAHCYGNQYNVWLGKNKLFQREPSAQHRWVSKSFPHPDYNMSLLNDDIPQPKDKSNDLMLLRLSEPADITDAVKPIDLPTEEPKLGSTCLASGWGSITPTKWQKPNDLQCVFIKLLPNENCTKPYLHKVTDVMLCAGEMGGGKDTCAGDSGGPLICDGILHGITSWGPVPCGKPNAPAIYTKLIKFASWIKDTMAKNP

Target ORF information:

RefSeq Version	XM_006540674.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus kallikrein 1-related peptidase b24 (Klk1b24), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006540674.3

ORF Insert Sequence:

ATGTGGTTCC TGATCCTGTT CCTAGCCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
GTCCAGTCTC GTGTGGTTGG AGGATTCAAA TGTGAGAAGA ATTCCCAACC CTGGCATGTG 
GCTGTGTTCC GCTACAACAA ATATATATGC GGGGGAGTCC TGTTGAACCC CAACTGGGTT 
CTCACAGCTG CCCACTGCTA TGGCAACCAG TATAATGTTT GGCTGGGCAA AAACAAGCTA 
TTCCAACGTG AACCCTCTGC TCAGCACCGA TGGGTCAGCA AAAGCTTCCC TCACCCTGAC 
TACAACATGA GCCTCCTGAA TGATGACATC CCGCAACCTA AGGACAAGAG CAATGACCTG 
ATGCTGCTCC GTCTCAGCGA GCCTGCTGAC ATCACAGATG CTGTGAAGCC CATCGACCTG 
CCCACTGAGG AGCCCAAGCT GGGGAGCACA TGCCTAGCCT CAGGCTGGGG CAGCATTACA 
CCCACGAAAT GGCAAAAGCC AAATGACCTT CAGTGTGTGT TCATCAAGCT CCTGCCCAAT 
GAGAACTGTA CCAAACCCTA CTTACATAAA GTCACAGATG TCATGCTGTG TGCAGGAGAG 
ATGGGTGGAG GCAAAGACAC TTGTGCGGGT GACTCAGGAG GCCCACTGAT CTGTGATGGT 
ATTCTCCACG GTATCACATC ATGGGGTCCT GTCCCATGTG GTAAACCCAA TGCGCCGGCC 
ATCTACACCA AACTTATTAA GTTTGCCTCC TGGATAAAAG ACACTATGGC CAAAAACCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome.
PLoS genetics11(12)e1005693(2015 Dec)
Isbel L,Srivastava R,Oey H,Spurling A,Daxinger L,Puthalakath H,Whitelaw E

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.
Biological chemistry387(6)637-41(2006 Jun)
Lundwall A,Band V,Blaber M,Clements JA,Courty Y,Diamandis EP,Fritz H,Lilja H,Malm J,Maltais LJ,Olsson AY,Petraki C,Scorilas A,Sotiropoulou G,Stenman UH,Stephan C,Talieri M,Yousef GM

Characterization of mouse glandular kallikrein 24 expressed in testicular Leydig cells.
The international journal of biochemistry & cell biology37(11)2333-43(2005 Nov)
Matsui H,Takano N,Takahashi T

Single-chain tissue-type plasminogen activator is a substrate of mouse glandular kallikrein 24.
Zoological science22(10)1105-11(2005 Oct)
Matsui H,Takano N,Moriyama A,Takahashi T

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.
Genomics84(1)147-56(2004 Jul)
Olsson AY,Lilja H,Lundwall A

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Klk1b24 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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